DE69521770D1 - Neue kondensierte indan-derivate und ihre pharmazeutisch verträglichen salze - Google Patents

Neue kondensierte indan-derivate und ihre pharmazeutisch verträglichen salze

Info

Publication number
DE69521770D1
DE69521770D1 DE69521770T DE69521770T DE69521770D1 DE 69521770 D1 DE69521770 D1 DE 69521770D1 DE 69521770 T DE69521770 T DE 69521770T DE 69521770 T DE69521770 T DE 69521770T DE 69521770 D1 DE69521770 D1 DE 69521770D1
Authority
DE
Germany
Prior art keywords
group
substituted
optionally substituted
ring
nitrogenous heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69521770T
Other languages
English (en)
Other versions
DE69521770T2 (de
Inventor
Shinji Okazaki
Tetsuji Asao
Motoji Wakida
Keisuke Ishida
Masato Washinosu
Teruhiro Utsugi
Yuji Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69521770D1 publication Critical patent/DE69521770D1/de
Publication of DE69521770T2 publication Critical patent/DE69521770T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69521770T 1994-05-20 1995-05-18 Neue kondensierte indan-derivate und ihre pharmazeutisch verträglichen salze Expired - Fee Related DE69521770T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10719094 1994-05-20
PCT/JP1995/000944 WO1995032187A1 (fr) 1994-05-20 1995-05-18 Nouveau derive d'indane fusionne et sel dudit derive acceptable pharmaceutiquement

Publications (2)

Publication Number Publication Date
DE69521770D1 true DE69521770D1 (de) 2001-08-23
DE69521770T2 DE69521770T2 (de) 2002-05-23

Family

ID=14452758

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69521770T Expired - Fee Related DE69521770T2 (de) 1994-05-20 1995-05-18 Neue kondensierte indan-derivate und ihre pharmazeutisch verträglichen salze

Country Status (21)

Country Link
US (3) US5733918A (de)
EP (1) EP0713870B1 (de)
KR (1) KR100190732B1 (de)
CN (1) CN1131216C (de)
AT (1) ATE203236T1 (de)
AU (1) AU685631B2 (de)
CA (1) CA2167382C (de)
DE (1) DE69521770T2 (de)
DK (1) DK0713870T3 (de)
ES (1) ES2158109T3 (de)
FI (1) FI111721B (de)
GR (1) GR3036795T3 (de)
HU (1) HU218308B (de)
IL (1) IL113778A (de)
NO (1) NO305555B1 (de)
NZ (1) NZ285448A (de)
PT (1) PT713870E (de)
RU (1) RU2124017C1 (de)
TW (1) TW440562B (de)
WO (1) WO1995032187A1 (de)
ZA (1) ZA954077B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3141148B2 (ja) * 1995-08-08 2001-03-05 大鵬薬品工業株式会社 縮合インダン誘導体及びその塩
US6956035B2 (en) * 2001-08-31 2005-10-18 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
US20030096833A1 (en) * 2001-08-31 2003-05-22 Jagtap Prakash G. Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof
PL370530A1 (en) * 2001-10-05 2005-05-30 F.Hoffmann-La Roche Ag Polycyclic compounds having anti-tumor activity
US6946472B2 (en) * 2002-04-30 2005-09-20 Hoffman-La Roche Inc. Polycyclic compounds exhibiting anti-tumor activities
CL2004000366A1 (es) * 2003-02-26 2005-01-07 Pharmacia Corp Sa Organizada B USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA.
JP2007501857A (ja) * 2003-02-28 2007-02-01 イノテック ファーマシューティカルズ コーポレーション 四環系ベンズアミド誘導体およびその使用方法
KR20060125909A (ko) * 2004-02-26 2006-12-06 이노텍 파마슈티컬스 코포레이션 이소퀴놀린 유도체 및 이의 사용 방법
US20050261288A1 (en) * 2004-02-26 2005-11-24 Prakash Jagtap Tetracyclic lactam derivatives and uses thereof
JP2008503466A (ja) * 2004-06-16 2008-02-07 イノテック ファーマシューティカルズ コーポレイション 勃起不全または尿失禁を治療または予防する方法
WO2006091769A1 (en) * 2005-02-24 2006-08-31 Janssen Pharmaceutica N.V. Novel quinoline derivatives as potassium ion channel openers
JP2008531563A (ja) * 2005-02-25 2008-08-14 イノテック ファーマシューティカルズ コーポレイション 四環スルホンアミド化合物およびこれらの使用法
KR20070116011A (ko) * 2005-02-25 2007-12-06 이노텍 파마슈티컬스 코포레이션 테트라사이클릭 아미노 및 카복사미도 화합물 및 이의 이용방법
BRPI0607703A2 (pt) * 2005-02-25 2009-09-22 Inotek Pharmaceutical S Corp compostos de isoquinolina e métodos de uso dos mesmos
RU2008110955A (ru) * 2005-08-24 2009-09-27 Инотек Фармасьютикалз Корпорейшн (Us) Инденоизохинолиноновые аналоги и способы их применения
WO2008106619A2 (en) * 2007-02-28 2008-09-04 Inotek Pharmaceuticals Corporation Indenoisoquinolinone analogs and methods of use thereof
CN103102304B (zh) * 2013-01-19 2015-03-11 安徽师范大学 N-磺酰基取代四氢异喹啉衍生物的制备方法
AU2014309788B2 (en) 2013-08-22 2017-02-16 Taiho Pharmaceutical Co., Ltd. Novel quinoline-substituted compound
JOP20190073A1 (ar) 2016-10-31 2019-04-07 Taiho Pharmaceutical Co Ltd مثبط انتقائي لمستقبل عامل نمو بشروي (egfr) لطافر إدخال exon 20
AU2018325819B2 (en) 2017-09-01 2024-02-01 Taiho Pharmaceutical Co., Ltd. Exon 18 and/or exon 21 mutant EGFR selective inhibitor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223506A (en) * 1991-06-04 1993-06-29 Glaxo Inc. Cyclic antitumor compounds

Also Published As

Publication number Publication date
DK0713870T3 (da) 2001-09-24
AU2454295A (en) 1995-12-18
CN1130903A (zh) 1996-09-11
EP0713870A4 (de) 1996-12-18
AU685631B2 (en) 1998-01-22
WO1995032187A1 (fr) 1995-11-30
NO305555B1 (no) 1999-06-21
IL113778A0 (en) 1995-08-31
DE69521770T2 (de) 2002-05-23
GR3036795T3 (en) 2002-01-31
FI960280A0 (fi) 1996-01-19
TW440562B (en) 2001-06-16
KR100190732B1 (ko) 1999-06-01
NO960239D0 (no) 1996-01-19
ZA954077B (en) 1996-01-19
US5710162A (en) 1998-01-20
CN1131216C (zh) 2003-12-17
NZ285448A (en) 1997-11-24
EP0713870B1 (de) 2001-07-18
ES2158109T3 (es) 2001-09-01
KR960703864A (ko) 1996-08-31
US6028079A (en) 2000-02-22
US5733918A (en) 1998-03-31
ATE203236T1 (de) 2001-08-15
HUT75651A (en) 1997-05-28
IL113778A (en) 1999-09-22
FI111721B (fi) 2003-09-15
CA2167382C (en) 1999-08-31
HU218308B (en) 2000-07-28
NO960239L (no) 1996-03-18
EP0713870A1 (de) 1996-05-29
CA2167382A1 (en) 1995-11-30
PT713870E (pt) 2001-11-30
RU2124017C1 (ru) 1998-12-27
FI960280A (fi) 1996-03-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee