BR9915604A - Peptìdios inibidores de tgfbeta1 - Google Patents
Peptìdios inibidores de tgfbeta1Info
- Publication number
- BR9915604A BR9915604A BR9915604-0A BR9915604A BR9915604A BR 9915604 A BR9915604 A BR 9915604A BR 9915604 A BR9915604 A BR 9915604A BR 9915604 A BR9915604 A BR 9915604A
- Authority
- BR
- Brazil
- Prior art keywords
- tgfbeta1
- inhibitory peptides
- peptides
- compositions
- inhibitory
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ESP9802465 | 1998-11-24 | ||
ES009802465A ES2146552B1 (es) | 1998-11-24 | 1998-11-24 | Peptidos inhibidores de tgf/31 |
PCT/ES1999/000375 WO2000031135A1 (es) | 1998-11-24 | 1999-11-23 | PEPTIDOS INHIBIDORES DE TGFβ1 |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9915604A true BR9915604A (pt) | 2001-08-07 |
BR9915604B1 BR9915604B1 (pt) | 2011-07-26 |
Family
ID=8305903
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9915604-0A BR9915604B1 (pt) | 1998-11-24 | 1999-11-23 | peptÍdios antagonistas de inibidores de tgf-beta1 e seu uso. |
Country Status (16)
Country | Link |
---|---|
US (2) | US7057013B1 (pt) |
EP (1) | EP1132403B1 (pt) |
JP (5) | JP3836677B2 (pt) |
CN (1) | CN1203091C (pt) |
AT (1) | ATE322505T1 (pt) |
AU (1) | AU767498B2 (pt) |
BR (1) | BR9915604B1 (pt) |
CA (1) | CA2352537C (pt) |
CY (1) | CY1105616T1 (pt) |
DE (1) | DE69930763T2 (pt) |
DK (1) | DK1132403T3 (pt) |
ES (2) | ES2146552B1 (pt) |
PT (1) | PT1132403E (pt) |
RU (1) | RU2232771C2 (pt) |
SI (1) | SI1132403T1 (pt) |
WO (1) | WO2000031135A1 (pt) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7723473B2 (en) | 1997-06-19 | 2010-05-25 | St. Louis University | Peptide antagonists of TGF-beta family members and therapeutic uses thereof |
JP2002087938A (ja) * | 2000-09-11 | 2002-03-27 | Shiseido Co Ltd | 養毛剤及びそのスクリーニング方法 |
EP1534737A4 (en) * | 2002-04-29 | 2007-10-31 | Univ Saint Louis | PEPTIDE ANTAGONISTS OF TGF-BETA FAMILY ELEMENTS AND THERAPEUTIC USES OF THESE ANTAGONISTS |
US8158589B2 (en) * | 2003-08-22 | 2012-04-17 | Proyecto Biomedicine Cima, S.L. | Peptides with the capacity to bind to transforming growth factor β1 (TGF-β1) |
ES2304069B1 (es) | 2003-08-22 | 2009-08-12 | Proyecto De Biomedicina Cima, S.L. | Peptidos con capacidad de unirse al factor transformante de crecimiento beta 1 (tgf-b1). |
CA2627298A1 (en) * | 2005-10-24 | 2007-05-03 | Proyecto De Biomedicina Cima, S.L. | Use of tgf-.beta.1 inhibitor peptides in the preparation of an immune response modulating agent |
US7582609B2 (en) | 2006-03-01 | 2009-09-01 | Digna Biotech, S.L. | Method for the treatment of skin fibrosis and suitable compositions for such treatment |
KR100879239B1 (ko) * | 2007-04-19 | 2009-01-16 | (주)케어젠 | Tgfp-cap 펩타이드 및 그의 용도 |
ES2327088B1 (es) * | 2007-08-20 | 2010-07-26 | Proyecto De Biomedicina Cima S.L. | Combinaciones terapeuticas para el tratamiento de las metastasis. |
WO2009029656A1 (en) | 2007-08-27 | 2009-03-05 | Auxagen, Inc. | METHODS FOR INHIBITING TGF-β |
JP4630914B2 (ja) | 2008-04-14 | 2011-02-09 | 株式会社日本ハイポックス | 肝線維化抑制剤 |
MX2010013759A (es) | 2008-06-13 | 2011-05-25 | Proyecto Biomedicina Cima Sl | Conjugados para la administracion de compuestos biologicamente activos. |
CN102159219B (zh) | 2008-09-16 | 2015-06-24 | 圣路易斯大学 | 提高转化生长因子-β信号发送的方法 |
CA2750559A1 (en) * | 2009-02-05 | 2010-08-12 | Digna Biotech, S.L. | Pharmaceutical formulations of tgf-.beta.1 inhibitor peptides |
ES2347627B1 (es) | 2009-03-06 | 2011-10-10 | Isdin, S.A. | Peptido para el tratamiento profilactico o terapeutico de tumores de la piel en estadios iniciales. |
KR100983182B1 (ko) * | 2009-08-14 | 2010-09-20 | (주)엔솔테크 | 신규 펩타이드 및 그 용도 |
MX2012005340A (es) | 2009-11-05 | 2012-12-05 | Proyecto Biomedicina Cima Sl | Sistemas de expresion regulada. |
RU2565539C2 (ru) * | 2010-02-18 | 2015-10-20 | Те Риджентс Оф Те Юниверсити Оф Калифорния | АНТИТЕЛА, НЕЙТРАЛИЗУЮЩИЕ ИНТЕГРИН ανβ8 |
CN102898508B (zh) * | 2011-08-12 | 2014-04-30 | 北京大学第一医院 | 封闭TGF-β受体或IL-10受体的多肽、其药物组合物及其用途 |
JP5963757B2 (ja) | 2011-09-05 | 2016-08-03 | 株式会社ポーラファルマ | Etfbの細胞異常増殖への適用方法及び異常増殖抑制剤 |
CU24181B1 (es) * | 2012-11-09 | 2016-04-25 | Ct De Inmunología Molecular | POLIPÉPTIDOS DERIVADOS DEL TGFß |
KR102168088B1 (ko) | 2013-03-14 | 2020-10-20 | 더 브리검 앤드 우먼즈 하스피털, 인크. | 상피 줄기 세포 확장 및 배양을 위한 조성물 및 방법 |
JP6403217B2 (ja) | 2013-07-30 | 2018-10-10 | 京都府公立大学法人 | 角膜内皮ecm治療薬 |
CN105658672A (zh) | 2013-08-22 | 2016-06-08 | 阿塞勒隆制药公司 | TGF-β受体II型变体及其用途 |
EP3804760A1 (en) * | 2013-10-31 | 2021-04-14 | Kyoto Prefectural Public University Corporation | Therapeutic drug for diseases related to endoplasmic reticulum cell death in corneal endothelium |
EP3685848B1 (en) | 2013-11-21 | 2021-09-15 | The Brigham and Women's Hospital, Inc. | Compositions and methods for treating pulmonary hypertension |
JP6955443B2 (ja) * | 2014-08-01 | 2021-10-27 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. | 肺動脈性肺高血圧症の処置に関する方法および組成物 |
IL299964A (en) | 2014-09-03 | 2023-03-01 | Massachusetts Inst Technology | Preparations, systems and methods for producing hair cells in the inner ear to treat hearing loss |
CN105821029A (zh) * | 2015-01-04 | 2016-08-03 | 彭霞 | 异源融合基因修饰的癌细胞/树突状细胞融合肿瘤疫苗及其制备方法 |
TWI726870B (zh) * | 2015-03-04 | 2021-05-11 | 美商健臻公司 | 具有高親和性、結合性及專一性之結合轉形生長因子-β1的scFv-Fc二聚體 |
EP3313420B1 (en) | 2015-06-25 | 2024-03-13 | The Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
WO2017024171A1 (en) | 2015-08-04 | 2017-02-09 | Acceleron Pharma Inc. | Methods for treating myeloproliferative disorders |
CA3010610A1 (en) | 2016-01-08 | 2017-07-13 | The Brigham And Women's Hospital, Inc. | Production of differentiated enteroendocrine cells and insulin producing cells |
KR101791526B1 (ko) | 2016-02-18 | 2017-11-01 | (주)케어젠 | 발모 촉진 활성을 나타내는 펩타이드 및 이의 용도 |
KR101841748B1 (ko) | 2016-02-18 | 2018-05-08 | (주)케어젠 | 멜라닌 생성 촉진 활성을 나타내는 펩타이드 및 이의 용도 |
US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
WO2017161001A1 (en) | 2016-03-15 | 2017-09-21 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion |
CA3048220A1 (en) | 2016-12-30 | 2018-07-05 | Frequency Therapeutics, Inc. | 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells |
EP4241848A3 (en) | 2017-05-04 | 2023-11-01 | Acceleron Pharma Inc. | Tgf-beta receptor type ii fusion proteins and uses thereof |
KR101954214B1 (ko) * | 2017-05-23 | 2019-03-06 | (주)케어젠 | 멜라닌 생성 촉진 활성을 나타내는 펩타이드 및 이의 용도 |
US11866427B2 (en) | 2018-03-20 | 2024-01-09 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
WO2019236766A1 (en) | 2018-06-06 | 2019-12-12 | Ideaya Biosciences, Inc. | Methods of culturing and/or expanding stem cells and/or lineage committed progenitor cells using lactam compounds |
WO2019234221A1 (en) | 2018-06-08 | 2019-12-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for stratification and treatment of a patient suffering from chronic lymphocytic leukemia |
EP3837352A1 (en) | 2018-08-17 | 2021-06-23 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by upregulating jag-1 |
US11617745B2 (en) | 2018-08-17 | 2023-04-04 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating FOXO |
CN109432431B (zh) | 2018-12-14 | 2020-06-30 | 中国药科大学 | 一种含有sumo抑制剂的组合物及应用 |
US20220162182A1 (en) | 2018-12-31 | 2022-05-26 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
KR102265432B1 (ko) | 2019-08-20 | 2021-06-15 | 주식회사 케어젠 | 피부 미백 활성을 갖는 펩타이드 및 이의 용도 |
CN110511285B (zh) * | 2019-08-27 | 2023-01-24 | 南京安吉生物科技有限公司 | 一种重组融合多肽及其应用 |
CN110483648A (zh) * | 2019-08-27 | 2019-11-22 | 南京安吉生物科技有限公司 | 一种融合多肽及其应用 |
CN116867797A (zh) * | 2020-12-23 | 2023-10-10 | 韩国科学技术研究院 | 能够抑制TGF-β信号传导的新型肽及其应用 |
KR20240000395A (ko) * | 2022-06-22 | 2024-01-02 | 주식회사 유씨아이테라퓨틱스 | TGF-β 신호전달을 억제할 수 있는 신규한 펩타이드 및 이의 용도 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8927546D0 (en) * | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
JPH06500574A (ja) * | 1991-05-10 | 1994-01-20 | ザ ソーク インスティテュート フォア バイオロジカル スタディーズ | アクチビン/TGF―βスーパーファミリーのレセプターのクローニングおよび組換えによる産生 |
FR2720069A1 (fr) * | 1994-05-19 | 1995-11-24 | Inst Nat Sante Rech Med | Dérivés de facteurs de croissance et d'hormones de la superfamille des TGFB, procédé pour leur obtention et leurs applications biologiques. |
US5824655A (en) * | 1995-02-15 | 1998-10-20 | The University Of Utah | Anti-transforming growth factor-β gene therapy |
-
1998
- 1998-11-24 ES ES009802465A patent/ES2146552B1/es not_active Expired - Fee Related
-
1999
- 1999-11-23 BR BRPI9915604-0A patent/BR9915604B1/pt not_active IP Right Cessation
- 1999-11-23 AT AT99957342T patent/ATE322505T1/de active
- 1999-11-23 DK DK99957342T patent/DK1132403T3/da active
- 1999-11-23 RU RU2001117230/04A patent/RU2232771C2/ru not_active IP Right Cessation
- 1999-11-23 US US09/831,253 patent/US7057013B1/en not_active Expired - Fee Related
- 1999-11-23 PT PT99957342T patent/PT1132403E/pt unknown
- 1999-11-23 CA CA2352537A patent/CA2352537C/en not_active Expired - Fee Related
- 1999-11-23 AU AU15077/00A patent/AU767498B2/en not_active Ceased
- 1999-11-23 SI SI9930897T patent/SI1132403T1/sl unknown
- 1999-11-23 EP EP99957342A patent/EP1132403B1/en not_active Expired - Lifetime
- 1999-11-23 WO PCT/ES1999/000375 patent/WO2000031135A1/es active IP Right Grant
- 1999-11-23 CN CNB99813614XA patent/CN1203091C/zh not_active Expired - Fee Related
- 1999-11-23 DE DE69930763T patent/DE69930763T2/de not_active Expired - Lifetime
- 1999-11-23 JP JP2000583961A patent/JP3836677B2/ja not_active Expired - Fee Related
- 1999-11-23 ES ES99957342T patent/ES2262349T3/es not_active Expired - Lifetime
-
2006
- 2006-04-10 JP JP2006107967A patent/JP4002287B2/ja not_active Expired - Fee Related
- 2006-04-11 US US11/401,744 patent/US7528226B2/en not_active Expired - Fee Related
- 2006-06-16 CY CY20061100805T patent/CY1105616T1/el unknown
-
2007
- 2007-02-19 JP JP2007037713A patent/JP4068654B2/ja not_active Expired - Fee Related
- 2007-10-02 JP JP2007259167A patent/JP4237807B2/ja not_active Expired - Fee Related
-
2008
- 2008-10-20 JP JP2008269650A patent/JP4272255B2/ja not_active Expired - Fee Related
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B25A | Requested transfer of rights approved |
Free format text: FUNDACION PARA LA INVESTIGACION MEDICA APLICADA (ES) |
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B25A | Requested transfer of rights approved |
Owner name: PROYECTO DE BIOMEDICINA CIMA, S.L. (ES) Free format text: TRANSFERIDO DE: FUNDACION PARA LA INVESTIGACION MEDICA APPLICADA |
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B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
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Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/07/2011, OBSERVADAS AS CONDICOES LEGAIS. |
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B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 16A ANUIDADE. |
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B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2342 DE 24-11-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |