ES2200324T3 - Nuevos derivados de pirimidina con actividad antisecretora, su procedimiento de preparacion, y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de pirimidina con actividad antisecretora, su procedimiento de preparacion, y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2200324T3
ES2200324T3 ES98911242T ES98911242T ES2200324T3 ES 2200324 T3 ES2200324 T3 ES 2200324T3 ES 98911242 T ES98911242 T ES 98911242T ES 98911242 T ES98911242 T ES 98911242T ES 2200324 T3 ES2200324 T3 ES 2200324T3
Authority
ES
Spain
Prior art keywords
methyl
pyrimidine
phenyl
tetrahydro
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98911242T
Other languages
English (en)
Spanish (es)
Inventor
Jong Wook Lee
Bong Yong Lee
Chang Seop Kim
Seung Kyu Lee
Keun Seog Song
Song Jin Lee
Woo Jeon Shim
Man Soon Hwang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yuhan Corp
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Application granted granted Critical
Publication of ES2200324T3 publication Critical patent/ES2200324T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES98911242T 1997-03-27 1998-03-24 Nuevos derivados de pirimidina con actividad antisecretora, su procedimiento de preparacion, y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2200324T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR9710862 1997-03-27
KR19970010863 1997-03-27
KR19970010862 1997-03-27
KR9710863 1997-03-27

Publications (1)

Publication Number Publication Date
ES2200324T3 true ES2200324T3 (es) 2004-03-01

Family

ID=26632616

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98911242T Expired - Lifetime ES2200324T3 (es) 1997-03-27 1998-03-24 Nuevos derivados de pirimidina con actividad antisecretora, su procedimiento de preparacion, y composiciones farmaceuticas que los contienen.

Country Status (21)

Country Link
US (1) US6352993B1 (Direct)
EP (1) EP1015444B1 (Direct)
JP (1) JP3176379B2 (Direct)
KR (1) KR100278857B1 (Direct)
CN (1) CN1118464C (Direct)
AR (1) AR012181A1 (Direct)
AT (1) ATE241613T1 (Direct)
AU (1) AU720385B2 (Direct)
BR (1) BR9808070A (Direct)
CA (1) CA2284795C (Direct)
DE (1) DE69815126T2 (Direct)
DK (1) DK1015444T3 (Direct)
ES (1) ES2200324T3 (Direct)
HU (1) HUP0000851A3 (Direct)
IN (1) IN188411B (Direct)
PT (1) PT1015444E (Direct)
RU (1) RU2203894C2 (Direct)
TR (1) TR199902383T2 (Direct)
TW (1) TW542831B (Direct)
UY (1) UY24938A1 (Direct)
WO (1) WO1998043968A1 (Direct)

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US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
AR038368A1 (es) 2002-02-01 2005-01-12 Novartis Ag Compuestos n-pirimidin-2-il-aminas sustituidas como inhibidores de ige, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento
AU2003254282A1 (en) 2002-08-01 2004-02-23 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
WO2005009980A1 (en) * 2003-07-22 2005-02-03 Neurogen Corporation Substituted pyridin-2-ylamine analogues
JP4800216B2 (ja) * 2003-10-24 2011-10-26 エグゼリクシス， インコーポレイテッド ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法
US20080280944A1 (en) 2003-11-03 2008-11-13 Paula Fernstrom Imidazo[1,2-A]Pyridine Derivatives For The Treatment Of Silent Gastro-Esophageal Reflux
KR101122376B1 (ko) * 2005-03-09 2012-03-26 주식회사유한양행 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법
US20090124645A1 (en) * 2005-10-14 2009-05-14 Neurosearch A/S Novel Pyrimidine-2,4-Diamine Derivatives and their Use as Modulators of Small-Conductance Calcium-Activated Potassium Channels
JP4946482B2 (ja) 2007-02-08 2012-06-06 船井電機株式会社 緩衝用梱包材及びｔｖ受像機の緩衝用梱包材
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
PL2308877T3 (pl) 2008-08-05 2014-07-31 Daiichi Sankyo Co Ltd Pochodne imidazopirydyn-2-onu
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
JP2013542243A (ja) 2010-11-15 2013-11-21 カトリーケ ウニヴェルシテイト ルーヴェン 新規な抗ウイルス性化合物
ES2587304T3 (es) 2011-02-25 2016-10-21 Yuhan Corporation Derivados de diaminopirimidina y procedimientos para la preparación de los mismos
AU2013221286B2 (en) * 2012-02-17 2017-06-15 Abbvie Inc. Diaminopyrimidines useful as inhibitors of the human respiratory syncytial virus (RSV)
CA2873674A1 (en) 2012-05-29 2013-12-05 Momentive Performance Materials Gmbh Preparation of isocyanato silanes
CN104918919A (zh) 2012-11-21 2015-09-16 Ptc医疗公司 取代的反向嘧啶Bmi-1抑制剂
MX2015011898A (es) 2013-03-13 2016-05-05 Genentech Inc Compuestos de pirazolo y usos de los mismos.
NZ748260A (en) 2013-08-30 2020-01-31 Ptc Therapeutics Inc Substituted pyrimidine bmi-1 inhibitors
US10125144B2 (en) 2013-10-07 2018-11-13 Kadmon Corporation, Llc Rho kinase inhibitors
WO2015076800A1 (en) 2013-11-21 2015-05-28 Ptc Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
JP2018502900A (ja) * 2014-10-22 2018-02-01 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム ジスコイジンドメイン受容体１を標的化する小分子阻害剤およびその使用
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
WO2017118639A1 (en) * 2016-01-04 2017-07-13 ObsEva S.A. Alpha-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
CN110461833A (zh) * 2017-04-05 2019-11-15 拜耳作物科学股份公司 2-氨基-5-氧基烷基嘧啶衍生物及其用于防治不希望的植物生长的用途
EP3836932A2 (en) 2018-08-17 2021-06-23 PTC Therapeutics, Inc. Method for treating pancreatic cancer
CN114685369B (zh) * 2022-05-17 2024-02-02 河南省科学院高新技术研究中心 一种利用离子液体制备1-甲基-1,2,3,4-四氢异喹啉的方法

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US4000138A (en) 1966-03-31 1976-12-28 Imperial Chemical Industries Limited Organic compounds and compositions containing them
GB1182584A (en) 1966-03-31 1970-02-25 Ici Ltd Pyrimidine derivates and the use thereof as fungicides
US3980781A (en) 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
GB1383409A (en) 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US4044136A (en) 1972-09-09 1977-08-23 Pfizer Inc. Aminoquinazoline therapeutic agents
US3956495A (en) 1973-10-30 1976-05-11 Eli Lilly And Company 2,4-Diaminoquinazolines as antithrombotic agents
US4755218A (en) 1985-12-31 1988-07-05 Monsanto Company Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
IL88507A (en) * 1987-12-03 1993-02-21 Smithkline Beckman Intercredit 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them
US4966622A (en) 1988-04-12 1990-10-30 Ciba-Geigy Corporation N-phenyl-N-pyrimidin-2-ylureas
HU206337B (en) * 1988-12-29 1992-10-28 Mitsui Petrochemical Ind Process for producing pyrimidine derivatives and pharmaceutical compositions
DE3901448A1 (de) 1989-01-19 1990-07-26 Basf Ag Emulsionscopolymerisate
EP0388838B1 (de) 1989-03-22 1996-01-10 Ciba-Geigy Ag Schädlingsbekämpfungsmittel
CA2015981A1 (en) * 1989-05-10 1990-11-10 Thomas H. Brown Compounds
GB8910722D0 (en) 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
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HUT64533A (en) 1990-11-06 1994-01-28 Pfizer Method for producing quinazoline derivatives for improving anti-tumoric activity and preparations containing said compounds
CA2108561A1 (en) * 1991-04-17 1992-10-18 Jotham W. Coe Pyrimidine derivatives for enhancing antitumor activity
US5276186A (en) 1992-03-11 1994-01-04 Ciba-Geigy Corporation Process for the production of guanidine derivatives
KR0144833B1 (ko) * 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
EP0713483B1 (en) * 1993-08-12 2003-01-15 AstraZeneca AB Amidine derivatives with nitric oxide synthetase activities
DK0640599T3 (da) 1993-08-26 1998-09-28 Ono Pharmaceutical Co 4-Aminopyrimidin-derivater
CN1142817A (zh) 1993-10-12 1997-02-12 杜邦麦克制药有限公司 1n-烷基-n-芳基嘧啶胺及其衍生物
RU2129549C1 (ru) 1994-08-13 1999-04-27 Юхан Корпорейшн Производные пиримидина и способы их получения
ES2165052T3 (es) * 1996-05-04 2002-03-01 Yuhan Corp Procedimiento para la preparacion de derivados de pirimidina.

Also Published As

Publication number Publication date
AU6523998A (en) 1998-10-22
RU2203894C2 (ru) 2003-05-10
JP3176379B2 (ja) 2001-06-18
CN1251586A (zh) 2000-04-26
HUP0000851A3 (en) 2002-04-29
WO1998043968A1 (en) 1998-10-08
DK1015444T3 (da) 2003-08-18
HK1026418A1 (en) 2000-12-15
US6352993B1 (en) 2002-03-05
ATE241613T1 (de) 2003-06-15
CA2284795C (en) 2004-01-20
PT1015444E (pt) 2003-10-31
TW542831B (en) 2003-07-21
IN188411B (Direct) 2002-09-21
AR012181A1 (es) 2000-09-27
DE69815126D1 (de) 2003-07-03
CN1118464C (zh) 2003-08-20
CA2284795A1 (en) 1998-10-08
AU720385B2 (en) 2000-06-01
HUP0000851A1 (hu) 2001-04-28
DE69815126T2 (de) 2004-04-08
KR19980080789A (ko) 1998-11-25
UY24938A1 (es) 2001-01-31
TR199902383T2 (xx) 2000-06-21
EP1015444B1 (en) 2003-05-28
JP2000513014A (ja) 2000-10-03
BR9808070A (pt) 2000-03-08
EP1015444A1 (en) 2000-07-05
KR100278857B1 (ko) 2001-01-15

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