ES2158109T3 - Nuevo derivado de indano fusionado y sal del mismo farmaceuticamente aceptable. - Google Patents

Nuevo derivado de indano fusionado y sal del mismo farmaceuticamente aceptable.

Info

Publication number
ES2158109T3
ES2158109T3 ES95918733T ES95918733T ES2158109T3 ES 2158109 T3 ES2158109 T3 ES 2158109T3 ES 95918733 T ES95918733 T ES 95918733T ES 95918733 T ES95918733 T ES 95918733T ES 2158109 T3 ES2158109 T3 ES 2158109T3
Authority
ES
Spain
Prior art keywords
group
substituted
optionally substituted
ring
nitrogenous heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95918733T
Other languages
English (en)
Inventor
Shinji Okazaki
Tetsuji Asao
Motoji Wakida
Keisuke Ishida
Masato Washinosu
Teruhiro Utsugi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2158109T3 publication Critical patent/ES2158109T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN DERIVADO DE INDANO FUNDIDO REPRESENTADO POR LA FORMULA GENERAL (1), UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, Y UN FARMACO ANTITUMOR, EN DONDE EL ANILLO A REPRESENTA UN ANILLO DE BENCENO O NAFTALENO OPCIONALMENTE SUSTITUIDO, O UN ANILLO DE BENCENO CON UN GRUPO ALQUILENODIOXI BAJO; EL ANILLO B REPRESENTA UN ANILLO DE BENCENO QUE PUEDE SER SUSTITUIDO O QUE TIENE UN GRUPO DE ALQUILENODIOXI BAJO; Y REPRESENTA -N=CR- O -CR=N-; R REPRESENTA -NR{SUB,1}R{SUB,2}, -OR{SUB,3} O UN GRUPO HETEROCICLICO NITROGENOSO OPCIONALMENTE SUSTITUIDO; R{SUB,1} Y R{SUB,2} SON EL MISMO O DIFERENTE EL UNO DEL OTRO Y CADA UNO REPRESENTA HIDROGENO, FENILO, UN GRUPO HETEROCICLICO NITROGENOSO OPCIONALMENTE SUSTITUIDO, O UN GRUPO DE ALQUILO BAJO QUE PUEDE SER SUSTITUIDO POR AL MENOS UN SUSTITUYENTE SELECCIONADO DEL GRUPO QUE CONSTA DE AMINO OPCIONALMENTE SUSTITUIDO, ALCOXI BAJO, FENILO, UN GRUPO HETEROCICLICO NITROGENOSO, UN GRUPO DE OXIDO DE AMINO SUSTITUIDO POR ALQUILO BAJO, E HIDROXI; Y R{SUB,3} REPRESENTA ALQUILO BAJO QUE PUEDE SER SUSTITUIDO POR AMINO SUSTITUIDO, CON TAL DE QUE SEA EXCLUIDO EL CASO DONDE R REPRESENTE UN GRUPO HETEROCICLICO NITROGENOSO OPCIONALMENTE SUSTITUIDO Y LOS ANILLOS A Y B REPRESENTEN CADA UNO UN ANILLO DE BENCENO NO SUSTITUIDO.
ES95918733T 1994-05-20 1995-05-18 Nuevo derivado de indano fusionado y sal del mismo farmaceuticamente aceptable. Expired - Lifetime ES2158109T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10719094 1994-05-20

Publications (1)

Publication Number Publication Date
ES2158109T3 true ES2158109T3 (es) 2001-09-01

Family

ID=14452758

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95918733T Expired - Lifetime ES2158109T3 (es) 1994-05-20 1995-05-18 Nuevo derivado de indano fusionado y sal del mismo farmaceuticamente aceptable.

Country Status (21)

Country Link
US (3) US5733918A (es)
EP (1) EP0713870B1 (es)
KR (1) KR100190732B1 (es)
CN (1) CN1131216C (es)
AT (1) ATE203236T1 (es)
AU (1) AU685631B2 (es)
CA (1) CA2167382C (es)
DE (1) DE69521770T2 (es)
DK (1) DK0713870T3 (es)
ES (1) ES2158109T3 (es)
FI (1) FI111721B (es)
GR (1) GR3036795T3 (es)
HU (1) HU218308B (es)
IL (1) IL113778A (es)
NO (1) NO305555B1 (es)
NZ (1) NZ285448A (es)
PT (1) PT713870E (es)
RU (1) RU2124017C1 (es)
TW (1) TW440562B (es)
WO (1) WO1995032187A1 (es)
ZA (1) ZA954077B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3141148B2 (ja) * 1995-08-08 2001-03-05 大鵬薬品工業株式会社 縮合インダン誘導体及びその塩
US6956035B2 (en) * 2001-08-31 2005-10-18 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
US20030096833A1 (en) * 2001-08-31 2003-05-22 Jagtap Prakash G. Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof
EP1436293B1 (en) 2001-10-05 2006-02-01 F. Hoffmann-La Roche Ag Polycyclic compounds having anti-tumor activity
US6946472B2 (en) * 2002-04-30 2005-09-20 Hoffman-La Roche Inc. Polycyclic compounds exhibiting anti-tumor activities
CL2004000366A1 (es) * 2003-02-26 2005-01-07 Pharmacia Corp Sa Organizada B USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA.
AU2004258801A1 (en) * 2003-02-28 2005-02-03 Inotek Pharmaceuticals Corporation Tetracyclic Benzamide Derivatives and methods of use thereof
EP1722797A4 (en) * 2004-02-26 2008-03-19 Inotek Pharmaceuticals Corp ISOCHINOLINE DERIVATIVES AND METHOD FOR THE APPLICATION THEREOF
WO2005082079A2 (en) * 2004-02-26 2005-09-09 Inotek Pharmaceuticals Corporation Tetracyclic lactam derivatives and uses thereof
JP2008503466A (ja) * 2004-06-16 2008-02-07 イノテック ファーマシューティカルズ コーポレイション 勃起不全または尿失禁を治療または予防する方法
US7790895B2 (en) * 2005-02-24 2010-09-07 Janssen Pharmaceutica Nv Quinoline derivatives as potassium ion channel openers
US20060287311A1 (en) * 2005-02-25 2006-12-21 Inotek Pharmaceuticals Corporation Tetracyclic Sulfonamide Compounds and methods of use thereof
KR20070116011A (ko) * 2005-02-25 2007-12-06 이노텍 파마슈티컬스 코포레이션 테트라사이클릭 아미노 및 카복사미도 화합물 및 이의 이용방법
KR20070116016A (ko) * 2005-02-25 2007-12-06 이노텍 파마슈티컬스 코포레이션 이소퀴놀린 화합물 및 그의 이용 방법
JP2009506060A (ja) * 2005-08-24 2009-02-12 イノテック ファーマシューティカルズ コーポレイション インデノイソキノリノン類縁体及びそれらの使用方法
CA2677046A1 (en) * 2007-02-28 2008-09-04 Inotek Pharmaceuticals Corporation Indenoisoquinolinone analogs and methods of use thereof
CN103102304B (zh) * 2013-01-19 2015-03-11 安徽师范大学 N-磺酰基取代四氢异喹啉衍生物的制备方法
WO2015025936A1 (ja) 2013-08-22 2015-02-26 大鵬薬品工業株式会社 新規キノリン置換化合物
JOP20190073A1 (ar) 2016-10-31 2019-04-07 Taiho Pharmaceutical Co Ltd مثبط انتقائي لمستقبل عامل نمو بشروي (egfr) لطافر إدخال exon 20
WO2019045036A1 (ja) 2017-09-01 2019-03-07 大鵬薬品工業株式会社 エクソン１８及び／又はエクソン２１変異型ｅｇｆｒ選択的阻害剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223506A (en) * 1991-06-04 1993-06-29 Glaxo Inc. Cyclic antitumor compounds

Also Published As

Publication number Publication date
HUT75651A (en) 1997-05-28
CA2167382A1 (en) 1995-11-30
NZ285448A (en) 1997-11-24
US5733918A (en) 1998-03-31
ATE203236T1 (de) 2001-08-15
FI111721B (fi) 2003-09-15
EP0713870B1 (en) 2001-07-18
DE69521770D1 (de) 2001-08-23
EP0713870A1 (en) 1996-05-29
KR100190732B1 (ko) 1999-06-01
EP0713870A4 (en) 1996-12-18
DK0713870T3 (da) 2001-09-24
IL113778A (en) 1999-09-22
NO960239L (no) 1996-03-18
CN1130903A (zh) 1996-09-11
DE69521770T2 (de) 2002-05-23
GR3036795T3 (en) 2002-01-31
HU218308B (en) 2000-07-28
TW440562B (en) 2001-06-16
AU2454295A (en) 1995-12-18
AU685631B2 (en) 1998-01-22
FI960280A (fi) 1996-03-18
IL113778A0 (en) 1995-08-31
FI960280A0 (fi) 1996-01-19
PT713870E (pt) 2001-11-30
RU2124017C1 (ru) 1998-12-27
KR960703864A (ko) 1996-08-31
NO305555B1 (no) 1999-06-21
CN1131216C (zh) 2003-12-17
ZA954077B (en) 1996-01-19
WO1995032187A1 (fr) 1995-11-30
CA2167382C (en) 1999-08-31
NO960239D0 (no) 1996-01-19
US6028079A (en) 2000-02-22
US5710162A (en) 1998-01-20

Similar Documents

Publication Publication Date Title
ES2158109T3 (es) Nuevo derivado de indano fusionado y sal del mismo farmaceuticamente aceptable.
FI956270A0 (fi) Piperdiinijohdannaisia ja menetelmä niiden valmistamiseksi
ATE339409T1 (de) Trizyklische verbindungen
FI891700A (fi) Menetelmä beta-laktaamijohdannaisten valmistamiseksi
FI931011A0 (fi) Kondenserade heterocykliska ketonderivat, deras framstaellning och anvaendning
ATE14880T1 (de) Cephalosporinverbindungen und ihre herstellung.
FI813851L (fi) 2-oxoazetidinderivat deras framstaellning och anvaendning
YU83993A (sh) Novi derivati piridon organske kiseline
KR950704333A (ko) 신규한 세펨 유도체(novel cephem derivatives)
ES2124413T3 (es) Derivados de piridazinona con actividad farmaceutica.
EP0785191A4 (en) INDANE FUSION DERIVATIVES AND THEIR SALTS
WO2001022951A3 (en) Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of multiple sclerosis
DK0466662T3 (da) 6,7-Disubstituerede-2-aminotetraliner, der er aktive som immunmodulatorer, samt farmaceutiske præparater indeholdende sådanne forbindelser
MX9700497A (es) Derivado de acido trifluorometilquinolinocarboxilico.
DE69634004D1 (de) Verknüpfte polycyclische heterocyclische verbindungen
CA2202031A1 (en) Condensed indan derivatives and salts thereof
ATE148462T1 (de) Isoxazole derivate als lichtschutzmittel

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 713870

Country of ref document: ES