MX2012005340A - Sistemas de expresion regulada. - Google Patents

Sistemas de expresion regulada.

Info

Publication number
MX2012005340A
MX2012005340A MX2012005340A MX2012005340A MX2012005340A MX 2012005340 A MX2012005340 A MX 2012005340A MX 2012005340 A MX2012005340 A MX 2012005340A MX 2012005340 A MX2012005340 A MX 2012005340A MX 2012005340 A MX2012005340 A MX 2012005340A
Authority
MX
Mexico
Prior art keywords
hepato
promoter
inducer agent
specific
operator
Prior art date
Application number
MX2012005340A
Other languages
English (en)
Inventor
Jesus Maria Prieto Valtuena
Gloria Gonzalez Aseguinolaza
Lucia Maria Vanrell Majo
Original Assignee
Proyecto Biomedicina Cima Sl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proyecto Biomedicina Cima Sl filed Critical Proyecto Biomedicina Cima Sl
Publication of MX2012005340A publication Critical patent/MX2012005340A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se relaciona con métodos y herramientas para la expresión inducible hepatoespecífica de un gen de interés mediante el uso de promotores bidireccionales hepatoespecíficos que se encuentran operativamente acoplados a dicho gen de interés y a un transactivador que es capaz de promover la transcripción en presencia de un determinado gen de interés. La invención se refiere también a construcciones génicas y viriones que permiten la expresión regulada hepatoespecifica así como al uso de los mismos para el tratamiento de enfermedades hepáticas.
MX2012005340A 2009-11-05 2010-11-04 Sistemas de expresion regulada. MX2012005340A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200902122 2009-11-05
PCT/ES2010/070715 WO2011054994A1 (es) 2009-11-05 2010-11-04 Sistemas de expresión regulada

Publications (1)

Publication Number Publication Date
MX2012005340A true MX2012005340A (es) 2012-12-05

Family

ID=43569271

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012005340A MX2012005340A (es) 2009-11-05 2010-11-04 Sistemas de expresion regulada.

Country Status (10)

Country Link
US (1) US20120225933A1 (es)
EP (1) EP2497830A1 (es)
JP (1) JP2014503173A (es)
CN (1) CN102712933A (es)
AU (1) AU2010316996A1 (es)
BR (1) BR112012010755A2 (es)
CA (1) CA2780671A1 (es)
MX (1) MX2012005340A (es)
RU (1) RU2012123145A (es)
WO (1) WO2011054994A1 (es)

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EP2525780B1 (en) * 2010-01-19 2022-09-07 Northwestern University Synthetic nanostructures including nucleic acids and/or other entities
SG11201507507PA (en) * 2013-03-15 2015-10-29 Univ Pennsylvania Compositions and methods for treating mpsi
CN105316352A (zh) * 2014-07-29 2016-02-10 深圳先进技术研究院 一种调节性表达目的基因的载体及其制备方法和应用
GB201420139D0 (en) 2014-11-12 2014-12-24 Ucl Business Plc Factor IX gene therapy
EP3184548A1 (en) 2015-12-23 2017-06-28 Miltenyi Biotec GmbH Chimeric antigen receptor with cytokine receptor activating or blocking domain
US11208669B2 (en) 2016-01-12 2021-12-28 University Of Cincinnati Lentivirus packaging system comprising a synthetic positive feedback loop
MA50016A (fr) 2017-07-06 2020-07-08 Univ Pennsylvania Thérapie génique médiée par aav9 pour traiter la mucopolysaccharidose de type i
CN107365785B (zh) * 2017-09-11 2020-02-18 东南大学 一种调控细胞内NF-κB活性的基因表达载体及其调控方法和应用
GB201813528D0 (en) 2018-08-20 2018-10-03 Ucl Business Plc Factor IX encoding nucleotides
US10842885B2 (en) 2018-08-20 2020-11-24 Ucl Business Ltd Factor IX encoding nucleotides
CA3173768A1 (en) 2020-10-13 2022-04-21 Brian Furmanski Viral vector constructs for delivery of nucleic acids encoding cytokines and uses thereof for treating cancer
WO2023178067A1 (en) * 2022-03-16 2023-09-21 Rutgers, The State University Of New Jersey Controlled muscle‐specific gene delivery
CN114891829B (zh) * 2022-05-24 2023-09-26 新乡医学院 一种肝特异性游离型表达载体和基因治疗载体及其应用
WO2024213573A1 (en) 2023-04-13 2024-10-17 Vector Biopharma Ag Inducible expression system

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Also Published As

Publication number Publication date
WO2011054994A1 (es) 2011-05-12
EP2497830A1 (en) 2012-09-12
AU2010316996A1 (en) 2012-06-14
RU2012123145A (ru) 2013-12-10
BR112012010755A2 (pt) 2015-09-22
CA2780671A1 (en) 2011-05-12
JP2014503173A (ja) 2014-02-13
CN102712933A (zh) 2012-10-03
US20120225933A1 (en) 2012-09-06

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