EP4200301C0 - Phospholipidverbindungen und verwendungen davon - Google Patents

Phospholipidverbindungen und verwendungen davon

Info

Publication number
EP4200301C0
EP4200301C0 EP21772895.5A EP21772895A EP4200301C0 EP 4200301 C0 EP4200301 C0 EP 4200301C0 EP 21772895 A EP21772895 A EP 21772895A EP 4200301 C0 EP4200301 C0 EP 4200301C0
Authority
EP
European Patent Office
Prior art keywords
phospholipid compounds
phospholipid
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP21772895.5A
Other languages
English (en)
French (fr)
Other versions
EP4200301B1 (de
EP4200301A1 (de
Inventor
Scott E Lazerwith
Jonathan William Medley
Philip A Morganelli
Devan Naduthambi
Thomas P Stratton
Peiyuan Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Priority to EP25159918.9A priority Critical patent/EP4537828A3/de
Publication of EP4200301A1 publication Critical patent/EP4200301A1/de
Application granted granted Critical
Publication of EP4200301C0 publication Critical patent/EP4200301C0/de
Publication of EP4200301B1 publication Critical patent/EP4200301B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP21772895.5A 2020-08-24 2021-08-23 Phospholipidverbindungen und verwendungen davon Active EP4200301B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP25159918.9A EP4537828A3 (de) 2020-08-24 2021-08-23 Phospholipidverbindungen und verwendungen davon

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063069449P 2020-08-24 2020-08-24
US202063092386P 2020-10-15 2020-10-15
US202163151509P 2021-02-19 2021-02-19
PCT/US2021/047145 WO2022046631A1 (en) 2020-08-24 2021-08-23 Phospholipid compounds and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP25159918.9A Division EP4537828A3 (de) 2020-08-24 2021-08-23 Phospholipidverbindungen und verwendungen davon

Publications (3)

Publication Number Publication Date
EP4200301A1 EP4200301A1 (de) 2023-06-28
EP4200301C0 true EP4200301C0 (de) 2025-02-26
EP4200301B1 EP4200301B1 (de) 2025-02-26

Family

ID=77802251

Family Applications (2)

Application Number Title Priority Date Filing Date
EP21772895.5A Active EP4200301B1 (de) 2020-08-24 2021-08-23 Phospholipidverbindungen und verwendungen davon
EP25159918.9A Pending EP4537828A3 (de) 2020-08-24 2021-08-23 Phospholipidverbindungen und verwendungen davon

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP25159918.9A Pending EP4537828A3 (de) 2020-08-24 2021-08-23 Phospholipidverbindungen und verwendungen davon

Country Status (18)

Country Link
US (3) US11773122B2 (de)
EP (2) EP4200301B1 (de)
JP (2) JP7559223B2 (de)
KR (1) KR20230057419A (de)
AU (2) AU2021330835B2 (de)
BR (1) BR112023002951A2 (de)
CA (1) CA3188373A1 (de)
CL (1) CL2023000524A1 (de)
CO (1) CO2023001953A2 (de)
CR (1) CR20230100A (de)
DO (1) DOP2023000037A (de)
ES (1) ES3015457T3 (de)
IL (1) IL300412A (de)
MX (1) MX2023002233A (de)
PE (1) PE20231847A1 (de)
PL (1) PL4200301T3 (de)
TW (2) TW202337471A (de)
WO (1) WO2022046631A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4185300A4 (de) 2020-07-24 2024-09-25 The Regents of the University of California Antivirale prodrugs, pharmazeutische formulierungen und verfahren
WO2022046631A1 (en) 2020-08-24 2022-03-03 Gilead Sciences, Inc. Phospholipid compounds and uses thereof
TW202344257A (zh) * 2020-10-16 2023-11-16 美商基利科學股份有限公司 磷脂化合物及其用途
TW202317144A (zh) 2021-06-14 2023-05-01 美商維納拓爾斯製藥公司 口服生物可利用的核苷類似物
JP7719954B2 (ja) 2021-08-18 2025-08-06 ギリアード サイエンシーズ， インコーポレイテッド リン脂質化合物並びにその製造方法及び使用方法
EP4469061A4 (de) * 2022-01-26 2025-10-08 Univ California Antivirale prodrugs, zwischen- und langwirkende formulierungen und verfahren
CN115251042B (zh) * 2022-09-08 2023-06-02 安徽科技学院 一种家禽精液稀释缓冲液及其制备和家禽精液冷存方法
WO2024120464A1 (zh) * 2022-12-09 2024-06-13 深圳市塔吉瑞生物医药有限公司 核苷酸类似物及其组合物及用途

Family Cites Families (175)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223263A (en) 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
EP0262876B1 (de) 1986-09-27 1992-04-29 Toyo Jozo Kabushiki Kaisha Nukleosid-Phospholipid-Konjugat
US7517858B1 (en) * 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability
AUPQ105499A0 (en) 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
HK1050627B (en) 1999-12-03 2008-12-24 The Regents Of The University Of California Phosphonate compounds
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
IL153078A0 (en) 2000-05-26 2003-06-24 Idenix Cayman Ltd Methods for treating hepatitis delta virus infection with beta-l-2' deoxy nucleosides
AUPR213700A0 (en) 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
BRPI0411900B8 (pt) 2003-06-26 2021-05-25 Biotron Ltd compostos e composições farmacêuticas compreendendo os mesmos
MY145634A (en) 2003-12-29 2012-03-15 Bristol Myers Squibb Co Pyrrolotriazine compounds as kinase inhibitors
US8101745B2 (en) 2004-12-16 2012-01-24 The Regents Of The University Of California Lung-targeted drugs
WO2006130217A2 (en) 2005-04-01 2006-12-07 The Regents Of The University Of California Substituted phosphate esters of nucleoside phosphonates
KR101419327B1 (ko) 2005-06-24 2014-07-14 바이오트론 리미티드 항바이러스 화합물 및 방법
KR101558403B1 (ko) 2007-08-03 2015-10-07 바이오트론 리미티드 Ｃ형 간염 바이러스 조성물 및 방법
WO2009132135A1 (en) 2008-04-23 2009-10-29 Gilead Sciences, Inc. 1' -substituted carba-nucleoside analogs for antiviral treatment
EP2313102A2 (de) 2008-07-03 2011-04-27 Biota Scientific Management Bicyclische nucleoside und nucleotide als therapeutische mittel
US8962580B2 (en) 2008-09-23 2015-02-24 Alnylam Pharmaceuticals, Inc. Chemical modifications of monomers and oligonucleotides with cycloaddition
NZ592357A (en) 2008-11-06 2013-09-27 Vascular Biogenics Ltd Oxidized lipid compounds and uses thereof
US8455451B2 (en) 2009-09-21 2013-06-04 Gilead Sciences, Inc. 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
CN102596979B (zh) 2009-09-21 2014-12-10 吉里德科学公司 用于制备1’-取代碳核苷类似物的方法和中间体
EA201200525A1 (ru) 2009-09-21 2012-09-28 Гайлид Сайэнсиз, Инк. 2'-фторзамещенные карба-нуклеозидные аналоги для противовирусного лечения
TWI472331B (zh) 2009-11-11 2015-02-11 Sumitomo Dainippon Pharma Co Ltd ８－氮雙環〔３‧２‧１〕辛烷－８－羧醯胺衍生物
US9198972B2 (en) 2010-01-28 2015-12-01 Alnylam Pharmaceuticals, Inc. Monomers and oligonucleotides comprising cycloaddition adduct(s)
TW201201815A (en) 2010-05-28 2012-01-16 Gilead Sciences Inc 1'-substituted-carba-nucleoside prodrugs for antiviral treatment
WO2012012465A1 (en) 2010-07-19 2012-01-26 Clarke, Michael, O'neil Hanrahan Methods for the preparation of diasteromerically pure phosphoramidate prodrugs
BR112013001553B1 (pt) 2010-07-22 2021-01-12 Gilead Sciences, Inc. compostos antivirais para o tratamento de infecções por paramyxoviridae e composições farmacêuticas que os compreendem
GEP20166496B (en) 2011-12-22 2016-06-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
EP2892893B2 (de) 2012-09-10 2019-10-16 F.Hoffmann-La Roche Ag 6-aminosäure-heteroaryldihydropyrimidine zur behandlung und prophylaxe der hepatitis-b-virusinfektion
EP3421482A1 (de) 2012-12-21 2019-01-02 Alios Biopharma, Inc. Substituierte nukleoside, nukleotide und analoga davon
SG10201800188SA (en) 2013-03-15 2018-02-27 Univ California Acyclic nucleoside phosphonate diesters
WO2014209979A1 (en) 2013-06-26 2014-12-31 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
PL3043865T3 (pl) 2013-09-11 2021-07-05 Institut National De La Santé Et De La Recherche Médicale (Inserm) SPOSOBY I KOMPOZYCjE FARMACEUTYCZNE W LECZENIU ZAKAŻENIA WIRUSEM ZAPALENIA WĄTROBY TYPU B
CN113712989A (zh) 2013-10-11 2021-11-30 艾丽奥斯生物制药有限公司 取代的核苷、核苷酸及其类似物
UA119050C2 (uk) 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
EP3099685B1 (de) 2014-01-30 2018-04-18 F.Hoffmann-La Roche Ag Neuartige dihydrochinolizinone zur behandlung und prophylaxe von hepatitis-b-virus-infektionen
JP6306750B2 (ja) 2014-03-07 2018-04-04 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウイルス感染症の治療および予防のための新規な６−縮合ヘテロアリールジヒドロピリミジン
MX2016014728A (es) 2014-05-13 2017-03-23 Hoffmann La Roche Dihidroquinolizidinonas novedosas para el tratamiento y profilaxis de la infeccion con virus de la hepatitis b.
EA201692537A1 (ru) 2014-06-24 2017-05-31 Элиос Биофарма, Инк. Замещенные нуклеозиды, нуклеотиды и их аналоги
ES2841310T3 (es) 2014-06-24 2021-07-08 Janssen Biopharma Inc Nucleósidos, nucleótidos y análogos sustituidos para su uso en el tratamiento de infecciones virales
WO2016012470A1 (en) 2014-07-25 2016-01-28 F. Hoffmann-La Roche Ag New amorphous and crystalline forms of (3s)-4-[[(4r)-4-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1, 4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
CN106573898B (zh) 2014-08-14 2018-11-09 豪夫迈·罗氏有限公司 治疗和预防乙型肝炎病毒感染的新的哒嗪酮和三嗪酮
TWI698444B (zh) 2014-10-29 2020-07-11 美商基利科學股份有限公司 製備核糖苷的方法
US9637485B2 (en) 2014-11-03 2017-05-02 Hoffmann-La Roche Inc. 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
WO2016102438A1 (en) 2014-12-23 2016-06-30 F. Hoffmann-La Roche Ag Process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidine analogues
US9676793B2 (en) 2014-12-23 2017-06-13 Hoffmann-Laroche Inc. Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same
WO2016107832A1 (en) 2014-12-30 2016-07-07 F. Hoffmann-La Roche Ag Novel tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis b virus infection
CN107109497A (zh) 2014-12-31 2017-08-29 豪夫迈·罗氏有限公司 通过实时PCR从细胞裂解物定量HBV cccDNA的高通量新方法
MA41338B1 (fr) 2015-01-16 2019-07-31 Hoffmann La Roche Composés de pyrazine pour le traitement de maladies infectieuses
EP3250685A1 (de) 2015-01-27 2017-12-06 F. Hoffmann-La Roche AG Rekombinante hbv-cccdna, verfahren zur erzeugung davon und verwendung davon
HK1244281B (zh) 2015-02-11 2020-02-07 F. Hoffmann-La Roche Ag 治疗和预防乙型肝炎病毒感染的2-氧代-6，7-二氢苯并[a]喹嗪-3-甲酸衍生物
WO2017024310A1 (en) 2015-08-06 2017-02-09 Chimerix, Inc. Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents
ES2918585T3 (es) 2015-09-16 2022-07-19 Gilead Sciences Inc Métodos para el tratamiento de infecciones por el virus Arenaviridae
WO2017156380A1 (en) 2016-03-10 2017-09-14 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
WO2017165489A1 (en) 2016-03-23 2017-09-28 Emory University Antiviral agents for treating zika and dengue virus infections
US10918623B2 (en) 2017-02-08 2021-02-16 Biotron Limited Methods of treating influenza
CN110869028B (zh) * 2017-03-14 2023-01-20 吉利德科学公司 治疗猫冠状病毒感染的方法
WO2019027905A1 (en) 2017-07-31 2019-02-07 January Therapeutics, Inc. ORGANOPHOSPHATE DERIVATIVES
JP2020534361A (ja) 2017-09-18 2020-11-26 ヤンセン・バイオファーマ・インコーポレイテッド 置換ヌクレオシド、ヌクレオチド、及びそのアナログ
CA3087192A1 (en) 2017-12-27 2019-07-04 Raymond F. Schinazi Combined modalities for nucleosides and/or nadph oxidase (nox) inhibitors as myeloid-specific antiviral agents
CN110054616B (zh) 2018-01-19 2021-11-23 南京圣和药业股份有限公司 三嗪类idh抑制剂的制备方法
JP2021516227A (ja) 2018-03-02 2021-07-01 ジャニュアリー セラピューティクス，インク． ナノ粒子組成物
BR112022008321A2 (pt) 2019-11-04 2022-07-26 Alector Llc Polipeptídeos isolados, polipeptídeo, ácido nucleico isolado, vetor de expressão, célula hospedeira, métodos para produzir um polipeptídeo, para tratar câncer, para tratar uma doença neurológica ou neurodegenerativa, para repolarizar células supressoras, para repolarizar macrófagos de tumor e para ativar células mieloides em um sujeito e composições farmacêuticas
TWI884403B (zh) * 2020-02-18 2025-05-21 美商基利科學股份有限公司 抗病毒化合物
CN113292565B (zh) 2020-02-24 2023-01-31 浙江森科建设有限公司 核苷类化合物及其制备方法和应用
CN111233929B (zh) 2020-02-28 2023-02-28 成都阿奇生物医药科技有限公司 一种核苷类似物的氘代物及其制备方法和用途
CN111393243B (zh) 2020-04-22 2022-12-13 深圳市宝安区新材料研究院 一种磷手性核苷类药物的合成方法及该方法得到的药物
EP4185300A4 (de) 2020-07-24 2024-09-25 The Regents of the University of California Antivirale prodrugs, pharmazeutische formulierungen und verfahren
WO2022046631A1 (en) 2020-08-24 2022-03-03 Gilead Sciences, Inc. Phospholipid compounds and uses thereof
CN112010916B (zh) 2020-09-09 2022-12-27 广东东阳光药业有限公司 核苷化合物的氨基磷酸酯衍生物及其用途
AU2021347288A1 (en) 2020-09-23 2023-05-04 Antares Therapeutics, Inc. Pyrrolo[3,2-c]pyridin-4-one derivatives useful in the treatment of cancer
TW202344257A (zh) 2020-10-16 2023-11-16 美商基利科學股份有限公司 磷脂化合物及其用途
JP2023545396A (ja) 2020-10-16 2023-10-30 ダナ－ファーバー キャンサー インスティテュート，インコーポレイテッド Ｈｅｌｉｏｓのピペリジニル低分子分解剤および使用方法
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors
CN112645982B (zh) 2020-12-22 2023-04-07 苏州正济药业有限公司 一种瑞德西韦关键中间体的制备和纯化方法
CA3211159A1 (en) 2021-02-19 2022-08-25 Kalvista Pharmaceuticals Limited Factor xiia inhibitors
US11795159B2 (en) 2021-05-26 2023-10-24 Purdue Research Foundation Compounds for the treatment of SARS
US11834408B2 (en) 2021-05-28 2023-12-05 Purdue Research Foundation Compounds for the treatment of SARS
TW202317144A (zh) 2021-06-14 2023-05-01 美商維納拓爾斯製藥公司 口服生物可利用的核苷類似物
CN115475171B (zh) 2021-06-16 2025-03-07 中国医学科学院医药生物技术研究所 一种具有抗冠状病毒活性的化合物及其应用
JPWO2022270478A1 (de) 2021-06-21 2022-12-29
CN115504940A (zh) 2021-06-23 2022-12-23 中国科学院上海药物研究所 一种酰胺类化合物、其制备方法和制药用途
WO2022268111A1 (zh) 2021-06-25 2022-12-29 前沿生物药业(南京)股份有限公司 抗病毒药物组合物及其制备方法和应用
KR102766444B1 (ko) 2021-06-28 2025-02-11 재단법인 대구경북첨단의료산업진흥재단 트리아지노인돌 유도체를 유효성분으로 하는 항바이러스제
WO2023279031A1 (en) 2021-06-29 2023-01-05 The Regents Of The University Of California Methods and compositions for treatment of covid-19
WO2023272571A1 (zh) 2021-06-30 2023-01-05 中国人民解放军军事科学院军事医学研究院 2,3-环氧丁二酰衍生物的医药用途
US20250057802A1 (en) 2021-07-08 2025-02-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Broad-spectrum antiviral drugs
IL309732A (en) 2021-07-09 2024-02-01 Aligos Therapeutics Inc Antiviral compounds
WO2023283831A1 (zh) 2021-07-14 2023-01-19 上海药明康德新药开发有限公司 病毒主蛋白酶抑制剂及其制备方法和用途
WO2023286844A1 (ja) 2021-07-15 2023-01-19 国立研究開発法人国立国際医療研究センター 抗ウイルス活性等の生理活性を有する化合物
EP4119145A1 (de) 2021-07-15 2023-01-18 Dompe' Farmaceutici S.P.A. Verbindungen zur behandlung von covid-19
US20250276955A1 (en) 2021-07-19 2025-09-04 Baylor College Of Medicine Coronavirus main protease inhibitors and methods using same
TW202321210A (zh) 2021-07-22 2023-06-01 瑞士商諾華公司 用於治療冠狀病毒相關疾病之化合物及組成物
WO2023003610A1 (en) 2021-07-23 2023-01-26 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
KR102806503B1 (ko) 2021-07-29 2025-05-16 가톨릭대학교 산학협력단 렘데시비르와 면역조절제 병용투여법을 통한 자가면역류마티스 질환 치료용 조성물
WO2023009187A1 (en) 2021-07-29 2023-02-02 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
US20240325386A1 (en) 2021-07-30 2024-10-03 Fujifilm Toyama Chemical Co., Ltd. Therapeutic agent for covid-19
CN117836272B (zh) 2021-08-02 2025-02-28 北京华益健康药物研究中心 用于治疗或预防冠状病毒感染的3cl蛋白酶小分子抑制剂及其用途
EP4130001A1 (de) 2021-08-03 2023-02-08 Studiengesellschaft Kohle mbH Verfahren zur direkten katalytischen glycosylierung von arenen
KR20240055745A (ko) 2021-08-03 2024-04-29 코크리스탈 파마, 아이엔씨. 코로나바이러스 억제제
MX2024001645A (es) 2021-08-06 2024-02-27 Intervet Int Bv Metodo para el tratamiento de las enfermedades virales veterinarias.
CN115703796A (zh) 2021-08-09 2023-02-17 苏州恩泰新材料科技有限公司 一种瑞德西韦重要中间体制备方法
JP2023026155A (ja) 2021-08-13 2023-02-24 国立研究開発法人理化学研究所 感染症治療薬
JP2024530904A (ja) 2021-08-17 2024-08-27 サウスウエスト リサーチ インスティテュート コロナウイルススパイク受容体結合ドメイン（ｒｂｄ）のｎ末端ドメイン（ｎｔｄ）を標的にする抗ウイルス薬
US20240350503A1 (en) 2021-08-17 2024-10-24 Ensieh FARAHANI Compounds for treatment of viral infections by neurotropic virus
US11963959B2 (en) 2021-08-17 2024-04-23 Southwest Research Institute Inhibitors for coronavirus
JP7719954B2 (ja) * 2021-08-18 2025-08-06 ギリアード サイエンシーズ， インコーポレイテッド リン脂質化合物並びにその製造方法及び使用方法
WO2023023631A1 (en) 2021-08-18 2023-02-23 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
EP4387629A1 (de) 2021-08-18 2024-06-26 Katholieke Universiteit Leuven KU Leuven Research & Development 6-substituierte und 6,7-disubstituierte 7-deazapurin-ribonukleosidanaloga
CN113648293B (zh) 2021-08-19 2022-07-05 山东达因海洋生物制药股份有限公司 对苯醌和/或对苯醌衍生物在制备抗新型冠状病毒药物中的应用
US20240391876A1 (en) 2021-08-19 2024-11-28 Arizona Board Of Regents On Behalf Of The University Of Arizona Quinacrine and derivatives thereof for treatment of viral infections
JPWO2023022231A1 (de) 2021-08-20 2023-02-23
AU2022331233A1 (en) 2021-08-20 2024-02-29 Shionogi & Co., Ltd. Nucleoside derivatives and prodrugs thereof having viral growth inhibitory action
CN115716833A (zh) 2021-08-26 2023-02-28 苏州旺山旺水生物医药有限公司 一种抗病毒核苷类似物的制备方法
US12234202B2 (en) 2021-08-27 2025-02-25 Ut-Battelle, Llc Covalent inhibitors of coronavirus papain-like protease
WO2023025319A1 (zh) 2021-08-27 2023-03-02 南京知和医药科技有限公司 一种新型的胞苷衍生物及其药物组合物和用途
TW202328093A (zh) 2021-08-31 2023-07-16 美商帕迪斯生物科學公司 半胱胺酸蛋白酶的結晶抑制劑及其使用的方法
CN115721661A (zh) 2021-09-01 2023-03-03 常晓宇 嘌呤核苷类药物预防或治疗冠状病毒感染性疾病的用途
CN115745960B (zh) 2021-09-02 2024-08-30 中国科学院上海药物研究所 一类含喹啉酮酰胺的化合物及其制备方法、药物组合物和用途
CN115737665A (zh) 2021-09-02 2023-03-07 广州谷森制药有限公司 胞苷衍生物和与其相关的抗病毒用途
JP2024178473A (ja) 2021-09-03 2024-12-25 塩野義製薬株式会社 ウイルス増殖阻害活性を有する二環性含窒素複素環誘導体およびそれらを含有する医薬組成物
KR20240057427A (ko) 2021-09-07 2024-05-02 상하이 치루 파마슈티컬 리서치 앤 디벨롭먼트 센터 리미티드 3CLpro 단백질 분해 효소 억제제
CN116375795A (zh) 2021-09-09 2023-07-04 广东众生睿创生物科技有限公司 酮酰胺衍生物及其应用
EP4148042A1 (de) 2021-09-10 2023-03-15 Centre National de la Recherche Scientifique Phenoxy-acetyl-thioureido-benzolsulfonamid-derivate und ihre verwendungen
WO2023043830A1 (en) 2021-09-15 2023-03-23 Clear Creek Bio, Inc. Combination therapies to treat viral infections
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
CN115819391A (zh) 2021-09-17 2023-03-21 中国科学院上海药物研究所 一类黄芩素衍生物、其制备方法和用途
WO2023044462A1 (en) 2021-09-17 2023-03-23 Pardes Biosciences, Inc. Cysteine protease inhibitor formulations and method of use thereof
WO2023042879A1 (ja) 2021-09-17 2023-03-23 塩野義製薬株式会社 ウイルス増殖阻害活性を有する二環性複素環誘導体およびそれらを含有する医薬組成物
CN115554303B (zh) 2021-09-18 2024-07-09 上海科技大学 一种三环类化合物、其制备方法及其应用
WO2023044171A1 (en) 2021-09-20 2023-03-23 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
WO2023048151A1 (ja) 2021-09-22 2023-03-30 塩野義製薬株式会社 ウイルス増殖阻害活性を有する環状ペプチド
WO2023049643A1 (en) 2021-09-23 2023-03-30 City Of Hope Inhibitors of sars-cov-2
EP4405357A1 (de) 2021-09-23 2024-07-31 Katholieke Universiteit Leuven KU Leuven Research & Development Ribonukleosidanaloga gegen -sars-cov-2
US12186309B2 (en) 2021-09-27 2025-01-07 The Governors Of The University Of Alberta RNA virus inhibitor compounds and uses thereof
WO2023054292A1 (ja) 2021-09-28 2023-04-06 塩野義製薬株式会社 トリアジン誘導体を含有する医薬組成物
TW202330513A (zh) 2021-09-28 2023-08-01 加拿大商愛彼特生物製藥公司 )抑制劑及其使用方法
CN115894587A (zh) 2021-09-30 2023-04-04 知和(山东)大药厂有限公司 一种核苷衍生物的制备及其在抗病毒药物领域中的用途
EP4159721A1 (de) 2021-09-30 2023-04-05 Qubit Pharmaceuticals Kondensierte piperidinederivate als inhibitoren der 3-chymotrypsin-ähnlichen protease von coronaviren
AU2022357033B2 (en) 2021-09-30 2026-01-08 Hainan Simcere Pharmaceutical Co., Ltd. Cyano compound, and preparation method therefor and use thereof
GB202114032D0 (en) 2021-09-30 2021-11-17 Univ Strathclyde Antivirals
WO2023054759A1 (ko) 2021-09-30 2023-04-06 한국화학연구원 2-아미노퀴나졸린 유도체 및 이를 포함하는 항바이러스용 조성물
KR20230049329A (ko) 2021-10-06 2023-04-13 (주)스파크바이오파마 피리미도디아제핀계 화합물 및 코로나바이러스 감염의 치료 또는 예방을 위한 이의 용도
TW202322799A (zh) 2021-10-06 2023-06-16 美商Ｃ４醫藥公司 冠狀病毒非結構性蛋白3降解化合物
CN115947758A (zh) 2021-10-07 2023-04-11 南京知和医药科技有限公司 一种核苷酸衍生物及其药物组合物和用途
WO2023063884A2 (en) 2021-10-12 2023-04-20 Nanyang Technological University Generation of chiral sulfinate esters
CA3235441A1 (en) 2021-10-13 2023-04-20 Clear Creek Bio, Inc. Compounds and methods for treating coronaviruses
CN115710297A (zh) 2021-10-20 2023-02-24 知和(山东)大药厂有限公司 一种新型核苷酸衍生物类及其药物组合物和用途
JP2024542143A (ja) 2021-11-04 2024-11-13 深セン安泰維生物医薬有限公司 イソ酪酸ヌクレオシド化合物の結晶形及び調製方法
CN115806570B (zh) 2021-11-15 2023-09-12 南京知和医药科技有限公司 一种拟肽衍生物及其药物组合物和用途
JP7253866B1 (ja) 2021-11-24 2023-04-07 塩野義製薬株式会社 トリアジン誘導体を含有する経口投与する製剤
US11541071B1 (en) 2021-12-16 2023-01-03 Ascletis BioScience Co., Ltd Nucleoside derivatives and methods of use thereof
CN115518058A (zh) 2021-12-29 2022-12-27 河北医科大学 N-环烷基取代的芳甲胺类化合物在制备抗病毒药物中的用途及结构和制备方法
US11760722B2 (en) 2022-01-18 2023-09-19 Ascletis Bioscience Co., Ltd. Inhibitors of cysteine proteases and methods of use thereof
WO2023054732A2 (ja) 2022-01-19 2023-04-06 塩野義製薬株式会社 新型コロナウイルス感染症治療用医薬
CN116925040B (zh) 2022-03-31 2025-07-29 陕西盘龙药业集团股份有限公司 一种靶向冠状病毒3CL蛋白酶的PROTACs及其制备方法与应用
CN115504964A (zh) 2022-04-12 2022-12-23 海创药业股份有限公司 氘代杂环酮类化合物及其用途
CN115650959B (zh) 2022-05-20 2023-10-20 南京济群医药科技股份有限公司 化合物的制备方法或纯化方法
CN115636817B (zh) 2022-06-20 2023-11-24 山东大学 含三唑环的靛红类衍生物及其制备方法与应用
CN116496266A (zh) 2022-07-08 2023-07-28 歌礼生物科技（杭州）有限公司 三嗪衍生物
CN115572298B (zh) 2022-07-22 2024-11-08 苏州旺山旺水生物医药股份有限公司 一种核苷类似物及其盐的晶型、制备方法和应用
CN115466225B (zh) 2022-08-16 2025-03-07 中国科学院上海药物研究所 一种酰胺类化合物及其制备方法、药物组合物和用途
CN115521208B (zh) 2022-09-21 2023-09-01 天津科技大学 新型冠状病毒3cl蛋白酶抑制剂和应用
CN115521316B (zh) 2022-09-23 2024-07-26 深圳安泰维生物医药有限公司 一种核苷类化合物或其中间体的制备方法和核苷类化合物的中间体
CN115521337A (zh) 2022-09-26 2022-12-27 南京康立瑞生物科技有限公司 一种瑞德西韦中间体的合成方法
CN115894498A (zh) 2022-10-01 2023-04-04 海化生命(厦门)科技有限公司 一种潜在抗病毒药物中间体bl及其合成方法
US11655255B2 (en) 2022-10-17 2023-05-23 Sph No.1 Biochemical & Pharmaceutical Co., Ltd. Method for catalytic asymmetric synthesis of phosphorus-stereogenic (P-stereogenic) nucleoside derivative and catalyst used therein
CN115894504A (zh) 2022-10-21 2023-04-04 深圳信立泰药业股份有限公司 一种冠状病毒3cl蛋白酶抑制剂及其用途
CN115651022A (zh) 2022-10-27 2023-01-31 南京康立瑞生物科技有限公司 一种高纯度瑞德西韦中间体的合成方法
CN115887471B (zh) 2022-11-01 2024-02-13 南开大学 瑞德西韦在制备治疗皮肤纤维化疾病药物中的应用
CN115894443B (zh) 2022-11-17 2024-03-29 上海市重大传染病和生物安全研究院 一种化合物艾奎斯韦及其应用
CN116514783A (zh) 2022-11-21 2023-08-01 歌礼生物科技（杭州）有限公司 三嗪衍生物
CN115819423B (zh) 2022-11-29 2024-11-22 武汉大学 一种瑞德西韦或其中间体的protac化合物及其制备方法与抗ev71的应用
CN115850338A (zh) 2022-12-12 2023-03-28 西安交通大学 一种含有双吖丙啶核苷类化合物及制备方法和应用
CN115947759A (zh) 2022-12-13 2023-04-11 安徽大学 一种治疗新冠药物瑞德西韦的制备方法
CN115785080B (zh) 2022-12-16 2024-10-11 陕西盘龙药业集团股份有限公司 一种尿嘧啶母核类化合物及其制备方法和应用

Also Published As

Publication number Publication date
AU2024201573A1 (en) 2024-04-04
TWI807399B (zh) 2023-07-01
ES3015457T3 (en) 2025-05-05
JP2024109964A (ja) 2024-08-14
IL300412A (en) 2023-04-01
CR20230100A (es) 2023-04-28
US20220081455A1 (en) 2022-03-17
PE20231847A1 (es) 2023-11-21
WO2022046631A1 (en) 2022-03-03
KR20230057419A (ko) 2023-04-28
AU2021330835A1 (en) 2023-03-30
TW202222323A (zh) 2022-06-16
EP4537828A2 (de) 2025-04-16
MX2023002233A (es) 2023-03-15
PL4200301T3 (pl) 2025-06-09
DOP2023000037A (es) 2023-07-09
JP7559223B2 (ja) 2024-10-01
US20230250117A1 (en) 2023-08-10
US12473314B2 (en) 2025-11-18
CA3188373A1 (en) 2022-03-03
EP4200301B1 (de) 2025-02-26
CO2023001953A2 (es) 2023-03-17
US20240025932A1 (en) 2024-01-25
AU2021330835B2 (en) 2023-12-14
CN116323630A (zh) 2023-06-23
US11773122B2 (en) 2023-10-03
CL2023000524A1 (es) 2023-09-29
BR112023002951A2 (pt) 2023-03-21
US12030904B2 (en) 2024-07-09
EP4200301A1 (de) 2023-06-28
JP2023538442A (ja) 2023-09-07
TW202337471A (zh) 2023-10-01
EP4537828A3 (de) 2025-05-28

Similar Documents

Publication Publication Date Title
EP4200301C0 (de) Phospholipidverbindungen und verwendungen davon
EP4262883C0 (de) Peg-lipide und lipidnanopartikel
EP4204391A4 (de) Lipidverbindungen und lipidnanopartikelzusammensetzungen
PT4196479T (pt) Compostos de piridotriazinas substituídos e suas utilizações
EP4342532C0 (de) Antiplättchenarzneimittel und verwendungen davon
DE112022004033A5 (de) Leuchte und Leuchtenanordnung
EP4329739A4 (de) Lipidnanomaterialien und verwendungen davon
EP4324833A4 (de) Alkynylphenylbenzamidverbindung und verwendung davon
EP4126844A4 (de) Amidverbindungen und verwendungen davon
EP4155299A4 (de) Fluorpyrimidinverbindung und fluorpyrimidinonverbindung
EP4359076C0 (de) Phenylpyrrolaminoguanidinsalze und formulierungen
EP4244205A4 (de) Ire1alpha-inhibitoren und verwendungen davon
EP4444274A4 (de) Zusammensetzungen mit modifizierten phospholipiden und verwendungen davon
EP4415713A4 (de) Bupivacain-multivesikuläre liposomformulierungen und verwendungen davon
EP4285772A4 (de) Einlegesohle und deren kombination
EP4350263A4 (de) Waschtrockner und waschtrockner
EP4198040C0 (de) Pt-dpephos-iod-komplex und pt-dpephos-brom-komplex
EP4265614A4 (de) Verbindung und zusammensetzung
EP4119545C0 (de) Pyrazolcarboxylatverbindung und verwendung davon
KR20240099208A9 (ko) EGFRvIII-표적화 화합물 및 그의 용도
EP4201945A4 (de) Phospholipid
EP4306531A4 (de) Phospholipid
EP4329806A4 (de) Anti-siglec-zusammensetzungen und verwendungen davon
EP4321524C0 (de) Lipid und zusammensetzung
EP4368719A4 (de) Transposonsystem und verwendungen davon

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: UNKNOWN

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20230213

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20230814

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40096311

Country of ref document: HK

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20240326

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAJ Information related to disapproval of communication of intention to grant by the applicant or resumption of examination proceedings by the epo deleted

Free format text: ORIGINAL CODE: EPIDOSDIGR1

GRAL Information related to payment of fee for publishing/printing deleted

Free format text: ORIGINAL CODE: EPIDOSDIGR3

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

INTC Intention to grant announced (deleted)
GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20240916

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602021026831

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

U01 Request for unitary effect filed

Effective date: 20250301

U07 Unitary effect registered

Designated state(s): AT BE BG DE DK EE FI FR IT LT LU LV MT NL PT RO SE SI

Effective date: 20250310

REG Reference to a national code

Ref country code: SK

Ref legal event code: T3

Ref document number: E 46320

Country of ref document: SK

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250526

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PL

Payment date: 20250602

Year of fee payment: 5

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250626

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250226

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IE

Payment date: 20250610

Year of fee payment: 5

U20 Renewal fee for the european patent with unitary effect paid

Year of fee payment: 5

Effective date: 20250709

REG Reference to a national code

Ref country code: GR

Ref legal event code: EP

Ref document number: 20250400930

Country of ref document: GR

Effective date: 20250613

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250226

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20250909

Year of fee payment: 5

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GR

Payment date: 20250716

Year of fee payment: 5

Ref country code: NO

Payment date: 20250808

Year of fee payment: 5

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: TR

Payment date: 20250808

Year of fee payment: 5

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20250703

Year of fee payment: 5

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20250901

Year of fee payment: 5

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CZ

Payment date: 20250730

Year of fee payment: 5

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SK

Payment date: 20250714

Year of fee payment: 5

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20251127