ES2242997T3 - Metodo para integrar genes en sitios especificos en celulas de mamifero por medio de recombinacion homologa y vectores para realizar el mismo. - Google Patents
Metodo para integrar genes en sitios especificos en celulas de mamifero por medio de recombinacion homologa y vectores para realizar el mismo.Info
- Publication number
- ES2242997T3 ES2242997T3 ES98910109T ES98910109T ES2242997T3 ES 2242997 T3 ES2242997 T3 ES 2242997T3 ES 98910109 T ES98910109 T ES 98910109T ES 98910109 T ES98910109 T ES 98910109T ES 2242997 T3 ES2242997 T3 ES 2242997T3
- Authority
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- Prior art keywords
- dna
- plasmid
- selectable marker
- cells
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- C07K2319/00—Fusion polypeptide
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- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
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- C12N2840/00—Vectors comprising a special translation-regulating system
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- C12N2840/00—Vectors comprising a special translation-regulating system
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| US08/819,866 US5830698A (en) | 1997-03-14 | 1997-03-14 | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
| US819866 | 1997-03-14 | ||
| US09/023,715 US5998144A (en) | 1997-03-14 | 1998-02-13 | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
| US23715 | 1998-02-13 |
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| ES2242997T3 true ES2242997T3 (es) | 2005-11-16 |
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| EA201991768A1 (ru) | 2017-01-31 | 2020-01-22 | Байоверетив Терапьютикс Инк. | Слитые белки на основе фактора ix и способы их получения и пути применения |
| JP7374883B2 (ja) | 2017-08-09 | 2023-11-07 | バイオベラティブ セラピューティクス インコーポレイテッド | 核酸分子およびその使用 |
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| JP2021521896A (ja) | 2018-04-27 | 2021-08-30 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | ヒト由来の抗（ポリｇａ）ジペプチドリピート（ｄｐｒ）抗体 |
| RS66972B1 (sr) | 2018-05-18 | 2025-07-31 | Bioverativ Therapeutics Inc | Metode lečenja hemofilije a |
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| CN119955796A (zh) | 2018-08-09 | 2025-05-09 | 比奥维拉迪维治疗股份有限公司 | 核酸分子及其用于非病毒基因疗法的用途 |
| JP7549582B2 (ja) * | 2018-10-01 | 2024-09-11 | ロンザ リミテッド | 予測可能かつ安定な導入遺伝子発現を有するｓｓｉ細胞および形成の方法 |
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| MX2023000156A (es) | 2020-06-24 | 2023-02-16 | Bioverativ Therapeutics Inc | Metodos para la eliminacion de factor viii libre de preparaciones de vectores lentivirales modificados para expresar dicha proteina. |
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| US5202238A (en) * | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| WO1991006667A1 (en) | 1989-11-06 | 1991-05-16 | Cell Genesys, Inc. | Production of proteins using homologous recombination |
| NZ245015A (en) | 1991-11-05 | 1995-12-21 | Transkaryotic Therapies Inc | Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production |
| WO1993024642A1 (en) * | 1992-06-04 | 1993-12-09 | Exemplar Corporation | Insertion of heterologous dna outside of known chromosomal genes |
| MX9305183A (es) * | 1992-08-27 | 1994-05-31 | Us Agriculture | Intron portatil, molecula de adn genomico viral, virus vivo y vacuna que los contiene y metodo para su obtencion. |
| US5648267A (en) * | 1992-11-13 | 1997-07-15 | Idec Pharmaceuticals Corporation | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same |
| US5830698A (en) * | 1997-03-14 | 1998-11-03 | Idec Pharmaceuticals Corporation | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
| CA2283740C (en) * | 1997-03-14 | 2006-06-27 | Idec Pharmaceuticals Corporation | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
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1998
- 1998-03-09 CA CA002283740A patent/CA2283740C/en not_active Expired - Fee Related
- 1998-03-09 IL IL13174698A patent/IL131746A0/xx not_active IP Right Cessation
- 1998-03-09 CZ CZ19993162A patent/CZ293355B6/cs not_active IP Right Cessation
- 1998-03-09 RO RO99-00972A patent/RO120148B1/ro unknown
- 1998-03-09 EP EP98910109A patent/EP0981637B1/en not_active Revoked
- 1998-03-09 PL PL335695A patent/PL191251B1/pl not_active IP Right Cessation
- 1998-03-09 ES ES98910109T patent/ES2242997T3/es not_active Expired - Lifetime
- 1998-03-09 CN CNB988049880A patent/CN1175111C/zh not_active Expired - Fee Related
- 1998-03-09 WO PCT/US1998/003935 patent/WO1998041645A1/en not_active Ceased
- 1998-03-09 PT PT98910109T patent/PT981637E/pt unknown
- 1998-03-09 AT AT98910109T patent/ATE296356T1/de not_active IP Right Cessation
- 1998-03-09 AU AU64435/98A patent/AU737155B2/en not_active Ceased
- 1998-03-09 BR BR9808584-0A patent/BR9808584A/pt not_active Application Discontinuation
- 1998-03-09 ID IDW991196A patent/ID24565A/id unknown
- 1998-03-09 DE DE69830312T patent/DE69830312T2/de not_active Revoked
- 1998-03-09 JP JP54053998A patent/JP4128227B2/ja not_active Expired - Fee Related
- 1998-03-10 IN IN616DE1998 patent/IN189732B/en unknown
- 1998-03-13 TW TW087103778A patent/TWI232239B/zh not_active IP Right Cessation
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1999
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- 1999-09-10 NO NO994397A patent/NO994397L/no not_active Application Discontinuation
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2002
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2004
- 2004-03-15 RU RU2004107694/13A patent/RU2004107694A/ru not_active Application Discontinuation
- 2004-04-06 US US10/817,950 patent/US7235360B2/en not_active Expired - Fee Related
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|---|---|
| PL335695A1 (en) | 2000-05-08 |
| BR9808584A (pt) | 2000-05-23 |
| IL131746A0 (en) | 2001-03-19 |
| CA2283740C (en) | 2006-06-27 |
| US20020192820A1 (en) | 2002-12-19 |
| WO1998041645A1 (en) | 1998-09-24 |
| RO120148B1 (ro) | 2005-09-30 |
| EP0981637A1 (en) | 2000-03-01 |
| AU737155B2 (en) | 2001-08-09 |
| CA2283740A1 (en) | 1998-09-24 |
| DE69830312D1 (de) | 2005-06-30 |
| CZ316299A3 (cs) | 2000-02-16 |
| NO994397D0 (no) | 1999-09-10 |
| PL191251B1 (pl) | 2006-04-28 |
| JP2001516221A (ja) | 2001-09-25 |
| CZ293355B6 (cs) | 2004-04-14 |
| DE69830312T2 (de) | 2006-02-02 |
| US6841383B2 (en) | 2005-01-11 |
| AU6443598A (en) | 1998-10-12 |
| ID24565A (id) | 2000-07-27 |
| RU2004107694A (ru) | 2005-08-27 |
| NO994397L (no) | 1999-11-09 |
| ATE296356T1 (de) | 2005-06-15 |
| EP0981637B1 (en) | 2005-05-25 |
| JP4128227B2 (ja) | 2008-07-30 |
| IN189732B (enExample) | 2003-04-19 |
| CN1255166A (zh) | 2000-05-31 |
| CN1175111C (zh) | 2004-11-10 |
| PT981637E (pt) | 2005-09-30 |
| US7235360B2 (en) | 2007-06-26 |
| TWI232239B (en) | 2005-05-11 |
| US6413777B1 (en) | 2002-07-02 |
| US20040166528A1 (en) | 2004-08-26 |
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