IL118664A - Pain-relieving compounds containing methylene-amino and oxy-linking groups, process for their preparation, pharmaceutical mixtures containing them and their uses for the preparation of pharmaceutical mixtures - Google Patents

Pain-relieving compounds containing methylene-amino and oxy-linking groups, process for their preparation, pharmaceutical mixtures containing them and their uses for the preparation of pharmaceutical mixtures

Info

Publication number
IL118664A
IL118664A IL11866496A IL11866496A IL118664A IL 118664 A IL118664 A IL 118664A IL 11866496 A IL11866496 A IL 11866496A IL 11866496 A IL11866496 A IL 11866496A IL 118664 A IL118664 A IL 118664A
Authority
IL
Israel
Prior art keywords
alkyl
formula
compound
optionally substituted
hydrogen
Prior art date
Application number
IL11866496A
Other languages
English (en)
Hebrew (he)
Other versions
IL118664A0 (en
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9512476.4A external-priority patent/GB9512476D0/en
Priority claimed from GBGB9601462.6A external-priority patent/GB9601462D0/en
Priority claimed from GBGB9606831.7A external-priority patent/GB9606831D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of IL118664A0 publication Critical patent/IL118664A0/xx
Publication of IL118664A publication Critical patent/IL118664A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyridine Compounds (AREA)
IL11866496A 1995-06-20 1996-06-16 Pain-relieving compounds containing methylene-amino and oxy-linking groups, process for their preparation, pharmaceutical mixtures containing them and their uses for the preparation of pharmaceutical mixtures IL118664A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9512476.4A GB9512476D0 (en) 1995-06-20 1995-06-20 Aromatic compounds
GBGB9601462.6A GB9601462D0 (en) 1996-01-25 1996-01-25 Aromatic compounds
GBGB9606831.7A GB9606831D0 (en) 1996-03-30 1996-03-30 Aromatic compounds

Publications (2)

Publication Number Publication Date
IL118664A0 IL118664A0 (en) 1996-10-31
IL118664A true IL118664A (en) 2001-12-23

Family

ID=27267781

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11866496A IL118664A (en) 1995-06-20 1996-06-16 Pain-relieving compounds containing methylene-amino and oxy-linking groups, process for their preparation, pharmaceutical mixtures containing them and their uses for the preparation of pharmaceutical mixtures

Country Status (29)

Country Link
US (2) US5994353A (es)
EP (1) EP0835246B1 (es)
JP (1) JP3949166B2 (es)
KR (1) KR19990023006A (es)
CN (1) CN1193963A (es)
AR (1) AR004495A1 (es)
AT (1) ATE207468T1 (es)
AU (1) AU700337B2 (es)
BG (1) BG63777B1 (es)
BR (1) BR9608956A (es)
CA (1) CA2220925A1 (es)
CZ (1) CZ290923B6 (es)
DE (1) DE69616323T2 (es)
DK (1) DK0835246T3 (es)
EE (1) EE9700341A (es)
ES (1) ES2165505T3 (es)
HR (1) HRP960288B1 (es)
HU (1) HUP9802317A3 (es)
IL (1) IL118664A (es)
MX (1) MX9710218A (es)
MY (1) MY116531A (es)
NO (1) NO311129B1 (es)
NZ (1) NZ311082A (es)
PL (1) PL324205A1 (es)
PT (1) PT835246E (es)
RO (1) RO119945B1 (es)
SK (1) SK282450B6 (es)
TW (1) TW434240B (es)
WO (1) WO1997000863A1 (es)

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TW434240B (en) 1995-06-20 2001-05-16 Zeneca Ltd Aromatic compounds, preparation thereof and pharmaceutical composition comprising same
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EP0752421B1 (en) 1995-07-07 2005-10-12 AstraZeneca AB Ortho-substituted aromatic compounds, containing three (het)aryl moieties, their preparation and their use as prostaglandin E2-(PGE2)-antagonists
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EP2797597B1 (en) 2011-12-28 2020-02-26 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
KR101971385B1 (ko) 2013-03-15 2019-04-22 글로벌 블러드 테라퓨틱스, 인크. 헤모글로빈 조정을 위한 화합물 및 이의 용도
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CN112500338A (zh) 2013-03-15 2021-03-16 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
AU2014237330A1 (en) 2013-03-15 2015-09-17 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
AU2015214182B2 (en) 2014-02-07 2020-04-30 Global Blood Therapeutics, Inc. Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
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EP0752421B1 (en) * 1995-07-07 2005-10-12 AstraZeneca AB Ortho-substituted aromatic compounds, containing three (het)aryl moieties, their preparation and their use as prostaglandin E2-(PGE2)-antagonists
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Also Published As

Publication number Publication date
EP0835246A1 (en) 1998-04-15
CZ290923B6 (cs) 2002-11-13
US5994353A (en) 1999-11-30
ES2165505T3 (es) 2002-03-16
BG63777B1 (bg) 2002-12-29
NO311129B1 (no) 2001-10-15
AR004495A1 (es) 1998-12-16
ATE207468T1 (de) 2001-11-15
DE69616323T2 (de) 2002-07-25
HRP960288B1 (en) 2003-02-28
NO975985D0 (no) 1997-12-19
HUP9802317A3 (en) 2001-11-28
CA2220925A1 (en) 1997-01-09
BR9608956A (pt) 1999-03-02
DE69616323D1 (de) 2001-11-29
HUP9802317A2 (hu) 1999-03-29
WO1997000863A1 (en) 1997-01-09
NO975985L (no) 1997-12-19
DK0835246T3 (da) 2002-01-21
EP0835246B1 (en) 2001-10-24
AU6232096A (en) 1997-01-22
JP3949166B2 (ja) 2007-07-25
IL118664A0 (en) 1996-10-31
CN1193963A (zh) 1998-09-23
PT835246E (pt) 2002-04-29
BG102173A (en) 1998-09-30
AU700337B2 (en) 1998-12-24
EE9700341A (et) 1998-06-15
TW434240B (en) 2001-05-16
MX9710218A (es) 1998-03-31
NZ311082A (en) 2000-01-28
PL324205A1 (en) 1998-05-11
SK173297A3 (en) 1998-07-08
US6365603B1 (en) 2002-04-02
KR19990023006A (ko) 1999-03-25
SK282450B6 (sk) 2002-02-05
CZ410997A3 (cs) 1998-03-18
MY116531A (en) 2004-02-28
RO119945B1 (ro) 2005-06-30
HRP960288A2 (en) 1998-02-28
JPH11508878A (ja) 1999-08-03

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