CA2689554C - 2-oxo-3-benzylbenzoxazol-2-one derivatives and related compounds as met kinase inhibitors for the treatment of tumours - Google Patents
2-oxo-3-benzylbenzoxazol-2-one derivatives and related compounds as met kinase inhibitors for the treatment of tumours Download PDFInfo
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- CA2689554C CA2689554C CA2689554A CA2689554A CA2689554C CA 2689554 C CA2689554 C CA 2689554C CA 2689554 A CA2689554 A CA 2689554A CA 2689554 A CA2689554 A CA 2689554A CA 2689554 C CA2689554 C CA 2689554C
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| DE102007026341A DE102007026341A1 (de) | 2007-06-06 | 2007-06-06 | Benzoxazolonderivate |
| DE102007026341.6 | 2007-06-06 | ||
| PCT/EP2008/003696 WO2008148449A1 (de) | 2007-06-06 | 2008-05-08 | 2-oxo-3-benzyl-benzoxazol-2-one derivate und verwandte verbindungen als met-kinase inhibitoren zur behandlung von tumoren |
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| Publication Number | Publication Date |
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| CA2689554A1 CA2689554A1 (en) | 2008-12-11 |
| CA2689554C true CA2689554C (en) | 2015-12-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2689554A Active CA2689554C (en) | 2007-06-06 | 2008-05-08 | 2-oxo-3-benzylbenzoxazol-2-one derivatives and related compounds as met kinase inhibitors for the treatment of tumours |
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| DE102008019907A1 (de) * | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
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| DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
| US9643922B2 (en) * | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
| AU2009283195A1 (en) * | 2008-08-18 | 2010-02-25 | Yale University | MIF modulators |
| US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
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| DE102009003975A1 (de) | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Benzothiazolonderivate |
| WO2012003338A1 (en) | 2010-07-01 | 2012-01-05 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
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| CN103242345B (zh) * | 2012-09-14 | 2015-03-11 | 日出实业集团有限公司 | 甲基吡啶磷中间体6-氯噁唑[4,5-b]吡啶-2(3H)酮的合成方法 |
| AR095883A1 (es) | 2013-04-18 | 2015-11-18 | Astellas Pharma Inc | Compuestos de acetamida heterocíclica |
| US9549988B2 (en) | 2013-06-09 | 2017-01-24 | RJS Biologics | Pharmaceutical compounds targeted by MIF affinity-tethered moieties |
| JP6864953B2 (ja) | 2014-12-09 | 2021-04-28 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Ａｘｌに対するヒトモノクローナル抗体 |
| WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
| KR101798840B1 (ko) | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
| US20200172483A1 (en) * | 2017-06-22 | 2020-06-04 | Curadev Pharma Limited | Heterocyclic small molecule modulators of human sting |
| TWI797176B (zh) | 2017-10-17 | 2023-04-01 | 西班牙商帕羅製藥有限公司 | ４-胺基嘧啶化合物之合成 |
| EP3937919A4 (en) | 2019-03-14 | 2023-04-12 | Board of Regents, The University of Texas System | SMALL MOLECULES GRB2 STABILIZER FOR INHIBITION OF RAS-MAP KINASE |
| CN115490578B (zh) * | 2022-09-23 | 2023-12-22 | 江苏理工学院 | 一种碳同位素标记的三氯生的制备方法 |
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-
2007
- 2007-06-06 DE DE102007026341A patent/DE102007026341A1/de not_active Withdrawn
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2008
- 2008-05-08 CN CN2008800183950A patent/CN101679401B/zh not_active Expired - Fee Related
- 2008-05-08 WO PCT/EP2008/003696 patent/WO2008148449A1/de not_active Ceased
- 2008-05-08 EA EA200901611A patent/EA200901611A1/ru unknown
- 2008-05-08 BR BRPI0812293-8A2A patent/BRPI0812293A2/pt not_active IP Right Cessation
- 2008-05-08 MX MX2009013077A patent/MX2009013077A/es not_active Application Discontinuation
- 2008-05-08 ES ES08749391T patent/ES2402540T3/es active Active
- 2008-05-08 CA CA2689554A patent/CA2689554C/en active Active
- 2008-05-08 KR KR1020107000014A patent/KR20100031531A/ko not_active Withdrawn
- 2008-05-08 EP EP08749391A patent/EP2150551B1/de not_active Not-in-force
- 2008-05-08 JP JP2010510658A patent/JP5662143B2/ja not_active Expired - Fee Related
- 2008-05-08 AU AU2008258366A patent/AU2008258366B2/en not_active Ceased
- 2008-05-08 US US12/663,206 patent/US8071593B2/en not_active Expired - Fee Related
- 2008-06-05 PE PE2008000958A patent/PE20090770A1/es not_active Application Discontinuation
- 2008-06-06 TW TW097121279A patent/TW200848030A/zh unknown
- 2008-06-06 AR ARP080102415A patent/AR066892A1/es unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| CN101679401B (zh) | 2012-12-12 |
| EP2150551B1 (de) | 2013-01-16 |
| US20110263596A1 (en) | 2011-10-27 |
| EP2150551A1 (de) | 2010-02-10 |
| TW200848030A (en) | 2008-12-16 |
| BRPI0812293A2 (pt) | 2014-11-25 |
| CA2689554A1 (en) | 2008-12-11 |
| JP5662143B2 (ja) | 2015-01-28 |
| ZA201000085B (en) | 2010-09-29 |
| WO2008148449A1 (de) | 2008-12-11 |
| AR066892A1 (es) | 2009-09-16 |
| CN101679401A (zh) | 2010-03-24 |
| IL202505A (en) | 2014-11-30 |
| US8071593B2 (en) | 2011-12-06 |
| MX2009013077A (es) | 2010-01-15 |
| DE102007026341A1 (de) | 2008-12-11 |
| JP2010529051A (ja) | 2010-08-26 |
| KR20100031531A (ko) | 2010-03-22 |
| AU2008258366B2 (en) | 2013-02-21 |
| IL202505A0 (en) | 2010-06-30 |
| ES2402540T3 (es) | 2013-05-06 |
| AU2008258366A1 (en) | 2008-12-11 |
| US20100280030A1 (en) | 2010-11-04 |
| US8431572B2 (en) | 2013-04-30 |
| PE20090770A1 (es) | 2009-06-24 |
| EA200901611A1 (ru) | 2010-06-30 |
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