IL119400A - Process for the preparation of enantiomerically pure imidazolyl compounds such as cilansetron by optical resolution with pyroglutamic acid - Google Patents

Process for the preparation of enantiomerically pure imidazolyl compounds such as cilansetron by optical resolution with pyroglutamic acid

Info

Publication number
IL119400A
IL119400A IL11940096A IL11940096A IL119400A IL 119400 A IL119400 A IL 119400A IL 11940096 A IL11940096 A IL 11940096A IL 11940096 A IL11940096 A IL 11940096A IL 119400 A IL119400 A IL 119400A
Authority
IL
Israel
Prior art keywords
addition salt
acid
mixture
enantiomer
compound
Prior art date
Application number
IL11940096A
Other languages
English (en)
Other versions
IL119400A0 (en
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Publication of IL119400A0 publication Critical patent/IL119400A0/xx
Publication of IL119400A publication Critical patent/IL119400A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
IL11940096A 1995-10-13 1996-10-10 Process for the preparation of enantiomerically pure imidazolyl compounds such as cilansetron by optical resolution with pyroglutamic acid IL119400A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95202765 1995-10-13

Publications (2)

Publication Number Publication Date
IL119400A0 IL119400A0 (en) 1997-01-10
IL119400A true IL119400A (en) 2000-02-29

Family

ID=8220714

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11940096A IL119400A (en) 1995-10-13 1996-10-10 Process for the preparation of enantiomerically pure imidazolyl compounds such as cilansetron by optical resolution with pyroglutamic acid

Country Status (24)

Country Link
US (1) US5663343A (xx)
EP (1) EP0768309B1 (xx)
JP (2) JP4590038B2 (xx)
KR (1) KR100459745B1 (xx)
CN (1) CN1060774C (xx)
AT (1) ATE224896T1 (xx)
AU (1) AU702594B2 (xx)
CA (1) CA2187484C (xx)
CZ (1) CZ288042B6 (xx)
DE (1) DE69623900T2 (xx)
DK (1) DK0768309T3 (xx)
DZ (1) DZ2104A1 (xx)
ES (1) ES2183908T3 (xx)
HK (1) HK1000446A1 (xx)
HU (1) HU226620B1 (xx)
IL (1) IL119400A (xx)
NO (1) NO307257B1 (xx)
NZ (1) NZ299562A (xx)
PT (1) PT768309E (xx)
RU (1) RU2162085C2 (xx)
SK (1) SK283471B6 (xx)
TW (1) TW513423B (xx)
UA (1) UA48947C2 (xx)
ZA (1) ZA968525B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19813661A1 (de) * 1997-08-01 1999-02-04 Solvay Pharm Gmbh Gegen Racemisierung stabilisierte pharmazeutische Zubereitungen von Cilansetron
US6372919B1 (en) * 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
GB0216027D0 (en) * 2002-07-10 2002-08-21 Arachnova Therapeutics Ltd New therapeutic use
US20040048874A1 (en) * 2001-05-22 2004-03-11 Bardsley Hazel Judith New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine
US7015333B2 (en) * 2002-11-18 2006-03-21 Solvay Pharmaceuticals B.V. Process for preparation of imidazolyl compounds
EP1424337A1 (en) * 2002-11-26 2004-06-02 Solvay Pharmaceuticals GmbH 4-hydroxy derivatives of 5,6,9,10-tetrahydro-10-((2-methyl-1h-imidazol-1-yl)methyl)-4h-pyrido-(3,2,1-jk)-carbazol-11(8h)-one
NZ541008A (en) * 2003-01-13 2007-09-28 Dynogen Pharmaceuticals Inc Method of treating functional bowel disorders
EP1567163B1 (en) * 2003-01-13 2007-04-11 Dynogen Pharmaceuticals Inc. Method of treating nausea, vomiting, retching or any combination thereof
JP2006522144A (ja) * 2003-04-04 2006-09-28 ダイノゲン ファーマシューティカルズ，インコーポレイテッド 下部尿路障害の治療方法
US20090018351A1 (en) * 2003-11-12 2009-01-15 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US7662831B2 (en) 2006-07-27 2010-02-16 Wyeth Llc Tetracyclic indoles as potassium channel modulators
US7601856B2 (en) 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
JP5156222B2 (ja) * 2006-11-28 2013-03-06 エムキュア ファーマシューティカルズ リミテッド 制吐作用化合物の新たな製造方法
GB0910373D0 (en) * 2009-06-16 2009-07-29 Filtrona Int Ltd Tabacco smoke filter
US9806720B1 (en) * 2016-10-07 2017-10-31 Analog Devices Global Compound semiconductor based inverter
CN112424149B (zh) 2018-05-18 2023-06-23 库拉肿瘤学公司 替吡法尼的合成

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7413843A (nl) * 1974-10-23 1976-04-27 Stamicarbon Optische scheiding van fenylglycine-amide.
US4463176A (en) * 1982-09-13 1984-07-31 Mead Johnson & Company Process for resolution of optical isomers
US4849527A (en) * 1982-09-13 1989-07-18 Bristol-Myers Company Process for resolution of optical isomers
LU88268I2 (xx) * 1984-01-25 1994-02-03
DE3885357T2 (de) * 1987-06-29 1994-03-24 Duphar Int Res Anellierte Indolderivate.
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
US5049563A (en) * 1988-07-07 1991-09-17 Duphar International Research B.V. Annelated indoleketones with an imidazolylalkyl substituent
DE4238553A1 (de) * 1992-11-14 1994-05-19 Kali Chemie Pharma Gmbh Neue Imidazol-1-yl-Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
NO964282D0 (no) 1996-10-09
CZ288042B6 (cs) 2001-04-11
JPH09183779A (ja) 1997-07-15
RU2162085C2 (ru) 2001-01-20
NO307257B1 (no) 2000-03-06
HU226620B1 (en) 2009-04-28
NZ299562A (en) 1997-09-22
IL119400A0 (en) 1997-01-10
US5663343A (en) 1997-09-02
HUP9602778A3 (en) 1997-08-28
SK283471B6 (sk) 2003-08-05
CA2187484A1 (en) 1997-04-14
CN1060774C (zh) 2001-01-17
PT768309E (pt) 2003-02-28
TW513423B (en) 2002-12-11
EP0768309B1 (en) 2002-09-25
JP4590038B2 (ja) 2010-12-01
AU702594B2 (en) 1999-02-25
UA48947C2 (uk) 2002-09-16
SK128796A3 (en) 1997-05-07
ZA968525B (en) 1997-05-20
ATE224896T1 (de) 2002-10-15
DZ2104A1 (fr) 2002-07-22
NO964282L (no) 1997-04-14
ES2183908T3 (es) 2003-04-01
CZ294796A3 (en) 1997-05-14
KR970021080A (ko) 1997-05-28
AU6585696A (en) 1997-04-17
CN1160053A (zh) 1997-09-24
KR100459745B1 (ko) 2005-01-26
EP0768309A1 (en) 1997-04-16
HU9602778D0 (en) 1996-11-28
JP2010159292A (ja) 2010-07-22
CA2187484C (en) 2006-09-05
HUP9602778A2 (en) 1997-05-28
DE69623900D1 (de) 2002-10-31
HK1000446A1 (en) 2003-01-10
DK0768309T3 (da) 2002-12-09
DE69623900T2 (de) 2003-07-31

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