ES2237834T3 - Bacteria lactobacillus helveticus que tiene alta capacidad de produccion de un tripeptido, producto lacteo fermentado y procedimiento para su preparacion. - Google Patents
Bacteria lactobacillus helveticus que tiene alta capacidad de produccion de un tripeptido, producto lacteo fermentado y procedimiento para su preparacion.Info
- Publication number
- ES2237834T3 ES2237834T3 ES98901520T ES98901520T ES2237834T3 ES 2237834 T3 ES2237834 T3 ES 2237834T3 ES 98901520 T ES98901520 T ES 98901520T ES 98901520 T ES98901520 T ES 98901520T ES 2237834 T3 ES2237834 T3 ES 2237834T3
- Authority
- ES
- Spain
- Prior art keywords
- pro
- lactic acid
- milk
- fermented
- bacteria
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 240000002605 Lactobacillus helveticus Species 0.000 title claims abstract description 29
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims description 22
- 235000021001 fermented dairy product Nutrition 0.000 title description 3
- 238000002360 preparation method Methods 0.000 title description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 152
- 229960000448 lactic acid Drugs 0.000 claims abstract description 76
- 239000004310 lactic acid Substances 0.000 claims abstract description 65
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 65
- 241000894006 Bacteria Species 0.000 claims abstract description 62
- DOFAQXCYFQKSHT-SRVKXCTJSA-N Val-Pro-Pro Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(O)=O)CCC1 DOFAQXCYFQKSHT-SRVKXCTJSA-N 0.000 claims abstract description 41
- 238000000855 fermentation Methods 0.000 claims abstract description 32
- 230000004151 fermentation Effects 0.000 claims abstract description 32
- 235000013967 Lactobacillus helveticus Nutrition 0.000 claims abstract description 28
- 229940054346 lactobacillus helveticus Drugs 0.000 claims abstract description 28
- 230000000694 effects Effects 0.000 claims abstract description 26
- 235000020183 skimmed milk Nutrition 0.000 claims abstract description 20
- 108010015385 valyl-prolyl-proline Proteins 0.000 claims abstract description 17
- 101710089384 Extracellular protease Proteins 0.000 claims abstract description 16
- 239000007787 solid Substances 0.000 claims abstract description 15
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 8
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000008103 glucose Substances 0.000 claims abstract description 8
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- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims abstract description 6
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims abstract description 5
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims abstract description 5
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- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims abstract description 4
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims abstract description 4
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- 229910002651 NO3 Inorganic materials 0.000 claims abstract description 4
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims abstract description 4
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- NGFMICBWJRZIBI-JZRPKSSGSA-N Salicin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O1)c1c(CO)cccc1 NGFMICBWJRZIBI-JZRPKSSGSA-N 0.000 claims abstract description 4
- 241000519999 Stachys Species 0.000 claims abstract description 4
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 4
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- 230000009603 aerobic growth Effects 0.000 claims abstract description 4
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- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 3
- 235000021240 caseins Nutrition 0.000 claims description 3
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- 235000013351 cheese Nutrition 0.000 claims description 2
- 235000021067 refined food Nutrition 0.000 claims description 2
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- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 description 11
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
- A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/137—Thickening substances
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/147—Helveticus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dairy Products (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9277949A JP3028411B2 (ja) | 1997-09-26 | 1997-09-26 | トリペプチド高生産性ラクトバチルス・ヘルベチカス乳酸菌 |
| JP27794997 | 1997-09-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2237834T3 true ES2237834T3 (es) | 2005-08-01 |
Family
ID=17590526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98901520T Expired - Lifetime ES2237834T3 (es) | 1997-09-26 | 1998-02-05 | Bacteria lactobacillus helveticus que tiene alta capacidad de produccion de un tripeptido, producto lacteo fermentado y procedimiento para su preparacion. |
Country Status (24)
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1142481T4 (da) | 1999-01-11 | 2009-12-21 | Calpis Co Ltd | Fremgangsmåde til fremstilling af fermenteret mælk indeholdende et peptid, der inhiberer et angiotensinomdannende enzym og fremgangsmåde til fremstilling af mælkeserum |
| FR2793257B1 (fr) * | 1999-05-06 | 2001-07-27 | Gervais Danone Sa | Bacteries lactiques a proprietes anxiolytiques, et leurs utilisations |
| FI113741B (fi) * | 1999-11-01 | 2004-06-15 | Valio Oy | Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi |
| JP4633876B2 (ja) * | 1999-11-11 | 2011-02-16 | カルピス株式会社 | トリペプチドの製造方法 |
| FI112031B (fi) | 2002-02-25 | 2003-10-31 | Valio Oy | Biologisesti aktiivisen tuotteen uusi käyttö |
| EP1492409A2 (en) * | 2002-04-03 | 2005-01-05 | Chr. Hansen A/S | Peptides with anti-hypertensive properties |
| JP4499564B2 (ja) * | 2002-08-09 | 2010-07-07 | セーホーエル．ハンセン アクティーゼルスカブ | 抗高血圧特性を有するペプチドの製造方法 |
| CA2509627A1 (en) | 2003-01-06 | 2004-07-22 | Unilever Plc | Fermented milk product comprising tripeptide vpp and/or ipp |
| TWI328457B (en) * | 2003-03-18 | 2010-08-11 | Suntory Holdings Ltd | Angiotensin-converting enzyme inhibitory peptides |
| US7718171B2 (en) | 2003-04-07 | 2010-05-18 | Chr. Hansen A/S | Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus |
| MXPA05011784A (es) | 2003-05-05 | 2006-01-26 | Unilever Nv | Producto de caseina hidrolizada que comprende tripeptidos isoleucina-prolina-prolina y/o valina-prolina-prolina. |
| JP4680571B2 (ja) * | 2003-12-25 | 2011-05-11 | カルピス株式会社 | 経口摂取用保湿剤 |
| EP1741437A4 (en) * | 2004-03-31 | 2009-06-24 | Calpis Co Ltd | FUNCTIONAL FOOD FOR ENHANCING THE ENDOGENOUS MELATONIN SECRETION RHYTHM AND FUNCTIONAL FOOD FOR IMPROVING CIRCADIAN RHYTHM |
| TW200536552A (en) * | 2004-03-31 | 2005-11-16 | Calpis Co Ltd | Hepatopathy preventive or inhibitory agents and functional food for preventing or inhibiting hepatopathy |
| WO2006004105A1 (ja) * | 2004-07-05 | 2006-01-12 | Calpis Co., Ltd. | ペプチド混合物の製造法、抗高血圧ペプチド含有発酵乳の製造法及び抗高血圧ペプチド製剤の製造法 |
| NZ554278A (en) | 2004-09-03 | 2009-11-27 | Chr Hansen As | Fermented milk or vegetable proteins comprising receoptor ligand and uses thereof |
| JPWO2006095764A1 (ja) * | 2005-03-09 | 2008-08-14 | カルピス株式会社 | 皮膚における紫外線感受性抑制剤及び機能性飲食品 |
| TW200740378A (en) * | 2005-06-24 | 2007-11-01 | Calpis Co Ltd | Epidermal differentiation and keratinization promoter and functional food and beverage for promoting epidermal keratinization |
| WO2007013426A1 (ja) * | 2005-07-26 | 2007-02-01 | Calpis Co., Ltd. | 発酵乳の製造方法及び発酵乳飲食品 |
| CN1903052B (zh) * | 2005-07-26 | 2010-04-28 | 天津科技大学 | 具有酪蛋白磷酸肽、抗血管紧张素转化酶肽和低聚半乳糖乳清粉的制备方法 |
| EA200870259A1 (ru) * | 2006-02-14 | 2009-02-27 | Калпис Ко., Лтд. | Сосудорасширяющее средство |
| ES2463453T3 (es) * | 2006-02-14 | 2014-05-28 | Calpis Co., Ltd. | Agente para uso en la profilaxis de la aterosclerosis |
| EP1820405B1 (fr) * | 2006-02-20 | 2011-03-30 | Compagnie Gervais Danone | Nouvelles souches de Lactobacillus Helveticus |
| DE602006005330D1 (de) * | 2006-02-20 | 2009-04-09 | Gervais Danone Sa | Neue Stämme von Lactobacillus helveticus |
| ES2320482T3 (es) * | 2006-02-20 | 2009-05-22 | Compagnie Gervais Danone | Nuevas cepas de lactobacillus helveticus. |
| PL1820851T3 (pl) | 2006-02-20 | 2012-07-31 | Gervais Danone Sa | Szczepy Lactobacillus helveticus nie fermentujące laktozy |
| CA2652388A1 (en) | 2006-05-15 | 2007-11-22 | Valio Ltd | New use of therapeutically useful peptides |
| ES2610811T3 (es) | 2006-06-16 | 2017-05-03 | Dupont Nutrition Biosciences Aps | Bacteria Streptococcus thermophilus |
| US20100021444A1 (en) * | 2006-09-04 | 2010-01-28 | Snow Brand Milk Products Co., Ltd. | Blood-adiponectin-concentration increase-accelerator and/or decrease-inhibitor thereof and visceral fat accumulation inhibitor |
| JP2008214253A (ja) | 2007-03-02 | 2008-09-18 | Snow Brand Milk Prod Co Ltd | 内臓脂肪減少剤 |
| BRPI0809319A2 (pt) * | 2007-03-27 | 2014-09-23 | Calpis Co Ltd | Agente para suprimir espessamento de parede de coração, agente profilático para hipertrofia cardíaca, agente profilático para insuficiência cardíaca, e, alimento funcional |
| TWI414305B (zh) * | 2007-03-27 | 2013-11-11 | Calpis Co Ltd | 腎衰竭預防劑 |
| CA2725611A1 (en) * | 2008-06-12 | 2009-12-17 | Nestec S.A. | Lactobacillus helveticus strains for producing hypotensive peptides |
| ES2381426T3 (es) * | 2008-12-29 | 2012-05-28 | Unilever N.V. | Productos de confitura congelados y bebidas que comprenden teobromina y cafeína |
| WO2011095389A1 (en) * | 2010-02-04 | 2011-08-11 | Unilever Nv | Use of theobromine for lowering central blood pressure |
| AU2011254726B2 (en) | 2010-05-19 | 2014-03-06 | Upfield Europe B.V. | Theobromine for increasing HDL-cholesterol |
| JP2010183918A (ja) * | 2010-06-01 | 2010-08-26 | Calpis Co Ltd | トリペプチドの製造方法 |
| CN103221531B (zh) * | 2010-11-09 | 2018-03-16 | 朝日集团控股株式会社 | 具有高蛋白质水解活性的瑞士乳杆菌 |
| JP5797891B2 (ja) * | 2010-11-09 | 2015-10-21 | カルピス株式会社 | Ｎｏｎ−ｄｉｐｐｅｒ型血圧日内変動による疾病発症リスク軽減剤 |
| RU2453593C1 (ru) * | 2011-04-21 | 2012-06-20 | Общество с ограниченной ответственностью "Бифилюкс" | Штамм lactobacillus helveticus, используемый для получения продукции, содержащей лактобактерии |
| US20120328735A1 (en) * | 2011-06-24 | 2012-12-27 | Naoto Uchida | Process for preparing casein-derived peptides by fermentation of lactic acid bacteria |
| DE202012012998U1 (de) | 2011-08-31 | 2014-06-13 | Daniel Elias | Bioaktive, regenerative Mischung zur Herstellung eines Ergänzungsnahrungsmittels |
| JP6374866B2 (ja) | 2012-08-22 | 2018-08-15 | クラフト・フーズ・グループ・ブランズ・エルエルシー | 発酵乳成分を有するプロセスチーズ及びその製造方法 |
| CN102960444A (zh) * | 2012-11-19 | 2013-03-13 | 陕西科技大学 | 一种基于瑞士乳杆菌发酵的含ace抑制肽的羊奶的制备方法 |
| CN104450574B (zh) * | 2014-12-10 | 2017-05-10 | 生合生物科技（南京）有限公司 | 一种瑞士乳杆菌lh43及其制作乳酸菌饮料的方法 |
| RU2577112C1 (ru) * | 2014-12-25 | 2016-03-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Горский государственный аграрный университет" | Штамм lactobacillus helveticus вкпм в-11175, полученный на доступных питательных средах |
| CN107674848A (zh) * | 2017-09-20 | 2018-02-09 | 云南乍甸乳业有限责任公司 | 一种酸奶发酵菌种的制备方法 |
| CN111227049B (zh) * | 2018-11-29 | 2022-08-12 | 内蒙古伊利实业集团股份有限公司 | 一种维持褐色植物基酸奶货架期内组织状态稳定性的方法 |
| CN109517763B (zh) * | 2018-12-27 | 2022-03-22 | 内蒙古农业大学 | 瑞士乳杆菌h11及其应用 |
| CN110226687A (zh) * | 2019-06-12 | 2019-09-13 | 宁波依萃健生物科技有限公司 | 一种解酒护肝组合物及制备方法 |
| DK3845069T3 (da) * | 2019-12-30 | 2022-11-28 | Gervais Danone Sa | Saccharosenegativ streptococcus thermophilus til anvendelse i fremstilling af fermenterede produkter |
| CN111979286B (zh) * | 2020-08-31 | 2021-11-26 | 鲁东大学 | 一种发酵法与酶法联合制备贝类高f值寡肽的方法 |
| CN112616925A (zh) * | 2020-12-30 | 2021-04-09 | 光明乳业股份有限公司 | 一种双蛋白发酵乳及其制备方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3846560A (en) * | 1971-07-22 | 1974-11-05 | Quaker Oats Co | Process of making a base for protein beverages |
| US3876806A (en) * | 1971-10-14 | 1975-04-08 | Quaker Oats Co | Process for the preparation of acid soluble polypeptides and carbonated beverages containing same |
| US4107334A (en) * | 1976-10-13 | 1978-08-15 | Pfizer Inc. | Modified protein |
| CH636248A5 (fr) * | 1979-03-09 | 1983-05-31 | Nestle Sa | Procede de preparation d'un hydrolysat de proteines purifie. |
| JPS60262561A (ja) * | 1984-06-08 | 1985-12-25 | House Food Ind Co Ltd | 大豆蛋白質水溶液の処理方法 |
| US4585757A (en) * | 1984-07-27 | 1986-04-29 | Texas Tech University Health Sciences Center | Hypotensive active peptides |
| US4687840A (en) * | 1986-02-11 | 1987-08-18 | Texas Tech University Health Sciences Center | Hypotensive active peptides |
| GB8823429D0 (en) * | 1988-10-05 | 1988-11-09 | Agricultural Genetics Co | Method for accelerated ripening of cheddar & related hard type cheese |
| DD300815A5 (de) * | 1989-07-07 | 1992-08-06 | Nestle Sa | Proteinhydrolyse |
| NL9000422A (nl) * | 1990-02-21 | 1991-09-16 | Nl Zuivelonderzoek Inst | Werkwijze voor de bereiding van een gefermenteerd melkprodukt. |
| DE69124274T2 (de) * | 1990-02-27 | 1997-08-14 | Agency Ind Science Techn | Oligopeptide, sie enthaltende pharmazeutische und Futterzusammensetzung und Benützung von Oligopeptiden |
| EP0457565B1 (en) * | 1990-05-18 | 1997-07-30 | Morinaga Milk Industry Co., Ltd. | Milk-protein hydrolyzates and compositions for use as hair and skin treating agent |
| JP2571734B2 (ja) * | 1991-08-23 | 1997-01-16 | 株式会社ヤクルト本社 | 乳酸菌飲料 |
| US5486461A (en) * | 1991-11-08 | 1996-01-23 | Novo Nordisk A/S | Casein hydrolyzate and method for production of such casein hydrolyzate |
| FI94088C (fi) * | 1992-03-13 | 1995-07-25 | Valio Oy | Menetelmä fenyylialaniinin poistamiseksi proteiinipitoisista koostumuksista |
| US5418218A (en) * | 1992-07-10 | 1995-05-23 | The University Of Maryland At Baltimore | Histidyl-proline diketopiperazine (cyclo his-pro) a cns-active pharmacologic agent |
| JP2782142B2 (ja) | 1992-07-23 | 1998-07-30 | カルピス株式会社 | アンジオテンシン変換酵素阻害剤及びその製造法 |
| JP2782153B2 (ja) | 1992-11-09 | 1998-07-30 | カルピス株式会社 | アンジオテンシン変換酵素阻害ペプチドの製造法 |
| US5656268A (en) * | 1995-04-21 | 1997-08-12 | Sorodsky; Michael | Biological product |
| US5618689A (en) * | 1995-05-25 | 1997-04-08 | Nestec S.A. | Enhanced procedures for preparing food hydrolysates |
| DE69712912T2 (de) * | 1996-12-23 | 2002-11-21 | Dsm Nv | Verfahren zur herstellung eines proteinhydrolysates |
| US6221423B1 (en) * | 1998-04-13 | 2001-04-24 | Protein Technologies Int'l Inc. | Short-chained peptide material |
| WO2001068113A1 (en) | 2000-03-10 | 2001-09-20 | Monsanto Technology Llc | Anti-hypertensive peptides |
| AU2001247334A1 (en) | 2000-03-10 | 2001-09-24 | Monsanto Company | Novel peptides with anti-hypertensive activity |
| CA2391063A1 (en) | 2000-03-13 | 2001-09-20 | Hiroshi Miyakawa | Protein hydrolyzate, manufacuring method therefor, and foods and drinks containing the protein hydrolyzate |
| US20030040475A1 (en) | 2001-01-16 | 2003-02-27 | Yasuhiro Toba | Agents for improving lipid metabolism and reducing high blood pressure |
| US6815426B2 (en) | 2001-02-16 | 2004-11-09 | E. I. Du Pont De Nemours And Company | Angiogenesis-inhibitory tripeptides, compositions and their methods of use |
| WO2002071854A1 (en) | 2001-03-09 | 2002-09-19 | Unilever N.V. | Fermented milk product |
| US6589574B2 (en) | 2001-03-19 | 2003-07-08 | Council Of Scientific & Industrial Research | Process for preparation of protein-hydrolysate from milk protein |
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1997
- 1997-09-26 JP JP9277949A patent/JP3028411B2/ja not_active Expired - Lifetime
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1998
- 1998-02-05 CA CA002304985A patent/CA2304985C/en not_active Expired - Fee Related
- 1998-02-05 US US09/508,840 patent/US6534304B1/en not_active Expired - Fee Related
- 1998-02-05 DE DE69829983T patent/DE69829983T2/de not_active Expired - Lifetime
- 1998-02-05 AU AU57802/98A patent/AU734422B2/en not_active Ceased
- 1998-02-05 ES ES98901520T patent/ES2237834T3/es not_active Expired - Lifetime
- 1998-02-05 AT AT98901520T patent/ATE294230T1/de active
- 1998-02-05 SK SK435-2000A patent/SK284755B6/sk not_active IP Right Cessation
- 1998-02-05 PL PL98339343A patent/PL188675B1/pl unknown
- 1998-02-05 WO PCT/JP1998/000481 patent/WO1999016862A1/ja active IP Right Grant
- 1998-02-05 CN CNB988115301A patent/CN1149279C/zh not_active Expired - Fee Related
- 1998-02-05 HU HU0003744A patent/HU225980B1/hu not_active IP Right Cessation
- 1998-02-05 KR KR10-2000-7003224A patent/KR100404154B1/ko not_active IP Right Cessation
- 1998-02-05 EP EP98901520A patent/EP1016709B1/en not_active Expired - Lifetime
- 1998-02-05 BR BR9813218-0A patent/BR9813218A/pt not_active Application Discontinuation
- 1998-02-05 CZ CZ20001082A patent/CZ291067B6/cs not_active IP Right Cessation
- 1998-02-05 PT PT98901520T patent/PT1016709E/pt unknown
- 1998-02-05 TR TR2000/00854T patent/TR200000854T2/xx unknown
- 1998-09-17 IN IN2795DE1998 patent/IN188418B/en unknown
- 1998-09-22 TW TW087115782A patent/TW526268B/zh not_active IP Right Cessation
- 1998-09-23 MY MYPI98004363A patent/MY118157A/en unknown
- 1998-09-25 ZA ZA988659A patent/ZA988659B/xx unknown
- 1998-09-25 AR ARP980104806A patent/AR017153A1/es active IP Right Grant
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2000
- 2000-04-26 BG BG104382A patent/BG64422B1/bg unknown
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2002
- 2002-12-05 US US10/310,628 patent/US7282354B2/en not_active Expired - Fee Related
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