ES2146552A1 - Peptidos inhibidores de tgf/31 - Google Patents

Peptidos inhibidores de tgf/31

Info

Publication number
ES2146552A1
ES2146552A1 ES009802465A ES9802465A ES2146552A1 ES 2146552 A1 ES2146552 A1 ES 2146552A1 ES 009802465 A ES009802465 A ES 009802465A ES 9802465 A ES9802465 A ES 9802465A ES 2146552 A1 ES2146552 A1 ES 2146552A1
Authority
ES
Spain
Prior art keywords
tgf
inhibitor peptides
compositions
manufacture
beta1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009802465A
Other languages
English (en)
Other versions
ES2146552B1 (es
Inventor
Saenz Ignacio Jose Ezquerro
Sagastibelza Juan Jose Lasarte
Valtuena Jesus Prieto
Cuesta Francisco Borras
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instituto Cientifico y Tecnologico de Navarra SA
Original Assignee
Instituto Cientifico y Tecnologico de Navarra SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES009802465A priority Critical patent/ES2146552B1/es
Application filed by Instituto Cientifico y Tecnologico de Navarra SA filed Critical Instituto Cientifico y Tecnologico de Navarra SA
Priority to CA2352537A priority patent/CA2352537C/en
Priority to BRPI9915604-0A priority patent/BR9915604B1/pt
Priority to CNB99813614XA priority patent/CN1203091C/zh
Priority to DK99957342T priority patent/DK1132403T3/da
Priority to DE69930763T priority patent/DE69930763T2/de
Priority to JP2000583961A priority patent/JP3836677B2/ja
Priority to US09/831,253 priority patent/US7057013B1/en
Priority to PT99957342T priority patent/PT1132403E/pt
Priority to EP99957342A priority patent/EP1132403B1/en
Priority to ES99957342T priority patent/ES2262349T3/es
Priority to AU15077/00A priority patent/AU767498B2/en
Priority to PCT/ES1999/000375 priority patent/WO2000031135A1/es
Priority to SI9930897T priority patent/SI1132403T1/sl
Priority to AT99957342T priority patent/ATE322505T1/de
Priority to RU2001117230/04A priority patent/RU2232771C2/ru
Publication of ES2146552A1 publication Critical patent/ES2146552A1/es
Publication of ES2146552B1 publication Critical patent/ES2146552B1/es
Application granted granted Critical
Priority to JP2006107967A priority patent/JP4002287B2/ja
Priority to US11/401,744 priority patent/US7528226B2/en
Priority to CY20061100805T priority patent/CY1105616T1/el
Priority to JP2007037713A priority patent/JP4068654B2/ja
Priority to JP2007259167A priority patent/JP4237807B2/ja
Priority to JP2008269650A priority patent/JP4272255B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Péptidos sintéticos antagonistas, obtenidos de TGF{b 1 o de sus receptores en el organismo, que pueden ser utilizados en la fabricación, tanto por sí solos como las secuencias génicas que los codifican y los sistemas recombinantes que los expresen, en la fabricación de composiciones útiles para el tratamiento de enfermedades hepáticas y más concretamente en casos de fibrosis. Dichas composiciones pueden incluir opcionalmente mimotopos de dichos péptidos activos.
ES009802465A 1998-11-24 1998-11-24 Peptidos inhibidores de tgf/31 Expired - Fee Related ES2146552B1 (es)

Priority Applications (22)

Application Number Priority Date Filing Date Title
ES009802465A ES2146552B1 (es) 1998-11-24 1998-11-24 Peptidos inhibidores de tgf/31
AT99957342T ATE322505T1 (de) 1998-11-24 1999-11-23 Tgf-g beta inhibitor-peptide
BRPI9915604-0A BR9915604B1 (pt) 1998-11-24 1999-11-23 peptÍdios antagonistas de inibidores de tgf-beta1 e seu uso.
RU2001117230/04A RU2232771C2 (ru) 1998-11-24 1999-11-23 Пептиды, ингибирующие трансформирующий фактор роста tgfбета1
DE69930763T DE69930763T2 (de) 1998-11-24 1999-11-23 Tgf-g beta inhibitor-peptide
JP2000583961A JP3836677B2 (ja) 1998-11-24 1999-11-23 ＴＧＦβ１−インヒビターペプチド
US09/831,253 US7057013B1 (en) 1998-11-24 1999-11-23 TGFβ1 inhibitor peptides
PT99957342T PT1132403E (pt) 1998-11-24 1999-11-23 Peptidos inibidores de tgf g beta1
EP99957342A EP1132403B1 (en) 1998-11-24 1999-11-23 Tgf g beta1 inhibitor peptides
ES99957342T ES2262349T3 (es) 1998-11-24 1999-11-23 Peptidos inhibidorers de tgf beta 1.
AU15077/00A AU767498B2 (en) 1998-11-24 1999-11-23 TGFbeta1 inhibitor peptides
PCT/ES1999/000375 WO2000031135A1 (es) 1998-11-24 1999-11-23 PEPTIDOS INHIBIDORES DE TGFβ1
CA2352537A CA2352537C (en) 1998-11-24 1999-11-23 Tgf.beta.1-inhibitor peptides
CNB99813614XA CN1203091C (zh) 1998-11-24 1999-11-23 TGFβ1－抑制肽
DK99957342T DK1132403T3 (da) 1998-11-24 1999-11-23 TGF G Beta1-inhibitorpeptider
SI9930897T SI1132403T1 (sl) 1998-11-24 1999-11-23 Peptidi inhibitorji tgf-g beta 1
JP2006107967A JP4002287B2 (ja) 1998-11-24 2006-04-10 ＴＧＦβ１−インヒビターペプチド
US11/401,744 US7528226B2 (en) 1998-11-24 2006-04-11 TGFβ1-inhibitor peptides
CY20061100805T CY1105616T1 (el) 1998-11-24 2006-06-16 ΠΕΠΤΙΔΙΑ ΑΝΑΣΤΟΛΕΙΣ ΤΟΥ TGFβ1
JP2007037713A JP4068654B2 (ja) 1998-11-24 2007-02-19 ＴＧＦβ１−インヒビターペプチド
JP2007259167A JP4237807B2 (ja) 1998-11-24 2007-10-02 ＴＧＦβ１−インヒビターペプチド
JP2008269650A JP4272255B2 (ja) 1998-11-24 2008-10-20 ＴＧＦβ１−インヒビターペプチド

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009802465A ES2146552B1 (es) 1998-11-24 1998-11-24 Peptidos inhibidores de tgf/31

Publications (2)

Publication Number Publication Date
ES2146552A1 true ES2146552A1 (es) 2000-08-01
ES2146552B1 ES2146552B1 (es) 2001-04-16

Family

ID=8305903

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009802465A Expired - Fee Related ES2146552B1 (es) 1998-11-24 1998-11-24 Peptidos inhibidores de tgf/31
ES99957342T Expired - Lifetime ES2262349T3 (es) 1998-11-24 1999-11-23 Peptidos inhibidorers de tgf beta 1.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES99957342T Expired - Lifetime ES2262349T3 (es) 1998-11-24 1999-11-23 Peptidos inhibidorers de tgf beta 1.

Country Status (16)

Country Link
US (2) US7057013B1 (es)
EP (1) EP1132403B1 (es)
JP (5) JP3836677B2 (es)
CN (1) CN1203091C (es)
AT (1) ATE322505T1 (es)
AU (1) AU767498B2 (es)
BR (1) BR9915604B1 (es)
CA (1) CA2352537C (es)
CY (1) CY1105616T1 (es)
DE (1) DE69930763T2 (es)
DK (1) DK1132403T3 (es)
ES (2) ES2146552B1 (es)
PT (1) PT1132403E (es)
RU (1) RU2232771C2 (es)
SI (1) SI1132403T1 (es)
WO (1) WO2000031135A1 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005019244A1 (es) * 2003-08-22 2005-03-03 Proyecto De Biomedicina Cima S.L. Péptidos con capacidad de unirse al factor transformante de crecimiento beta 1 (tgf-beta1)
CN112689641A (zh) * 2019-08-20 2021-04-20 凯尔格恩有限公司 具有皮肤美白活性的肽以及其用途

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US7723473B2 (en) 1997-06-19 2010-05-25 St. Louis University Peptide antagonists of TGF-beta family members and therapeutic uses thereof
JP2002087938A (ja) * 2000-09-11 2002-03-27 Shiseido Co Ltd 養毛剤及びそのスクリーニング方法
AU2003234734A1 (en) * 2002-04-29 2003-11-17 Saint Louis University Peptide antagonists of tgf-beta family members and therapeutic uses thereof
US8158589B2 (en) 2003-08-22 2012-04-17 Proyecto Biomedicine Cima, S.L. Peptides with the capacity to bind to transforming growth factor β1 (TGF-β1)
AU2005337776B2 (en) * 2005-10-24 2013-01-31 Proyecto De Biomedicina Cima, S.L. Use of TGF-Beta1 inhibitor peptides in the preparation of an immune response modulating agent
US7582609B2 (en) * 2006-03-01 2009-09-01 Digna Biotech, S.L. Method for the treatment of skin fibrosis and suitable compositions for such treatment
KR100879239B1 (ko) * 2007-04-19 2009-01-16 (주)케어젠 Ｔｇｆｐ－ｃａｐ 펩타이드 및 그의 용도
ES2327088B1 (es) * 2007-08-20 2010-07-26 Proyecto De Biomedicina Cima S.L. Combinaciones terapeuticas para el tratamiento de las metastasis.
WO2009029656A1 (en) 2007-08-27 2009-03-05 Auxagen, Inc. METHODS FOR INHIBITING TGF-β
JP4630914B2 (ja) 2008-04-14 2011-02-09 株式会社日本ハイポックス 肝線維化抑制剤
US20110293557A1 (en) 2008-06-13 2011-12-01 Proyecto De Biomedicina Cima, S.L. Conjugates for the administration of biologically active compounds
US8487006B2 (en) * 2008-09-16 2013-07-16 Auxagen, Inc. Method of enhancing TGF-β signalling
CA2750559A1 (en) * 2009-02-05 2010-08-12 Digna Biotech, S.L. Pharmaceutical formulations of tgf-.beta.1 inhibitor peptides
ES2347627B1 (es) * 2009-03-06 2011-10-10 Isdin, S.A. Peptido para el tratamiento profilactico o terapeutico de tumores de la piel en estadios iniciales.
KR100983182B1 (ko) * 2009-08-14 2010-09-20 (주)엔솔테크 신규 펩타이드 및 그 용도
BR112012010755A2 (pt) 2009-11-05 2015-09-22 Proyecto Biomedicina Cima Sl constructo de gene que permite a expressão hepato-específica induzível de um polinucleotídeo de interesse em resposta a um agente indutor, vetor, genoma viral recombinante, vírion, método in vitro para a expressão de um polinucleotídeo de interesse em uma célula de origem hepática, composição farmacêutica e operador-promotor bi-direcional induzível adequado para a expressão hepato-específica induzível de dois polinucleotídeos de interesse por um agente indutor
CN102834412B (zh) * 2010-02-18 2016-01-20 加利福尼亚大学董事会 整合素αVβ8中和抗体
CN102898508B (zh) * 2011-08-12 2014-04-30 北京大学第一医院 封闭TGF-β受体或IL-10受体的多肽、其药物组合物及其用途
KR101856114B1 (ko) 2011-09-05 2018-06-20 가부시키가이샤 폴라 파마 Ｅｔｆｂ의 세포 이상증식에 대한 적용 방법 및 이상증식 억제제
CU24181B1 (es) * 2012-11-09 2016-04-25 Ct De Inmunología Molecular POLIPÉPTIDOS DERIVADOS DEL TGFß
PT2970890T (pt) 2013-03-14 2020-04-24 Massachusetts Inst Technology Composições e métodos para expansão e cultura de células estaminais epiteliais
JP6403217B2 (ja) 2013-07-30 2018-10-10 京都府公立大学法人 角膜内皮ｅｃｍ治療薬
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KR20230019500A (ko) 2014-09-03 2023-02-08 더 브리검 앤드 우먼즈 하스피털, 인크. 청력 손실의 치료를 위해 내이 털세포를 생성하기 위한 조성물, 시스템, 및 방법
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KR101791526B1 (ko) * 2016-02-18 2017-11-01 (주)케어젠 발모 촉진 활성을 나타내는 펩타이드 및 이의 용도
KR101841748B1 (ko) * 2016-02-18 2018-05-08 (주)케어젠 멜라닌 생성 촉진 활성을 나타내는 펩타이드 및 이의 용도
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WO1992020793A1 (en) * 1991-05-10 1992-11-26 The Salk Institute For Biological Studies CLONING AND RECOMBINANT PRODUCTION OF RECEPTOR(S) OF THE ACTIVIN/TGF-β SUPERFAMILY
FR2720069A1 (fr) * 1994-05-19 1995-11-24 Inst Nat Sante Rech Med Dérivés de facteurs de croissance et d'hormones de la superfamille des TGFB, procédé pour leur obtention et leurs applications biologiques.
WO1996025178A1 (en) * 1995-02-15 1996-08-22 The University Of Utah ANTI-TRANSFORMING GROWTH FACTOR-β GENE THERAPY

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GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO1992020793A1 (en) * 1991-05-10 1992-11-26 The Salk Institute For Biological Studies CLONING AND RECOMBINANT PRODUCTION OF RECEPTOR(S) OF THE ACTIVIN/TGF-β SUPERFAMILY
FR2720069A1 (fr) * 1994-05-19 1995-11-24 Inst Nat Sante Rech Med Dérivés de facteurs de croissance et d'hormones de la superfamille des TGFB, procédé pour leur obtention et leurs applications biologiques.
WO1996025178A1 (en) * 1995-02-15 1996-08-22 The University Of Utah ANTI-TRANSFORMING GROWTH FACTOR-β GENE THERAPY

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005019244A1 (es) * 2003-08-22 2005-03-03 Proyecto De Biomedicina Cima S.L. Péptidos con capacidad de unirse al factor transformante de crecimiento beta 1 (tgf-beta1)
ES2304069A1 (es) * 2003-08-22 2008-09-01 Proyecto De Biomedicina Cima, S.L. Peptidos con capacidad de unirse al factor transformante de crecimiento beta 1 (tgf-b1).
US7666841B2 (en) 2003-08-22 2010-02-23 Proyecto De Biomedicina Cima, S.L. Peptides with the capacity to bind to transforming growth factor β1 (TGF-β1)
AU2010212466B2 (en) * 2003-08-22 2012-07-19 Proyecto De Biomedicina Cima, S.L. Peptides with the capacity to bind to transforming growth factor beta1 (TGF beta1)
CN112689641A (zh) * 2019-08-20 2021-04-20 凯尔格恩有限公司 具有皮肤美白活性的肽以及其用途
CN112689641B (zh) * 2019-08-20 2023-11-07 凯尔格恩有限公司 具有皮肤美白活性的肽以及其用途

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JP2007186519A (ja) 2007-07-26
ES2146552B1 (es) 2001-04-16
ATE322505T1 (de) 2006-04-15
EP1132403A1 (en) 2001-09-12
RU2232771C2 (ru) 2004-07-20
US7057013B1 (en) 2006-06-06
SI1132403T1 (sl) 2006-08-31
BR9915604A (pt) 2001-08-07
CN1328569A (zh) 2001-12-26
JP2009040796A (ja) 2009-02-26
JP2002530431A (ja) 2002-09-17
EP1132403B1 (en) 2006-04-05
CA2352537A1 (en) 2000-06-02
DE69930763D1 (en) 2006-05-18
US20070014767A1 (en) 2007-01-18
JP4237807B2 (ja) 2009-03-11
AU1507700A (en) 2000-06-13
CY1105616T1 (el) 2010-07-28
JP4068654B2 (ja) 2008-03-26
DK1132403T3 (da) 2006-08-14
DE69930763T2 (de) 2006-11-30
JP2008056685A (ja) 2008-03-13
WO2000031135A1 (es) 2000-06-02
JP3836677B2 (ja) 2006-10-25
ES2262349T3 (es) 2006-11-16
JP2006241166A (ja) 2006-09-14
US7528226B2 (en) 2009-05-05
JP4272255B2 (ja) 2009-06-03
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AU767498B2 (en) 2003-11-13
CN1203091C (zh) 2005-05-25
BR9915604B1 (pt) 2011-07-26
JP4002287B2 (ja) 2007-10-31

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