ES2199220T3 - Derivado de indol, procedimiento para su produccion y usos medicinales del mismo. - Google Patents

Derivado de indol, procedimiento para su produccion y usos medicinales del mismo.

Info

Publication number
ES2199220T3
ES2199220T3 ES93921084T ES93921084T ES2199220T3 ES 2199220 T3 ES2199220 T3 ES 2199220T3 ES 93921084 T ES93921084 T ES 93921084T ES 93921084 T ES93921084 T ES 93921084T ES 2199220 T3 ES2199220 T3 ES 2199220T3
Authority
ES
Spain
Prior art keywords
epoxy
didehydro
indolomorphinan
dihydroxy
cyclopropylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93921084T
Other languages
English (en)
Spanish (es)
Inventor
Hiroshi 2-3-8 Tsunishi Nagase
Akira Toray Kamakurayamaryo Mizusuna
Koji L-202 Toray Koshigoeshataku Kawai
Izumi Sakakibara 54 Higashikibogaoka Nakatani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of ES2199220T3 publication Critical patent/ES2199220T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
ES93921084T 1992-09-29 1993-09-29 Derivado de indol, procedimiento para su produccion y usos medicinales del mismo. Expired - Lifetime ES2199220T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP25984192 1992-09-29
JP25984192 1992-09-29

Publications (1)

Publication Number Publication Date
ES2199220T3 true ES2199220T3 (es) 2004-02-16

Family

ID=17339733

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93921084T Expired - Lifetime ES2199220T3 (es) 1992-09-29 1993-09-29 Derivado de indol, procedimiento para su produccion y usos medicinales del mismo.

Country Status (14)

Country Link
US (2) US6087369A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0614898B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP3605825B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR100301093B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1043766C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE239732T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU672033B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2124455C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69332945T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2199220T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI942499A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO941977L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW271440B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1994007896A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2124455C (en) 1992-09-29 2004-09-14 Hiroshi Nagase Indole derivatives, process for producing the same and medicinal uses of the same
US5464841A (en) * 1993-11-08 1995-11-07 Univ Minnesota Use of delta opioid receptor antagonists to treat immunoregulatory disorders
SE9401728D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds II
SE9401727D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds I
US5578725A (en) * 1995-01-30 1996-11-26 Regents Of The University Of Minnesota Delta opioid receptor antagonists
JP3123080B2 (ja) * 1995-09-26 2001-01-09 東レ株式会社 「インドール誘導体およびその医薬用途」
US5994327A (en) * 1995-11-17 1999-11-30 Astra Ab Process for the preparation of morphinans
CA2242609A1 (en) * 1996-01-10 1997-07-17 Smithkline Beecham S.P.A. Heterocycle-condensed morphinoid derivatives (ii)
WO1998031684A1 (fr) * 1997-01-16 1998-07-23 Toray Industries, Inc. Derives d'indolomorphinane et medicaments/remedes preventifs contre les troubles cerebraux
US6172078B1 (en) 1997-03-31 2001-01-09 Toray Industries, Inc. Quinolinomorphinane derivatives and medicinal use thereof
US5986141A (en) * 1998-09-29 1999-11-16 Eastman Chemical Company Process for the production of cyclopropanemethylamine
CN1204139C (zh) * 1999-08-24 2005-06-01 东丽株式会社 神经性疼痛治疗剂
US8205237B2 (en) 2000-09-14 2012-06-19 Cox Ingemar J Identifying works, using a sub-linear time search, such as an approximate nearest neighbor search, for initiating a work-based action, such as an action on the internet
US7232829B2 (en) 2001-04-06 2007-06-19 Regents Of The University Of Minnesota Therapeutic compounds and methods
AU2002305323A1 (en) 2001-05-04 2002-11-18 Tularik Inc. Fused heterocyclic compounds
US6809104B2 (en) 2001-05-04 2004-10-26 Tularik Inc. Fused heterocyclic compounds
CA2474306A1 (en) * 2002-01-25 2003-08-07 Regents Of The University Of Minnesota Selective analgesic agents
JP4547266B2 (ja) 2002-11-06 2010-09-22 アムジエン・インコーポレーテツド 縮合複素環化合物
EP1595541A1 (en) * 2004-05-12 2005-11-16 Alcasynn Pharmaceuticals Gmbh Use of opioid receptor antagonist compounds for the prevention and/or treatment of diseases associated with the target calcineurin
EP3077398B1 (en) 2013-12-05 2020-03-11 The University of Bath Novel opioid compounds and their uses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3631829A1 (de) * 1986-09-19 1988-07-28 Hoechst Ag Klonierung und verwendung des transaminase gens-tyrb
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
JP2906654B2 (ja) * 1989-11-28 1999-06-21 東レ株式会社 免疫抑制剤及びその製造方法
JPH04342529A (ja) * 1991-05-21 1992-11-30 Toray Ind Inc 抗アレルギー剤
US5225417A (en) * 1992-01-21 1993-07-06 G. D. Searle & Co. Opioid agonist compounds
US5354863A (en) * 1992-01-21 1994-10-11 G. D. Searle & Co. Opioid agonist compounds
US5352680A (en) * 1992-07-15 1994-10-04 Regents Of The University Of Minnesota Delta opioid receptor antagonists to block opioid agonist tolerance and dependence
CA2124455C (en) * 1992-09-29 2004-09-14 Hiroshi Nagase Indole derivatives, process for producing the same and medicinal uses of the same
US5457208A (en) * 1993-06-21 1995-10-10 Regents Of The University Of Minnesota Kappa opioid receptor antagonists
JP3123080B2 (ja) * 1995-09-26 2001-01-09 東レ株式会社 「インドール誘導体およびその医薬用途」

Also Published As

Publication number Publication date
US6291470B1 (en) 2001-09-18
CA2124455C (en) 2004-09-14
EP0614898B1 (en) 2003-05-07
FI942499L (fi) 1994-07-27
DE69332945T2 (de) 2004-05-19
DE69332945D1 (de) 2003-06-12
AU672033B2 (en) 1996-09-19
KR100301093B1 (ko) 2001-10-22
NO941977L (no) 1994-07-29
FI942499A7 (fi) 1994-07-27
CA2124455A1 (en) 1994-04-14
AU4834193A (en) 1994-04-26
CN1092425A (zh) 1994-09-21
EP0614898A4 (en) 1994-10-12
EP0614898A1 (en) 1994-09-14
ATE239732T1 (de) 2003-05-15
FI942499A0 (fi) 1994-05-27
NO941977D0 (no) 1994-05-27
US6087369A (en) 2000-07-11
TW271440B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1996-03-01
JP3605825B2 (ja) 2004-12-22
CN1043766C (zh) 1999-06-23
WO1994007896A1 (fr) 1994-04-14

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