ATE429517T1 - Vervielfältigung und nachweis von ebv barf1 zur diagnose von nasopharyngealen karzinom - Google Patents
Vervielfältigung und nachweis von ebv barf1 zur diagnose von nasopharyngealen karzinomInfo
- Publication number
- ATE429517T1 ATE429517T1 AT99910326T AT99910326T ATE429517T1 AT E429517 T1 ATE429517 T1 AT E429517T1 AT 99910326 T AT99910326 T AT 99910326T AT 99910326 T AT99910326 T AT 99910326T AT E429517 T1 ATE429517 T1 AT E429517T1
- Authority
- AT
- Austria
- Prior art keywords
- ebv
- detection
- diagnosis
- amplification
- barf1
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title abstract 3
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 101150010153 BARF1 gene Proteins 0.000 title 1
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 title 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 title 1
- 201000011216 nasopharynx carcinoma Diseases 0.000 title 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 abstract 4
- 230000003321 amplification Effects 0.000 abstract 3
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 3
- 108091034117 Oligonucleotide Proteins 0.000 abstract 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 2
- 230000003211 malignant effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000014509 gene expression Effects 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 210000004976 peripheral blood cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/705—Specific hybridization probes for herpetoviridae, e.g. herpes simplex, varicella zoster
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98200655 | 1998-03-04 | ||
| EP98204231 | 1998-12-14 | ||
| PCT/EP1999/001392 WO1999045155A2 (en) | 1998-03-04 | 1999-03-01 | Oligonucleotides for the amplification and detection of epstein barr virus (ebv) nucleic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE429517T1 true ATE429517T1 (de) | 2009-05-15 |
Family
ID=26150077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99910326T ATE429517T1 (de) | 1998-03-04 | 1999-03-01 | Vervielfältigung und nachweis von ebv barf1 zur diagnose von nasopharyngealen karzinom |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7026112B1 (de) |
| EP (1) | EP1060271B1 (de) |
| JP (1) | JP4472171B2 (de) |
| KR (1) | KR100718028B1 (de) |
| AT (1) | ATE429517T1 (de) |
| AU (1) | AU757404B2 (de) |
| CA (1) | CA2321654C (de) |
| DE (1) | DE69940770D1 (de) |
| ES (1) | ES2323562T3 (de) |
| ID (1) | ID27442A (de) |
| WO (1) | WO1999045155A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60236068D1 (de) | 2001-01-31 | 2010-06-02 | Mayo Foundation | Nachweis von herpex-simplex-virus |
| US7691571B2 (en) | 2001-01-31 | 2010-04-06 | Mayo Foundation For Medical Education And Research | Detection of bordetella |
| US7074598B2 (en) | 2002-09-25 | 2006-07-11 | Mayo Foundation For Medical Education And Research | Detection of vancomycin-resistant enterococcus spp. |
| US7365176B2 (en) | 2002-09-26 | 2008-04-29 | Mayo Foundation For Medical Education And Research | Detection of Epstein-Barr virus |
| US7074599B2 (en) | 2002-09-27 | 2006-07-11 | Mayo Foundation For Medical Education And Research | Detection of mecA-containing Staphylococcus spp. |
| US7427475B2 (en) | 2003-11-18 | 2008-09-23 | Mayo Foundation For Medical Education And Research | Detection of group B streptococcus |
| JP4182227B2 (ja) * | 2005-09-09 | 2008-11-19 | 国立大学法人 岡山大学 | ウイルス潜伏感染の検査方法および検査用キット |
| WO2012072515A2 (en) * | 2010-11-29 | 2012-06-07 | Centre National De La Recherche Scientifique (Cnrs) | Lmp1 a diagnostic and prognostic marker for epstein-barr virus (ebv)-associated lymphoma |
| US20190049453A1 (en) * | 2016-02-09 | 2019-02-14 | The General Hospital Corporation | Classification and Treatment of Gastric Cancer |
| AU2019314449B2 (en) * | 2018-08-01 | 2026-01-08 | Gen-Probe Incorporated | Compositions and methods for detecting nucleic acids of Epstein-Barr virus |
| WO2021081296A1 (en) * | 2019-10-24 | 2021-04-29 | Joshua Labaer | Novel antibodies for detecting epstein barr virus-positive gastric cancer |
| CN112176110A (zh) * | 2020-11-04 | 2021-01-05 | 上海思路迪生物医学科技有限公司 | 基于捕获测序的eb病毒检测技术 |
| CN116590468A (zh) * | 2023-02-22 | 2023-08-15 | 卡秋(江苏)生物科技有限公司 | 一种用于eb病毒检测的原位杂交试剂盒及其使用方法 |
| CN116536415A (zh) * | 2023-05-10 | 2023-08-04 | 首都医科大学附属北京儿童医院 | 用于检测caebv和im的eb病毒基因组差异甲基化基因的物质、试剂盒及其应用 |
| CN117230258B (zh) * | 2023-11-10 | 2024-04-09 | 苏州驾玉生物医药有限公司 | 一种提高灵敏度的培养扩增联合pcr的eb病毒检测方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| IE873041L (en) | 1987-11-11 | 1989-05-11 | Ailbe Brennan | Viral antigens, diagnostic assay therefor and vaccines¹containing them |
| CA1340807C (en) * | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| NZ244820A (en) * | 1991-10-25 | 1994-01-26 | Isis Pharmaceuticals Inc | Oligonucleotide inhibitor of epstein-barr virus. |
| GB9125891D0 (en) | 1991-12-05 | 1992-02-05 | Inst Of Cancer The Research | Antiviral agent |
| ES2298325T3 (es) | 1992-03-13 | 2008-05-16 | Biomerieux B.V. | Peptidos y secuencias de acido nucleico relacionadas con el virus epstein barr. |
| CA2135646A1 (en) * | 1992-05-11 | 1993-11-25 | Kenneth G. Draper | Method and reagent for inhibiting viral replication |
| JP3360737B2 (ja) * | 1992-05-13 | 2002-12-24 | 株式会社ヤトロン | エプスタイン−バールウイルスの検出方法 |
| JPH0628568A (ja) * | 1992-06-11 | 1994-02-04 | Sanden Corp | 商品収納装置 |
| DE4344742A1 (de) * | 1993-06-09 | 1994-12-15 | Boehringer Mannheim Gmbh | Verfahren zur Immobilisierung von Nukleinsäuren |
| ES2166757T3 (es) | 1993-07-23 | 2002-05-01 | Hans Prof Dr Wolf | Secuencias de adn del virus de epstein-barr que codifican un antigeno de la capsida del virus de interes diagnostico, clones de expresion obtenidos por la reaccion en cadena de la polimerasa y el uso de este antigeno recombinante en ensayos de diagnostico. |
| US5942391A (en) | 1994-06-22 | 1999-08-24 | Mount Sinai School Of Medicine | Nucleic acid amplification method: ramification-extension amplification method (RAM) |
| JP4553412B2 (ja) | 1996-02-28 | 2010-09-29 | アクゾ・ノベル・エヌ・ベー | マイコプラズマ・ニューモニエ（Ｍｙｃｏｐｌａｓｍａｐｎｅｕｍｏｎｉａｅ）の増幅、検出および型別のためのプライマーおよびプローブ |
| US5837854A (en) * | 1996-04-05 | 1998-11-17 | University Of Massachusetts | Oligonucleotides with anti-Epstein-Barr virus activity |
| JPH09307882A (ja) * | 1996-05-16 | 1997-11-28 | Toshiba Corp | 画像によるプラント監視装置 |
| JP2956585B2 (ja) * | 1996-06-04 | 1999-10-04 | 三菱自動車工業株式会社 | 車両用変速機の変速制御装置 |
| DE19627932A1 (de) | 1996-07-11 | 1998-01-15 | Boehringer Mannheim Gmbh | Sensitiver Epstein-Barr-Virus DNA-Nachweis |
-
1999
- 1999-03-01 US US09/623,329 patent/US7026112B1/en not_active Expired - Lifetime
- 1999-03-01 WO PCT/EP1999/001392 patent/WO1999045155A2/en not_active Ceased
- 1999-03-01 EP EP99910326A patent/EP1060271B1/de not_active Expired - Lifetime
- 1999-03-01 DE DE69940770T patent/DE69940770D1/de not_active Expired - Lifetime
- 1999-03-01 KR KR1020007009811A patent/KR100718028B1/ko not_active Expired - Lifetime
- 1999-03-01 JP JP2000534686A patent/JP4472171B2/ja not_active Expired - Lifetime
- 1999-03-01 CA CA2321654A patent/CA2321654C/en not_active Expired - Lifetime
- 1999-03-01 AT AT99910326T patent/ATE429517T1/de not_active IP Right Cessation
- 1999-03-01 ID IDW20001704A patent/ID27442A/id unknown
- 1999-03-01 AU AU29321/99A patent/AU757404B2/en not_active Expired
- 1999-03-01 ES ES99910326T patent/ES2323562T3/es not_active Expired - Lifetime
-
2003
- 2003-12-23 US US10/744,635 patent/US20040180331A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU757404B2 (en) | 2003-02-20 |
| DE69940770D1 (de) | 2009-06-04 |
| WO1999045155A9 (en) | 1999-11-25 |
| JP2002505122A (ja) | 2002-02-19 |
| EP1060271A2 (de) | 2000-12-20 |
| AU2932199A (en) | 1999-09-20 |
| WO1999045155A3 (en) | 2000-05-04 |
| US20040180331A1 (en) | 2004-09-16 |
| KR20010041614A (ko) | 2001-05-25 |
| WO1999045155A2 (en) | 1999-09-10 |
| JP4472171B2 (ja) | 2010-06-02 |
| KR100718028B1 (ko) | 2007-05-16 |
| CA2321654A1 (en) | 1999-09-10 |
| ID27442A (id) | 2001-04-12 |
| CA2321654C (en) | 2011-02-15 |
| EP1060271B1 (de) | 2009-04-22 |
| ES2323562T3 (es) | 2009-07-20 |
| US7026112B1 (en) | 2006-04-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |