AU2001235668A1 - Xanthine derivatives, intermediates and use for treating osteoporosis - Google Patents

Xanthine derivatives, intermediates and use for treating osteoporosis

Info

Publication number
AU2001235668A1
AU2001235668A1 AU2001235668A AU3566801A AU2001235668A1 AU 2001235668 A1 AU2001235668 A1 AU 2001235668A1 AU 2001235668 A AU2001235668 A AU 2001235668A AU 3566801 A AU3566801 A AU 3566801A AU 2001235668 A1 AU2001235668 A1 AU 2001235668A1
Authority
AU
Australia
Prior art keywords
intermediates
xanthine derivatives
treating osteoporosis
derivatives
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001235668A
Inventor
Gunter Johannes Billen
Yamina Bouali
Francois Nique
Yusuke Satoh
Jean-Paul Vevert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of AU2001235668A1 publication Critical patent/AU2001235668A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention concerns xanthine derivatives of formula (I) and their salts wherein: R1 represents a monocyclic or polycyclic system containing 0, 1, 2, 3 or 4 substituted or unsubstituted heteroatoms; R2 = H, R4, -(CH2)n-R4 or (CH2)m-O-R4, with R4 = R1 or substituted or unsubstituted alkyl; R3 = H; n and m = 1, 2 or 3. The invention also concerns the method for preparing said derivatives and intermediates of said method, their use as medicine and pharmaceutical compositions containing them.
AU2001235668A 2000-02-15 2001-02-14 Xanthine derivatives, intermediates and use for treating osteoporosis Abandoned AU2001235668A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0001845A FR2804958B1 (en) 2000-02-15 2000-02-15 XANTHINE DERIVATIVES, PREPARATION METHOD AND INTERMEDIATES THEREOF, THEIR APPLICATION AS MEDICAMENT AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
FR0001845 2000-02-15
PCT/FR2001/000420 WO2001060824A1 (en) 2000-02-15 2001-02-14 Xanthine derivatives, intermediates and use for treating osteoporosis

Publications (1)

Publication Number Publication Date
AU2001235668A1 true AU2001235668A1 (en) 2001-08-27

Family

ID=8847004

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001235668A Abandoned AU2001235668A1 (en) 2000-02-15 2001-02-14 Xanthine derivatives, intermediates and use for treating osteoporosis

Country Status (9)

Country Link
EP (1) EP1257552B1 (en)
AT (1) ATE273979T1 (en)
AU (1) AU2001235668A1 (en)
DE (1) DE60104986T2 (en)
DK (1) DK1257552T3 (en)
ES (1) ES2227134T3 (en)
FR (1) FR2804958B1 (en)
PT (1) PT1257552E (en)
WO (1) WO2001060824A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7495004B2 (en) 2002-06-17 2009-02-24 Glaxo Group Limited Purine derivatives as liver X receptor agonists
US8703777B2 (en) 2008-01-04 2014-04-22 Intellikine Llc Certain chemical entities, compositions and methods
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
JP2014501790A (en) 2011-01-10 2014-01-23 インフィニティー ファーマシューティカルズ， インコーポレイテッド Process for the preparation of isoquinolinone and solid form of isoquinolinone
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
WO2015003881A1 (en) * 2013-07-08 2015-01-15 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
US20150320755A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
SG10201912456RA (en) 2016-06-24 2020-02-27 Infinity Pharmaceuticals Inc Combination therapies
CN109503583A (en) * 2018-12-14 2019-03-22 南京纽邦生物科技有限公司 The preparation method of 1,7- dimethyl xanthine and its intermediate, intermediate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE176470T1 (en) * 1990-10-18 1999-02-15 Kyowa Hakko Kogyo Kk XANTHINE DERIVATIVES
EP0825993A1 (en) * 1995-05-19 1998-03-04 Chiroscience Limited Xanthines and their therapeutic use
JPH09169665A (en) * 1995-12-21 1997-06-30 Kenichi Miyamoto Agent for treatment osteoporosis
SI0812844T1 (en) * 1996-06-07 2003-02-28 Hoechst Aktiengesellschaft Use of theophyllin derivatives for the treatment and prophylaxis fo shock conditions, novel xanthine compounds and processes for the production thereof
GB9703044D0 (en) * 1997-02-14 1997-04-02 Glaxo Group Ltd Phenyl xanthine esters and amides
JPH1192379A (en) * 1997-07-24 1999-04-06 Kunio Takaoka Preventive or therapeutic agent for osteopathy

Also Published As

Publication number Publication date
ATE273979T1 (en) 2004-09-15
FR2804958B1 (en) 2005-07-08
ES2227134T3 (en) 2005-04-01
DE60104986D1 (en) 2004-09-23
WO2001060824A1 (en) 2001-08-23
DE60104986T2 (en) 2005-08-25
EP1257552B1 (en) 2004-08-18
FR2804958A1 (en) 2001-08-17
PT1257552E (en) 2005-01-31
DK1257552T3 (en) 2004-12-20
EP1257552A1 (en) 2002-11-20

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