ES2164837T3 - Formulacion oral de olanzapina. - Google Patents

Formulacion oral de olanzapina.

Info

Publication number
ES2164837T3
ES2164837T3 ES96301997T ES96301997T ES2164837T3 ES 2164837 T3 ES2164837 T3 ES 2164837T3 ES 96301997 T ES96301997 T ES 96301997T ES 96301997 T ES96301997 T ES 96301997T ES 2164837 T3 ES2164837 T3 ES 2164837T3
Authority
ES
Spain
Prior art keywords
formulation
olanzapine
oral formulation
cellulose
oral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96301997T
Other languages
English (en)
Inventor
George Randall Cochran
Tommy Clifford Morris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23624847&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2164837(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2164837T3 publication Critical patent/ES2164837T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

LA INVENCION PROPORCIONA UNA FORMULACION ORAL SOLIDA FARMACEUTICAMENTE REFINADA DE OLANZAPINA Y UN PROCESO PARA REALIZAR DICHA FORMULACION. LA FORMULACION COMPRENDE OLANZAPINA COMO UN INGREDIENTE ACTIVO MEZCLADO INTIMAMENTE CON UN AGENTE DE DILATACION; SUSTANCIA AGLUTINANTE, DESINTEGRANTE, UN AGENTE DE DILATACION SECO PARA ASEGURAR LA FRIABILIDAD ADECUADA, Y UN LUBRICANTE; EN DONDE DICHA FORMULACION ORAL SOLIDA ES CUBIERTA CON UN POLIMERO SELECCIONADO DEL GRUPO QUE CONSTA DE HIDROXIPROPIL METILCELULOSA, HIDROXIETIL CELULOSA, METILHIDROXIETILCELULOSA, CARBOXIMETILCELULOSA DE SODIO, HIDROXIPROPILCELULOSA, POLIVINIL PIRROLIDONA, COPOLIMERO DE ESTER DE ACIDO METACRILATOMETILACRILATO DIMETILAMINOETILICO, COPOLIMERO DE ETILACRILATO-METILMETACRILATO, METILCELULOSA Y ETILCELULOSA.
ES96301997T 1995-03-24 1996-03-22 Formulacion oral de olanzapina. Expired - Lifetime ES2164837T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41046595A 1995-03-24 1995-03-24

Publications (1)

Publication Number Publication Date
ES2164837T3 true ES2164837T3 (es) 2002-03-01

Family

ID=23624847

Family Applications (2)

Application Number Title Priority Date Filing Date
ES00204708T Expired - Lifetime ES2232379T3 (es) 1995-03-24 1996-03-22 Formulacion de 2-metil-tieno-benzodiacepina de uso oral.
ES96301997T Expired - Lifetime ES2164837T3 (es) 1995-03-24 1996-03-22 Formulacion oral de olanzapina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES00204708T Expired - Lifetime ES2232379T3 (es) 1995-03-24 1996-03-22 Formulacion de 2-metil-tieno-benzodiacepina de uso oral.

Country Status (46)

Country Link
US (4) US5919485A (es)
EP (2) EP0733367B1 (es)
JP (1) JPH11502848A (es)
KR (1) KR100408172B1 (es)
CN (1) CN1178662C (es)
AP (1) AP679A (es)
AR (2) AR001405A1 (es)
AT (3) ATE206924T1 (es)
AU (1) AU696601B2 (es)
BG (1) BG62594B1 (es)
BR (1) BR9607791A (es)
CA (1) CA2216372C (es)
CH (1) CH691217A5 (es)
CO (1) CO4700474A1 (es)
CR (1) CR5278A (es)
CZ (1) CZ296007B6 (es)
DE (3) DE19681287T1 (es)
DK (3) DK0733367T3 (es)
EA (1) EA000938B1 (es)
EE (1) EE03551B1 (es)
EG (1) EG24077A (es)
ES (2) ES2232379T3 (es)
FI (1) FI973749A (es)
GB (1) GB2313783B (es)
HU (1) HU225269B1 (es)
IL (1) IL117611A (es)
IS (1) IS1903B (es)
LT (1) LT4350B (es)
LU (1) LU90115B1 (es)
LV (1) LV11983B (es)
MY (1) MY113440A (es)
NO (1) NO320388B1 (es)
NZ (1) NZ306111A (es)
OA (1) OA10511A (es)
PE (1) PE44997A1 (es)
PL (1) PL188316B1 (es)
PT (2) PT733367E (es)
RO (1) RO118370B1 (es)
SE (1) SE9703206L (es)
SI (3) SI1093815T1 (es)
SK (1) SK283745B6 (es)
TR (1) TR199701018T1 (es)
TW (1) TW426526B (es)
UA (1) UA44766C2 (es)
WO (1) WO1996029995A1 (es)
ZA (1) ZA962338B (es)

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CR5278A (es) * 1995-03-24 1996-07-04 Lilly Co Eli Formulacion oral de 2-metil-tieno-benzodiacepina
CN1230883A (zh) * 1996-09-24 1999-10-06 伊莱利利公司 包衣颗粒制剂
US20020035071A1 (en) * 1997-07-08 2002-03-21 Josef Pitha Mimicking the metabolic effects of caloric restriction by administration of glucose antimetabolites
US20060116330A1 (en) * 1997-07-08 2006-06-01 The Iams Company Methods of mimicking the metabolic effects of caloric restriction by administration of mannoheptulose
US8563522B2 (en) * 1997-07-08 2013-10-22 The Iams Company Method of maintaining and/or attenuating a decline in quality of life
US6617321B2 (en) 1997-09-30 2003-09-09 Eli Lilly And Company 2-methyl-thieno-benzodiazepine formulation
US7022698B2 (en) 1999-12-28 2006-04-04 U & I Pharmaceuticals, Ltd. Pharmaceutical compositions containing new polymorphic forms of olanzapine and uses thereof
AU779452B2 (en) * 1999-12-28 2005-01-27 Cipla Limited New polymorphic forms of olanzapine
US6348458B1 (en) 1999-12-28 2002-02-19 U & I Pharmaceuticals Ltd. Polymorphic forms of olanzapine
US6740753B2 (en) 2001-01-04 2004-05-25 Geneva Pharmaceuticals, Inc. Olanzapine crystal modification
US20030070584A1 (en) 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
US20030072731A1 (en) * 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing starch or dextrin
US20030072729A1 (en) * 2001-05-15 2003-04-17 Christopher Szymczak Simethicone as weight gain enhancer
US8309118B2 (en) 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
GB0203061D0 (en) * 2002-02-08 2002-03-27 Novartis Ag Organic compounds
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
WO2003086361A1 (en) * 2002-04-18 2003-10-23 Dr. Reddy's Laboratories Ltd. Rapidly dispersing solid oral compositions
ATE500258T1 (de) 2002-05-31 2011-03-15 Sandoz Ag Verfahren zur herstellung von olanzapin form i
SI21270A (sl) * 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
US7029112B2 (en) * 2002-08-05 2006-04-18 Mars, Incorporated Ink-jet printing on surface modified edibles and products made
US8168170B2 (en) * 2002-10-03 2012-05-01 The Procter And Gamble Company Compositions having an inner core and at least three surrounding layers
PL202856B1 (pl) * 2002-12-20 2009-07-31 Adamed Spo & Lstrok Ka Z Ogran Sposób otrzymywania farmaceutycznie czystej polimorficznej postaci I olanzapiny
WO2005009407A2 (en) * 2003-07-29 2005-02-03 Ranbaxy Laboratories Limited Oral pharmaceutical formulations of olanzapine
EP1670441A4 (en) * 2003-10-07 2012-05-02 Andrx Pharmaceuticals Llc FAST RESOLUTION FORMULATION
CA2546200A1 (en) * 2003-11-18 2005-06-02 3M Innovative Properties Company Olanzapine containing transdermal drug delivery compositions
US8877178B2 (en) * 2003-12-19 2014-11-04 The Iams Company Methods of use of probiotic bifidobacteria for companion animals
US7785635B1 (en) 2003-12-19 2010-08-31 The Procter & Gamble Company Methods of use of probiotic lactobacilli for companion animals
US8894991B2 (en) * 2003-12-19 2014-11-25 The Iams Company Canine probiotic Lactobacilli
US20050152884A1 (en) * 2003-12-19 2005-07-14 The Procter & Gamble Company Canine probiotic Bifidobacteria globosum
US20050158294A1 (en) * 2003-12-19 2005-07-21 The Procter & Gamble Company Canine probiotic Bifidobacteria pseudolongum
ES2253091B1 (es) * 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
US7932249B2 (en) 2005-01-05 2011-04-26 Eli Lilly And Company Olanzapine pamoate dihydrate
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
US20060240101A1 (en) * 2005-04-22 2006-10-26 Shubha Chungi Orally disintegrating pharmaceutical tablet formulations of olanzapine
JP4938005B2 (ja) * 2005-05-31 2012-05-23 ザ・アイムス・カンパニー ネコ科動物プロバイオティックであるラクトバシラス
JP4938006B2 (ja) * 2005-05-31 2012-05-23 ザ・アイムス・カンパニー ネコ科動物プロバイオティク・ビフィドバクテリア
US20070014847A1 (en) * 2005-07-05 2007-01-18 Ahmed Salah U Coated capsules and methods of making and using the same
JP2009502807A (ja) * 2005-07-22 2009-01-29 ミリアド ジェネティクス， インコーポレイテッド 薬剤含有率の高い製剤および投与量形態
WO2007049304A2 (en) * 2005-10-27 2007-05-03 Jubilant Organosys Limited Stable coated pharmaceutical formulation of olanzapine and process for preparing the same
GB0522473D0 (en) * 2005-11-03 2005-12-14 Actavis Group A pharmaceutical formulation
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US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
US20070293479A1 (en) * 2006-05-18 2007-12-20 Osinga Niels J Olanzapine pharmaceutical composition
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AR063043A1 (es) * 2006-09-29 2008-12-23 Synthon Bv Composicion farmaceutica de olanzapina
WO2008093303A2 (en) 2007-02-01 2008-08-07 The Iams Company Method for decreasing inflammation and stress in a mammal using glucose antimetaboltes, avocado or avocado extracts
DK2246051T3 (da) * 2008-01-31 2014-01-13 Kyorin Seiyaku Kk Fremgangsmåde til fremstilling af oralt sig hurtigt opløsende tablet omfattende imidafenacin som aktiv bestanddel
US9771199B2 (en) 2008-07-07 2017-09-26 Mars, Incorporated Probiotic supplement, process for making, and packaging
US8505322B2 (en) * 2009-03-25 2013-08-13 Pax Scientific, Inc. Battery cooling
US20110048048A1 (en) * 2009-03-25 2011-03-03 Thomas Gielda Personal Cooling System
GB2473981B (en) * 2009-03-25 2012-02-22 Caitin Inc Thermodynamic cycle for cooling a working fluid
US20110051549A1 (en) * 2009-07-25 2011-03-03 Kristian Debus Nucleation Ring for a Central Insert
US10104903B2 (en) 2009-07-31 2018-10-23 Mars, Incorporated Animal food and its appearance
US8365540B2 (en) * 2009-09-04 2013-02-05 Pax Scientific, Inc. System and method for heat transfer
WO2012153347A2 (en) 2011-05-04 2012-11-15 Zentiva K.S. Oral pharmaceutical composition of olanzapine form 1
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
US9517212B1 (en) * 2012-11-15 2016-12-13 Chandra Zaveri Medicated adhesive pad arrangement
CN103919782B (zh) * 2013-01-15 2016-12-28 天津药物研究院有限公司 一种含有奥氮平的药物组合物及其制备方法
EP3043778B1 (en) * 2013-09-13 2017-09-06 Bayer Pharma Aktiengesellschaft Pharmaceutical compositions containing refametinib
CN107007559B (zh) * 2017-04-21 2020-05-15 浙江京新药业股份有限公司 一种稳定的口服药物组合物及其制备方法
CN110709061B (zh) * 2017-06-02 2023-09-08 Xeris药物公司 抗沉淀的小分子药物制剂
CN113143878A (zh) * 2021-03-19 2021-07-23 杭州新诺华医药有限公司 奥氮平组合物及其制备方法

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CR5278A (es) * 1995-03-24 1996-07-04 Lilly Co Eli Formulacion oral de 2-metil-tieno-benzodiacepina
US5696115A (en) * 1995-04-21 1997-12-09 Eli Lilly And Company Method for treating nicotine withdrawal

Also Published As

Publication number Publication date
HU225269B1 (en) 2006-08-28
TW426526B (en) 2001-03-21
DK173323B1 (da) 2000-07-24
CO4700474A1 (es) 1998-12-29
CZ296007B6 (cs) 2005-12-14
SI0733367T1 (en) 2002-06-30
AT405606B (de) 1999-10-25
AP679A (en) 1998-09-28
IS4565A (is) 1997-09-22
US6190698B1 (en) 2001-02-20
DE69615887T2 (de) 2002-04-11
PE44997A1 (es) 1997-10-23
CA2216372C (en) 2007-11-20
FI973749A0 (fi) 1997-09-22
KR19980703189A (ko) 1998-10-15
ATE206924T1 (de) 2001-11-15
BG101901A (en) 1998-10-30
AU5428096A (en) 1996-10-16
ATA902296A (de) 1999-02-15
CN1178662C (zh) 2004-12-08
DE69634053T2 (de) 2005-12-22
TR199701018T1 (xx) 1998-01-21
US6780433B2 (en) 2004-08-24
CN1179102A (zh) 1998-04-15
LT4350B (lt) 1998-05-25
EP0733367B1 (en) 2001-10-17
SE9703206D0 (sv) 1997-09-05
US20010018071A1 (en) 2001-08-30
NO974363D0 (no) 1997-09-22
EA000938B1 (ru) 2000-06-26
EP1093815B1 (en) 2004-12-15
CZ300197A3 (en) 1997-12-17
PT733367E (pt) 2002-03-28
DK0733367T3 (da) 2001-11-26
NZ306111A (en) 1999-02-25
CA2216372A1 (en) 1996-10-03
BR9607791A (pt) 1998-07-07
ES2232379T3 (es) 2005-06-01
FI973749A (fi) 1997-09-22
EE03551B1 (et) 2001-12-17
NO320388B1 (no) 2005-11-28
JPH11502848A (ja) 1999-03-09
EP1093815A1 (en) 2001-04-25
AU696601B2 (en) 1998-09-17
LT97149A (en) 1998-01-26
IL117611A (en) 2002-05-23
IS1903B (is) 2003-11-20
SI9620041A (sl) 1998-06-30
PT1093815E (pt) 2005-03-31
MY113440A (en) 2002-02-28
NO974363L (no) 1997-11-17
PL188316B1 (pl) 2005-01-31
UA44766C2 (uk) 2002-03-15
MX9707186A (es) 1997-11-29
US20050085462A1 (en) 2005-04-21
EG24077A (en) 2008-05-11
LV11983A (lv) 1998-03-20
LU90115B1 (fr) 1997-09-10
GB2313783B (en) 1998-11-18
DE19681287T1 (de) 1998-03-19
AP9701064A0 (en) 1997-10-31
US5919485A (en) 1999-07-06
SE9703206L (sv) 1997-09-05
ZA962338B (en) 1997-09-22
ATE284695T1 (de) 2005-01-15
EP0733367A1 (en) 1996-09-25
DE69634053D1 (de) 2005-01-20
PL322579A1 (en) 1998-02-02
SK128297A3 (en) 1998-03-04
CH691217A5 (de) 2001-05-31
EE9700328A (et) 1998-06-15
BG62594B1 (bg) 2000-03-31
OA10511A (en) 2002-04-24
WO1996029995A1 (en) 1996-10-03
DK109097A (da) 1997-11-12
DE69615887D1 (de) 2001-11-22
LV11983B (en) 1998-07-20
GB2313783A (en) 1997-12-10
SI1093815T1 (en) 2005-06-30
EA199700260A1 (ru) 1998-02-26
HUP9800410A2 (hu) 1998-07-28
CR5278A (es) 1996-07-04
IL117611A0 (en) 1996-07-23
RO118370B1 (ro) 2003-05-30
GB9719817D0 (en) 1997-11-19
HUP9800410A3 (en) 2000-01-28
DK1093815T3 (da) 2005-04-25
KR100408172B1 (ko) 2004-02-18
SK283745B6 (sk) 2003-12-02
AR001405A1 (es) 1997-10-22
US7229643B2 (en) 2007-06-12
AR002720A1 (es) 1998-04-29

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