HUP0000851A1 - Új pirimidinszármazékok, előállítási eljárásaik, és e vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Új pirimidinszármazékok, előállítási eljárásaik, és e vegyületeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0000851A1
HUP0000851A1 HU0000851A HUP0000851A HUP0000851A1 HU P0000851 A1 HUP0000851 A1 HU P0000851A1 HU 0000851 A HU0000851 A HU 0000851A HU P0000851 A HUP0000851 A HU P0000851A HU P0000851 A1 HUP0000851 A1 HU P0000851A1
Authority
HU
Hungary
Prior art keywords
methyl
group
hydrogen
alkyl
benzyl
Prior art date
Application number
HU0000851A
Other languages
English (en)
Inventor
Man Soon Hwang
Chang Seop Kim
Bong Yong Lee
Jong Wook Lee
Seung Kyu Lee
Song Jin Lee
Woo Jeon Shim
Keun Seog Song
Original Assignee
Yuhan Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corporation filed Critical Yuhan Corporation
Publication of HUP0000851A1 publication Critical patent/HUP0000851A1/hu
Publication of HUP0000851A3 publication Critical patent/HUP0000851A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

A találmány kiváló szekrécióellenes hatással rendelkező (I) általánosképletű, új pirimidinszármazékokra - amelyek képletében ha A piperidinocsoport vagy -NH-B általános képletű csoport, ahol B alkil-, alkenil-, cikloalkil-, alkoxi-etil-, adott esetbenszubsztituált fenil-etil-, 3-(trifluor-metil)-benzil-, (1-naftil)-metil-, 4-metil-2-tiazolil- vagy 4-fenil-2-tiazolil-csoport; R1 hidrogénatom vagy metilcsoport; és R2, R3, R4 és R5 hidrogénatom; vagy ha A (II) általános képletű csoport, ha R1 hidroxi-metil- vagy alkoxi-metil-csoport; R2, R3, R4, R5 és R6 hidrogénatom; és R7 hidrogén- vagy halogénatom; vagy ha R1 hidrogénatom vagy metilcsoport; R7 hidrogén- vagy halogénatom; és R2, R3, R4, R5 és R6 közül egynek vagy kettőnek a jelentése hidroxi-,metoxicsoport vagy (III) általános képletű csoport, <><> amelyben Z alkil-, adott esetben szubsztituált alkenil-, cikloalkil-, (benzil-oxi)-alkil-, (alkoxi-karbonil)-alkil-, morfolino-metil-, piperidino-metil-, (4-szubsztituált piperazino)-metil-, adott esetbenszubsztituált fenil-, naftil-, adott esetben szubsztiutált benzil-,(2-tienil)-metil-, 1-szubsztituált 2-pirrolidinil- vagy -CHR8NHR9képletű csoport, ahol R8 hidrogénatom, metil-, izopropil-, benzil-, (benzil-oxi)-metil-,(metil-tio)-etil-,[(benzil-oxi)-karbonil]-metil-, karbamoil-metil-,karbamoil-etil- vagy (1-benzil-4-imidazolil)-metil-csoport; és R9 hidrogénatom vagy terc-butoxi-karbonil-csoport; és a továbbiakjelentése hidrogénatom vagy metilcsoport - vagy gyógyszerészetilegelfogadható sóikra vonatkozik. Ó
HU0000851A 1997-03-27 1998-03-24 Novel pyrimidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them HUP0000851A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19970010862 1997-03-27
KR19970010863 1997-03-27
PCT/KR1998/000058 WO1998043968A1 (en) 1997-03-27 1998-03-24 Novel pyrimidine derivatives and processes for the preparation thereof

Publications (2)

Publication Number Publication Date
HUP0000851A1 true HUP0000851A1 (hu) 2001-04-28
HUP0000851A3 HUP0000851A3 (en) 2002-04-29

Family

ID=26632616

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000851A HUP0000851A3 (en) 1997-03-27 1998-03-24 Novel pyrimidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them

Country Status (22)

Country Link
US (1) US6352993B1 (hu)
EP (1) EP1015444B1 (hu)
JP (1) JP3176379B2 (hu)
KR (1) KR100278857B1 (hu)
CN (1) CN1118464C (hu)
AR (1) AR012181A1 (hu)
AT (1) ATE241613T1 (hu)
AU (1) AU720385B2 (hu)
BR (1) BR9808070A (hu)
CA (1) CA2284795C (hu)
DE (1) DE69815126T2 (hu)
DK (1) DK1015444T3 (hu)
ES (1) ES2200324T3 (hu)
HK (1) HK1026418A1 (hu)
HU (1) HUP0000851A3 (hu)
IN (1) IN188411B (hu)
PT (1) PT1015444E (hu)
RU (1) RU2203894C2 (hu)
TR (1) TR199902383T2 (hu)
TW (1) TW542831B (hu)
UY (1) UY24938A1 (hu)
WO (1) WO1998043968A1 (hu)

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KR100272471B1 (ko) 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
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CA2493618A1 (en) 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
CA2533397A1 (en) * 2003-07-22 2005-02-03 Neurogen Corporation Substituted pyridin-2-ylamine analogues
JP4800216B2 (ja) * 2003-10-24 2011-10-26 エグゼリクシス， インコーポレイテッド ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法
AU2004285394B2 (en) 2003-11-03 2009-01-08 Astrazeneca Ab Imidazo (1,2-A) pyridine derivatives for the treatment of silent gastro-esophageal reflux
KR101122376B1 (ko) * 2005-03-09 2012-03-26 주식회사유한양행 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법
EP1940804A2 (en) * 2005-10-14 2008-07-09 NeuroSearch A/S Novel pyrimidine-2,4-diamine derivatives and their use as modulators of small-conductance calcium-activated potassium channels
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
PT2308877E (pt) 2008-08-05 2014-05-02 Daiichi Sankyo Co Ltd Derivados de imidazopiridin-2-ona
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
JP2013542243A (ja) 2010-11-15 2013-11-21 カトリーケ ウニヴェルシテイト ルーヴェン 新規な抗ウイルス性化合物
AU2012221927B2 (en) 2011-02-25 2016-04-28 Yuhan Corporation Diaminopyrimidine derivatives and processes for the preparation thereof
WO2013123401A1 (en) * 2012-02-17 2013-08-22 Abbvie Inc. Diaminopyrimidines useful as inhibitors of the human respiratory syncytial virus (rsv)
IN2014MN02314A (hu) 2012-05-29 2015-08-07 Momentive Performance Mat Inc
CA2892045C (en) 2012-11-21 2022-05-31 Ptc Therapeutics, Inc. Substituted reverse pyrimidine bmi-1 inhibitors
WO2014139326A1 (en) 2013-03-13 2014-09-18 Genentech, Inc. Pyrazolo compounds and uses thereof
NZ748260A (en) * 2013-08-30 2020-01-31 Ptc Therapeutics Inc Substituted pyrimidine bmi-1 inhibitors
WO2015054317A1 (en) * 2013-10-07 2015-04-16 Kadmon Corporation, Llc Rho kinase inhibitors
US10584115B2 (en) 2013-11-21 2020-03-10 Ptc Therapeutics, Inc. Substituted pyridine and pyrazine BMI-1 inhibitors
CA2965336A1 (en) * 2014-10-22 2016-04-28 The Board Of Regents Of The University Of Texas System Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
JP6933322B2 (ja) * 2016-01-04 2021-09-08 メルク セローノ エス．エー． ヒドロキシプロピルチアゾリジンカルボキサミド誘導体のｌ−バリネート及びその塩形態、結晶多形
WO2018184978A1 (de) * 2017-04-05 2018-10-11 Bayer Cropscience Aktiengesellschaft 2-amino-5-oxyalkyl-pyrimidinderivate und deren verwendung zur bekämpfung unerwünschten pflanzenwachstums
CN114685369B (zh) * 2022-05-17 2024-02-02 河南省科学院高新技术研究中心 一种利用离子液体制备1-甲基-1,2,3,4-四氢异喹啉的方法

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Also Published As

Publication number Publication date
TR199902383T2 (xx) 2000-06-21
AU6523998A (en) 1998-10-22
TW542831B (en) 2003-07-21
DE69815126T2 (de) 2004-04-08
JP3176379B2 (ja) 2001-06-18
ATE241613T1 (de) 2003-06-15
CN1251586A (zh) 2000-04-26
DE69815126D1 (de) 2003-07-03
CA2284795C (en) 2004-01-20
UY24938A1 (es) 2001-01-31
EP1015444A1 (en) 2000-07-05
AR012181A1 (es) 2000-09-27
AU720385B2 (en) 2000-06-01
DK1015444T3 (da) 2003-08-18
EP1015444B1 (en) 2003-05-28
ES2200324T3 (es) 2004-03-01
KR100278857B1 (ko) 2001-01-15
RU2203894C2 (ru) 2003-05-10
HUP0000851A3 (en) 2002-04-29
JP2000513014A (ja) 2000-10-03
KR19980080789A (ko) 1998-11-25
IN188411B (hu) 2002-09-21
HK1026418A1 (en) 2000-12-15
BR9808070A (pt) 2000-03-08
WO1998043968A1 (en) 1998-10-08
PT1015444E (pt) 2003-10-31
CA2284795A1 (en) 1998-10-08
CN1118464C (zh) 2003-08-20
US6352993B1 (en) 2002-03-05

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees