ES2185769T3 - Oxidos de polietileno con un resto sacarido en un extremo y un grupo funcional diferente en el otro extremo y procedimientos de produccion de los mismos. - Google Patents

Oxidos de polietileno con un resto sacarido en un extremo y un grupo funcional diferente en el otro extremo y procedimientos de produccion de los mismos.

Info

Publication number
ES2185769T3
ES2185769T3 ES96909364T ES96909364T ES2185769T3 ES 2185769 T3 ES2185769 T3 ES 2185769T3 ES 96909364 T ES96909364 T ES 96909364T ES 96909364 T ES96909364 T ES 96909364T ES 2185769 T3 ES2185769 T3 ES 2185769T3
Authority
ES
Spain
Prior art keywords
denote
rest
functional group
oligomero
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96909364T
Other languages
English (en)
Inventor
Kazunori Kataoka
Yukio Nagasaki
Masao Kato
Teruo Okano
Teruo Nakamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2185769T3 publication Critical patent/ES2185769T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
    • C08G65/2606—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Abstract

LA INVENCION DESCRIBE UN OLIGOMERO O POLIMERO HETEROTELEQUELICO QUE ESTA REPRESENTADO POR LA FORMULA INDICADA, EN LA CUAL A DENOTA UN RESTO SACARIDO, L DENOTA UN GRUPO DE ENLACE REPRESENTADO POR LA FORMULA INDICADA O ( - CH 2 ) 4 , EN LA CUAL R 1 Y R 2 DENOTAN INDEPENDIENTEMENTE ALQUILO, ARALQUILO O ARILO INFERIOR, X DENOTA UN ENLACE SENCILLO O - CH 2 CH 2 - , Z DENOTA UN GRUPO QUE FORMA UN ETER O ES TER INSATURADO, O UN GRUPO FUNCIONAL TAL COMO HALOGENO QUE SE UNE A - CH 2 CH 2 , N DENOTA UN NUMERO ENTERO DESDE 5 - 10.000, Y M DENOTA UN NUMERO ENTERO DESDE 0 O 2 - 10.000. ESTA INVENCION TAMBIEN DESCRIBE UN PROCEDIMIENTO PARA PRODUCIR EL ANTERIOR OLIGOMERO O POLIMERO, Y ADEMAS UNA MICELA DE ELEVADO PESO MOLECULAR CON EL USO DE UN POLIMERO EN BLOQUE DE POLI(OXIDO DE ETILENO) - POLIESTER QUE PRESENTA UN RESTO SACARIDO EN UN EXTREMO. SE ESPERA QUE DICHO OLIGOMERO O POLIMERO MUESTRA UNA EXCELENTE BIODISPONIBILIDAD Y TAMBIEN SE ESPERA QUE PUEDA UTILIZARSE EN EL CAMPO TAL COMO DE LOS VEHICULOS PARA LA ADMINISTRACION DE FARMACOS O REACTIVOS DE DIAGNOSTICO.
ES96909364T 1995-04-14 1996-04-12 Oxidos de polietileno con un resto sacarido en un extremo y un grupo funcional diferente en el otro extremo y procedimientos de produccion de los mismos. Expired - Lifetime ES2185769T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8937395 1995-04-14

Publications (1)

Publication Number Publication Date
ES2185769T3 true ES2185769T3 (es) 2003-05-01

Family

ID=13968897

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96909364T Expired - Lifetime ES2185769T3 (es) 1995-04-14 1996-04-12 Oxidos de polietileno con un resto sacarido en un extremo y un grupo funcional diferente en el otro extremo y procedimientos de produccion de los mismos.

Country Status (20)

Country Link
US (2) US5973069A (es)
EP (1) EP0852243B1 (es)
JP (1) JP4036472B2 (es)
KR (1) KR19990007804A (es)
CN (1) CN1085690C (es)
AT (1) ATE226966T1 (es)
AU (1) AU5289096A (es)
BR (1) BR9604895A (es)
CA (1) CA2218140A1 (es)
DE (1) DE69624581T2 (es)
DK (1) DK0852243T3 (es)
ES (1) ES2185769T3 (es)
HU (1) HU221090B1 (es)
MX (1) MX9707887A (es)
NO (1) NO974728L (es)
NZ (1) NZ304991A (es)
PT (1) PT852243E (es)
RU (1) RU2193574C2 (es)
SI (1) SI9620064A (es)
WO (1) WO1996032434A1 (es)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133347A (en) * 1999-07-09 2000-10-17 Mbt Holding Ag Oligomeric dispersant
US6861459B2 (en) * 1999-07-09 2005-03-01 Construction Research & Technology Gmbh Oligomeric dispersant
US6908955B2 (en) * 1999-07-09 2005-06-21 Construction Research & Technology Gmbh Oligomeric dispersant
JP2001048978A (ja) 1999-08-04 2001-02-20 Nano Career Kk オキサゾリン由来のポリマーセグメントを有するブロックコポリマー
JP2001208754A (ja) * 2000-01-26 2001-08-03 Kazunori Kataoka 生物学的な被検体を検出するための組成物
JP2001247591A (ja) * 2000-03-02 2001-09-11 Natl Inst Of Advanced Industrial Science & Technology Meti 重合性グルコフラノース誘導体およびその製造方法
EP1279959A4 (en) * 2000-05-11 2006-07-05 Toudai Tlo Ltd POLYMER COMPOSITION FOR FORMING THE SURFACE OF A BIOSENSOR
JP4063510B2 (ja) * 2001-07-13 2008-03-19 ナノキャリア株式会社 薬物含有高分子ミセルの凍結乾燥用組成物およびその凍結乾燥製剤
CN1798832B (zh) 2001-07-26 2010-04-28 片冈一则 含有动物培养细胞球状体的培养细胞构成物及其用途
WO2003018665A1 (en) 2001-08-22 2003-03-06 Bioartificial Gel Technologies Inc. Process for the preparation of activated polyethylene glycols
WO2003076933A1 (fr) * 2002-03-11 2003-09-18 Toudai Tlo, Ltd. Surface en poly(ethylene oxyde) a structure de type pinceau presentant une densite elevee
US20060127899A1 (en) * 2002-05-08 2006-06-15 Ralf Krahmer Active carbohydrate containing protecting reagents for chemical modifications, their production and use
JPWO2005073370A1 (ja) * 2004-01-31 2008-01-10 株式会社トランスパレント 酵素複合体
US7351787B2 (en) * 2004-03-05 2008-04-01 Bioartificial Gel Technologies, Inc. Process for the preparation of activated polyethylene glycols
EP1897900B1 (en) 2005-06-09 2013-08-07 NanoCarrier Co., Ltd. Process for production of polymerized coordination compound of platinum complex
JP5277439B2 (ja) 2006-03-01 2013-08-28 国立大学法人 東京大学 核酸内包高分子ミセル複合体
KR20080106219A (ko) * 2006-03-06 2008-12-04 나노캬리아 가부시키가이샤 소수성 화합물의 안정화제
EP2011516A4 (en) * 2006-04-24 2010-06-23 Nanocarrier Co Ltd PROCESS FOR THE PRODUCTION OF A POLYMERIC MICELLE THAT CONTAINS A CHEMICAL PRODUCT OF LOW MOLECULAR WEIGHT ENCAPSULATED IN IT
CN101489574A (zh) 2006-07-18 2009-07-22 那野伽利阿株式会社 内包生理活性多肽或蛋白质的高分子聚合物胶束及其制造方法
EP2087912B1 (en) 2006-11-22 2017-05-10 The University of Tokyo Sirna carrier using disulfide-bridged polymeric micelle
US20080161535A1 (en) * 2006-12-21 2008-07-03 Wiggins Michael S Thickening and wetting agents
CN101952324B (zh) * 2007-07-12 2014-08-13 巴斯夫欧洲公司 基于硝化纤维素的分散剂
US8075909B2 (en) 2007-09-04 2011-12-13 University Of Florida Research Foundation, Incorporated Contact lens based bioactive agent delivery system
EP2284210B1 (en) 2008-04-30 2017-12-06 The University of Tokyo Charge conversional ternary polyplex
AU2009263529B2 (en) 2008-06-24 2013-09-26 Nanocarrier Co., Ltd. Liquid composition comprising cisplatin-coordinating compound
JP5651468B2 (ja) 2008-06-26 2015-01-14 独立行政法人科学技術振興機構 Ｍｒｉ造影能を有する重合体−金属錯体複合体、並びにそれを用いたｍｒｉ造影用及び／又は抗腫瘍用組成物
TW201120063A (en) * 2009-08-21 2011-06-16 Idemitsu Kosan Co Sugar derivative having a polymerizable group, and resist material using said sugar derivative
WO2011043980A1 (en) 2009-10-07 2011-04-14 Sanford Burnham Medical Research Institute Methods and compositions related to clot-binding lipid compounds
JP4829351B2 (ja) 2010-02-05 2011-12-07 ナノキャリア株式会社 易崩壊型ポリマーミセル組成物
EP2555802A1 (en) 2010-04-08 2013-02-13 Sanford-Burnham Medical Research Institute Methods and compositions for enhanced delivery of compounds
JP5843763B2 (ja) 2010-05-21 2016-01-13 国立研究開発法人科学技術振興機構 物質内包ベシクル及びその製造方法
WO2012005376A1 (ja) 2010-07-09 2012-01-12 国立大学法人 東京大学 核酸送達用組成物及び担体組成物、それを用いた医薬組成物、並びに核酸送達方法
WO2012118778A1 (en) 2011-02-28 2012-09-07 Sanford-Burnham Medical Research Institute Truncated car peptides and methods and compositions using truncated car peptides
US10179801B2 (en) 2011-08-26 2019-01-15 Sanford-Burnham Medical Research Institute Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides
RU2538211C2 (ru) * 2012-09-12 2015-01-10 Федеральное государственное бюджетное учреждение науки Институт высокомолекулярных соединений Российской академии наук Способ получения углеводсодержащих полимеров
JP6049854B2 (ja) 2013-03-01 2016-12-27 国立研究開発法人科学技術振興機構 物質内包ベシクル及びその製造方法
WO2014157150A1 (ja) * 2013-03-25 2014-10-02 日油株式会社 ベンジリデンアセタールリンカーを有する親水性ポリマー誘導体
CA2911495A1 (en) 2013-05-17 2014-11-20 Nanocarrier Co., Ltd. Polymeric micelle pharmaceutical composition
JP2015046867A (ja) 2013-07-31 2015-03-12 株式会社リコー 撮像装置
JP6108369B2 (ja) 2013-08-06 2017-04-05 国立研究開発法人科学技術振興機構 核酸内包高分子ミセル複合体及びその製造方法
JP6145612B2 (ja) 2013-08-23 2017-06-14 国立大学法人 東京大学 高分子ナノ粒子複合体、及びそれを含むｍｒｉ造影用組成物
JP5971264B2 (ja) 2014-01-10 2016-08-17 Ｊｆｅスチール株式会社 極厚肉油井管用ねじ継手
WO2016210423A2 (en) 2015-06-25 2016-12-29 Sanford Burnham Prebys Medical Discovery Institute Compositions for delivery to and treatment of atherosclerotic plaques
DE102017003004A1 (de) * 2017-03-23 2018-09-27 Friedrich-Schiller-Universität Jena Kationische Polymere mit D-Fructose-Substituenten
US20200190142A1 (en) 2017-05-02 2020-06-18 Stanford Burnham Prebys Medical Discovery Institute Tumor associated monocyte/macrophage binding peptide and methods of use thereof
WO2020161602A1 (en) 2019-02-04 2020-08-13 University Of Tartu Bi-specific extracellular matrix binding peptides and methods of use thereof
EP3808757A1 (en) 2019-10-14 2021-04-21 École Polytechnique Fédérale de Lausanne (EPFL) Renewable monomer and polymer thereof
CN112029084B (zh) * 2020-08-31 2021-10-26 华南理工大学 一种以硫代羧酸为引发剂简便、可控合成α-巯基-ω-羟基聚醚的方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3163056D1 (en) * 1980-06-20 1984-05-17 Goldschmidt Ag Th Process for the production of polymers with at least one terminal primary hydroxyl group
EP0154316B1 (en) * 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Chemically modified lymphokine and production thereof
GB8427886D0 (en) * 1984-11-03 1984-12-12 Manchester Inst Science Tech Formation of polyols
JPS61152393A (ja) * 1984-12-26 1986-07-11 株式会社日立製作所 複合材の切断方法および切断金型
JPS63152393A (ja) * 1986-07-03 1988-06-24 Takeda Chem Ind Ltd グリコシル誘導体
US5037969A (en) * 1986-07-03 1991-08-06 Takeda Chemical Industries, Ltd. Glycosyl derivatives and use thereof
JPH07103208B2 (ja) * 1990-02-14 1995-11-08 エルフ アトケム ソシエテ アノニム 官能性多元ブロックマクロモノマーと、その製造方法
DE4039193A1 (de) * 1990-12-08 1992-06-11 Bayer Ag In wasser dispergierbare, elektrolytstabile polyetherester-modifizierte polyurethanionomere
WO1992004048A2 (en) * 1990-08-30 1992-03-19 The Biomembrane Institute Inhibition of metastasis potential and invasiveness by oligosaccharides or oligosaccharide antigens or antibodies
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
JP2593032B2 (ja) * 1992-02-07 1997-03-19 新技術事業団 両末端ヘテロ官能性ポリエーテル並びに該ポリエーテルを製造する方法及び重合開始剤
DE4313117C2 (de) * 1993-04-22 1995-09-28 Grillo Werke Ag Fettsäureester von Methylglukosid-Derivaten, Verfahren zu ihrer Herstellung und Verwendung
DE4317231A1 (de) * 1993-05-24 1994-12-01 Wolff Walsrode Ag Thermoplastische Celluloseetherester-Mischpfropfpolymerisate und Verfahren zu ihrer Herstellung
JP3465307B2 (ja) * 1993-08-05 2003-11-10 日本油脂株式会社 ポリアルキレンオキシド誘導体および製造方法
JP3407397B2 (ja) * 1994-05-06 2003-05-19 日本油脂株式会社 ポリオキシアルキレン誘導体および製造方法
JP3508207B2 (ja) * 1994-05-30 2004-03-22 日本油脂株式会社 ポリオキシアルキレン誘導体の製造方法
JP3508234B2 (ja) * 1994-09-22 2004-03-22 日本油脂株式会社 ポリオキシアルキレン誘導体の製造方法

Also Published As

Publication number Publication date
NO974728L (no) 1997-12-05
HUP9801120A2 (hu) 1998-08-28
NZ304991A (en) 2000-02-28
PT852243E (pt) 2003-03-31
HUP9801120A3 (en) 1998-12-28
US6090317A (en) 2000-07-18
US5973069A (en) 1999-10-26
SI9620064A (sl) 1998-06-30
KR19990007804A (ko) 1999-01-25
CN1187212A (zh) 1998-07-08
MX9707887A (es) 1997-11-29
CN1085690C (zh) 2002-05-29
RU2193574C2 (ru) 2002-11-27
DK0852243T3 (da) 2003-02-24
BR9604895A (pt) 1999-11-30
DE69624581D1 (de) 2002-12-05
EP0852243B1 (en) 2002-10-30
AU5289096A (en) 1996-10-30
CA2218140A1 (en) 1996-10-17
NO974728D0 (no) 1997-10-13
ATE226966T1 (de) 2002-11-15
EP0852243A4 (en) 1998-08-26
EP0852243A1 (en) 1998-07-08
JP4036472B2 (ja) 2008-01-23
WO1996032434A1 (fr) 1996-10-17
HU221090B1 (en) 2002-08-28
DE69624581T2 (de) 2003-05-15

Similar Documents

Publication Publication Date Title
ES2185769T3 (es) Oxidos de polietileno con un resto sacarido en un extremo y un grupo funcional diferente en el otro extremo y procedimientos de produccion de los mismos.
Mayordomo Contributions to the study of resource-bounded measure
DE69123795T3 (de) Pharmazeutische Zusammensetzung zur rektalen Verabreichung von Wirkstoffen mit topischer medizinischer Wirkung im Dickdarmniveau
ES2188787T3 (es) Compuesto medicamentoso de micela copolimera y metodo para su preparacion.
DE60214173D1 (de) Negativ geladenes amphiphiles blockcopolymer als arzneistoffträger und komplex davon mit postitiv geladenem arzneistoff
GR1000456B (el) Μεθοδος παρασκευης φαρμακευτικων συνθεσεων που περιλαμβανουν κυκλοσπορινες.
PT99108A (pt) Processo de preparacao de uma composicao farmaceutica a base de portadores naoaquosos de perfluorocarbonetos ou silicone fluorado
ES2110377T1 (es) Formulacion galenica de fenofibrato y aplicacion de la misma.
CO4560480A1 (es) Espesadores asociativos
PT1318791E (pt) Composicao farmaceutica semi-solida de isotretinoina
IL183296A0 (en) Multivalent vaccine composition with mixed carrier
AR033859A1 (es) Inhibidores de la metaloproteinasa de la matriz
DE60220519D1 (de) Mizellares arzneistoffverabreichungssystem für hydrophobe arzneistoffe
DE602004018772D1 (de) Pharmazeutische zusammensetzungen - ph-sensitive blockcopolymere und einen hydrophoben wirkstoff enthaltend
ES2058081T3 (es) Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos.
CY1106257T1 (el) ΧΡΗΣΗ ΠΑΡΑΓΩΓΩΝ ΠΥΡΙΔΑΖΙΝΟ [4,5-(b)]-ΙΝΔΟΛΗ -1-ΑΚΕΤΑΜΙΔΗ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΣΚΕΥΑΣΜΑΤΩΝ ΠΟΥ ΠΡΟΟΡΙΖΟΝΤΑΙ ΓΙΑ ΝΟΣΟΥΣ ΠΟΥ ΣΥΝΔΕΟΝΤΑΙ ΜΕ ΤΗ ΔΥΣΛΕΙΤΟΥΡΓΙΑ ΤΩΝ ΥΠΟΔΟΧΕΩΝ ΠEPΙΦEPΙΚΟΥ ΤΥΠΟΥ ΣΤΙΣ ΒΕΝΖΟΔΙΑΖΕΠΙΝΕΣ
DK1372729T3 (da) Nedbrydelige polymere til injektion
ES2095840T3 (es) Conjugado de anticuerpo-farmaco.
DE60220796D1 (de) Positiv geladenes amphiphiles blockcopolymer als arzneistoffträger und komplex davon mit negativ geladenem arzneistoff
BR112016006287A2 (pt) método de tratamento de uma formação subterrânea
AR030016A1 (es) Derivados de 4-oxo-3,5-dihidro-4h-piridazino [4,5-b]indol-1-carboxamida, medicamento y composicion farmaceutica que comprenden a dichos derivados
DK1268522T3 (da) LH-RH-antagonister samt fremstilling deraf og anvendelse deraf som lægemidler
ES2049938T3 (es) Procedimiento de condensacion de al menos un epoxido sobre al menos un anhidrido ciclico en presencia de un catalizador a base de al menos un complejo nitrogenado de titanio.
EA200200370A1 (ru) Препараты эстрамустинфосфата и сульфоалкиловых эфиров циклодекстринов для парентерального применения
PT1259515E (pt) Derivados da tienopiridina e a sua utilizacao como agentes anti-inflamatorios