ES2273371T3 - Metodo de amplificacion de acido nucleico basado en ramificacion extension (rami) y transcripcion in vitro. - Google Patents

Metodo de amplificacion de acido nucleico basado en ramificacion extension (rami) y transcripcion in vitro. Download PDF

Info

Publication number
ES2273371T3
ES2273371T3 ES97935208T ES97935208T ES2273371T3 ES 2273371 T3 ES2273371 T3 ES 2273371T3 ES 97935208 T ES97935208 T ES 97935208T ES 97935208 T ES97935208 T ES 97935208T ES 2273371 T3 ES2273371 T3 ES 2273371T3
Authority
ES
Spain
Prior art keywords
baselineskip
amplification
nucleic acid
probe
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97935208T
Other languages
English (en)
Spanish (es)
Inventor
David Y. Zhang
Margaret Brandwein
Terence Hsuih
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hamilton Thorne Biosciences Inc
Original Assignee
Hamilton Thorne Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hamilton Thorne Biosciences Inc filed Critical Hamilton Thorne Biosciences Inc
Application granted granted Critical
Publication of ES2273371T3 publication Critical patent/ES2273371T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6862—Ligase chain reaction [LCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ES97935208T 1996-07-31 1997-07-30 Metodo de amplificacion de acido nucleico basado en ramificacion extension (rami) y transcripcion in vitro. Expired - Lifetime ES2273371T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US690494 1996-07-31
US08/690,494 US5942391A (en) 1994-06-22 1996-07-31 Nucleic acid amplification method: ramification-extension amplification method (RAM)

Publications (1)

Publication Number Publication Date
ES2273371T3 true ES2273371T3 (es) 2007-05-01

Family

ID=24772690

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97935208T Expired - Lifetime ES2273371T3 (es) 1996-07-31 1997-07-30 Metodo de amplificacion de acido nucleico basado en ramificacion extension (rami) y transcripcion in vitro.

Country Status (7)

Country Link
US (3) US5942391A (https=)
EP (1) EP0915991B1 (https=)
JP (1) JP2001514483A (https=)
AT (1) ATE339515T1 (https=)
DE (1) DE69736668T2 (https=)
ES (1) ES2273371T3 (https=)
WO (1) WO1998004746A1 (https=)

Families Citing this family (268)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261808B1 (en) * 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US7135312B2 (en) 1993-04-15 2006-11-14 University Of Rochester Circular DNA vectors for synthesis of RNA and DNA
WO2000033244A2 (en) * 1998-11-27 2000-06-08 Synaptics (Uk) Limited Position sensor
US20070269799A9 (en) * 1994-06-22 2007-11-22 Zhang David Y Nucleic acid amplification methods
US6593086B2 (en) * 1996-05-20 2003-07-15 Mount Sinai School Of Medicine Of New York University Nucleic acid amplification methods
US5942391A (en) * 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
DK0862656T3 (da) * 1995-11-21 2001-04-09 Univ Yale Unimolekylær segmentamplifikation og -detektering
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
ATE238434T1 (de) 1995-12-05 2003-05-15 Jorn Erland Koch Eine in kaskaden verlaufende vervielfältigungsreaktion von nukleinsäuren
US20020150921A1 (en) * 1996-02-09 2002-10-17 Francis Barany Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
EP2369007B1 (en) 1996-05-29 2015-07-29 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US20040229221A1 (en) * 1997-05-08 2004-11-18 Trustees Of Columbia University In The City Of New York Method to detect mutations in a nucleic acid using a hybridization-ligation procedure
JP4294740B2 (ja) * 1997-05-23 2009-07-15 ソレクサ・インコーポレイテッド 分析物の系列的プロセシングのためのシステムおよび装置
ATE429517T1 (de) * 1998-03-04 2009-05-15 Biomerieux Bv Vervielfältigung und nachweis von ebv barf1 zur diagnose von nasopharyngealen karzinom
AU3601599A (en) * 1998-03-25 1999-10-18 Ulf Landegren Rolling circle replication of padlock probes
US8063190B2 (en) * 1998-06-02 2011-11-22 Tom Robin Caine Boyde Nucleic acid-linked conjugates and methods for making and using them
EP1090293B2 (en) 1998-06-24 2019-01-23 Illumina, Inc. Decoding of array sensors with microspheres
US6218118B1 (en) * 1998-07-09 2001-04-17 Agilent Technologies, Inc. Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry
WO2000004193A1 (en) * 1998-07-20 2000-01-27 Yale University Method for detecting nucleic acids using target-mediated ligation of bipartite primers
AU5570699A (en) * 1998-08-17 2000-03-06 Packard Bioscience Company Rolling circle-based analysis of polynucleotide sequence
JP3267576B2 (ja) * 1998-11-09 2002-03-18 三光純薬株式会社 プローブ高分子の形成方法
WO2000036141A1 (en) * 1998-12-15 2000-06-22 Diatech Pty. Ltd. A method of amplification of a circularised nucleic acid probe
US6830884B1 (en) * 1998-12-15 2004-12-14 Molecular Staging Inc. Method of amplification
US7033753B1 (en) 1999-01-15 2006-04-25 University Of Rochester Compositions and methods for nonenzymatic ligation of oligonucleotides and detection of genetic polymorphisms
GB9904991D0 (en) * 1999-03-05 1999-04-28 Univ Nottingham Genetic screening
DE60025172T2 (de) * 1999-03-18 2006-09-21 Exiqon A/S Einstufige probezubereitung und bestimmung von nukleinsäure in biologischen proben
US6506594B1 (en) * 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
JP2002541475A (ja) * 1999-04-12 2002-12-03 ナノゲン／ベクトン・ディッキンソン・パートナーシップ 鎖置換増幅およびバイオエレクトロニック・マイクロチップ技術を用いる核酸配列の増幅および分離
US6326173B1 (en) 1999-04-12 2001-12-04 Nanogen/Becton Dickinson Partnership Electronically mediated nucleic acid amplification in NASBA
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
WO2000068434A2 (en) * 1999-05-07 2000-11-16 Yale University Multiple tag analysis
EP1190100B1 (en) * 1999-05-20 2012-07-25 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
JP2003530817A (ja) 1999-06-01 2003-10-21 ベイラー カレッジ オブ メディスン 聴覚障害、変形性関節症および細胞の異常増殖に関するａｔｏｎａｌ関連配列の治療用途のための組成物および方法
US6964847B1 (en) * 1999-07-14 2005-11-15 Packard Biosciences Company Derivative nucleic acids and uses thereof
DE60026641T2 (de) * 1999-07-15 2007-01-25 Qiagen Gmbh Verfahren zur Trennung von teilchenförmigen Substraten aus einer Lösung indem man den Teilchenverlust minimiert
EP1136568A4 (en) 1999-10-04 2004-12-15 Olympus Optical Corp Ltd METHOD FOR DETERMINING NUCLEIC ACID
US7534568B2 (en) 1999-10-29 2009-05-19 Hologic Inc. Methods for detection of a target nucleic acid by forming a cleavage structure with a cleavage resistant probe
US7118860B2 (en) * 1999-10-29 2006-10-10 Stratagene California Methods for detection of a target nucleic acid by capture
US6528254B1 (en) 1999-10-29 2003-03-04 Stratagene Methods for detection of a target nucleic acid sequence
US6248535B1 (en) * 1999-12-20 2001-06-19 University Of Southern California Method for isolation of RNA from formalin-fixed paraffin-embedded tissue specimens
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7361488B2 (en) 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
WO2001057268A2 (en) * 2000-02-07 2001-08-09 Illumina, Inc. Nucleic acid detection methods using universal priming
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
DK1259643T3 (da) * 2000-02-07 2009-02-23 Illumina Inc Fremgangsmåde til detektion af nukleinsyre ved anvendelse af universel priming
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
EP1130113A1 (en) * 2000-02-15 2001-09-05 Johannes Petrus Schouten Multiplex ligation dependent amplification assay
ATE412774T1 (de) 2000-02-16 2008-11-15 Illumina Inc Parallele genotypisierung mehrerer patientenproben
US7205129B1 (en) 2000-02-28 2007-04-17 Qiagen Gmbh Method for reducing artifacts in nucleic acid amplification
DE60141205D1 (de) * 2000-04-03 2010-03-18 Cytyc Corp Nachweis und typisierung des papillomavirus mittels pna-sonden
US6936443B2 (en) * 2000-04-03 2005-08-30 Cytyc Corporation Detection and typing of human papillomavirus using PNA probes
US6368801B1 (en) * 2000-04-12 2002-04-09 Molecular Staging, Inc. Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase
WO2001079548A2 (en) 2000-04-14 2001-10-25 Cornell Research Foundation, Inc. Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction
US6291187B1 (en) 2000-05-12 2001-09-18 Molecular Staging, Inc. Poly-primed amplification of nucleic acid sequences
AU2001265121A1 (en) * 2000-05-30 2001-12-11 Applera Corporation Methods for detecting target nucleic acids using coupled ligation and amplification
US6531283B1 (en) 2000-06-20 2003-03-11 Molecular Staging, Inc. Protein expression profiling
US6323009B1 (en) 2000-06-28 2001-11-27 Molecular Staging, Inc. Multiply-primed amplification of nucleic acid sequences
US6420144B1 (en) 2000-06-28 2002-07-16 Salus Therapeutics, Inc. Method for automated molecular cloning
CA2411794A1 (en) 2000-06-30 2002-01-10 Molecular Staging, Inc. Signal amplification with lollipop probes
DE60131903T2 (de) * 2000-10-24 2008-11-27 The Board of Trustees of the Leland S. Stanford Junior University, Palo Alto Direkte multiplex charakterisierung von genomischer dna
WO2002061133A2 (en) 2000-11-09 2002-08-08 Yale University Nucleic acid detection using structured probes
AR031640A1 (es) * 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
EP1352094B1 (en) * 2001-01-15 2011-03-09 Cytyc Corporation Nucleic acid extraction solution and use thereof
GB0101397D0 (en) * 2001-01-19 2001-03-07 Amersham Pharm Biotech Uk Ltd Suppression of non-specific nucleic acid amplication
GB0104163D0 (en) * 2001-02-20 2001-04-11 Crime Solutions Ltd Security system
US6573051B2 (en) * 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
EP1262563A3 (en) * 2001-05-31 2003-02-05 Takara Bio Inc. Method for immobilizing DNA on a surface
JP4473573B2 (ja) * 2001-07-26 2010-06-02 ストラタジーン カリフォルニア 多部位突然変異誘発
US6977148B2 (en) * 2001-10-15 2005-12-20 Qiagen Gmbh Multiple displacement amplification
US7361489B2 (en) * 2001-10-15 2008-04-22 Mount Sinai School Of Medicine Of New York University Nucleic acid amplification methods
US7297485B2 (en) * 2001-10-15 2007-11-20 Qiagen Gmbh Method for nucleic acid amplification that results in low amplification bias
US20050037353A1 (en) * 2001-10-15 2005-02-17 Zhang David Y. Highly sensitive methods for protein detection in proteomics
US6617137B2 (en) * 2001-10-15 2003-09-09 Molecular Staging Inc. Method of amplifying whole genomes without subjecting the genome to denaturing conditions
US7632671B2 (en) * 2001-11-29 2009-12-15 Sun-Wing Tong Molecular detection and assay by electrobiochip micro-array
CA2467814A1 (en) * 2001-12-03 2003-06-12 Illumina, Inc. Multiplexed methylation detection methods
WO2003060163A2 (en) * 2001-12-28 2003-07-24 Keygene N.V. Discrimination and detection of target nucleotide sequences using mass spectrometry
US8395769B2 (en) * 2002-01-10 2013-03-12 Chemimage Corporation Method for analysis of pathogenic microorganisms using raman spectroscopic techniques
ATE556714T1 (de) 2002-02-01 2012-05-15 Life Technologies Corp Doppelsträngige oligonukleotide
EP1572902B1 (en) 2002-02-01 2014-06-11 Life Technologies Corporation HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US7553619B2 (en) 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
US8030000B2 (en) 2002-02-21 2011-10-04 Alere San Diego, Inc. Recombinase polymerase amplification
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
US7270981B2 (en) 2002-02-21 2007-09-18 Asm Scientific, Inc. Recombinase polymerase amplification
US20030175828A1 (en) * 2002-03-15 2003-09-18 Lazar James G. Signal amplification by Hybrid Capture
US20030236205A1 (en) * 2002-06-21 2003-12-25 Zhang David Y. Hybridization signal amplification method (HSAM) nanostructures for diagnostic and therapeutic uses
AU2003304195B8 (en) 2002-07-15 2008-08-28 Board Of Regents, The University Of Texas System Combinatorial protein library screening by periplasmic expression
KR20120002613A (ko) 2002-08-12 2012-01-06 제네렉스, 인코포레이티드 폭스바이러스 및 암과 관련된 방법 및 조성물
US20040086892A1 (en) * 2002-11-06 2004-05-06 Crothers Donald M. Universal tag assay
EP1567669B1 (en) * 2002-12-02 2010-03-24 Illumina Cambridge Limited Determination of methylation of nucleic acid sequences
WO2004050916A1 (en) * 2002-12-02 2004-06-17 Solexa Limited Recovery of original template
US20040115643A1 (en) * 2002-12-12 2004-06-17 Lizardi Paul M. Thermodynamic equilibrium extension of primers
US20040121338A1 (en) * 2002-12-19 2004-06-24 Alsmadi Osama A. Real-time detection of rolling circle amplification products
US7955795B2 (en) * 2003-06-06 2011-06-07 Qiagen Gmbh Method of whole genome amplification with reduced artifact production
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
US6977153B2 (en) 2002-12-31 2005-12-20 Qiagen Gmbh Rolling circle amplification of RNA
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
US8043834B2 (en) 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
US20040248103A1 (en) * 2003-06-04 2004-12-09 Feaver William John Proximity-mediated rolling circle amplification
US20040248104A1 (en) * 2003-06-05 2004-12-09 Zohar Yakhini Methods and reagents for profiling quantities of nucleic acids
EP1633888B1 (en) 2003-06-17 2009-03-25 Keygene N.V. Means and method for the detection of target nucleotide sequences using ligation assays with improved oligonucleotide probe pairs
WO2005054466A2 (en) 2003-07-25 2005-06-16 Ambion, Inc. Methods and compositions for preparing rna from a fixed sample
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
US20050266417A1 (en) * 2003-09-12 2005-12-01 Francis Barany Methods for identifying target nucleic acid molecules
AU2003295732A1 (en) * 2003-11-21 2005-07-14 Mount Sinai School Of Medicine Of New York University Nucleic acid amplification methods
CA2552949C (en) * 2004-01-07 2012-10-02 Third Wave Technologies, Inc. Determination of hepatitis c virus genotype
WO2005072133A2 (en) * 2004-01-27 2005-08-11 Zoragen, Inc. Nucleic acid detection
US7622281B2 (en) * 2004-05-20 2009-11-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for clonal amplification of nucleic acid
US7566532B1 (en) 2004-07-02 2009-07-28 Quest Diagnostics Investments Incorporated Methods for detecting retroviruses
US7309589B2 (en) 2004-08-20 2007-12-18 Vironix Llc Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing
CA2581086C (en) 2004-09-14 2023-11-07 The Regents Of The University Of Colorado, A Body Corporate Method for treatment with bucindolol based on genetic targeting
MX2007008344A (es) * 2005-01-07 2007-09-06 De Ruiter Seeds R & D Bv Virus de planta designado virus torrado del tomate.
WO2006076650A2 (en) * 2005-01-12 2006-07-20 Applera Corporation Compositions, methods, and kits for selective amplification of nucleic acids
US8309303B2 (en) 2005-04-01 2012-11-13 Qiagen Gmbh Reverse transcription and amplification of RNA with simultaneous degradation of DNA
US7989166B2 (en) * 2005-04-12 2011-08-02 In Situ Rcp A/S Circle probes and their use in the identification of biomolecules
EP1871897B1 (en) * 2005-04-12 2010-09-29 Olink AB Methods for production of oligonucleotides
WO2007096702A2 (en) 2005-07-25 2007-08-30 Asm Scientific, Inc. Methods for multiplexing recombinase polymerase amplification
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
KR101772375B1 (ko) * 2005-09-07 2017-08-29 신라젠(주) Ｇｍ-ｃｓｆ를 발현하는 폭스바이러스를 사용한 전이성 및/또는 전신 파종성 암의 전신 치료법
EP1762627A1 (de) 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
EP1969137B1 (en) 2005-11-22 2011-10-05 Stichting Dienst Landbouwkundig Onderzoek Multiplex nucleic acid detection
GB0524069D0 (en) * 2005-11-25 2006-01-04 Solexa Ltd Preparation of templates for solid phase amplification
JPWO2007063807A1 (ja) * 2005-11-29 2009-05-07 オリンパス株式会社 核酸の一次構造変化の解析方法
AU2007281934B2 (en) 2006-01-18 2012-11-15 University Of Chicago Compositions and methods related to Staphylococcal bacterium proteins
WO2007083766A1 (ja) * 2006-01-20 2007-07-26 Olympus Corporation 分子内プローブによる核酸配列の検出方法
US20080057499A1 (en) * 2006-02-06 2008-03-06 Affymetrix, Inc. Methods for high specificity whole genome amplification and hybridization
WO2007092538A2 (en) * 2006-02-07 2007-08-16 President And Fellows Of Harvard College Methods for making nucleotide probes for sequencing and synthesis
WO2007107710A1 (en) * 2006-03-17 2007-09-27 Solexa Limited Isothermal methods for creating clonal single molecule arrays
US8071308B2 (en) 2006-05-04 2011-12-06 Alere San Diego, Inc. Recombinase polymerase amplification
WO2007133682A2 (en) * 2006-05-11 2007-11-22 Geneohm Sciences, Inc. 100% sequence identity detection methods for variable genomes
EP1878803A1 (en) * 2006-07-10 2008-01-16 Wageningen Universiteit Methods of detecting root knot nematodes
CN100460519C (zh) * 2006-08-29 2009-02-11 中国科学院南海海洋研究所 检测对虾传染性皮下及造血组织坏死病毒的试剂盒及方法
WO2009016433A2 (en) 2006-09-15 2009-02-05 Ottawa Health Research Institute Oncolytic rhabdovirus
US20080242560A1 (en) * 2006-11-21 2008-10-02 Gunderson Kevin L Methods for generating amplified nucleic acid arrays
DK2102239T3 (da) 2006-11-30 2012-05-29 Res Dev Foundation Forbedrede immunoglobulin-biblioteker
EP1939303A1 (en) 2006-12-27 2008-07-02 Wageningen Universiteit Method for detecting cyst nematodes
WO2008093098A2 (en) 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
WO2008096146A1 (en) 2007-02-07 2008-08-14 Solexa Limited Preparation of templates for methylation analysis
NL1033431C2 (nl) 2007-02-20 2008-08-21 Expressive Res Bv Bepaling van kwaliteitskenmerken bij land- of tuinbouwproducten.
EP2155789B1 (en) 2007-05-01 2013-07-24 Research Development Foundation Immunoglobulin fc libraries
US9689031B2 (en) 2007-07-14 2017-06-27 Ionian Technologies, Inc. Nicking and extension amplification reaction for the exponential amplification of nucleic acids
CA2718905A1 (en) 2008-03-17 2009-09-24 Expressive Research B.V. Expression-linked gene discovery
JP2009268665A (ja) * 2008-05-07 2009-11-19 Canon Inc 吸入装置
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
US9650668B2 (en) 2008-09-03 2017-05-16 Nabsys 2.0 Llc Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
EP2341929B1 (en) 2008-10-06 2017-01-25 University Of Chicago Compositions and methods related to bacterial emp proteins
WO2010068102A1 (en) 2008-12-10 2010-06-17 Monsanto Invest N.V. Novel plant virus
DE102008062372B3 (de) * 2008-12-17 2010-06-17 Medizinische Hochschule Hannover Nachweiskonjugat und Verfahren zur Analyse
WO2010071431A1 (en) 2008-12-19 2010-06-24 Monsanto Invest N.V. Method of breeding cysdv-resistant cucumber plants
HUE026855T2 (en) 2009-04-03 2016-07-28 Univ Chicago Compositions and methods related to protein a (spa) variants
US12129514B2 (en) 2009-04-30 2024-10-29 Molecular Loop Biosolutions, Llc Methods and compositions for evaluating genetic markers
EP2425240A4 (en) 2009-04-30 2012-12-12 Good Start Genetics Inc METHOD AND COMPOSITION FOR EVALUATING GENETIC MARKERS
JP5847076B2 (ja) 2009-05-20 2016-01-20 バイオサイト インコーポレイテッド Ｄｎａグリコシラーゼ／リアーゼおよびａｐエンドヌクレアーゼ基質
EP2438196B1 (en) 2009-06-05 2016-12-21 Alere San Diego, Inc. Recombinase polymerase amplification reagents and kits
US9587270B2 (en) 2009-06-29 2017-03-07 Luminex Corporation Chimeric primers with hairpin conformations and methods of using same
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
EP2294912A1 (en) 2009-09-04 2011-03-16 Wageningen Universiteit Method for increasing the level of zeaxanthin in a plant line, method for selecting a plant or part thereof, including a seed and tuber, and use thereof
US9512481B2 (en) 2009-09-11 2016-12-06 The Regents Of The University Of Colorado, A Body Corporate Polymorphisms in the PDE3A gene
ES2848650T3 (es) 2009-09-14 2021-08-11 Sillajen Biotherapeutics Inc Terapia combinada contra el cáncer con virus vaccinia oncolítico
WO2011049439A1 (en) 2009-10-19 2011-04-28 Universiteit Twente Method for selecting bone forming mesenchymal stem cells
WO2011070440A2 (en) 2009-12-10 2011-06-16 Ottawa Hospital Research Institute Oncolytic rhabdovirus
ES2587191T3 (es) 2009-12-23 2016-10-21 Arca Biopharma, Inc. Métodos y composiciones para enfermedades y afecciones cardiovasculares
DK2526209T3 (en) 2010-01-18 2015-04-07 Univ Utrecht Holding Bv Means and methods for distinguishing between fecv and fipv
EP2555794A4 (en) 2010-04-05 2014-01-15 Univ Chicago COMPOSITIONS AND METHODS RELATING TO PROTEIN A (SPA) ANTIBODIES AS IMMUNE REACTION AMPLIFIERS
US20110262989A1 (en) * 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
WO2011162612A1 (en) 2010-06-25 2011-12-29 Wageningen Universiteit Method for modulating the level of phosphorylation of starch in a plant line, method for selecting a plant or part thereof, including a seed and tuber, and use thereof
CA2803298C (en) 2010-07-02 2020-07-14 The University Of Chicago Compositions and methods related to protein a (spa) variants
US10174364B2 (en) 2010-07-16 2019-01-08 Stichting Vu-Vumc Method of analysing a blood sample of a subject for the presence of a disease marker
EP2614074A1 (en) 2010-09-09 2013-07-17 The University of Chicago Methods and compositions involving protective staphylococcal antigens
US8715933B2 (en) 2010-09-27 2014-05-06 Nabsys, Inc. Assay methods using nicking endonucleases
WO2012049279A1 (en) 2010-10-14 2012-04-19 Universitaet Des Saarlandes MEANS AND METHODS APPLYING SINGLE NUCLEOTIDE PRIMER EXTENSION WITH ION PAIR-, REVERSED-PHASE HPLC (SIRPH) FOR THE DIAGNOSIS OF SNPs
US8859201B2 (en) 2010-11-16 2014-10-14 Nabsys, Inc. Methods for sequencing a biomolecule by detecting relative positions of hybridized probes
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
AU2012204467B2 (en) 2011-01-04 2016-08-18 Sillajen, Inc. Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus
EP3567121B1 (en) 2011-01-17 2023-08-30 Life Technologies Corporation Workflow for detection of ligands using nucleic acids
US8952132B2 (en) 2011-02-07 2015-02-10 Research Development Foundation Engineered immunoglobulin FC polypeptides
WO2012109574A2 (en) 2011-02-11 2012-08-16 Nabsys, Inc. Assay methods using dna binding proteins
EP2681566A2 (en) 2011-02-28 2014-01-08 University of Iowa Research Foundation Anti-müllerian hormone changes in pregnancy and prediction ofadverse pregnancy outcomes and gender
AU2012226530B2 (en) 2011-03-08 2016-12-01 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
NL2006378C2 (en) 2011-03-11 2012-09-12 Univ Wageningen Tyclv resistance.
US10174365B2 (en) 2011-03-18 2019-01-08 Stichting Vu-Vumc Method of analysing a blood sample of a subject for the presence of a disease marker
US9085631B2 (en) 2011-04-08 2015-07-21 Nov Vac APS Proteins and nucleic acids useful in vaccines targeting Staphylococcus aureus
US9567649B2 (en) 2011-04-28 2017-02-14 Jørn Erland Koch System for identification of microorganism and detection of infectious disease
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
WO2012165943A1 (en) 2011-05-27 2012-12-06 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg A method of analysing a blood sample of a subject for the presence of an infectious disease marker
EP2718427B1 (en) 2011-06-08 2017-01-11 Children's Hospital of Eastern Ontario Research Institute Inc. Compositions for glioblastoma treatment
DK2729580T3 (en) 2011-07-08 2015-12-14 Keygene Nv SEQUENCE BASED genotyping BASED ON OLIGONUKLEOTIDLIGERINGSASSAYS
WO2013010074A1 (en) 2011-07-13 2013-01-17 Primeradx, Inc. Multimodal methods for simultaneous detection and quantification of multiple nucleic acids in a sample
WO2013022342A1 (en) 2011-08-09 2013-02-14 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg A method of analysing a blood sample of a subject for the presence of a foetal disease or condition marker
WO2013036799A2 (en) 2011-09-09 2013-03-14 Fred Hutchinson Cancer Research Center Methods and compositions involving nkg2d inhibitors and cancer
US9352312B2 (en) 2011-09-23 2016-05-31 Alere Switzerland Gmbh System and apparatus for reactions
EP2766388A1 (en) 2011-10-12 2014-08-20 Møller, Niels Iversen Peptides derived from campylobacter jejuni and their use in vaccination
CA2852665A1 (en) 2011-10-17 2013-04-25 Good Start Genetics, Inc. Analysis methods
ES2645418T3 (es) 2011-12-22 2017-12-05 Ibis Biosciences, Inc. Amplificación de una secuencia de un ácido ribonucleico
US9701959B2 (en) 2012-02-02 2017-07-11 Invenra Inc. High throughput screen for biologically active polypeptides
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
US9193994B2 (en) * 2012-04-20 2015-11-24 Samsung Electronics Co., Ltd. Polynucleotide and use thereof
JP6670106B2 (ja) 2012-04-26 2020-03-18 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ ブドウ球菌コアグラーゼ抗原およびその使用方法
EP2859111B1 (en) 2012-06-08 2020-07-08 Ionian Technologies, LLC Nucleic acid amplifications
EP3741846A3 (en) 2012-09-23 2021-03-24 Erasmus University Medical Center Rotterdam Human betacoronavirus lineage c and identification of n-terminal dipeptidyl peptidase as its virus receptor
US9914966B1 (en) 2012-12-20 2018-03-13 Nabsys 2.0 Llc Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation
US10294516B2 (en) 2013-01-18 2019-05-21 Nabsys 2.0 Llc Enhanced probe binding
US10125373B2 (en) 2013-01-22 2018-11-13 Arizona Board Of Regents On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
JP2016513115A (ja) 2013-02-21 2016-05-12 チルドレンズ ホスピタル オブ イースタン オンタリオ リサーチ インスティチュート インコーポレイテッド ワクチン組成物
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
CA2904181A1 (en) 2013-03-13 2014-10-09 Anahit Aghvanyan Sandwich immunoassay comprising anchoring reagent
EP2971159B1 (en) 2013-03-14 2019-05-08 Molecular Loop Biosolutions, LLC Methods for analyzing nucleic acids
KR102758333B1 (ko) 2013-08-28 2025-01-23 벡톤 디킨슨 앤드 컴퍼니 대량의 동시 단일 세포 분석
MX2016004283A (es) 2013-10-03 2016-10-12 Oklahoma Med Res Found Biomarcadores para la actividad, e intesidad y arrebato de la enfermedad lupus eritematoso sistemico.
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
US11473140B2 (en) * 2013-11-26 2022-10-18 Lc Sciences Lc Highly selective omega primer amplification of nucleic acid sequences
EP3077820B1 (en) 2013-12-03 2025-02-26 Evaxion Biotech A/S Proteins and nucleic acids useful in vaccines targeting staphylococcus aureus
WO2017062863A1 (en) 2015-10-09 2017-04-13 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US10767222B2 (en) 2013-12-11 2020-09-08 Accuragen Holdings Limited Compositions and methods for detecting rare sequence variants
US11053548B2 (en) 2014-05-12 2021-07-06 Good Start Genetics, Inc. Methods for detecting aneuploidy
EP3143401A4 (en) 2014-05-15 2017-10-11 Meso Scale Technologies, LLC Improved assay methods
GB2528647A (en) * 2014-07-10 2016-02-03 Momentum Bioscience Ltd Detecting viable microorganisms
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
JP2017536087A (ja) 2014-09-24 2017-12-07 グッド スタート ジェネティクス， インコーポレイテッド 遺伝子アッセイのロバストネスを増大させるためのプロセス制御
EP3777883A1 (en) 2014-11-13 2021-02-17 Evaxion Biotech ApS Peptides derived from acinetobacter baumannii and their use in vaccination
CA2969145A1 (en) 2014-11-26 2016-06-02 The Regents Of The University Of California Therapeutic compositions comprising transcription factors and methods of making and using the same
WO2016112073A1 (en) 2015-01-06 2016-07-14 Good Start Genetics, Inc. Screening for structural variants
WO2016113252A2 (en) 2015-01-12 2016-07-21 Evaxion Biotech Aps Proteins and nucleic acids useful in vaccines targeting klebsiella pneumoniae
WO2016130516A1 (en) 2015-02-09 2016-08-18 Research Development Foundation Engineered immunoglobulin fc polypeptides displaying improved complement activation
EP3070178B1 (en) 2015-03-20 2020-02-12 Albert-Ludwigs-Universität Freiburg Method for diagnosing breast cancer
EP4116316A1 (en) 2015-07-04 2023-01-11 Evaxion Biotech A/S Proteins and nucleic acids useful in vaccines targeting pseudomonas aeruginosa
US10526408B2 (en) 2015-08-28 2020-01-07 Research Development Foundation Engineered antibody FC variants
AU2016352829B2 (en) 2015-11-10 2022-11-10 Vilmorin & Cie Resistance to ToLCNDV in squash
WO2017096322A1 (en) 2015-12-03 2017-06-08 Accuragen Holdings Limited Methods and compositions for forming ligation products
EP3419654B1 (en) 2016-02-22 2022-04-27 Evaxion Biotech A/S Proteins and nucleic acids useful in vaccines targeting staphylococcus aureus
CN109511265B (zh) 2016-05-16 2023-07-14 安可济控股有限公司 通过链鉴定改进测序的方法
CN109844133A (zh) 2016-08-15 2019-06-04 安可济控股有限公司 检测罕见序列变体的组合物和方法
WO2018075633A2 (en) * 2016-10-19 2018-04-26 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis c virus
WO2018127545A1 (en) 2017-01-05 2018-07-12 Evaxion Biotech Aps Vaccines targeting pseudomonas aeruginosa
AU2018213315A1 (en) 2017-01-26 2019-07-25 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
US12140592B2 (en) 2017-06-16 2024-11-12 Oklahoma Medical Research Foundation Biomarkers for assessing risk of transitioning to systemic lupus erythematosus classification and disease pathogenesis
CN120210336A (zh) 2017-10-06 2025-06-27 10X基因组学有限公司 Rna模板化连接
WO2019126313A1 (en) * 2017-12-22 2019-06-27 The University Of Chicago Multiplex 5mc marker barcode counting for methylation detection in cell-free dna
CN120905352A (zh) 2018-04-02 2025-11-07 埃努梅拉分子股份有限公司 用于对核酸分子进行计数的方法、系统和组合物
WO2019241290A1 (en) 2018-06-12 2019-12-19 Accuragen Holdings Limited Methods and compositions for forming ligation products
AU2019287163B2 (en) 2018-06-12 2025-08-21 Keygene N.V. Nucleic acid amplification method
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
CN112770776B (zh) 2018-07-30 2025-08-19 瑞德库尔有限责任公司 用于样品处理或分析的方法和系统
US12510539B2 (en) 2018-10-18 2025-12-30 Progentec Diagnostics, Inc. Biomarkers for a systemic lupus erythematosus (SLE) disease activity immune index that characterizes disease activity
US20210349088A1 (en) 2018-10-18 2021-11-11 Oklahoma Medical Research Foundation Biomarkers For A Systemic Lupus Erythematosus (SLE) Disease Activity Immune Index That Characterizes Disease Activity
WO2020083904A1 (en) 2018-10-22 2020-04-30 Evaxion Biotech Aps Vaccines targeting m. catharrhalis
CA3127572A1 (en) 2019-02-21 2020-08-27 Keygene N.V. Genotyping of polyploids
WO2020174044A1 (en) 2019-02-27 2020-09-03 Evaxion Biotech Aps Vaccines targeting h. influenzae
CN120098057A (zh) 2019-03-01 2025-06-06 中尺度技术有限责任公司 用于免疫方法的被电化学发光标记的探针、使用这类探针的方法和包含这类探针的试剂盒
EP3947718A4 (en) 2019-04-02 2022-12-21 Enumera Molecular, Inc. METHODS, SYSTEMS AND COMPOSITIONS FOR COUNTING NUCLEIC ACID MOLECULES
US12514914B2 (en) 2019-05-14 2026-01-06 The University Of Chicago Methods and compositions comprising Staphylococcus protein a (SpA) variants
CN119220641A (zh) 2019-05-31 2024-12-31 10X基因组学有限公司 检测目标核酸分子的方法
EP3772543B1 (en) 2019-08-09 2023-09-27 Albert-Ludwigs-Universität Freiburg Method for diagnosing breast cancer
US20220296622A1 (en) 2019-09-16 2022-09-22 The Children's Hospital Of Philadelphia Compositions and methods for the treatment of swi-snf mutant tumors
US20230050225A1 (en) 2020-01-06 2023-02-16 Evaxion Biotech A/S Vaccines targeting Neisseria gonorrhoeae
EP4097251A1 (en) 2020-01-29 2022-12-07 10X Genomics, Inc. Compositions and methods for analyte detection
AU2021345359A1 (en) 2020-09-21 2023-05-11 Enumera Molecular, Inc. Compositions and methods for isolation of cell-free dna
JP2024526293A (ja) 2021-07-05 2024-07-17 エヴァクシオン・バイオテック・アクティエセルスカブ 淋菌を標的とするワクチン
EP4536276A1 (en) 2022-06-10 2025-04-16 Research Development Foundation Engineered fcriib selective igg1 fc variants and uses thereof

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957858A (en) * 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
US4786600A (en) * 1984-05-25 1988-11-22 The Trustees Of Columbia University In The City Of New York Autocatalytic replication of recombinant RNA
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US4925785A (en) * 1986-03-07 1990-05-15 Biotechnica Diagnostics, Inc. Nucleic acid hybridization assays
US5449602A (en) * 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
ATE92538T1 (de) * 1988-01-21 1993-08-15 Genentech Inc Verstaerkung und nachweis von nukleinsaeuresequenzen.
US4988617A (en) * 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
EP0426756A4 (en) * 1988-07-26 1991-11-21 Genelabs Incorporated Rna and dna amplification techniques
US5185243A (en) 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US5112734A (en) * 1989-05-26 1992-05-12 Gene-Trak Systems Target-dependent synthesis of an artificial gene for the synthesis of a replicatable rna
US5200314A (en) * 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
CA2046713A1 (en) * 1990-10-16 1992-04-17 Richard M. Martinelli Amplification of midivariant dna templates
ATE159763T1 (de) * 1990-12-31 1997-11-15 Promega Corp Nuklein-säure amplifikation mit dns abhängigen rns polymerasen aktivität von rns-replikasen
JP3080178B2 (ja) * 1991-02-18 2000-08-21 東洋紡績株式会社 核酸配列の増幅方法およびそのための試薬キット
JP3085409B2 (ja) * 1991-03-29 2000-09-11 東洋紡績株式会社 標的核酸配列の検出方法およびそのための試薬キット
CA2124797C (en) * 1991-12-23 2004-03-30 Bruce D. Irvine Hiv probes for use in solution phase sandwich hybridization assays
US5834202A (en) 1992-08-04 1998-11-10 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
US5422252A (en) * 1993-06-04 1995-06-06 Becton, Dickinson And Company Simultaneous amplification of multiple targets
AU690124B2 (en) * 1993-06-09 1998-04-23 Gamera Bioscience Corporation Magnetic cycle reaction
US5601978A (en) 1993-09-03 1997-02-11 Abbott Laboratories Oligonucleotides and methods for the detection of chlamydia trachomatis
NL9301957A (nl) * 1993-11-11 1995-06-01 U Gene Research Bv Werkwijze voor het identificeren van micro-organismen, en daarvoor bruikbare hulpmiddelen.
US5523204A (en) * 1993-12-10 1996-06-04 Becton Dickinson And Company Detection of nucleic acids in cells by strand displacement amplification
SE9400522D0 (sv) 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
US5876924A (en) * 1994-06-22 1999-03-02 Mount Sinai School Of Medicine Nucleic acid amplification method hybridization signal amplification method (HSAM)
EP0717782A1 (en) * 1994-06-22 1996-06-26 Mount Sinai School Of Medicine Of The City University Of New York Ligation-dependent amplification for the detection of infectious pathogens and abnormal genes
US5942391A (en) * 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
US5616465A (en) 1995-08-09 1997-04-01 The Regents Of The University Of California Detection and isolation of nucleic acid sequences using competitive hybridization probes
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
DK0862656T3 (da) * 1995-11-21 2001-04-09 Univ Yale Unimolekylær segmentamplifikation og -detektering
WO2000004193A1 (en) 1998-07-20 2000-01-27 Yale University Method for detecting nucleic acids using target-mediated ligation of bipartite primers
JP2002525049A (ja) 1998-09-15 2002-08-13 イェール ユニバーシティ ローリングサークル増幅を用いる分子クローニング
EP1112385A1 (en) 1998-09-15 2001-07-04 Yale University Artificial long terminal repeat vectors
JP2002540802A (ja) 1999-04-06 2002-12-03 イェール ユニバーシティ 配列標識の固定されたアドレス分析
WO2001012855A2 (en) 1999-08-13 2001-02-22 Yale University Binary encoded sequence tags

Also Published As

Publication number Publication date
US20030190604A1 (en) 2003-10-09
ATE339515T1 (de) 2006-10-15
EP0915991A4 (en) 2002-10-25
JP2001514483A (ja) 2001-09-11
EP0915991B1 (en) 2006-09-13
US6569647B1 (en) 2003-05-27
US5942391A (en) 1999-08-24
WO1998004746A1 (en) 1998-02-05
DE69736668T2 (de) 2007-09-13
DE69736668D1 (de) 2006-10-26
US6855523B2 (en) 2005-02-15
EP0915991A1 (en) 1999-05-19

Similar Documents

Publication Publication Date Title
ES2273371T3 (es) Metodo de amplificacion de acido nucleico basado en ramificacion extension (rami) y transcripcion in vitro.
JP4528885B1 (ja) 検体解析方法およびそれに用いるアッセイキット
ES2320604T3 (es) Identificacion de polimorfismos del adn mediante la utilizacion de citometria de flujo.
KR102592367B1 (ko) 게놈 및 치료학적 적용을 위한 핵산 분자의 클론 복제 및 증폭을 위한 시스템 및 방법
US6238866B1 (en) Detector for nucleic acid typing and methods of using the same
JP2854904B2 (ja) 遺伝子の検査方法
JP2001521373A (ja) 核酸増幅法：ハイブリダイゼーションシグナル増幅法（ｈｓａｍ）
JP5740112B2 (ja) コロナウイルスのためのｌａｍｐ増幅用核酸プライマーセット
JP2005508599A (ja) 核酸の増幅方法
WO1995035390A1 (en) Ligation-dependent amplification for the detection of infectious pathogens and abnormal genes
JP2005511030A (ja) 核酸の増幅方法
US9416398B2 (en) Generic buffer for amplification
JP2692702B2 (ja) 単純ヘルペスウイルスの検出方法およびそのための試薬
AU741141B2 (en) Specific and sensitive method for detecting nucleic acids
EP0465528A1 (en) Process for nucleic acid detection by binary amplification
JP3789317B2 (ja) 特定の核酸を検出定量するための等長プライマー伸長法およびキット
JP4909413B2 (ja) 一般化された方法―特異的な配列補完（ｄｓｆ）により可能になる連続的アダプター連結および増幅を用いたハイスループット突然変異スクリーニング法およびキット
WO2012036111A1 (ja) 多検体解析のためのプライマー、プローブおよび方法
Chhabra et al. Molecular detection methods of foodborne viruses
JP5676846B2 (ja) ヘリコバクター属の微生物由来の核酸を特異的に増幅するためのプライマーセット、前記微生物を検知および／または分類するための方法
JP2011004733A (ja) 複数検体中の標的核酸を検出するマイクロアレイ
JP3016994B2 (ja) Ｃ群ロタウイルス検出用ヌクレオチド、ｃ群ロタウイルス検出法およびｃ群ロタウイルス検出用試薬キット
JP2008283891A (ja) 二本鎖核酸の検出方法及びクローニング方法
JPH03210197A (ja) 蛍光標識ｄｎａの調製方法及びキット
JP4528889B1 (ja) 検体解析方法およびそこにおいて使用されるアッセイキット