NO960239D0 - Kondenserte indanderivater og farmasöytisk akseptable salter derav - Google Patents
Kondenserte indanderivater og farmasöytisk akseptable salter deravInfo
- Publication number
- NO960239D0 NO960239D0 NO960239A NO960239A NO960239D0 NO 960239 D0 NO960239 D0 NO 960239D0 NO 960239 A NO960239 A NO 960239A NO 960239 A NO960239 A NO 960239A NO 960239 D0 NO960239 D0 NO 960239D0
- Authority
- NO
- Norway
- Prior art keywords
- group
- substituted
- optionally substituted
- ring
- nitrogenous heterocyclic
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- 125000003392 indanyl group Chemical class C1(CCC2=CC=CC=C12)* 0.000 title 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical class C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical class C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polyesters Or Polycarbonates (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10719094 | 1994-05-20 | ||
| PCT/JP1995/000944 WO1995032187A1 (en) | 1994-05-20 | 1995-05-18 | Novel fused indan derivative and pharmaceutically acceptable salt thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO960239D0 true NO960239D0 (no) | 1996-01-19 |
| NO960239L NO960239L (no) | 1996-03-18 |
| NO305555B1 NO305555B1 (no) | 1999-06-21 |
Family
ID=14452758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO960239A NO305555B1 (no) | 1994-05-20 | 1996-01-19 | Kondenserte indan-derivater og farmas°ytisk akseptable salter derav, preparat og anti-tumormiddel |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US5733918A (no) |
| EP (1) | EP0713870B1 (no) |
| KR (1) | KR100190732B1 (no) |
| CN (1) | CN1131216C (no) |
| AT (1) | ATE203236T1 (no) |
| AU (1) | AU685631B2 (no) |
| CA (1) | CA2167382C (no) |
| DE (1) | DE69521770T2 (no) |
| DK (1) | DK0713870T3 (no) |
| ES (1) | ES2158109T3 (no) |
| FI (1) | FI111721B (no) |
| GR (1) | GR3036795T3 (no) |
| HU (1) | HU218308B (no) |
| IL (1) | IL113778A (no) |
| NO (1) | NO305555B1 (no) |
| NZ (1) | NZ285448A (no) |
| PT (1) | PT713870E (no) |
| RU (1) | RU2124017C1 (no) |
| TW (1) | TW440562B (no) |
| WO (1) | WO1995032187A1 (no) |
| ZA (1) | ZA954077B (no) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3141148B2 (ja) * | 1995-08-08 | 2001-03-05 | 大鵬薬品工業株式会社 | 縮合インダン誘導体及びその塩 |
| DE19538088A1 (de) * | 1995-10-13 | 1997-04-17 | Bernd Prof Dr Clement | Phenanthridinderivate und ihre Herstellung |
| US20030096833A1 (en) * | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
| US6956035B2 (en) * | 2001-08-31 | 2005-10-18 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| PL370530A1 (en) | 2001-10-05 | 2005-05-30 | F.Hoffmann-La Roche Ag | Polycyclic compounds having anti-tumor activity |
| US6946472B2 (en) * | 2002-04-30 | 2005-09-20 | Hoffman-La Roche Inc. | Polycyclic compounds exhibiting anti-tumor activities |
| CL2004000366A1 (es) * | 2003-02-26 | 2005-01-07 | Pharmacia Corp Sa Organizada B | USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA. |
| AU2004258801A1 (en) * | 2003-02-28 | 2005-02-03 | Inotek Pharmaceuticals Corporation | Tetracyclic Benzamide Derivatives and methods of use thereof |
| RU2006134024A (ru) * | 2004-02-26 | 2008-04-10 | Инотек Фармасьютикалз Корпорейшн (Us) | Тетрациклические производные лактама и их использование |
| WO2005082368A1 (en) * | 2004-02-26 | 2005-09-09 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| EP1784186A4 (en) * | 2004-06-16 | 2008-05-14 | Inotek Pharmaceuticals Corp | METHOD FOR TREATING AND PREVENTING EFFECTS AND ENTIRE INCONTINENCE |
| CN101128431B (zh) * | 2005-02-24 | 2011-05-25 | 詹森药业有限公司 | 作为钾离子通道打开剂的喹啉衍生物 |
| EP1855676A4 (en) * | 2005-02-25 | 2008-05-21 | Inotek Pharmaceuticals Corp | TETRAZYCLIC AMINO AND CARBOXAMIDE COMPOUNDS AND METHOD FOR THEIR USE |
| KR20070116016A (ko) * | 2005-02-25 | 2007-12-06 | 이노텍 파마슈티컬스 코포레이션 | 이소퀴놀린 화합물 및 그의 이용 방법 |
| US20060287311A1 (en) * | 2005-02-25 | 2006-12-21 | Inotek Pharmaceuticals Corporation | Tetracyclic Sulfonamide Compounds and methods of use thereof |
| AU2006283078A1 (en) * | 2005-08-24 | 2007-03-01 | Inotek Pharmaceuticals Corporation | Indenoisoquinolinone Analogs and methods of use thereof |
| US8119654B2 (en) * | 2007-02-28 | 2012-02-21 | Inotek Pharmaceuticals Corporation | Indenoisoquinolinone analogs and methods of use thereof |
| CN103102304B (zh) * | 2013-01-19 | 2015-03-11 | 安徽师范大学 | N-磺酰基取代四氢异喹啉衍生物的制备方法 |
| EP3037424B1 (en) | 2013-08-22 | 2017-11-08 | Taiho Pharmaceutical Co., Ltd. | Novel quinoline-substituted compound |
| JOP20190073A1 (ar) | 2016-10-31 | 2019-04-07 | Taiho Pharmaceutical Co Ltd | مثبط انتقائي لمستقبل عامل نمو بشروي (egfr) لطافر إدخال exon 20 |
| JP7065103B2 (ja) | 2017-09-01 | 2022-05-11 | 大鵬薬品工業株式会社 | エクソン１８及び／又はエクソン２１変異型ｅｇｆｒ選択的阻害剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60169482A (ja) * | 1984-02-14 | 1985-09-02 | Mitsubishi Chem Ind Ltd | アミノ化フタライド−イソキノリン類の製法 |
| JPH0633263B2 (ja) * | 1985-05-27 | 1994-05-02 | 鐘淵化学工業株式会社 | ７−ヒドロキシグアニン誘導体及びその製造方法並びにそれを有効成分とする抗腫瘍剤 |
| SU1574598A1 (ru) * | 1987-11-03 | 1990-06-30 | Институт Химической Кинетики И Горения Со Ан Ссср | Способ получени 4-диалкиламино-2-алкил(или фенил)нафто[2,3- @ ]хинолин-7,12-дионов |
| US5223506A (en) * | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
-
1995
- 1995-05-17 TW TW084104882A patent/TW440562B/zh not_active IP Right Cessation
- 1995-05-18 WO PCT/JP1995/000944 patent/WO1995032187A1/ja not_active Ceased
- 1995-05-18 DK DK95918733T patent/DK0713870T3/da active
- 1995-05-18 CA CA002167382A patent/CA2167382C/en not_active Expired - Fee Related
- 1995-05-18 HU HU9600130A patent/HU218308B/hu not_active IP Right Cessation
- 1995-05-18 NZ NZ285448A patent/NZ285448A/en unknown
- 1995-05-18 KR KR1019960700277A patent/KR100190732B1/ko not_active Expired - Fee Related
- 1995-05-18 EP EP95918733A patent/EP0713870B1/en not_active Expired - Lifetime
- 1995-05-18 US US08/578,542 patent/US5733918A/en not_active Expired - Fee Related
- 1995-05-18 RU RU96105034A patent/RU2124017C1/ru not_active IP Right Cessation
- 1995-05-18 DE DE69521770T patent/DE69521770T2/de not_active Expired - Fee Related
- 1995-05-18 AT AT95918733T patent/ATE203236T1/de not_active IP Right Cessation
- 1995-05-18 AU AU24542/95A patent/AU685631B2/en not_active Ceased
- 1995-05-18 CN CN95190639A patent/CN1131216C/zh not_active Expired - Fee Related
- 1995-05-18 IL IL11377895A patent/IL113778A/xx not_active IP Right Cessation
- 1995-05-18 PT PT95918733T patent/PT713870E/pt unknown
- 1995-05-18 ZA ZA954077A patent/ZA954077B/xx unknown
- 1995-05-18 ES ES95918733T patent/ES2158109T3/es not_active Expired - Lifetime
-
1996
- 1996-01-19 NO NO960239A patent/NO305555B1/no unknown
- 1996-01-19 FI FI960280A patent/FI111721B/fi active
- 1996-09-12 US US08/713,224 patent/US5710162A/en not_active Expired - Fee Related
-
1997
- 1997-08-12 US US08/909,934 patent/US6028079A/en not_active Expired - Fee Related
-
2001
- 2001-10-04 GR GR20010401657T patent/GR3036795T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69521770T2 (de) | 2002-05-23 |
| CN1130903A (zh) | 1996-09-11 |
| IL113778A0 (en) | 1995-08-31 |
| NO960239L (no) | 1996-03-18 |
| TW440562B (en) | 2001-06-16 |
| FI111721B (fi) | 2003-09-15 |
| DK0713870T3 (da) | 2001-09-24 |
| EP0713870A1 (en) | 1996-05-29 |
| US5710162A (en) | 1998-01-20 |
| US6028079A (en) | 2000-02-22 |
| WO1995032187A1 (en) | 1995-11-30 |
| US5733918A (en) | 1998-03-31 |
| EP0713870A4 (en) | 1996-12-18 |
| IL113778A (en) | 1999-09-22 |
| ATE203236T1 (de) | 2001-08-15 |
| KR960703864A (ko) | 1996-08-31 |
| FI960280A0 (fi) | 1996-01-19 |
| EP0713870B1 (en) | 2001-07-18 |
| FI960280A7 (fi) | 1996-03-18 |
| NZ285448A (en) | 1997-11-24 |
| PT713870E (pt) | 2001-11-30 |
| AU2454295A (en) | 1995-12-18 |
| KR100190732B1 (ko) | 1999-06-01 |
| RU2124017C1 (ru) | 1998-12-27 |
| CA2167382A1 (en) | 1995-11-30 |
| HU218308B (en) | 2000-07-28 |
| NO305555B1 (no) | 1999-06-21 |
| HUT75651A (en) | 1997-05-28 |
| ZA954077B (en) | 1996-01-19 |
| AU685631B2 (en) | 1998-01-22 |
| GR3036795T3 (en) | 2002-01-31 |
| DE69521770D1 (de) | 2001-08-23 |
| ES2158109T3 (es) | 2001-09-01 |
| CA2167382C (en) | 1999-08-31 |
| CN1131216C (zh) | 2003-12-17 |
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