ES2183908T3 - Procedimiento para la preparacion de compuestos de imidazolilo enantiomericamente puros. - Google Patents
Procedimiento para la preparacion de compuestos de imidazolilo enantiomericamente puros.Info
- Publication number
- ES2183908T3 ES2183908T3 ES96202829T ES96202829T ES2183908T3 ES 2183908 T3 ES2183908 T3 ES 2183908T3 ES 96202829 T ES96202829 T ES 96202829T ES 96202829 T ES96202829 T ES 96202829T ES 2183908 T3 ES2183908 T3 ES 2183908T3
- Authority
- ES
- Spain
- Prior art keywords
- acid
- addition salt
- composition
- imidazolil
- enantiomerically pure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 10
- 239000000203 mixture Substances 0.000 abstract 8
- 150000003839 salts Chemical class 0.000 abstract 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 239000012452 mother liquor Substances 0.000 abstract 2
- 238000000926 separation method Methods 0.000 abstract 2
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 abstract 1
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 abstract 1
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000006340 racemization Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
LA INVENCION SE REFIERE A UN METODO PARA LA PREPARACION DE UNA COMPOSICION DE IMIDAZOLILO ENANTIOMERICAMENTE PURO DE LA FORMULA GENERAL EN DONDE: N ES 0 O 1; M ES 1 O 2; R{SUB,1} ES NITROGENO, METILO O ETILO; Y C{SUP,*} DENOTA UN CENTRO QUIRAL; ASI COMO SU SAL DE ADICION FARMACEUTICAMENTE ACEPTABLE; MEDIANTE A) AÑADIR UN ACIDO CARBOXILICO EN FORMA OPTICAMENTE ACTIVA A UNA SOLUCION DE UNA MEZCLA RACEMICA DE LA COMPOSICION I DE MAS ARRIBA, SEGUIDA DE LA SEPARACION DE LA SAL DE ADICION ACIDA CRISTALIZADA DE DICHA MEZCLA DE ENANTIOMEROS DE LA COMPOSICION I ENRIQUECIDA EN UN ENANTIOMERO, DESDE EL LICOR MADRE ENRIQUECIDO EN EL OTRO ENANTIOMERO B) CUANDO LA SAL DE ADICION ACIDA CRISTALIZADA ESTA ENRIQUECIDA EN EL ENANTIOMERO NO DESEADO, SEPARAR ENTONCES LA MEZCLA DE ENANTIOMEROS DEL LICOR MADRE DE DICHO ACIDO CARBOXILICO OPTICAMENTE ACTIVO, SEGUIDO DE LA ADICION DE UNA MEZCLA RACEMICA DE DICHO ACIDO CARBOXILICO A UNA SOLUCION DE LA MEZCLA OBTENIDA DE ISOMEROS DE I, Y LA SEPARACION DE LA SAL DE ADICION ACIDA CRISTALIZADA DE DICHA MEZCLA, ENRIQUECIDA EN EL ENANTIOMERO DESEADO, DESDE EL LICOR MADRE, Y (C) OPCIONALMENTE VOLVER A CRISTALIZAR EL PRODUCTO HASTA OBTENER LA PUREZA ENANTIOMERICA DESEADA, Y A CONTINUACION (D) CONVERTIR ESTA SAL DE ADICION ACIDA DEL ENANTIOMERO DESEADO EN LA COMPOSICION DE IMIDAZOLILO ENANTIOMERICAMENTE PURO DESEADA DE LA FORMULA GENERAL I O EN SU SAL DE ADICION ACIDA FARMACEUTICAMENTE ACEPTABLE, CARACTERIZADO EN QUE SE UTILIZA ACIDO PIROGLUTAMICO COMO DICHO ACIDO CARBOXILICO. LA INVENCION SE REFIERE ADEMAS A UN METODO DE RACEMIZACION Y A UNA NUEVA SAL DE ADICION ACIDA DE ESTA COMPOSICION DE FORMULA I Y ACIDO D-PIROGLUTAMICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95202765 | 1995-10-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2183908T3 true ES2183908T3 (es) | 2003-04-01 |
Family
ID=8220714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96202829T Expired - Lifetime ES2183908T3 (es) | 1995-10-13 | 1996-10-10 | Procedimiento para la preparacion de compuestos de imidazolilo enantiomericamente puros. |
Country Status (24)
Country | Link |
---|---|
US (1) | US5663343A (es) |
EP (1) | EP0768309B1 (es) |
JP (2) | JP4590038B2 (es) |
KR (1) | KR100459745B1 (es) |
CN (1) | CN1060774C (es) |
AT (1) | ATE224896T1 (es) |
AU (1) | AU702594B2 (es) |
CA (1) | CA2187484C (es) |
CZ (1) | CZ288042B6 (es) |
DE (1) | DE69623900T2 (es) |
DK (1) | DK0768309T3 (es) |
DZ (1) | DZ2104A1 (es) |
ES (1) | ES2183908T3 (es) |
HK (1) | HK1000446A1 (es) |
HU (1) | HU226620B1 (es) |
IL (1) | IL119400A (es) |
NO (1) | NO307257B1 (es) |
NZ (1) | NZ299562A (es) |
PT (1) | PT768309E (es) |
RU (1) | RU2162085C2 (es) |
SK (1) | SK283471B6 (es) |
TW (1) | TW513423B (es) |
UA (1) | UA48947C2 (es) |
ZA (1) | ZA968525B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19813661A1 (de) * | 1997-08-01 | 1999-02-04 | Solvay Pharm Gmbh | Gegen Racemisierung stabilisierte pharmazeutische Zubereitungen von Cilansetron |
US6372919B1 (en) * | 2001-01-11 | 2002-04-16 | Dov Pharmaceutical, Inc. | (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent |
US20040048874A1 (en) * | 2001-05-22 | 2004-03-11 | Bardsley Hazel Judith | New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine |
GB0216027D0 (en) * | 2002-07-10 | 2002-08-21 | Arachnova Therapeutics Ltd | New therapeutic use |
US7015333B2 (en) * | 2002-11-18 | 2006-03-21 | Solvay Pharmaceuticals B.V. | Process for preparation of imidazolyl compounds |
EP1424337A1 (en) * | 2002-11-26 | 2004-06-02 | Solvay Pharmaceuticals GmbH | 4-hydroxy derivatives of 5,6,9,10-tetrahydro-10-((2-methyl-1h-imidazol-1-yl)methyl)-4h-pyrido-(3,2,1-jk)-carbazol-11(8h)-one |
JP2006516977A (ja) * | 2003-01-13 | 2006-07-13 | ダイノゲン ファーマシューティカルズ,インコーポレイテッド | 悪心、嘔吐、レッチング、またはそれらの任意の組み合わせの治療方法 |
EP2286817A3 (en) * | 2003-01-13 | 2011-06-15 | Edusa Pharmaceuticals, Inc | Method of treating functional bowel disorders |
ES2290741T3 (es) * | 2003-04-04 | 2008-02-16 | Dynogen Pharmaceuticals Inc. | Metodo de tratamiento de trastornos del tracto urinario inferior. |
EP1706394B1 (en) * | 2003-11-12 | 2014-12-17 | Dr. Reddy's Laboratories, Inc. | Preparation of escitalopram |
US20070043100A1 (en) | 2005-08-16 | 2007-02-22 | Hagen Eric J | Novel polymorphs of azabicyclohexane |
US20080045725A1 (en) | 2006-04-28 | 2008-02-21 | Murry Jerry A | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane |
US7601856B2 (en) | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
US7662831B2 (en) | 2006-07-27 | 2010-02-16 | Wyeth Llc | Tetracyclic indoles as potassium channel modulators |
JP5156222B2 (ja) * | 2006-11-28 | 2013-03-06 | エムキュア ファーマシューティカルズ リミテッド | 制吐作用化合物の新たな製造方法 |
GB0910373D0 (en) * | 2009-06-16 | 2009-07-29 | Filtrona Int Ltd | Tabacco smoke filter |
US9806720B1 (en) * | 2016-10-07 | 2017-10-31 | Analog Devices Global | Compound semiconductor based inverter |
US11542244B2 (en) | 2018-05-18 | 2023-01-03 | Kura Oncology, Inc. | Synthesis of tipifarnib |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7413843A (nl) * | 1974-10-23 | 1976-04-27 | Stamicarbon | Optische scheiding van fenylglycine-amide. |
US4463176A (en) * | 1982-09-13 | 1984-07-31 | Mead Johnson & Company | Process for resolution of optical isomers |
US4849527A (en) * | 1982-09-13 | 1989-07-18 | Bristol-Myers Company | Process for resolution of optical isomers |
NL190373C (nl) * | 1984-01-25 | 1994-02-01 | Glaxo Group Ltd | Een 3-gesubstitueerde aminomethyl-2,3-dihydro-4(1h)-carbazolon, werkwijze ter bereiding daarvan, alsmede een farmaceutisch preparaat. |
ES2059491T3 (es) * | 1987-06-29 | 1994-11-16 | Duphar Int Res | Derivados de indol con anillos condensados. |
GB8812636D0 (en) * | 1988-05-27 | 1988-06-29 | Glaxo Group Ltd | Chemical compounds |
US5049563A (en) * | 1988-07-07 | 1991-09-17 | Duphar International Research B.V. | Annelated indoleketones with an imidazolylalkyl substituent |
DE4238553A1 (de) * | 1992-11-14 | 1994-05-19 | Kali Chemie Pharma Gmbh | Neue Imidazol-1-yl-Verbindungen enthaltende Arzneimittel |
-
1996
- 1996-09-26 AU AU65856/96A patent/AU702594B2/en not_active Ceased
- 1996-10-03 TW TW085112098A patent/TW513423B/zh not_active IP Right Cessation
- 1996-10-08 SK SK1287-96A patent/SK283471B6/sk not_active IP Right Cessation
- 1996-10-08 JP JP28461296A patent/JP4590038B2/ja not_active Expired - Fee Related
- 1996-10-08 CZ CZ19962947A patent/CZ288042B6/cs not_active IP Right Cessation
- 1996-10-09 DZ DZ960148A patent/DZ2104A1/fr active
- 1996-10-09 HU HU9602778A patent/HU226620B1/hu not_active IP Right Cessation
- 1996-10-09 ZA ZA968525A patent/ZA968525B/xx unknown
- 1996-10-09 CA CA002187484A patent/CA2187484C/en not_active Expired - Fee Related
- 1996-10-09 NO NO964282A patent/NO307257B1/no not_active IP Right Cessation
- 1996-10-09 RU RU96120366/04A patent/RU2162085C2/ru not_active IP Right Cessation
- 1996-10-10 KR KR1019960044972A patent/KR100459745B1/ko not_active IP Right Cessation
- 1996-10-10 IL IL11940096A patent/IL119400A/xx not_active IP Right Cessation
- 1996-10-10 ES ES96202829T patent/ES2183908T3/es not_active Expired - Lifetime
- 1996-10-10 AT AT96202829T patent/ATE224896T1/de active
- 1996-10-10 US US08/728,794 patent/US5663343A/en not_active Expired - Lifetime
- 1996-10-10 DK DK96202829T patent/DK0768309T3/da active
- 1996-10-10 PT PT96202829T patent/PT768309E/pt unknown
- 1996-10-10 DE DE69623900T patent/DE69623900T2/de not_active Expired - Lifetime
- 1996-10-10 EP EP96202829A patent/EP0768309B1/en not_active Expired - Lifetime
- 1996-10-10 CN CN96122637A patent/CN1060774C/zh not_active Expired - Fee Related
- 1996-10-10 UA UA96103876A patent/UA48947C2/uk unknown
- 1996-10-11 NZ NZ299562A patent/NZ299562A/en not_active IP Right Cessation
-
1997
- 1997-07-19 HK HK97101586A patent/HK1000446A1/xx not_active IP Right Cessation
-
2010
- 2010-04-15 JP JP2010094211A patent/JP2010159292A/ja active Pending
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