KR100275976B1 - 인돌로피롤로카르바졸 유도체 - Google Patents

인돌로피롤로카르바졸 유도체 Download PDF

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Publication number
KR100275976B1
KR100275976B1 KR1019920022729A KR920022729A KR100275976B1 KR 100275976 B1 KR100275976 B1 KR 100275976B1 KR 1019920022729 A KR1019920022729 A KR 1019920022729A KR 920022729 A KR920022729 A KR 920022729A KR 100275976 B1 KR100275976 B1 KR 100275976B1
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KR
South Korea
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group
groups
compound
formula
lower alkyl
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Expired - Fee Related
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KR1019920022729A
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English (en)
Korean (ko)
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KR930010039A (ko
Inventor
가쓰히사 고지리
히사오 곤도
히로하루 아라까와
미쓰루 오오꾸보
히로유끼 스다
Original Assignee
나가사까 겐지로
반유 세이야꾸 가부시키가이샤
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Publication of KR930010039A publication Critical patent/KR930010039A/ko
Application granted granted Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Silicon Polymers (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1019920022729A 1991-11-29 1992-11-28 인돌로피롤로카르바졸 유도체 Expired - Fee Related KR100275976B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP34191691 1991-11-29
JP91-341916 1991-11-29
JP6926992 1992-02-18
JP92-69269 1992-02-18
JP25730692 1992-09-01
JP91-257306 1992-09-01

Publications (2)

Publication Number Publication Date
KR930010039A KR930010039A (ko) 1993-06-21
KR100275976B1 true KR100275976B1 (ko) 2001-02-01

Family

ID=27300000

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920022729A Expired - Fee Related KR100275976B1 (ko) 1991-11-29 1992-11-28 인돌로피롤로카르바졸 유도체

Country Status (27)

Country Link
EP (1) EP0545195B1 (enExample)
JP (1) JP2629542B2 (enExample)
KR (1) KR100275976B1 (enExample)
AT (1) ATE130617T1 (enExample)
AU (1) AU650376B2 (enExample)
BG (1) BG61036B1 (enExample)
CA (1) CA2083534C (enExample)
CZ (1) CZ287304B6 (enExample)
DE (1) DE69206242T2 (enExample)
DK (1) DK0545195T3 (enExample)
DZ (1) DZ1634A1 (enExample)
ES (1) ES2079774T3 (enExample)
FI (1) FI106864B (enExample)
GR (1) GR3018527T3 (enExample)
HU (3) HU9203754D0 (enExample)
IL (1) IL103844A (enExample)
MX (1) MX9206847A (enExample)
MY (1) MY114655A (enExample)
NO (1) NO178929C (enExample)
NZ (1) NZ245203A (enExample)
PL (1) PL171468B1 (enExample)
RO (1) RO113469B1 (enExample)
RU (1) RU2117671C1 (enExample)
SA (1) SA93130351B1 (enExample)
TW (1) TW224469B (enExample)
WO (1) WO1993011145A1 (enExample)
YU (1) YU48963B (enExample)

Families Citing this family (34)

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PT760375E (pt) * 1994-05-09 2004-04-30 Banyu Pharma Co Ltd Derivado de indolopiprolocarbazole anti-tumoral
WO1995030682A1 (en) * 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyprolocarbazole derivative
WO1995034663A1 (en) * 1994-06-13 1995-12-21 Banyu Pharmaceutical Co., Ltd. Gene coding for glycosyltransferase and use thereof
WO1996004293A1 (en) * 1994-08-02 1996-02-15 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazoles
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
US5591855A (en) * 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
AU6836696A (en) * 1995-09-05 1997-03-27 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5616724A (en) * 1996-02-21 1997-04-01 Cephalon, Inc. Fused pyrrolo[2,3-c]carbazole-6-ones
AU710669B2 (en) * 1996-08-22 1999-09-23 Bristol-Myers Squibb Company Cytotoxic amino sugar and related sugar derivatives of indolopyrrolocarbazoles
GB9811624D0 (en) * 1998-05-29 1998-07-29 Merck Sharp & Dohme Therapeutic use
US6013646A (en) * 1998-07-02 2000-01-11 Bayer Corporation Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
WO2004083228A1 (ja) 1999-09-10 2004-09-30 Katsuhisa Kojiri インドロピロロカルバゾール誘導体及び抗腫瘍剤
FR2801054B1 (fr) * 1999-11-17 2003-06-13 Adir Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES2210127T3 (es) 2000-02-24 2004-07-01 Banyu Pharmaceutical Co., Ltd. Procedimiento para preparar derivados de indolopirrolocarbazol, compuestos intermedios y procedimiento de preparacion de los compuestos intermedios.
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6555677B2 (en) 2000-10-31 2003-04-29 Merck & Co., Inc. Phase transfer catalyzed glycosidation of an indolocarbazole
RU2003131269A (ru) 2001-03-22 2005-05-10 Бристол-Маерс Сквибб Компани (Us) Производные индолопирролокарбазолов и сахаров, цитотоксические и селективные по отношению к топоизомеразе i
US6559299B2 (en) 2001-03-29 2003-05-06 Merck & Co., Inc. Preparation and isolation of indolocarbazole glycosides
AP2004003120A0 (en) * 2002-03-26 2004-09-30 Banyu Pharma Co Ltd Combined use of antitumor indolopyrrolocarbazole derivatives and other antitumor agent
CA2398828A1 (en) 2002-08-09 2004-02-09 Merck & Co., Inc. A pharmaceutical composition containing an indolopyrrolocarbazole derivative
EP1541582A1 (en) * 2002-08-23 2005-06-15 Banyu Pharmaceutical Co., Ltd. Process for producing indolopyrrolocarbazole derivative
AU2003248103A1 (en) * 2003-07-24 2005-02-14 Banyu Pharmaceutical Co., Ltd Indolopyrrolocarbazole derivative and antitumor agent
AU2004272457A1 (en) * 2003-09-16 2005-03-24 Banyu Pharmaceutical Co., Ltd. Novel indolopyrrolocarbazole derivative with antitumor activity
US7169802B2 (en) 2003-12-23 2007-01-30 Cephalon, Inc. Fused pyrrolocarbazoles
US7241779B2 (en) * 2003-12-23 2007-07-10 Cephalon, Inc. Fused pyrrolocarbazoles
RU2255089C1 (ru) * 2003-12-26 2005-06-27 Закрытое акционерное общество "АСГЛ-Исследовательские Лаборатории" Производные гликозидов индоло[2,3-а]пирроло[3,4-с]карбазол-5,7-дионов, обладающие цитотоксической и противоопухолевой активностью
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
JP2012509282A (ja) 2008-11-19 2012-04-19 セファロン、インク． インダゾロ［５，４−ａ］ピロロ［３，４−ｃ］カルバゾール化合物の新しい形態

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Rebeccamycin analogs, their production and pharmaceutical compositions containing them
JPH0725787B2 (ja) * 1990-03-06 1995-03-22 ブリストル−マイヤーズ スクイブ カンパニー 臭化物前駆物質物質供給によるレベカマイシン類似体
WO1992018507A1 (en) * 1991-04-11 1992-10-29 Schering Corporation Anti-tumor and anti-psoriatic agents

Also Published As

Publication number Publication date
FI925422A0 (fi) 1992-11-27
PL304729A1 (en) 1995-01-09
GR3018527T3 (en) 1996-03-31
JPH06128283A (ja) 1994-05-10
DE69206242D1 (de) 1996-01-04
HU217611B (hu) 2000-03-28
CZ287304B6 (cs) 2000-10-11
CA2083534C (en) 2003-01-28
AU2963792A (en) 1993-06-03
MY114655A (en) 2002-12-31
HU9203754D0 (en) 1993-03-29
EP0545195B1 (en) 1995-11-22
EP0545195A1 (en) 1993-06-09
YU48963B (sh) 2003-01-31
NO924593L (no) 1993-06-01
DK0545195T3 (da) 1995-12-18
FI106864B (fi) 2001-04-30
SA93130351B1 (ar) 2005-10-16
HU211254A9 (en) 1995-11-28
WO1993011145A1 (en) 1993-06-10
NO924593D0 (no) 1992-11-27
RO113469B1 (ro) 1998-07-30
HUT65699A (en) 1994-07-28
IL103844A0 (en) 1993-04-04
PL171468B1 (pl) 1997-05-30
MX9206847A (es) 1993-06-30
IL103844A (en) 1997-09-30
BG97970A (bg) 1994-04-29
BG61036B1 (bg) 1996-09-30
CA2083534A1 (en) 1993-05-30
DE69206242T2 (de) 1996-03-28
NO178929B (no) 1996-03-25
TW224469B (enExample) 1994-06-01
NO178929C (no) 1996-07-03
CZ350892A3 (en) 1993-10-13
DZ1634A1 (fr) 2002-02-17
JP2629542B2 (ja) 1997-07-09
ATE130617T1 (de) 1995-12-15
YU102692A (sh) 1996-02-19
FI925422L (fi) 1993-05-30
KR930010039A (ko) 1993-06-21
NZ245203A (en) 1997-07-27
RU2117671C1 (ru) 1998-08-20
AU650376B2 (en) 1994-06-16
ES2079774T3 (es) 1996-01-16

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