ES2293015T3 - Imidazopirazinas como inhibidores de cinasas dependientes de ciclinas. - Google Patents

Imidazopirazinas como inhibidores de cinasas dependientes de ciclinas. Download PDF

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Publication number
ES2293015T3
ES2293015T3 ES03754658T ES03754658T ES2293015T3 ES 2293015 T3 ES2293015 T3 ES 2293015T3 ES 03754658 T ES03754658 T ES 03754658T ES 03754658 T ES03754658 T ES 03754658T ES 2293015 T3 ES2293015 T3 ES 2293015T3
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Spain
Prior art keywords
group
aryl
alkyl
heteroaryl
chosen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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ES03754658T
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English (en)
Spanish (es)
Inventor
Kamil Paruch
Timothy J. Guzi
Michael P. Dwyer
Ronald J. Doll
Viyyoor M. Girijavallabhan
Alan K. Mallams
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES03754658T 2002-09-23 2003-09-19 Imidazopirazinas como inhibidores de cinasas dependientes de ciclinas. Expired - Lifetime ES2293015T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41299702P 2002-09-23 2002-09-23
US412997P 2002-09-23

Publications (1)

Publication Number Publication Date
ES2293015T3 true ES2293015T3 (es) 2008-03-16

Family

ID=32030951

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03754658T Expired - Lifetime ES2293015T3 (es) 2002-09-23 2003-09-19 Imidazopirazinas como inhibidores de cinasas dependientes de ciclinas.

Country Status (18)

Country Link
US (2) US6919341B2 (enExample)
EP (1) EP1543008B1 (enExample)
JP (1) JP4799864B2 (enExample)
KR (1) KR20050057520A (enExample)
CN (1) CN1694886A (enExample)
AR (1) AR041347A1 (enExample)
AT (1) ATE377600T1 (enExample)
AU (1) AU2003272476B2 (enExample)
CA (1) CA2499756C (enExample)
DE (1) DE60317353T2 (enExample)
ES (1) ES2293015T3 (enExample)
MX (1) MXPA05003120A (enExample)
MY (1) MY134589A (enExample)
NZ (2) NZ563374A (enExample)
PE (1) PE20050081A1 (enExample)
TW (1) TW200413378A (enExample)
WO (1) WO2004026877A1 (enExample)
ZA (1) ZA200502375B (enExample)

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Also Published As

Publication number Publication date
TW200413378A (en) 2004-08-01
DE60317353D1 (de) 2007-12-20
MXPA05003120A (es) 2005-06-22
PE20050081A1 (es) 2005-03-01
JP2006507253A (ja) 2006-03-02
US6919341B2 (en) 2005-07-19
AR041347A1 (es) 2005-05-11
NZ563374A (en) 2009-06-26
EP1543008A1 (en) 2005-06-22
CA2499756A1 (en) 2004-04-01
ATE377600T1 (de) 2007-11-15
DE60317353T2 (de) 2008-08-28
US20040063715A1 (en) 2004-04-01
ZA200502375B (en) 2005-09-27
JP4799864B2 (ja) 2011-10-26
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