ES2402540T3 - Derivados de2-oxo-3-bencil-benzoxazol-2-ona y compuestos relacionados como inhibidores de Met-quinasa para el tratamiento de tumores - Google Patents

Derivados de2-oxo-3-bencil-benzoxazol-2-ona y compuestos relacionados como inhibidores de Met-quinasa para el tratamiento de tumores Download PDF

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Publication number
ES2402540T3
ES2402540T3 ES08749391T ES08749391T ES2402540T3 ES 2402540 T3 ES2402540 T3 ES 2402540T3 ES 08749391 T ES08749391 T ES 08749391T ES 08749391 T ES08749391 T ES 08749391T ES 2402540 T3 ES2402540 T3 ES 2402540T3
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ES
Spain
Prior art keywords
oxo
methyl
benzoxazol
phenyl
ylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08749391T
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English (en)
Spanish (es)
Inventor
Oliver Schadt
Dieter Dorsch
Frank Stieber
Andree Blaukat
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Merck Patent GmbH
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Merck Patent GmbH
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Publication date
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Publication of ES2402540T3 publication Critical patent/ES2402540T3/es
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ES08749391T 2007-06-06 2008-05-08 Derivados de2-oxo-3-bencil-benzoxazol-2-ona y compuestos relacionados como inhibidores de Met-quinasa para el tratamiento de tumores Active ES2402540T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007026341A DE102007026341A1 (de) 2007-06-06 2007-06-06 Benzoxazolonderivate
DE102007026341 2007-06-06
PCT/EP2008/003696 WO2008148449A1 (de) 2007-06-06 2008-05-08 2-oxo-3-benzyl-benzoxazol-2-one derivate und verwandte verbindungen als met-kinase inhibitoren zur behandlung von tumoren

Publications (1)

Publication Number Publication Date
ES2402540T3 true ES2402540T3 (es) 2013-05-06

Family

ID=39739806

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08749391T Active ES2402540T3 (es) 2007-06-06 2008-05-08 Derivados de2-oxo-3-bencil-benzoxazol-2-ona y compuestos relacionados como inhibidores de Met-quinasa para el tratamiento de tumores

Country Status (18)

Country Link
US (2) US8071593B2 (cg-RX-API-DMAC7.html)
EP (1) EP2150551B1 (cg-RX-API-DMAC7.html)
JP (1) JP5662143B2 (cg-RX-API-DMAC7.html)
KR (1) KR20100031531A (cg-RX-API-DMAC7.html)
CN (1) CN101679401B (cg-RX-API-DMAC7.html)
AR (1) AR066892A1 (cg-RX-API-DMAC7.html)
AU (1) AU2008258366B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0812293A2 (cg-RX-API-DMAC7.html)
CA (1) CA2689554C (cg-RX-API-DMAC7.html)
DE (1) DE102007026341A1 (cg-RX-API-DMAC7.html)
EA (1) EA200901611A1 (cg-RX-API-DMAC7.html)
ES (1) ES2402540T3 (cg-RX-API-DMAC7.html)
IL (1) IL202505A (cg-RX-API-DMAC7.html)
MX (1) MX2009013077A (cg-RX-API-DMAC7.html)
PE (1) PE20090770A1 (cg-RX-API-DMAC7.html)
TW (1) TW200848030A (cg-RX-API-DMAC7.html)
WO (1) WO2008148449A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201000085B (cg-RX-API-DMAC7.html)

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EP3937919A4 (en) 2019-03-14 2023-04-12 Board of Regents, The University of Texas System SMALL MOLECULES GRB2 STABILIZER FOR INHIBITION OF RAS-MAP KINASE
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Also Published As

Publication number Publication date
CN101679401B (zh) 2012-12-12
EP2150551B1 (de) 2013-01-16
US20110263596A1 (en) 2011-10-27
EP2150551A1 (de) 2010-02-10
TW200848030A (en) 2008-12-16
BRPI0812293A2 (pt) 2014-11-25
CA2689554A1 (en) 2008-12-11
JP5662143B2 (ja) 2015-01-28
ZA201000085B (en) 2010-09-29
WO2008148449A1 (de) 2008-12-11
AR066892A1 (es) 2009-09-16
CN101679401A (zh) 2010-03-24
CA2689554C (en) 2015-12-01
IL202505A (en) 2014-11-30
US8071593B2 (en) 2011-12-06
MX2009013077A (es) 2010-01-15
DE102007026341A1 (de) 2008-12-11
JP2010529051A (ja) 2010-08-26
KR20100031531A (ko) 2010-03-22
AU2008258366B2 (en) 2013-02-21
IL202505A0 (en) 2010-06-30
AU2008258366A1 (en) 2008-12-11
US20100280030A1 (en) 2010-11-04
US8431572B2 (en) 2013-04-30
PE20090770A1 (es) 2009-06-24
EA200901611A1 (ru) 2010-06-30

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