AR004495A1 - Compuestos derivados de acido amino sustituido arilo y heteroarilo carboxilico; composicion farmaceutica que los contiene; uso de los compuestos; proceso para preparar dichos compuestos y compuestos utiles como material de partida. - Google Patents
Compuestos derivados de acido amino sustituido arilo y heteroarilo carboxilico; composicion farmaceutica que los contiene; uso de los compuestos; proceso para preparar dichos compuestos y compuestos utiles como material de partida.Info
- Publication number
- AR004495A1 AR004495A1 ARP960103226A AR10322696A AR004495A1 AR 004495 A1 AR004495 A1 AR 004495A1 AR P960103226 A ARP960103226 A AR P960103226A AR 10322696 A AR10322696 A AR 10322696A AR 004495 A1 AR004495 A1 AR 004495A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- alkyl
- optionally substituted
- formula
- linking group
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pyridine Compounds (AREA)
Abstract
La invención se relaciona con un compuesto derivado de ácido amino sustituído arilo y heteroarilo carboxílico de la fórmula I,donde A es un fenilonaftilo,piridilo, pirazinilo, piridazinilo, pirimidilo, tienilo, tiazolilo, oxazolilo otiad iazolilo opcionalmente sustituído con por lo menos dos átomosde carbono adyacentes, con la salvedad de que los grupos CH(R3)N(R2)B-R1 y -OR4 se ubican en una relación de 1,2 entre sí en los átomos de carbono del anilloel átomo del anillo enposición orto con respecto al grupo de enlace OR4 (y por lo tanto en la posición 3 en relación con el grupo de enlace-CHR3NR2-) no estásustituído; B es un fenilo, piridilo, tiazolilo, oxazolilo, tienilo, tiadiazolilo,imidazolilo,pirazinilo, pirid azinilo o pirimidilo opcionalmentesustituído; R1 está ubicado en el anillo B en una relación 1,3 o 1,4 con el grupo de enlace -CH(R3)N(R2)- y es carboxi, carboxi C1-3-alquilo, tetrazolilo,tetrazolil C1-3-alquilo, ácidotetrónico, ácido hidroxámic o, ácido sulfónico, o R1 tiene la fórmula -CONRaRal donde Ra es hidrógeno o C1-6 alquilo y Ral eshidrógeno, C1-6-alquilo (opcionalmente sustituído), C2-6-alquenilo (siempre que la doble ligadura no se encuentre en laposición 1), C2-6-alquinilo (siem pre qula triple ligadura no se encuentre en la posición 1), carboxifenilo heterociclilo de 5 o 6 miembros o heteroarilo de 5 o 6 miembros o Ra y Raljunto con el nitrógeno de la amida al cual seencuentran unidos (NRaRal) forman un residuo de aminoácido o un éster del mismo, o R1 es de la fórmula-CONHSO2Rb donde Rb es C1-6-alquilo (sustituído opcionalmente, C2-6-alquenilo (siempre que la doble ligadura no esté en la posición 1)C2-6-alquinilo(siempre que la triple ligadura no se enc uentre en la posición 1), heterociclilo de 5 ó 6 miembros, fenilo o heteroarilo de 5 ó 6 miembros,
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9512476.4A GB9512476D0 (en) | 1995-06-20 | 1995-06-20 | Aromatic compounds |
| GBGB9601462.6A GB9601462D0 (en) | 1996-01-25 | 1996-01-25 | Aromatic compounds |
| GBGB9606831.7A GB9606831D0 (en) | 1996-03-30 | 1996-03-30 | Aromatic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR004495A1 true AR004495A1 (es) | 1998-12-16 |
Family
ID=27267781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960103226A AR004495A1 (es) | 1995-06-20 | 1996-06-20 | Compuestos derivados de acido amino sustituido arilo y heteroarilo carboxilico; composicion farmaceutica que los contiene; uso de los compuestos; proceso para preparar dichos compuestos y compuestos utiles como material de partida. |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5994353A (es) |
| EP (1) | EP0835246B1 (es) |
| JP (1) | JP3949166B2 (es) |
| KR (1) | KR19990023006A (es) |
| CN (1) | CN1193963A (es) |
| AR (1) | AR004495A1 (es) |
| AT (1) | ATE207468T1 (es) |
| AU (1) | AU700337B2 (es) |
| BG (1) | BG63777B1 (es) |
| BR (1) | BR9608956A (es) |
| CA (1) | CA2220925A1 (es) |
| CZ (1) | CZ290923B6 (es) |
| DE (1) | DE69616323T2 (es) |
| DK (1) | DK0835246T3 (es) |
| EE (1) | EE9700341A (es) |
| ES (1) | ES2165505T3 (es) |
| HR (1) | HRP960288B1 (es) |
| HU (1) | HUP9802317A3 (es) |
| IL (1) | IL118664A (es) |
| MX (1) | MX9710218A (es) |
| MY (1) | MY116531A (es) |
| NO (1) | NO311129B1 (es) |
| NZ (1) | NZ311082A (es) |
| PL (1) | PL324205A1 (es) |
| PT (1) | PT835246E (es) |
| RO (1) | RO119945B1 (es) |
| SK (1) | SK282450B6 (es) |
| TW (1) | TW434240B (es) |
| WO (1) | WO1997000863A1 (es) |
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| GB9514160D0 (en) * | 1994-07-25 | 1995-09-13 | Zeneca Ltd | Aromatic compounds |
| GB9417532D0 (en) * | 1994-08-31 | 1994-10-19 | Zeneca Ltd | Aromatic compounds |
| TW434240B (en) * | 1995-06-20 | 2001-05-16 | Zeneca Ltd | Aromatic compounds, preparation thereof and pharmaceutical composition comprising same |
| TW502026B (en) * | 1995-06-20 | 2002-09-11 | Zeneca Ltd | Aromatic compounds useful as antagonists of e-type prostaglandins, processes for the preparation thereof, pharmaceutical compositions comprising the compounds, and intermediates |
| US5834468A (en) * | 1995-07-07 | 1998-11-10 | Zeneca Limited | Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists |
| US6242474B1 (en) | 1997-06-27 | 2001-06-05 | Fujisawa Pharmaceutical Co., Ltd. | Aromatic ring derivatives |
| GB9903476D0 (en) * | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Therapeutic agents |
| SE0100873D0 (sv) * | 2001-03-13 | 2001-03-13 | Astrazeneca Ab | Method of treatment |
| EP1369129A4 (en) * | 2001-03-14 | 2005-08-03 | Ono Pharmaceutical Co | ANTIDEPRESSOR REMEDIES CONTAINING AN EP1 ANTAGONIST AS ACTIVE INGREDIENT |
| WO2003035064A1 (en) | 2001-10-23 | 2003-05-01 | Applied Research Systems Ars Holding N.V. | Pyrazolidinone compounds as ligands of the prostaglandin ep2 and/or ep4 receptors |
| WO2003043655A1 (fr) * | 2001-11-19 | 2003-05-30 | Ono Pharmaceutical Co., Ltd. | Remedes pour la frequence urinaire |
| ATE455758T1 (de) | 2001-12-20 | 2010-02-15 | Merck Serono Sa | Pyrrolidin-derivatie als prostaglandin- modulatoren |
| WO2003103604A2 (en) | 2002-06-01 | 2003-12-18 | Applied Research Systems Ars Holding N.V | Gamma lactams as prostaglandin agonists and use thereof |
| US7696243B2 (en) | 2004-12-06 | 2010-04-13 | Merck Serono, S.A. | Pyrrolidin-2-one derivatives for use as DP1 receptor agonists |
| ES2321535T3 (es) | 2004-12-23 | 2009-06-08 | Glaxo Group Limited | Compuestos de piridina para el tratamiento de enfermedades mediadas por prostaglandinas. |
| US7767710B2 (en) * | 2005-05-25 | 2010-08-03 | Calosyn Pharma, Inc. | Method for treating osteoarthritis |
| US20060269579A1 (en) * | 2005-05-25 | 2006-11-30 | Musculoskeletal Research Llc | Compositions for treating osteoarthritis |
| ES2437323T3 (es) | 2007-02-16 | 2014-01-10 | Ono Pharmaceutical Co., Ltd. | Agente terapéutico para trastornos de la micción |
| US20090163440A1 (en) * | 2007-09-26 | 2009-06-25 | Waddell David D | Ion-Channel Regulator Compositions and Methods of Using Same |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
| HUE035069T2 (en) | 2011-12-28 | 2018-05-02 | Global Blood Therapeutics Inc | Substituted benzaldehyde compounds and their use to increase tissue oxygenation |
| WO2013102145A1 (en) | 2011-12-28 | 2013-07-04 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
| US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| PE20161035A1 (es) | 2013-03-15 | 2016-11-13 | Global Blood Therapeutics Inc | Compuestos y usos de estos para la modulacion de la hemoglobina |
| US10100043B2 (en) | 2013-03-15 | 2018-10-16 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| KR20150132146A (ko) | 2013-03-15 | 2015-11-25 | 글로벌 블러드 테라퓨틱스, 인크. | 헤모글로빈 조정을 위한 화합물 및 이의 용도 |
| CA2903022C (en) | 2013-03-15 | 2021-11-09 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| JP6809681B2 (ja) | 2014-02-07 | 2021-01-06 | グローバル ブラッド セラピューティクス インコーポレイテッド | ２−ヒドロキシ−６−（（２−（１−イソプロピル−１ｈ−ピラゾール−５−イル）ピリジン−３−イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形 |
| MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
| TW201731509A (zh) | 2015-12-04 | 2017-09-16 | 全球血液治療公司 | 針對２-羥基-６-（（２-（１-異丙基-１ｈ-吡唑-５-基）吡啶-３-基）甲氧基）-苯甲醛之劑量方案 |
| TWI663160B (zh) | 2016-05-12 | 2019-06-21 | 全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
| TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| EP3860975B1 (en) | 2018-10-01 | 2023-10-18 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
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| GB9420557D0 (en) * | 1994-10-12 | 1994-11-30 | Zeneca Ltd | Aromatic compounds |
| US5530157A (en) * | 1995-02-16 | 1996-06-25 | Scios Nova Inc. | Anti-inflammatory benzoic acid derivatives |
| TW434240B (en) * | 1995-06-20 | 2001-05-16 | Zeneca Ltd | Aromatic compounds, preparation thereof and pharmaceutical composition comprising same |
| TW502026B (en) * | 1995-06-20 | 2002-09-11 | Zeneca Ltd | Aromatic compounds useful as antagonists of e-type prostaglandins, processes for the preparation thereof, pharmaceutical compositions comprising the compounds, and intermediates |
| US5834468A (en) * | 1995-07-07 | 1998-11-10 | Zeneca Limited | Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists |
| TW454123B (en) | 1999-01-28 | 2001-09-11 | Ibm | Method and system for enabling pervasive computing devices to communicate with each other |
-
1996
- 1996-06-12 TW TW085107056A patent/TW434240B/zh not_active IP Right Cessation
- 1996-06-16 IL IL11866496A patent/IL118664A/en not_active IP Right Cessation
- 1996-06-17 BR BR9608956A patent/BR9608956A/pt not_active Application Discontinuation
- 1996-06-17 RO RO97-02367A patent/RO119945B1/ro unknown
- 1996-06-17 US US08/973,887 patent/US5994353A/en not_active Expired - Fee Related
- 1996-06-17 NZ NZ311082A patent/NZ311082A/xx unknown
- 1996-06-17 DE DE69616323T patent/DE69616323T2/de not_active Expired - Fee Related
- 1996-06-17 EP EP96920936A patent/EP0835246B1/en not_active Expired - Lifetime
- 1996-06-17 EE EE9700341A patent/EE9700341A/xx unknown
- 1996-06-17 KR KR1019970709476A patent/KR19990023006A/ko not_active Application Discontinuation
- 1996-06-17 PL PL96324205A patent/PL324205A1/xx unknown
- 1996-06-17 AU AU62320/96A patent/AU700337B2/en not_active Ceased
- 1996-06-17 HU HU9802317A patent/HUP9802317A3/hu unknown
- 1996-06-17 PT PT96920936T patent/PT835246E/pt unknown
- 1996-06-17 CN CN96196398A patent/CN1193963A/zh active Pending
- 1996-06-17 JP JP50365397A patent/JP3949166B2/ja not_active Expired - Fee Related
- 1996-06-17 DK DK96920936T patent/DK0835246T3/da active
- 1996-06-17 CA CA002220925A patent/CA2220925A1/en not_active Abandoned
- 1996-06-17 SK SK1732-97A patent/SK282450B6/sk unknown
- 1996-06-17 MX MX9710218A patent/MX9710218A/es not_active IP Right Cessation
- 1996-06-17 AT AT96920936T patent/ATE207468T1/de not_active IP Right Cessation
- 1996-06-17 ES ES96920936T patent/ES2165505T3/es not_active Expired - Lifetime
- 1996-06-17 CZ CZ19974109A patent/CZ290923B6/cs not_active IP Right Cessation
- 1996-06-17 WO PCT/GB1996/001442 patent/WO1997000863A1/en not_active Application Discontinuation
- 1996-06-18 HR HR960288A patent/HRP960288B1/xx not_active IP Right Cessation
- 1996-06-18 MY MYPI96002451A patent/MY116531A/en unknown
- 1996-06-20 AR ARP960103226A patent/AR004495A1/es not_active Application Discontinuation
-
1997
- 1997-12-19 NO NO19975985A patent/NO311129B1/no unknown
-
1998
- 1998-01-09 BG BG102173A patent/BG63777B1/bg unknown
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1999
- 1999-09-13 US US09/395,229 patent/US6365603B1/en not_active Expired - Fee Related
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