ES2153760A1 - Inhibidor de metalocarboxipeptidasas como agente fibrinolitico. - Google Patents
Inhibidor de metalocarboxipeptidasas como agente fibrinolitico.Info
- Publication number
- ES2153760A1 ES2153760A1 ES009802524A ES9802524A ES2153760A1 ES 2153760 A1 ES2153760 A1 ES 2153760A1 ES 009802524 A ES009802524 A ES 009802524A ES 9802524 A ES9802524 A ES 9802524A ES 2153760 A1 ES2153760 A1 ES 2153760A1
- Authority
- ES
- Spain
- Prior art keywords
- inhibitor
- metalocarboxypeptidases
- fibrinolytic agent
- same
- refers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Inhibidor de metalocarboxipeptidasas como agente fibrinolitíco. La invención trata del gen de un inhibidor de metalocarboxipeptidasas de la sanguijuela Hirudo medicinalis, secuencia del mismo y de la proteína por él codificada, de la caracterización de la misma. La invención también se refiere a su aplicación farmacológica como agente fibrinolítico.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009802524A ES2153760B1 (es) | 1998-11-25 | 1998-11-25 | Inhibidor de metalocarboxipeptidasas como agente fibrinolitico. |
PCT/ES1999/000378 WO2000031140A1 (es) | 1998-11-25 | 1999-11-24 | Inhibidor de metalocarboxipeptidasas como agente fibrinolitico |
CA002352600A CA2352600A1 (en) | 1998-11-25 | 1999-11-24 | Inhibitor of metalocarboxypeptidases as fibrinolytic agent |
AU15610/00A AU761061B2 (en) | 1998-11-25 | 1999-11-24 | Inhibitor of metalocarboxypeptidases as fibrinolytic agent |
EP99958191A EP1132406A1 (en) | 1998-11-25 | 1999-11-24 | Inhibitor of metalocarboxypeptidases as fibrinolytic agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009802524A ES2153760B1 (es) | 1998-11-25 | 1998-11-25 | Inhibidor de metalocarboxipeptidasas como agente fibrinolitico. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2153760A1 true ES2153760A1 (es) | 2001-03-01 |
ES2153760B1 ES2153760B1 (es) | 2001-07-01 |
Family
ID=8305983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009802524A Expired - Lifetime ES2153760B1 (es) | 1998-11-25 | 1998-11-25 | Inhibidor de metalocarboxipeptidasas como agente fibrinolitico. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1132406A1 (es) |
AU (1) | AU761061B2 (es) |
CA (1) | CA2352600A1 (es) |
ES (1) | ES2153760B1 (es) |
WO (1) | WO2000031140A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20140193468A1 (en) * | 2001-03-23 | 2014-07-10 | Histogenics Corporation | Methods for preparation of neo-cartilage constructs |
CA2623565A1 (en) | 2005-09-28 | 2007-04-05 | Biovascular, Inc. | Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation |
CN100405060C (zh) * | 2006-01-24 | 2008-07-23 | 李振国 | 一种水蛭指纹图谱的建立方法和水蛭药材的鉴别方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995001375A1 (en) * | 1993-07-01 | 1995-01-12 | Merck Patent Gmbh | Inhibitor of collagen-stimulated platelet aggregation |
US5587360A (en) * | 1990-10-10 | 1996-12-24 | Merck Patent Gmbh | Platelet adhesion inhibitor |
US5783421A (en) * | 1993-04-09 | 1998-07-21 | Bio-Technology General Corp. | DNA encoding novel polypeptide having Factor Xa inhibitory activity |
-
1998
- 1998-11-25 ES ES009802524A patent/ES2153760B1/es not_active Expired - Lifetime
-
1999
- 1999-11-24 CA CA002352600A patent/CA2352600A1/en not_active Abandoned
- 1999-11-24 AU AU15610/00A patent/AU761061B2/en not_active Ceased
- 1999-11-24 EP EP99958191A patent/EP1132406A1/en not_active Withdrawn
- 1999-11-24 WO PCT/ES1999/000378 patent/WO2000031140A1/es not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5587360A (en) * | 1990-10-10 | 1996-12-24 | Merck Patent Gmbh | Platelet adhesion inhibitor |
US5783421A (en) * | 1993-04-09 | 1998-07-21 | Bio-Technology General Corp. | DNA encoding novel polypeptide having Factor Xa inhibitory activity |
WO1995001375A1 (en) * | 1993-07-01 | 1995-01-12 | Merck Patent Gmbh | Inhibitor of collagen-stimulated platelet aggregation |
Non-Patent Citations (2)
Title |
---|
BASKOVA, I.P. et al. "Inhibition of plasma Kallikrein, Kininase and Kinin-like activities from the medical leeches", THROMBOSIS RESEARCH, 1992, Vol. 67, paginas 721-730. Todo el documento. * |
POHLIG, G. et al. "Purification, characterization and biological evaluation of recombinant leech-derived tryptase inhibitor (rLDTI) expressed at high level in the yeast Saccharomyces cerevisial", EUR. J. BIOCHEM., 1996, Vol. 241, paginas 619-626. Todo el documento. * |
Also Published As
Publication number | Publication date |
---|---|
EP1132406A1 (en) | 2001-09-12 |
AU1561000A (en) | 2000-06-13 |
ES2153760B1 (es) | 2001-07-01 |
CA2352600A1 (en) | 2000-06-02 |
WO2000031140A1 (es) | 2000-06-02 |
AU761061B2 (en) | 2003-05-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20010301 Kind code of ref document: A1 Effective date: 20010301 |
|
NE1A | Request for restoration |
Effective date: 20051125 |