MX9707887A - Polioxietileno que tiene un azucar en un extremo y un grupo funcional diferente en el otro extremo, y un metodo para la produccion del mismo. - Google Patents

Polioxietileno que tiene un azucar en un extremo y un grupo funcional diferente en el otro extremo, y un metodo para la produccion del mismo.

Info

Publication number
MX9707887A
MX9707887A MX9707887A MX9707887A MX9707887A MX 9707887 A MX9707887 A MX 9707887A MX 9707887 A MX9707887 A MX 9707887A MX 9707887 A MX9707887 A MX 9707887A MX 9707887 A MX9707887 A MX 9707887A
Authority
MX
Mexico
Prior art keywords
saccharide residue
functional group
producing
same
different functional
Prior art date
Application number
MX9707887A
Other languages
English (en)
Inventor
Kazunori Kataoka
Yukio Nagasaki
Masao Kato
Teruo Okano
Teruo Nakamura
Original Assignee
Kazunori Kataoka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kazunori Kataoka filed Critical Kazunori Kataoka
Publication of MX9707887A publication Critical patent/MX9707887A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
    • C08G65/2606—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Abstract

Esta invencion provee un oligomero o polímero heterotelequélico que está representado por la siguiente formula: A--(-CH2CH2O)n-1 (-C- L O-)m X-Z en donde A denota un residuo de azucar, L denota un grupo de union representado por la siguiente formula: --CH-O-C-CH o (-CH2-)--4 en donde R1 y R2 independientemente denotan alquilo inferior, arilo o alquilarilo, X denota un solo enlace o -CH2CH2-, Z denota un grupo que forma un éster o éter insaturado, o un grupo funcional tal como halogeno que se une a -CH2CH2-, n denota un entero de 5-10,000, y m denota un entero de 0 o 2 - 10,000; esta invencion también provee un procedimiento para producir el oligomero o polímero anterior, y además de una micela de peso molecular alto con el uso un polímero de bloque de oxido de polietileno/poliéster que tiene un residuo de azucar en su extremo terminal; se espera que dicho oligomero i polímero exhiba excelente biodisponibilidad, y también se espera que se utilice en el campo como vehículo para surtido de fármaco o reactivos de diagnostico.
MX9707887A 1995-04-14 1996-04-12 Polioxietileno que tiene un azucar en un extremo y un grupo funcional diferente en el otro extremo, y un metodo para la produccion del mismo. MX9707887A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8937395 1995-04-14
PCT/JP1996/001020 WO1996032434A1 (fr) 1995-04-14 1996-04-12 Oxydes de polyethylene ayant un groupe saccharide a une extremite et un groupe fonctionnel different a l'autre extremite, et procede pour produire lesdits oxydes de polyethylene

Publications (1)

Publication Number Publication Date
MX9707887A true MX9707887A (es) 1997-11-29

Family

ID=13968897

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9707887A MX9707887A (es) 1995-04-14 1996-04-12 Polioxietileno que tiene un azucar en un extremo y un grupo funcional diferente en el otro extremo, y un metodo para la produccion del mismo.

Country Status (20)

Country Link
US (2) US5973069A (es)
EP (1) EP0852243B1 (es)
JP (1) JP4036472B2 (es)
KR (1) KR19990007804A (es)
CN (1) CN1085690C (es)
AT (1) ATE226966T1 (es)
AU (1) AU5289096A (es)
BR (1) BR9604895A (es)
CA (1) CA2218140A1 (es)
DE (1) DE69624581T2 (es)
DK (1) DK0852243T3 (es)
ES (1) ES2185769T3 (es)
HU (1) HU221090B1 (es)
MX (1) MX9707887A (es)
NO (1) NO974728L (es)
NZ (1) NZ304991A (es)
PT (1) PT852243E (es)
RU (1) RU2193574C2 (es)
SI (1) SI9620064A (es)
WO (1) WO1996032434A1 (es)

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Also Published As

Publication number Publication date
HUP9801120A2 (hu) 1998-08-28
DK0852243T3 (da) 2003-02-24
EP0852243B1 (en) 2002-10-30
AU5289096A (en) 1996-10-30
CN1085690C (zh) 2002-05-29
NZ304991A (en) 2000-02-28
DE69624581T2 (de) 2003-05-15
US6090317A (en) 2000-07-18
US5973069A (en) 1999-10-26
HUP9801120A3 (en) 1998-12-28
ATE226966T1 (de) 2002-11-15
ES2185769T3 (es) 2003-05-01
CA2218140A1 (en) 1996-10-17
PT852243E (pt) 2003-03-31
NO974728L (no) 1997-12-05
JP4036472B2 (ja) 2008-01-23
KR19990007804A (ko) 1999-01-25
BR9604895A (pt) 1999-11-30
EP0852243A4 (en) 1998-08-26
HU221090B1 (en) 2002-08-28
SI9620064A (sl) 1998-06-30
CN1187212A (zh) 1998-07-08
EP0852243A1 (en) 1998-07-08
RU2193574C2 (ru) 2002-11-27
NO974728D0 (no) 1997-10-13
DE69624581D1 (de) 2002-12-05
WO1996032434A1 (fr) 1996-10-17

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