ATE322505T1 - Tgf-g beta inhibitor-peptide - Google Patents

Tgf-g beta inhibitor-peptide

Info

Publication number
ATE322505T1
ATE322505T1 AT99957342T AT99957342T ATE322505T1 AT E322505 T1 ATE322505 T1 AT E322505T1 AT 99957342 T AT99957342 T AT 99957342T AT 99957342 T AT99957342 T AT 99957342T AT E322505 T1 ATE322505 T1 AT E322505T1
Authority
AT
Austria
Prior art keywords
tgf
beta inhibitor
inhibitor peptides
compositions
manufacture
Prior art date
Application number
AT99957342T
Other languages
English (en)
Inventor
Saenz Ignacio Jose Ezquerro
Sagastibelza Juan Jose Lasarte
Valtuena Jesus Prieto
Cuesta Francisco Borras
Original Assignee
Proyecto Biomedicina Cima Sl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proyecto Biomedicina Cima Sl filed Critical Proyecto Biomedicina Cima Sl
Application granted granted Critical
Publication of ATE322505T1 publication Critical patent/ATE322505T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT99957342T 1998-11-24 1999-11-23 Tgf-g beta inhibitor-peptide ATE322505T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009802465A ES2146552B1 (es) 1998-11-24 1998-11-24 Peptidos inhibidores de tgf/31

Publications (1)

Publication Number Publication Date
ATE322505T1 true ATE322505T1 (de) 2006-04-15

Family

ID=8305903

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99957342T ATE322505T1 (de) 1998-11-24 1999-11-23 Tgf-g beta inhibitor-peptide

Country Status (16)

Country Link
US (2) US7057013B1 (de)
EP (1) EP1132403B1 (de)
JP (5) JP3836677B2 (de)
CN (1) CN1203091C (de)
AT (1) ATE322505T1 (de)
AU (1) AU767498B2 (de)
BR (1) BR9915604B1 (de)
CA (1) CA2352537C (de)
CY (1) CY1105616T1 (de)
DE (1) DE69930763T2 (de)
DK (1) DK1132403T3 (de)
ES (2) ES2146552B1 (de)
PT (1) PT1132403E (de)
RU (1) RU2232771C2 (de)
SI (1) SI1132403T1 (de)
WO (1) WO2000031135A1 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7723473B2 (en) 1997-06-19 2010-05-25 St. Louis University Peptide antagonists of TGF-beta family members and therapeutic uses thereof
JP2002087938A (ja) * 2000-09-11 2002-03-27 Shiseido Co Ltd 養毛剤及びそのスクリーニング方法
AU2003234734A1 (en) * 2002-04-29 2003-11-17 Saint Louis University Peptide antagonists of tgf-beta family members and therapeutic uses thereof
ES2304069B1 (es) * 2003-08-22 2009-08-12 Proyecto De Biomedicina Cima, S.L. Peptidos con capacidad de unirse al factor transformante de crecimiento beta 1 (tgf-b1).
US8158589B2 (en) * 2003-08-22 2012-04-17 Proyecto Biomedicine Cima, S.L. Peptides with the capacity to bind to transforming growth factor β1 (TGF-β1)
JP5112322B2 (ja) * 2005-10-24 2013-01-09 プロイェクト、デ、ビオメディシナ、シーマ、ソシエダッド、リミターダ 免疫応答調節剤の製造におけるＴＧＦ−β１インヒビターペプチドの使用
US7582609B2 (en) * 2006-03-01 2009-09-01 Digna Biotech, S.L. Method for the treatment of skin fibrosis and suitable compositions for such treatment
KR100879239B1 (ko) * 2007-04-19 2009-01-16 (주)케어젠 Ｔｇｆｐ－ｃａｐ 펩타이드 및 그의 용도
ES2327088B1 (es) * 2007-08-20 2010-07-26 Proyecto De Biomedicina Cima S.L. Combinaciones terapeuticas para el tratamiento de las metastasis.
EP2192904B1 (de) * 2007-08-27 2016-08-17 Auxagen, Inc. VERFAHREN ZUR HEMMUNG VON TGF-beta
JP4630914B2 (ja) 2008-04-14 2011-02-09 株式会社日本ハイポックス 肝線維化抑制剤
RU2567667C2 (ru) 2008-06-13 2015-11-10 Проекто Де Биомедисина Сима, С.Л. Конъюгаты для введения биологически активных соединений
US8487006B2 (en) * 2008-09-16 2013-07-16 Auxagen, Inc. Method of enhancing TGF-β signalling
CA2750559A1 (en) * 2009-02-05 2010-08-12 Digna Biotech, S.L. Pharmaceutical formulations of tgf-.beta.1 inhibitor peptides
ES2347627B1 (es) 2009-03-06 2011-10-10 Isdin, S.A. Peptido para el tratamiento profilactico o terapeutico de tumores de la piel en estadios iniciales.
KR100983182B1 (ko) 2009-08-14 2010-09-20 (주)엔솔테크 신규 펩타이드 및 그 용도
BR112012010755A2 (pt) 2009-11-05 2015-09-22 Proyecto Biomedicina Cima Sl constructo de gene que permite a expressão hepato-específica induzível de um polinucleotídeo de interesse em resposta a um agente indutor, vetor, genoma viral recombinante, vírion, método in vitro para a expressão de um polinucleotídeo de interesse em uma célula de origem hepática, composição farmacêutica e operador-promotor bi-direcional induzível adequado para a expressão hepato-específica induzível de dois polinucleotídeos de interesse por um agente indutor
SG183356A1 (en) * 2010-02-18 2012-09-27 Univ California INTEGRIN aVß8 NEUTRALIZING ANTIBODY
CN102898508B (zh) * 2011-08-12 2014-04-30 北京大学第一医院 封闭TGF-β受体或IL-10受体的多肽、其药物组合物及其用途
JP5963757B2 (ja) 2011-09-05 2016-08-03 株式会社ポーラファルマ Ｅｔｆｂの細胞異常増殖への適用方法及び異常増殖抑制剤
CU24181B1 (es) * 2012-11-09 2016-04-25 Ct De Inmunología Molecular POLIPÉPTIDOS DERIVADOS DEL TGFß
NZ713219A (en) 2013-03-14 2017-04-28 Massachusetts Inst Technology Compositions and methods for epithelial stem cell expansion and culture
US11730722B2 (en) 2013-07-30 2023-08-22 Kyoto Prefectural Public University Corporation Corneal endothelium ECM therapeutic medicaments
EP3036262A4 (de) 2013-08-22 2017-03-01 Acceleron Pharma Inc. Varianten von tgf-beta-rezeptortyp ii und verwendungen davon
EP3064222B1 (de) 2013-10-31 2020-10-21 Kyoto Prefectural Public University Corporation Therapeutikum enthaltend einen tgf-beta signalblocker für erkrankungen im zusammenhang mit endoplasmatischem retikulumszelltod im hornhautendothel
EP3685848B1 (de) 2013-11-21 2021-09-15 The Brigham and Women's Hospital, Inc. Zusammensetzungen und verfahren zur behandlung pulmonaler hypertonie
CN106794233B (zh) 2014-08-01 2021-11-12 布里格姆及妇女医院股份有限公司 与肺动脉高压的治疗有关的组合物和方法
CN107073042A (zh) 2014-09-03 2017-08-18 布里格海姆妇女医院公司 用于产生内耳毛细胞来治疗听力损失的组合物、系统和方法
CN105821029A (zh) * 2015-01-04 2016-08-03 彭霞 异源融合基因修饰的癌细胞/树突状细胞融合肿瘤疫苗及其制备方法
TWI726870B (zh) * 2015-03-04 2021-05-11 美商健臻公司 具有高親和性、結合性及專一性之結合轉形生長因子-β１的ｓｃＦｖ-Ｆｃ二聚體
WO2016210292A1 (en) 2015-06-25 2016-12-29 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
KR20180035884A (ko) 2015-08-04 2018-04-06 악셀레론 파마 인코포레이티드 골수증식성 장애를 치료하기 위한 방법
EP3400286A1 (de) 2016-01-08 2018-11-14 Massachusetts Institute Of Technology Herstellung von differenzierten enteroendokrinen zellen und insulinproduzierenden zellen
KR101841748B1 (ko) * 2016-02-18 2018-05-08 (주)케어젠 멜라닌 생성 촉진 활성을 나타내는 펩타이드 및 이의 용도
KR101791526B1 (ko) * 2016-02-18 2017-11-01 (주)케어젠 발모 촉진 활성을 나타내는 펩타이드 및 이의 용도
US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
US10213511B2 (en) 2016-03-02 2019-02-26 Frequency Therapeutics, Inc. Thermoreversible compositions for administration of therapeutic agents
US20190119642A1 (en) 2016-03-15 2019-04-25 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion
KR20190104359A (ko) 2016-12-30 2019-09-09 프리퀀시 테라퓨틱스, 인크. 줄기/전구체 지지 세포의 자가 재생을 유도하기 위한 1h-피롤-2,5-다이온 화합물 및 이의 사용 방법
KR20240023201A (ko) 2017-05-04 2024-02-20 악셀레론 파마 인코포레이티드 Tgf-베타 수용체 유형 ii 융합 단백질 및 이의 용도
KR101954214B1 (ko) * 2017-05-23 2019-03-06 (주)케어젠 멜라닌 생성 촉진 활성을 나타내는 펩타이드 및 이의 용도
JP2021518413A (ja) 2018-03-20 2021-08-02 アイカーン スクール オブ メディシン アット マウント サイナイ キナーゼ阻害剤化合物及び組成物ならびに使用方法
US20210254006A1 (en) 2018-06-06 2021-08-19 Ideaya Biosciences, Inc. Methods of culturing and/or expanding stem cells and/or lineage committed progenitor cells using lactam compounds
WO2019234221A1 (en) 2018-06-08 2019-12-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for stratification and treatment of a patient suffering from chronic lymphocytic leukemia
JP2021533788A (ja) 2018-08-17 2021-12-09 フリークエンシー セラピューティクス インコーポレイテッド Ｊａｇ−１を上方制御することにより有毛細胞を生成するための組成物及び方法
US11617745B2 (en) 2018-08-17 2023-04-04 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by downregulating FOXO
CN109432431B (zh) 2018-12-14 2020-06-30 中国药科大学 一种含有sumo抑制剂的组合物及应用
EP3906233B1 (de) 2018-12-31 2024-01-31 Icahn School of Medicine at Mount Sinai Kinaseinhibitorverbindungen und zusammensetzungen und verfahren zur verwendung
KR102265432B1 (ko) 2019-08-20 2021-06-15 주식회사 케어젠 피부 미백 활성을 갖는 펩타이드 및 이의 용도
CN110511285B (zh) * 2019-08-27 2023-01-24 南京安吉生物科技有限公司 一种重组融合多肽及其应用
CN110483648A (zh) * 2019-08-27 2019-11-22 南京安吉生物科技有限公司 一种融合多肽及其应用
KR20220091406A (ko) * 2020-12-23 2022-06-30 한국과학기술연구원 TGF-β 신호전달을 억제할 수 있는 신규한 펩타이드 및 이의 용도
WO2023249439A1 (ko) * 2022-06-22 2023-12-28 주식회사 유씨아이테라퓨틱스 TGF-β 신호전달을 억제할 수 있는 신규한 펩타이드 및 이의 용도

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
JPH06500574A (ja) * 1991-05-10 1994-01-20 ザ　ソーク　インスティテュート　フォア　バイオロジカル　スタディーズ アクチビン／ＴＧＦ―βスーパーファミリーのレセプターのクローニングおよび組換えによる産生
FR2720069A1 (fr) * 1994-05-19 1995-11-24 Inst Nat Sante Rech Med Dérivés de facteurs de croissance et d'hormones de la superfamille des TGFB, procédé pour leur obtention et leurs applications biologiques.
US5824655A (en) * 1995-02-15 1998-10-20 The University Of Utah Anti-transforming growth factor-β gene therapy

Also Published As

Publication number Publication date
US20070014767A1 (en) 2007-01-18
JP4272255B2 (ja) 2009-06-03
JP2002530431A (ja) 2002-09-17
JP2006241166A (ja) 2006-09-14
DE69930763D1 (en) 2006-05-18
JP4068654B2 (ja) 2008-03-26
BR9915604A (pt) 2001-08-07
US7528226B2 (en) 2009-05-05
RU2232771C2 (ru) 2004-07-20
PT1132403E (pt) 2006-07-31
BR9915604B1 (pt) 2011-07-26
AU767498B2 (en) 2003-11-13
CA2352537A1 (en) 2000-06-02
WO2000031135A1 (es) 2000-06-02
DE69930763T2 (de) 2006-11-30
US7057013B1 (en) 2006-06-06
JP2007186519A (ja) 2007-07-26
JP2008056685A (ja) 2008-03-13
DK1132403T3 (da) 2006-08-14
SI1132403T1 (sl) 2006-08-31
CY1105616T1 (el) 2010-07-28
ES2146552A1 (es) 2000-08-01
CN1328569A (zh) 2001-12-26
JP4237807B2 (ja) 2009-03-11
JP4002287B2 (ja) 2007-10-31
EP1132403A1 (de) 2001-09-12
JP3836677B2 (ja) 2006-10-25
CA2352537C (en) 2011-11-15
JP2009040796A (ja) 2009-02-26
ES2146552B1 (es) 2001-04-16
AU1507700A (en) 2000-06-13
EP1132403B1 (de) 2006-04-05
ES2262349T3 (es) 2006-11-16
CN1203091C (zh) 2005-05-25

Similar Documents

Publication Publication Date Title
ATE322505T1 (de) Tgf-g beta inhibitor-peptide
MXPA02001911A (es) Anticuerpos ctla-4 humanos y sus usos.
EE03693B1 (et) Isoleeritud dimeerne fibroblastide aktivatsioonivalk alfa ja selle kasutusalad
ID26819A (id) Turunan imidazo piridina yang menghambat sekresi asam lambung
FI935585A0 (fi) Pyrrolopyrimidiner
DE60115602D1 (de) Verwendung von säurestabilen subtilisinproteasen in tierfutter
DE69731373D1 (de) Cc-chemokinzeptor c-c ckr-5, dessen derivate und verwendungen
SE9802729D0 (sv) Novel Compounds
GB9806632D0 (en) Peptide factor
ES2184077T3 (es) Nuevas fenantridinas sustituidas en la posicion 6.
FI972308A0 (fi) 2-substituoituja 1,2,5-tiadiatsolidin-3-oni-1,1-dioksideja ja niitä sisältäviä koostumuksia ja menetelmiä niiden käyttämiseksi
DE60045681D1 (de) Vaskuläre adhesionsmoleküle und modulierung ihrer funktion
CA2123315A1 (en) Therapeutic agents which are antagonists or partial agonists of human interleukin 4
DE68907635D1 (de) Loetmaterial fuer brillengestelle und brillengestelle, bei denen dieses loetmaterial verwendet ist.
DE69033756T2 (de) Gene, die für MACIF Proteine kodieren, Expressionsvektoren mit diesem Genen, und Transformantenzellen mit diesem Proteinen
ITMI920955A1 (it) Idrogeli di tipo polietereammidoamminico come materiali eparinizzabili
NO20002408D0 (no) 5-HT1F antagonister
SI1187612T1 (en) Use of riluzole for the treatment of multiple sclerosis
DK1790655T3 (da) Biologisk aktive peptider
PE20399A1 (es) Muteina ob
DK1012286T3 (da) Allelvariant af humant STAT3
ATE282609T1 (de) Neue substituierte n-methyl-n-(4-(4-(1h- benzimidazol-2-yl) (1,4)diazepan-1-yl)-2- (aryl)butyl)benzamide zur behandlung von allergischen krankheiten
ID27656A (id) Turunan azabisikloheptana n-tersubstitusi, pembuatan dan penggunaannya
ATE246690T1 (de) Thiazolopyrimidine verwendbar als tnf-alpha inhibitoren
DE69719190D1 (de) Kolostrum enthaltende pharmazeutische zusammensetzungen und deren verwendung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1132403

Country of ref document: EP