ES2079774T3 - Derivados de indolopirrolocarbazol. - Google Patents

Derivados de indolopirrolocarbazol.

Info

Publication number
ES2079774T3
ES2079774T3 ES92119904T ES92119904T ES2079774T3 ES 2079774 T3 ES2079774 T3 ES 2079774T3 ES 92119904 T ES92119904 T ES 92119904T ES 92119904 T ES92119904 T ES 92119904T ES 2079774 T3 ES2079774 T3 ES 2079774T3
Authority
ES
Spain
Prior art keywords
grupo
group
inferior
amino
carbamoilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92119904T
Other languages
English (en)
Spanish (es)
Inventor
Kojiri Katsuhisa
Kondo Hisao
Arakawa Hiroharu
Mitsuru Ohkubo
Suda Hiroyuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Application granted granted Critical
Publication of ES2079774T3 publication Critical patent/ES2079774T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Silicon Polymers (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES92119904T 1991-11-29 1992-11-23 Derivados de indolopirrolocarbazol. Expired - Lifetime ES2079774T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP34191691 1991-11-29
JP6926992 1992-02-18
JP25730692 1992-09-01

Publications (1)

Publication Number Publication Date
ES2079774T3 true ES2079774T3 (es) 1996-01-16

Family

ID=27300000

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92119904T Expired - Lifetime ES2079774T3 (es) 1991-11-29 1992-11-23 Derivados de indolopirrolocarbazol.

Country Status (27)

Country Link
EP (1) EP0545195B1 (enExample)
JP (1) JP2629542B2 (enExample)
KR (1) KR100275976B1 (enExample)
AT (1) ATE130617T1 (enExample)
AU (1) AU650376B2 (enExample)
BG (1) BG61036B1 (enExample)
CA (1) CA2083534C (enExample)
CZ (1) CZ287304B6 (enExample)
DE (1) DE69206242T2 (enExample)
DK (1) DK0545195T3 (enExample)
DZ (1) DZ1634A1 (enExample)
ES (1) ES2079774T3 (enExample)
FI (1) FI106864B (enExample)
GR (1) GR3018527T3 (enExample)
HU (3) HU9203754D0 (enExample)
IL (1) IL103844A (enExample)
MX (1) MX9206847A (enExample)
MY (1) MY114655A (enExample)
NO (1) NO178929C (enExample)
NZ (1) NZ245203A (enExample)
PL (1) PL171468B1 (enExample)
RO (1) RO113469B1 (enExample)
RU (1) RU2117671C1 (enExample)
SA (1) SA93130351B1 (enExample)
TW (1) TW224469B (enExample)
WO (1) WO1993011145A1 (enExample)
YU (1) YU48963B (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995030682A1 (en) * 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyprolocarbazole derivative
DE69532198T2 (de) * 1994-05-09 2004-08-26 Banyu Pharmaceutical Co., Ltd. Antitumor-indolopyrolocarbazolderivat
DE69531686T2 (de) * 1994-06-13 2004-07-15 Banyu Pharmaceutical Co., Ltd. Glycosyltransferase kodierendes gen und seine verwendung
WO1996004293A1 (en) * 1994-08-02 1996-02-15 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazoles
US5591855A (en) * 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
WO1997009339A1 (fr) * 1995-09-05 1997-03-13 Banyu Pharmaceutical Co., Ltd. Derives antitumoraux d'indolopyrrolocarbazole
US5616724A (en) * 1996-02-21 1997-04-01 Cephalon, Inc. Fused pyrrolo[2,3-c]carbazole-6-ones
NZ333536A (en) * 1996-08-22 1999-10-28 Bristol Myers Squibb Co Cytotoxic amino sugar and related sugar derivatives of indolopyrrolocarbazoles, and use as antitumour agents
GB9811624D0 (en) * 1998-05-29 1998-07-29 Merck Sharp & Dohme Therapeutic use
US6013646A (en) * 1998-07-02 2000-01-11 Bayer Corporation Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6703373B1 (en) 1999-09-10 2004-03-09 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives and antitumor agents
FR2801054B1 (fr) * 1999-11-17 2003-06-13 Adir Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TR200302314T4 (tr) 2000-02-24 2004-01-21 Banyu Pharmaceutical Co., Ltd. İndolopirolokarbazol türevinin hazırlanması için bir işlem, hazırlık işlemindeki ara ürünler ve ara ürünlerin hazırlanmsı için bir işlem.
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6555677B2 (en) 2000-10-31 2003-04-29 Merck & Co., Inc. Phase transfer catalyzed glycosidation of an indolocarbazole
RU2003131269A (ru) 2001-03-22 2005-05-10 Бристол-Маерс Сквибб Компани (Us) Производные индолопирролокарбазолов и сахаров, цитотоксические и селективные по отношению к топоизомеразе i
US6559299B2 (en) 2001-03-29 2003-05-06 Merck & Co., Inc. Preparation and isolation of indolocarbazole glycosides
PL370866A1 (en) * 2002-03-26 2005-05-30 Banyu Pharmaceutical Co, Ltd. Use of antitumor indolopyrrolocarbazole derivative and other anticancer agent in combination
CA2398828A1 (en) 2002-08-09 2004-02-09 Merck & Co., Inc. A pharmaceutical composition containing an indolopyrrolocarbazole derivative
KR20050058444A (ko) * 2002-08-23 2005-06-16 반유 세이야꾸 가부시끼가이샤 인돌로피롤로카르바졸 유도체의 제조법
WO2005010017A1 (ja) * 2003-07-24 2005-02-03 Banyu Pharmaceutical Co., Ltd インドロピロロカルバゾール誘導体及び抗腫瘍剤
US20070042975A1 (en) * 2003-09-16 2007-02-22 Koji Yamada Novel indolopyrrolocarbazole derivative with antitumor activity
US7241779B2 (en) 2003-12-23 2007-07-10 Cephalon, Inc. Fused pyrrolocarbazoles
US7169802B2 (en) 2003-12-23 2007-01-30 Cephalon, Inc. Fused pyrrolocarbazoles
RU2255089C1 (ru) * 2003-12-26 2005-06-27 Закрытое акционерное общество "АСГЛ-Исследовательские Лаборатории" Производные гликозидов индоло[2,3-а]пирроло[3,4-с]карбазол-5,7-дионов, обладающие цитотоксической и противоопухолевой активностью
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
CA2742790C (en) 2008-11-19 2018-02-13 Cephalon, Inc. Novel forms of an indazolo[5,4-a]pyrrolo [3,4-c] carbazole compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Rebeccamycin analogs, their production and pharmaceutical compositions containing them
JPH0725787B2 (ja) * 1990-03-06 1995-03-22 ブリストル−マイヤーズ スクイブ カンパニー 臭化物前駆物質物質供給によるレベカマイシン類似体
CA2108146A1 (en) * 1991-04-11 1992-10-12 Stuart W. Mccombie Anti-tumor and anti-psoriatic agents

Also Published As

Publication number Publication date
PL304729A1 (en) 1995-01-09
TW224469B (enExample) 1994-06-01
IL103844A (en) 1997-09-30
CZ287304B6 (cs) 2000-10-11
DZ1634A1 (fr) 2002-02-17
FI106864B (fi) 2001-04-30
NO924593D0 (no) 1992-11-27
NO924593L (no) 1993-06-01
YU48963B (sh) 2003-01-31
CA2083534A1 (en) 1993-05-30
YU102692A (sh) 1996-02-19
DE69206242D1 (de) 1996-01-04
DE69206242T2 (de) 1996-03-28
RU2117671C1 (ru) 1998-08-20
ATE130617T1 (de) 1995-12-15
PL171468B1 (pl) 1997-05-30
KR930010039A (ko) 1993-06-21
NZ245203A (en) 1997-07-27
EP0545195B1 (en) 1995-11-22
JP2629542B2 (ja) 1997-07-09
FI925422L (fi) 1993-05-30
SA93130351B1 (ar) 2005-10-16
IL103844A0 (en) 1993-04-04
KR100275976B1 (ko) 2001-02-01
RO113469B1 (ro) 1998-07-30
MY114655A (en) 2002-12-31
HU211254A9 (en) 1995-11-28
BG97970A (bg) 1994-04-29
EP0545195A1 (en) 1993-06-09
GR3018527T3 (en) 1996-03-31
FI925422A0 (fi) 1992-11-27
HU9203754D0 (en) 1993-03-29
HU217611B (hu) 2000-03-28
HUT65699A (en) 1994-07-28
CA2083534C (en) 2003-01-28
NO178929B (no) 1996-03-25
NO178929C (no) 1996-07-03
CZ350892A3 (en) 1993-10-13
JPH06128283A (ja) 1994-05-10
DK0545195T3 (da) 1995-12-18
WO1993011145A1 (en) 1993-06-10
AU2963792A (en) 1993-06-03
MX9206847A (es) 1993-06-30
BG61036B1 (bg) 1996-09-30
AU650376B2 (en) 1994-06-16

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