Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/73—Polysaccharides
  • A61K8/731—Cellulose; Quaternized cellulose derivatives
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
  • A61K8/345—Alcohols containing more than one hydroxy group
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/74—Biological properties of particular ingredients
  • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
  • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Definitions

• the present invention relates to a cosmetic composition
• a cosmetic composition comprising: one or more substances selected from sulfated cellulose and a salt thereof; and polyhydric alcohol.
• hyaluronic acid which has moisturizing ability
• hyaluronidase which is a degrading enzyme for hyaluronic acid.
• inflammation caused by hyaluronidase occurs based on the following mechanism: hyaluronic acid and glycosaminoglycan are degraded by hyaluronidase, and accordingly, cell surfaces or support matrix substances are destroyed. Then, cells are exposed and damaged by various substances such as pathogens, inflammation mediating substances, inflammatory agents and preservative agents. As a result, people with sensitive skin become highly sensitive to chemical substances contained in cosmetics.
• Sulfated polysaccharides are known as compounds which inhibit the action of hyaluronidase and have moisturizing ability, i.e., hyaluronidase inhibitor compounds. It is thought that sulfated polysaccharides inhibit the activity of hyaluronidase to promote regeneration of cell surfaces and protective connection tissue matrices, thereby realizing anti-inflammatory action and tissue regeneration.
• Chondroitin sulfate is generally known as a typical example of sulfated polysaccharide.
• sulfated cellulose which has ability to inhibit hyaluronidase activity about 100 times that of chondroitin sulfate, is known (see Japanese Laid-Open Patent Publication No. 2006-274245 ).
• cosmetic composition in which such a substance having high ability to inhibit hyaluronidase activity and moisturizing effect is blended.
• a cosmetic composition having a moisturizing effect and high ability to inhibit hyaluronidase activity, in which such a substance is blended, is desired.
• One problem of the present invention is to provide a cosmetic composition, which has a moisturizing effect, and whose ability to inhibit hyaluronidase activity is high.
• Another problem of the present invention is to provide a cosmetic composition having the above-described effect and excellent chemical stability.
• the present inventors diligently made researches in order to solve the above-described problems. As a result, the present inventors found that, by using one or more substances selected from sulfated cellulose and a salt thereof in combination with polyhydric alcohol, the ability of sulfated cellulose and the salt thereof to inhibit hyaluronidase activity is further improved, and that, by further blending an electrolyte having pH buffering ability, the obtained cosmetic composition has excellent stability.
• the present invention was achieved based on the above-described findings.
• the present invention is constituted by the following matters:
• the cosmetic composition of the present invention has a moisturizing effect, and its ability to inhibit hyaluronidase activity is high, and therefore, skin roughness caused by drying can be reduced. For this reason, the cosmetic composition of the present invention can be provided to people with sensitive skin, who are highly sensitive to chemical substances contained in cosmetics.
• Sulfated cellulose to be used in the present invention is a compound, which is electrolyzed by sulfating a part or all of hydroxyl groups in cellulose, and to which water solubility is imparted.
• Sulfated cellulose of the present invention can be obtained by reacting cellulose with a sulfating agent to sulfate a part or all of hydroxyl groups in cellulose.
• Cellulose which is a raw material of sulfated cellulose to be used in the present invention, is not particularly limited as long as it is derived from plants, and publicly-known crosslinked or noncrosslinked celluloses can be used.
• crystalline cellulose is preferably used since it has high strength and is slightly soluble in water, thereby allowing inclusion of sulfur in sulfated cellulose at a high concentration.
• crystalline cellulose having the average degree of polymerization of 100 to 300 is preferably used, since sulfated cellulose which is chemically stable and excellent in hydrolysis resistance can be obtained thereby, and effects of a cosmetic composition is less likely to be decrease over time.
• the sulfating agent to be reacted with cellulose is not particularly limited as long as it is generally used.
• sulfuric anhydride or a complex of N,N-dimethylformamide and sulfuric anhydride is preferred.
• the complex of N,N-dimethylformamide and sulfuric anhydride is a compound which is formed by mixing N,N-dimethylformamide and sulfuric anhydride.
• the mixing ratio between N,N-dimethylformamide and sulfuric anhydride is preferably within a range in which there is an excess amount of N,N-dimethylformamide with respect to sulfuric anhydride, and the concentration of sulfuric anhydride in the mixture is more preferably 10 to 30 wt%.
• the concentration of sulfuric anhydride is within this range, sulfation reaction of cellulose can be sufficiently progressed, and in addition, the sulfur concentration can be easily controlled.
• the use amount of the sulfating agent can be arbitrary selected depending on a desired sulfation ratio (or sulfur concentration) and reaction conditions, but the sulfating agent is suitably used in an amount of 1.2 to 3 equivalents per a hydroxyl group in cellulose.
• sulfated cellulose which is obtained by sulfating crystalline cellulose having the average degree of polymerization of 100 to 300 using, as a sulfating agent, sulfuric anhydride or a complex of N,N-dimethylformamide and sulfuric anhydride, is preferably used.
• the amount of sulfate ester (or sulfur concentration) in sulfated cellulose can be controlled by the feed ratio of the sulfating agent which may be reacted with hydroxyl groups relative to cellulose.
• the solvent to be used for sulfation of cellulose is not particularly limited as long as the sulfating agent does not react therewith.
• Specific examples of the solvent include N,N-dimethylformamide, dimethylsulfoxide, heterocyclic solvents such as dioxane and pyridine, and tertiary amine solvents such as triethylamine.
• the use amount of reaction solvent is 1 to 100 volumes, and preferably 1 to 10 volumes based on the weight of cellulose.
• the reaction temperature is not particularly limited to a low temperature, and is preferably 10 to 25°C.
• Sulfation reaction of cellulose is carried out by dissolving or suspending cellulose in a solvent, and thereafter dropping the sulfating agent therein. Dropping time of the sulfating agent is preferably 0.01 to 2 hours.
• This reaction is a reaction between primary and secondary hydroxyl groups, and the sulfating agent.
• a reaction of primary hydroxyl groups progresses in a short time, but a reaction of secondary hydroxyl groups does not progress in a short time. Therefore, the reaction time is preferably 1 to 48 hours.
• stirring is carried out at a suitable rate for sufficient mixing.
• an alcoholic solvent such as methanol and ethanol is added to the reaction solution to precipitate the obtained sulfated cellulose.
• the reaction may be terminated by addition of distilled water, followed by neutralization by alkali.
• the obtained mixture is filtrated or centrifuged to remove impurities, and the alcoholic solvent is dropped again on the filtrate to be crystallized, thereby obtaining sulfated cellulose.
• a biologically acceptable salt of sulfated cellulose may also be used.
• such salts include salt with inorganic base, salt with organic base and salt with basic amino acid.
• Specific examples of salts with inorganic base include lithium salt, potassium salt, sodium salt, beryllium salt, magnesium salt, and calcium salt.
• Specific examples of salts with organic base include triethylamine salt.
• Specific examples of salts of basic amino acid include arginine salt, lysine salt and histidine salt.
• the salts of sulfated cellulose to be used in the present invention include those in both anhydrous and hydrated forms.
• sodium salt is preferred since it is easily produced, has high moisturizing effect and ability to inhibit hyaluronidase activity, and is relatively inexpensive.
• salts of sulfated cellulose can be obtained by reaction between sulfated cellulose and inorganic base, organic base or basic amino acid.
• the weight average molecular weight of the sulfated cellulose compound to be used in the present invention is preferably 1,000 to 200,000, and more preferably 50,000 to 100,000.
• the sulfur concentration of the sulfated cellulose compound is preferably 6.5 to 19.0 wt%, and more preferably 12.0 to 17.0 wt%.
• the solubility of the sulfated cellulose compound in pure water at 20°C is preferably 3 g/L or higher, more preferably 10 g/L or higher, and even more preferably 15 g/L or higher.
• the upper limit of the solubility is not particularly limited, but in general, it is preferably about less than 20 g/L.
• a cosmetic compound obtained has an excellent moisturizing effect and ability to inhibit hyaluronidase activity, and therefore, skin roughness due to drying can be reduced.
• the weight average molecular weight of the sulfated cellulose compound can be obtained by the gel filtration method.
• the sulfur concentration of the sulfated cellulose compound refers to the content of sulfur per the dry weight of the sulfated cellulose compound, and it can be obtained by flask combustion - ion chromatography.
• the solubility of the sulfated cellulose compound in pure water at 20°C can be obtained by measuring the weight of the compound solved in 10 mL of pure water at 20°C.
• the polyhydric alcohol to be used in the present invention is not particularly limited as long as it is a compound having at least two hydroxyl groups linked to a linear, branched or cyclic hydrocarbon.
• Specific examples of the polyhydric alcohol include 1,2-ethanediol, diethylene glycol, triethylene glycol, polyethylene glycol, 1,2-propanediol, 1,3-propanediol, dipropylene glycol, 2-amino-2-methyl-1,3-propanediol, polypropylene glycol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 3-methyl-1,3-butanediol, glycerin, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,5-pentanediol, 1,2,3-pentanetriol, 2,3,4-pentanet
• 1,3-butanediol, 1,2-propanediol, polyethylene glycol, 1,2-pentanediol, 1,2-hexanediol, sorbitol, etc. are preferred.
• the polyhydric alcohol may equally be used in both anhydrous and hydrated forms.
• the polyhydric alcohol to be used in the present invention may be prepared using any one of various known techniques such as organic synthesis, extraction and purification from a naturally-occurring product, or fermentation by microorganisms. Polyhydric alcohols obtained thereby may be used without particular limitation.
• any of the forms may be used for the polyhydric alcohol in the present invention, such as fine powders, microcrystals, liquids, pellets, viscous fluids, gels and the like.
• the most suitable form for cosmetic composition products of the present invention may be selected.
• the cosmetic composition of the present invention contains: one or more substances selected from the sulfated cellulose compounds; and polyhydric alcohol as essential components.
• the cosmetic composition of the present invention retains a suitable concentration of the sulfated cellulose compound and exerts an excellent moisturizing effect and ability to inhibit hyaluronidase activity.
• the content of the sulfated cellulose compound in the cosmetic composition of the present invention is not particularly limited, but in terms of the cost of raw materials for products and the concentration range in which a desired moisturizing effect and effect of inhibiting hyaluronidase activity can be exerted, the content is arbitrary set within a range of preferably 0.0001 to 50 wt%, and more preferably 0.001 to 1 wt%.
• the content of polyhydric alcohol in the cosmetic composition of the present invention is not particularly limited, but in terms of the cost of raw materials for products and the concentration range in which a desired moisturizing effect can be exerted, the content is arbitrary set within a range of preferably 0.0001 to 80 wt%, and more preferably 0.001 to 50 wt%.
• the preferable range of the content ratio between the sulfated cellulose compound and polyhydric alcohol in the cosmetic composition of the present invention slightly varies depending on the form of the cosmetic composition.
• the content of the sulfated cellulose compound is preferably 0.01 to 5 wt%, and more preferably 0.1 to 1 wt%
• the content of polyhydric alcohol is preferably 0.1 to 80 wt%, and more preferably 0.5 to 15 wt%.
• the content of the sulfated cellulose compound is preferably 0.01 to 5 wt%, and more preferably 0.05 to 1 wt%, and the content of polyhydric alcohol is preferably 1 to 20 wt%, and more preferably 3 to 10 wt%.
• the content of the sulfated cellulose compound is preferably 0.01 to 5.0 wt%, and more preferably 0.1 to 1 wt%, and the content of polyhydric alcohol is preferably 0.5 to 20 wt%, and more preferably 1 to 10 wt%.
• the content of the sulfated cellulose compound is preferably 0.01 to 5 wt%, and more preferably 0.1 to 1 wt%, and the content of polyhydric alcohol is preferably 1 to 30 wt%, and more preferably 5 to 15 wt%.
• the content of the sulfated cellulose compound is preferably 0.01 to 10 wt%, and more preferably 0.1 to 1 wt%, and the content of polyhydric alcohol is preferably 1 to 10 wt%, and more preferably 1 to 5 wt%.
• the content of the sulfated cellulose compound is preferably 0.01 to 5 wt%, and more preferably 0.1 to 1 wt%, and the content of polyhydric alcohol is preferably 5 to 30 wt%, and more preferably 5 to 20 wt%.
• the cosmetic composition of the present invention can exert an excellent moisturizing effect, but a sulfate ester group contained in sulfated cellulose may generally be a reactive spot of hydrolysis reaction under acidic conditions. In particular, under strongly-acidic conditions, there is a possibility that hydrolysis reaction is caused at an accelerated rate. For this reason, in addition to the sulfated cellulose compound and polyhydric alcohol, an electrolyte having pH buffering ability is preferably contained in the cosmetic composition of the present invention.
• the electrolyte having pH buffering ability to be used in the present invention is not particularly limited, but is preferably a combination of weak acid and weak acid salt.
• electrolyte having pH buffering ability to be used in the present invention include phosphoric acid-metal salt of phosphoric acid, acetic acid-metal salt of acetic acid, lactic acid-metal salt of lactic acid, succinic acid-metal salt solution of succinic acid, tartaric acid-metal salt of tartaric acid, citric acid-metal salt of citric acid, and malic acid-metal salt of malic acid.
• the type of metal salt is not particularly limited, but in terms of the solubility, sodium salt or potassium salt is preferred.
• the content of the electrolyte having pH buffering ability (for example, when using a combination of weak acid and weak acid salt, the total amount thereof) in the cosmetic composition of the present invention is not particularly limited, but because of exertion of sufficient buffering effect, the content is arbitrary set within a range of preferably 0.001 to 30 wt%, and more preferably 0.01 to 10 wt%.
• pH of the cosmetic composition of the present invention is arbitrary set within a range of preferably 5.5 to 7.0, more preferably 5.5 to 6.5, and even more preferably 5.5 to 6.2.
• the cosmetic composition of the present invention may be selected depending on a specific product formation of the cosmetic composition from fine powders, microcrystals, liquids, or pellets.
• the cosmetic composition of the present invention may be formed into granules, gels, or viscous fluids by mixing it with, for example, an excipient, thickener or gelling agent.
• the cosmetic composition of the present invention may be formulated in various forms such as a capsule, powder, granule, solid, liquid, gel, foam, emulsion, cream, ointment, sheet, mousse, powder dispersion, multilayer, and aerosol.
• the cosmetic composition of the present invention finds applications in hair treating agents such as hair dressings (e.g., hair sprays, hair tonics, hair gels, hair lotions, hair oils, hair essences, hair waters, and hair waxes), shampoos, finishing rinses, hair treatments, hair creams, hair mousses, hair setting lotions, hair colors, hair dyes (e.g., one-part hair dyes and two-part hair dyes), perm solutions (e.g., permanent wave solutions, hair straightening solutions, and permanent wave holding agents), hair growth tonics, pilatories, and anti-hair loss agents.
• hair dressings e.g., hair sprays, hair tonics, hair gels, hair lotions, hair oils, hair essences, hair waters, and hair waxes
• shampoos finishing rinses
• hair treatments e.g., hair creams, hair mousses, hair setting lotions, hair colors, hair dyes (e.g., one-part hair dyes and two-part hair dyes), perm solutions (e.
• compositions include, for example, skin care cosmetics such as toners, serums, whitening toners, milky lotions, whitening milky lotions, creams, whitening creams, ointments, whitening ointments, lotions, whitening lotions, oils, and facial packs.
• skin care cosmetics such as toners, serums, whitening toners, milky lotions, whitening milky lotions, creams, whitening creams, ointments, whitening ointments, lotions, whitening lotions, oils, and facial packs.
• makeup cosmetics such as foundations, liquid foundations, lipsticks, eye shadows, powders, blushers, eye liners, mascaras, and eyebrow pencils.
• Another application of the composition according to the present invention includes, for example, skin cleansers such as soap, cleansing creams, cleansing lotions, cleansing milks, facial washes, and body shampoos.
• finishing cosmetics such as manicures.
• Other applications of the composition according to the present invention include, for
• the cosmetic composition of the present invention may contain the following exemplary ingredients that are arbitrarily selected and combined as additives to provide a cosmetic composition having a larger variety of functions: active ingredients such as pigmentation inhibitors, tyrosinase inhibitors, melanocyte melanogenesis inhibitors, melanogenesis promoters, humectants, cell activators/metabolic activators, antioxidants, active oxygen scavengers/radical production inhibitors, lipometabolism promoters, UV blockers/UV absorption promoters, astringents, anti-inflammatory agents/interleukin inhibitors/antiphlogistics, antiseborrheic agents, antimicrobial agents/antiviral agents, blood flow enhancers/blood vessel stimulators, anti-androgen agents, structural proteolytic enzyme (e.g., elastase, collagenase, keratin protease, serine protease, a proteolytic enzyme, e.g., elastase, collagena
• the content in the preparation is not specifically limited but it may generally be within the concentration range of from 0.0001 to 50 wt%.
• the cosmetic composition of the present invention may contain a pigmentation inhibitor.
• the pigmentation inhibitor include p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfonamide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or salts thereof and their derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid derivatives, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, and dioxane derivatives.
• the cosmetic composition of the present invention may contain a tyrosinase inhibitor.
• tyrosinase inhibitor include ascorbic acid or salts thereof and their derivatives, hydroquinone or salts thereof and their derivatives, kojic acid or salts thereof and their derivatives, tocopherol or salts thereof and their derivatives, tocotrienol or salts thereof and their derivatives, N-acetyl tyrosine or salts thereof and their derivatives, glutathione or salts thereof and their derivatives, and ellagic acid or salts thereof and their derivatives.
• the cosmetic composition of the present invention may contain a melanocyte melanogenesis inhibitor.
• the melanocyte melanogenesis inhibitor include lobeline or lobeline derivatives, liquiritin derivatives, phenylchroman derivatives, chromone derivatives, azelaic acid derivatives, phosphatidylglucosamine, lysophosphatidylglucosamine, phenylhydroquinone, 3-beta-D-glucopyranosyl manool, 3-beta-D-maltopyranosyl manool, substituted amino acid derivatives, benzolactam derivatives, and indolactam derivatives.
• the cosmetic composition of the present invention may contain a melanogenesis promoter.
• the melanogenesis promoter include salicylic acid or salts thereof and their derivatives, salicyl alcohol or salts thereof and their derivatives, apigenin, amentoflavone, Zanthoxylum piperitum extract, Aralia cordata extract, Angelica pubescens extract, Anemone flaccida extract, kashi extract, Circaea cordata extract, and Ageratum conyzoides L. extract.
• the cosmetic composition of the present invention may contain a humectant.
• humectant include gum arabic, benzoin gum, dammar gum, guaiac gum, Irish moss, karaya gum, tragacanth gum, carob gum, quince seed, agar or derivatives thereof, casein, glucose, galactose, mannose, xylose, fructose, maltose, isomaltose, cellobiose, gentiobiose, and trehalose.
• the cosmetic composition of the present invention may contain a cell activator/metabolic activator.
• a cell activator/metabolic activator include vitamin A group: retinol or salts thereof and their derivatives, retinal or salts thereof and their derivatives, dehydroretinal or salts thereof and their derivatives, and retinoic acid or salts thereof and their derivatives.
• the cosmetic composition of the present invention may contain an antioxidant.
• the antioxidant include ascorbic acid or salts thereof and their derivatives, stearic acid ester, tocopherol or salts thereof and their derivatives, dihydropyridine derivatives, benzochroman derivatives, norujihidoroguasereten acid, butylhydroxytoluene (BHT), and butylhydroxyanisole (BHA).
• the cosmetic composition of the present invention may contain an active oxygen scavenger/radical scavenger.
• active oxygen scavenger/radical scavenger include superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or derivatives thereof, gallic acid or salts thereof and their derivatives, and curcumin or salts thereof and their derivatives.
• the cosmetic composition of the present invention may contain a lipometabolism promoter.
• the lipometabolism promoter include phthalazine derivatives, Cocculus trilobus (MU FANG JI) extract, Cirsium japonicum extract, Cephalonoplos segetum extract, Cirsium borealinipponense extract, Cirsium maritimum extract, Cirsium japonicum extract, Rhaponticum uniflorum extract, Theobroma cacao extract, Gentianella alborosea extract, Sinomenium acutum (FAN JI) extract, Curcuma zedoaria (E ZHU) extract, Fumaria officinalis extract, and Platycodon grandiflorum (JIE GENG, JIE GENG GEN) extract.
• MU FANG JI Cocculus trilobus
• Cephalonoplos segetum extract Cirsium borealinipponense extract
• Cirsium maritimum extract Cirsium japonicum extract
• the cosmetic composition of the present invention may contain a UV blocker/UV absorption promoter.
• a UV blocker/UV absorption promoter include benzophenone derivatives, 1,2-dihydroxy-4-(2-hydroxyethyl)benzene derivatives, paraaminobenzoic acid derivatives, methoxycinnamic acid derivatives, anthranilic acid derivatives, urocanic acid derivatives, coumarin derivatives, amino acid-based compounds, benzotriazole derivatives, and tetrazole derivatives.
• the cosmetic composition of the present invention may contain an astringent.
• astringent include succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, aluminum potassium sulfate, resorcin, ferric chloride, and tannins.
• the cosmetic composition of the present invention may contain an anti-inflammatory agent/interleukin inhibitor/histamine release inhibitor.
• the anti-inflammatory agent/interleukin inhibitor/histamine release inhibitor include quinolinone derivatives, dibenzoxepin derivatives, thiotropocin, phthalimide derivatives, flurbiprofen, felbinac, bufexamac, suprofen, 1,4-diphenylpropylpiperazine derivatives, and calyxin compounds.
• the cosmetic composition of the present invention may contain an antiseborrheic agent.
• the antiseborrheic agent include chroman derivatives, pyridoxine or salts thereof and their derivatives, pyridoxal or salts thereof and their derivatives, pyridoxiamine or salts thereof and their derivatives, sulfur, Cannabis sativa (HUO MA REN) extract, Lamium album var. barbatum (ZOKUDAN) extract, Nasturtium officinale (cresson) extract, Valeriana fauriei (KISSOUKON) extract, and Clematis extract.
• the cosmetic composition of the present invention may contain an antimicrobial agent.
• the antimicrobial agent include acrinol, sulfur, gluconic acidcalcium, chlorhexidine gluconate, sulfamin, mercurochrome, lactoferrin or hydrolysates thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, calcium hypochlorite, iodine compounds, and iodoform.
• the cosmetic composition of the present invention may contain a blood flow enhancer/blood vessel stimulator.
• a blood flow enhancer/blood vessel stimulator include tocopherol or salts thereof and their derivatives, tocotrienol or salts thereof and their derivatives, cepharanthine, carpronium chloride, eugenol derivatives, minoxidil, capsicum tincture, and nonylic vanillylamide.
• the cosmetic composition of the present invention may contain an anti-androgen agent.
• the anti-androgen agent include follicular hormone, isoflavone, oxendolone, 4',5,7-trihydroxy-8-prenylflavanone, 4',5,7-trihydroxy-8-prenylflavone, 3,3',4',5,7-pentahydroxy-8-prenylflavone, nicorandil, and cyclosporine acid.
• the cosmetic composition of the present invention may contain a structural proteolytic enzyme (e.g., a matrix metalloproteinase such as elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme) inhibitor/structural proteolytic enzyme expression inhibitor.
• a structural proteolytic enzyme e.g., a matrix metalloproteinase such as elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme
• structural proteolytic enzyme inhibitor/structural proteolytic enzyme expression inhibitor examples include adenine derivatives, carbostyril derivatives or salts thereof, dicarboxylic acids, rosmarinic acid, ursolic acid, oleanolic acid, hydroxamic acid derivatives, esculetin derivatives, anthocyanidins, and nordihydroguaiaretic acid.
• the cosmetic composition of the present invention may contain a structural protein synthesis promoter.
• the structural protein synthesis promoter include ethanolamine derivatives, pentoxifylline, serine derivatives, geraniol, crocetin, methyl 4-(2-ethylhexyloxy)-2-hydroxybenzoate, methyl 2-hydroxy-4-(3,5,5-trimethylhexyloxy)benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4-(2-cyclohexylethoxy)-2-hydroxybenzoae, and methyl 4-(3,7-dimethyl-6-octenyloxy)-2-hydroxybenzoate.
• the cosmetic composition of the present invention may contain mucopolysaccharides (e.g., hyaluronic acid, and chondroitin sulfuric acid) degrading enzyme inhibitor.
• mucopolysaccharides degrading enzyme inhibitor include anacardic acid or derivatives thereof, isoprenylated benzophenone derivatives, Epimedium grandiflorum var. thunbergianum extract, Epimedium grandiflorum Morr. var.
• Grandiflorum (YIN YANG HUO) extract Polygonatum falcatum extract, Polygonatum sibiricum (HUANG JING) extract, Origanum rotundifolium extract, Dryopteridaceae extract, Polygala tenuifolia extract, and Prunus jamasakura extract.
• the cosmetic composition of the present invention may contain mucopolysaccharides synthesis promoter.
• mucopolysaccharides synthesis promoter include stilbene derivatives or salts thereof, mollugin or salts thereof and their derivatives, N-acetylglucosamine, Linum usitatissimum extract, Broussonetia papyrifera (CHOJITSU) extract, Broussonetia kazinoki extract, Origanum majorana L. extract, Artocarpus altilis extract, and Hirakotoji extract.
• the cosmetic composition of the present invention may contain an intercellular lipid production promoter/intercellular lipid condition modifier.
• the intercellular lipid production promoter/intercellular lipid condition modifier include phospholipids, sterins, N-acetylneuraminic acid, N-glucosol neuraminic acid, gangliosides, oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glycoglycerolipids, pentoxifylline, and 3-deazaadenosine.
• the cosmetic composition of the present invention may contain a keratolytic agent/stratum corneum removal promoter.
• a keratolytic agent/stratum corneum removal promoter include tropolone and derivatives thereof, resorcin, lactic acid, urea, salicylic acid, guanidine, ethanolamine, Trichosanthes kirilowii var. japonica (KAROKON) extract, Trigonella foenum-graecum extract, Lablab purpureus (BIAN DOU) extract, Lens esculenta extract, Cicer arietinum extract, and Vigna radiata extract.
• tropolone and derivatives thereof include tropolone and derivatives thereof, resorcin, lactic acid, urea, salicylic acid, guanidine, ethanolamine, Trichosanthes kirilowii var. japonica (KAROKON) extract, Trigonella foenum-graecum extract, Lablab purpureus (B
• the cosmetic composition of the present invention may contain a plasminogen-activator competitive inhibitor.
• plasminogen-activator competitive inhibitor include Arnica unalaschkensis var. tschonoskyi extract, Humulus japonicus extract, Humulus lupulus var. cordifolius extract, and Rubus idaeus extract.
• the cosmetic composition of the present invention may contain a Maillard reaction inhibitor.
• the Maillard reaction inhibitor include aminoguanidine, flavanones, 2-hydroxyphenylalkylamine derivatives or salts thereof, phenylpropenoic acid derivatives, citric acid or salts thereof, Acorus gramineus (SHI CHANG GEN) extract, Bletilla striata extract, Mallotus japonicus extract, Diospyros kaki (including SHI DI) extract, and Morus alba extract.
• the cosmetic composition of the present invention may contain testosterone 5 alpha-reductase inhibitor/hair papilla activating agent/hair growth promoter.
• Specific examples of the testosterone 5 alpha-reductase inhibitor/hair papilla activating agent/hair growth promoter include gamma-amino-beta-hydroxybutyric acid esters, amineoxides, alkylbetaines, pyrimidine-N-oxide derivatives, p-menthane-3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-o-N-pentadecylglycero-D-glucoside, and glyceride sulfates such as monopentadecanoic acid glyceride sulfuric acid ester salt.
• the cosmetic composition of the present invention may contain a hair matrix cell proliferation inhibitor/hair growth inhibitor.
• the hair matrix cell proliferation inhibitor/hair growth inhibitor include phthalazinones, benzoxazinones, phosphonic acid derivatives, cyproterone, 5-alpha-androstene-3alpha,17beta-diol, medroxyprogesterone, norethisterone, mestanolone, Iris tectorum (Ichihatsu) extract, HE SHOU WU ( Polygonum multiflorum radix) extract, Kantou extract, Cremastra appendiculata extract, Gracilaria bursa-pastoris extract, CANG ZHU ( Atractylodes lancea rhizome) extract, Genista tinctoria extract, FU PING CAO ( Spirodela polyrrhiza leaf) extract, myrrh ( Commiphora myrrha ) extract, Champia parvula extract, and Sargassum
• the cosmetic composition of the present invention may contain a hair swelling agent/hair protector.
• the hair swelling agent/hair protector include ethanolamine, urea, guanidine, silicones, blueberry ( Vaccinium corymbosum ) extract, and mango extract.
• the cosmetic composition of the present invention may contain an odor counteractant.
• the odor counteractant include Anethum graveolens extract, Elemi ( Canarium luzonicum ) extract, dammar ( Agathis dammara ) extract, vanilla beans extract, and Pinus thunbergii extract.
• ingredients derived from a plant source which are used by being added to the cosmetic composition of the present invention as additives, include plant extracts such as Sabia japonica (QING FENG TENG) extract, Gastrodia elata Blume f. viridis extract, Ribes sativum extract, Ulmus parvifolia (ROUYUPI) extract, aguai guasu extract, abiu extract, abiurana-abiu extract, yellow sapote extract, Cananga odorata extract, and Orchis graminifolia extract.
• plant extracts such as Sabia japonica (QING FENG TENG) extract, Gastrodia elata Blume f. viridis extract, Ribes sativum extract, Ulmus parvifolia (ROUYUPI) extract, aguai guasu extract, abiu extract, abiurana-abiu extract, yellow sapote extract, Cananga odorata extract, and Or
• ingredients derived from a plant source which are used by being added to the cosmetic composition of the present invention as additives, include Dunaliella sp. extract, Chlorococcus sp. extract, Pandorina morum extract, Volvox aureus extract, Volvox sp. extract, Palmella extract, Tetraspora extract, Spirogyra sp. and Mougeotia sp. extract, Draparnaldia extract, and Ulothrix zonata extract.
• ingredients derived from an animal source which are used by being added to the cosmetic composition of the present invention as additives, include cockscomb extract, placenta extract derived from bovine placenta, swine placenta or human placenta, extract derived from swine or bovine stomach, duodenum, intestine, or spleen or degradation products thereof, extract derived from bovine or swine brain tissue, collagen derivatives such as water-soluble collagen and acylated collagen, and collagen hydrolysate.
• ingredients derived from a microorganism source which are used by being added to the cosmetic composition of the present invention as additives, include yeast metabolites, yeast extracts, bacteria metabolites, bacteria extract, metabolites of mold or mushroom, actinomycete metabolite, extract from mold or mushroom, actinomycete extract, Bacillus natto metabolite, Bacillus natto extract, rice fermented extract, rice bran (red bran, white bran) fermented extract, euglena extract or degradation products thereof or their water-soluble derivatives, lactic fermented raw milk or nonfat dry milk product, and trehalose or derivatives thereof.
• Materials derived from a plant or animal or microorganism source may comprise any sites, cells, tissues, organs, and metabolites derived from a transgenic lines or cell fusion products.
• tissue-derived cultured cells e.g., cultured cells derived from animals, such as fibroblasts, Langerhans cells, macrophages, epidermal cells, and liver cells
• undifferentiated cells e.g., undifferentiated cells, cells under differentiation processes, and metabolites thereof, which may be obtained by cultivation of sites, cells, tissues, organs, etc., may be used.
• sea water such as deep water, e.g., sea water salt, dried sea water, inorganic salts obtained from the Dead Sea or Atlantic Ocean or Pacific Ocean (e.g., sodium chloride, magnesium chloride, and potassium chloride), and sea mud or fango.
• Extracts derived from a plant or animal or microorganism source and other extracts derived from naturally-occurring materials, which are used as additives, may be obtained by carrying out standard procedures (for example, an appropriate combination of grinding, milling, washing, extraction, degradation, fermentation or metabolic shifting by microorganisms, fractionation, purification, compression, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, and bleaching) depending on the type and formation of the product to which they are to be added, and then performing selection from any of the resulting materials.
• standard procedures for example, an appropriate combination of grinding, milling, washing, extraction, degradation, fermentation or metabolic shifting by microorganisms, fractionation, purification, compression, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, and bleaching
• inorganic pigments inorganic reducing agents, oxidizing reducing agents, dyes, fragrances including: natural animal essences such as musk, civet, castoreum, and ambergris; botanical fragrances; and other synthetic fragrances, pigments and coloring agents, fats and oils, waxes, mineral oils, fatty acids including natural fatty acids and synthetic fatty acids, alcohols, esters, metal soaps, anionic surfactants, sulfated oils, anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants, natural surfactants, amino acid surfactants, silicone surfactants, silicone compounds, and hair treatment agents. Additional specific examples of the above-described additives are described in Japanese Laid-Open Patent Publication No. 2005-350454 and EP Laid-Open Publication No. 1604647 , and therefore these publications can be referred to.
• additives may also be used in combination in the present invention: hormones, sequestrants, pH adjusting agents, chelating agents, antiseptic/antifungal agents, agents capable of generating a cool sensation, stabilizers, emulsifiers, animal and plant proteins and degradation products thereof, animal and plant polysaccharides and degradation products thereof, animal and plant glycoproteins and degradation products thereof, antiphlogistic/antiallergic agents, wound healing agents, foam boosters, thickeners, enzymes, purified waters (e.g., electronic water, small clustering), deodorants/deodorization agents.
• hormones e.g., sequestrants, pH adjusting agents, chelating agents, antiseptic/antifungal agents, agents capable of generating a cool sensation, stabilizers, emulsifiers, animal and plant proteins and degradation products thereof, animal and plant polysaccharides and degradation products thereof, animal and plant glycoproteins and degradation products thereof, antiphlogistic/antiallergic agents, wound healing agents, foam boosters, thicken
• the cosmetic composition of the present invention is produced using a method in which one or more substances selected from the sulfated cellulose compounds, polyhydric alcohol, and if required, the above-described various additives are weighed independently to have a ratio suitable to an application, and thereafter these materials are mixed together.
• Publicly-known production apparatuses and production conditions may be employed depending on the properties and application of the cosmetic composition.
• hair dressing in the case of hair dressing, it may be prepared, for example, by dissolving POE hydrogenated castor oil, fragrance, etc. in a mixture of ethanol, 1,3-butanediol, etc., adding to the mixture purified water in which the sulfated cellulose compounds, a UV blocker, a preservative agent, etc. are dissolved, and stirring the mixture homogeneously.
• the production method is not limited thereto.
• shampoo it may be prepared, for example, by mixing lauryldimethylamine oxide or the like with a cationic compound such as stearyl dimethylamine, adding to the mixture purified water in which the sulfated cellulose compounds, propylene glycol, carboxyvinyl polymer, a pH adjusting agent, etc. are dissolved to be emulsified, and stirring the mixture homogeneously.
• a cationic compound such as stearyl dimethylamine
• the production method is not limited thereto.
• finishing rinse, hair treatment, hair cream or the like it may be prepared, for example, by adding polyhydric alcohol such as 1,2-pentanediol to a mixture of tertiary ammonium chloride, isopropyl palmitate, etc., adding to the mixture purified water in which the sulfated cellulose compounds, a pH adjusting agent, etc. are dissolved to be emulsified, and stirring the mixture homogeneously.
• polyhydric alcohol such as 1,2-pentanediol
• a mixture of tertiary ammonium chloride isopropyl palmitate, etc.
• adding to the mixture purified water in which the sulfated cellulose compounds, a pH adjusting agent, etc. are dissolved to be emulsified, and stirring the mixture homogeneously.
• the production method is not limited thereto.
• a first solution may be prepared by mixing a basic organic compound such as diaminotoluene sulfate salt with ammonia water, adding to the mixture alcohols such as oleyl alcohol and 1,2-propanediol, adding to the mixture purified water in which the sulfated cellulose compounds, sodium sulfite, etc. are dissolved, and stirring the mixture homogeneously.
• a second solution may be prepared by adding purified water in which fragrance, etc. are dissolved to a mixture of hydrogen peroxide water, 1,3-butanediol, etc., and stirring the mixture homogeneously.
• the production method is not limited thereto.
• hair growth tonic, pilatory or the like it may be prepared, for example, by dissolving capsicum tincture, tocopherol acetate, etc. in ethanol, 1,5-pentanediol or the like, adding to the mixture purified water in which the sulfated cellulose compounds, sodium glutamate, resorcin, etc. are dissolved, and stirring the mixture homogeneously.
• the production method is not limited thereto.
• toner it may be prepared, for example, by dissolving POE hydrogenated castor oil, fragrance, etc. in a mixture of ethanol and isoprene glycol or the like, adding to the mixture purified water in which the sulfated cellulose compounds, a UV blocker, a preservative agent, etc. are dissolved, further adding a pH adjusting agent thereto, and stirring the mixture homogeneously.
• the production method is not limited thereto.
• serum it may be prepared, for example, by dissolving sorbitan sesquiisostearate, decamethylcyclopentasiloxane, etc. in alcohols such as 1,2-propanediol, and adding to the mixture purified water in which the sulfated cellulose compounds, a pH adjusting agent, etc. are dissolved.
• the production method is not limited thereto.
• milky lotion it may be prepared, for example, by mixing olive oil, liquid paraffin, POE oleyl ether, sorbitan sesquioleate, a preservative agent, etc., adding to the mixture purified water in which the sulfated cellulose compounds, hyaluronic acid, propylene glycol, carboxy vinyl polymer, a pH adjusting agent, etc. are dissolved to be emulsified, adding to the obtained mixture ethanol, a UV blocker, pigment, fragrance, etc., and stirring the mixture homogeneously.
• the production method is not limited thereto.
• cream it may be prepared, for example, by mixing cetyl alcohol, stearyl alcohol, stearic acid, liquid paraffin, petrolatum, sorbitan monostearate, POE monostearate, a preservative agent, etc., adding to the mixture purified water in which the sulfated cellulose compounds, 1,3-butylene glycol, a pH adjusting agent, etc. are dissolved to be emulsified, cooling the mixture and thereafter further adding dipotassium glycyrrhizinate, a UV blocker, pigment, fragrance, etc., and stirring the mixture homogeneously.
• the production method is not limited thereto.
• foundation it may be prepared, for example, by dissolving dipropylene glycol, etc. in decamethylcyclopentasiloxane or the like, mixing the mixture with an inorganic compound such as hydrophobic treated titanium oxide and hydrophobic treated talc, etc., adding to the mixture purified water in which the sulfated cellulose compounds, fragrance, etc. are dissolved, and stirring the mixture homogeneously.
• an inorganic compound such as hydrophobic treated titanium oxide and hydrophobic treated talc, etc.
• the production method is not limited thereto.
• liquid foundation it may be prepared, for example, by dissolving ethanol, etc. in decamethylcyclopentasiloxane or the like, mixing the mixture with hydrophobic treated titanium oxide, spherical resin powder, etc., adding to the mixture purified water in which the sulfated cellulose compounds, fragrance, etc. are dissolved, and stirring the mixture homogeneously.
• the production method is not limited thereto.
• lipstick it may be prepared, for example, by dissolving ceresin wax, cadelin wax, etc. in decamethylcyclopentasiloxane, mixing the mixture with the sulfated cellulose compounds, propylene glycol dicaprate, polyglyceryl diisostearate, etc., and thereafter adding pigment such as Red No. 201, hydrophobic treated mica-titanium, etc. thereto and stirring the mixture homogeneously.
• the production method is not limited thereto.
• eye shadow it may be prepared, for example, by mixing hydrophobic-treated chromium oxide, ultramarine, titanium-coated mica, etc. with decamethylcyclopentasiloxane or the like, adding polyhydric alcohols such as propylene glycol thereto, adding to the mixture purified water in which the sulfated cellulose compounds, fragrance, etc. are dissolved, and stirring the mixture homogeneously.
• the production method is not limited thereto.
• facial wash it may be prepared, for example, by mixing glycerin with triethanolamine lauryl phosphate, etc., adding to the mixture purified water in which the sulfated cellulose compounds, lauryl hydroxysulfobetaine, etc. and fragrance are dissolved, and stirring the mixture homogeneously.
• the production method is not limited thereto.
• body shampoo it may be prepared, for example, by mixing fatty acid salts such as potassium laurate and potassium myristate with 1,2-propanediol, amino-modified aminomethylpolysiloxane, etc., adding to the mixture purified water in which the sulfated cellulose compounds, fragrance, etc. are dissolved, and stirring the mixture homogeneously.
• fatty acid salts such as potassium laurate and potassium myristate
• 1,2-propanediol, amino-modified aminomethylpolysiloxane etc.
• the production method is not limited thereto.
• bath agent it may be prepared, for example, by mixing sodium hydrogen carbonate with sodium borate, adding to the mixture a product in which sodium hyaluronate, hydroxymethylcellulose, fragrance, etc. are added to the sulfated cellulose compounds and fine sorbitol powder, adding sodium sulfate anhydrous thereto, and stirring the mixture homogeneously.
• the production method is not limited thereto.
• patch it may be prepared, for example, by dissolving 1-menthol, polyacrylic acid, carboxymethylcellulose sodium, etc. in glycerin, further adding sorbitol, caster oil, etc. thereto, adding to the mixture purified water in which the sulfated cellulose compounds are dissolved, and stirring the mixture homogeneously.
• the production method is not limited thereto.
• N,N-dimethylformamide solution having 19.7 wt% of complex of N,N-dimethylformamide and sulfuric anhydride (the complex: 620 ⁇ 10 -3 mol) was added dropwise to the mixture for 9 minutes, retaining the temperature of the content in the flask so that it did not exceed 25°C. After retaining at room temperature for 24 hours, the flask was iced, and 400 g of water was added dropwise to the reaction solution. Further, using 5M sodium hydroxide aqueous solution (165 g), pH of the mixture was adjusted to 10, and after that, using 1M HCl aqueous solution (4.3 g), pH of the reaction solution was adjusted to 7.
• N,N-dimethylformamide solution having 19.7 wt% of complex of N,N-dimethylformamide and sulfuric anhydride was prepared as described below.
• Sodium cellulose sulfate obtained in Synthesis Example 1 was diluted with 0.1% aqueous solution of glycerin to be prepared to have the concentration of 0.015 mg/mL.
• Sodium cellulose sulfate obtained in Synthesis Example 1 was diluted with ion exchange water to be prepared to have the concentration of 0.015 mg/mL.
• Example 1 Each of the prepared products in Example 1 and Comparative Example 1 was subjected to examination regarding inhibition of activity of hyaluronidase derived from bovine testis.
• the reagent used in the examination is manufactured by Wako Pure Chemical Industries, Ltd., unless otherwise specified.
• Control solution 1 was prepared in a manner similar to that for the preparation of the above-described test solutions except that 0.1 mol/L acetate buffer solution (pH 4.0) was used instead of Solution A and pure water was used instead of aqueous solution of sodium cellulose sulfate.
• the absorbance Q 1 of Control solution 1 at 585 nm was measured as in the case of the test solutions.
• Control solution 2 was prepared in a manner similar to that for the preparation of the above-described test solutions except that pure water was used instead of aqueous solution of sodium cellulose sulfate.
• the absorbance Q 2 of Control solution 2 at 585 nm was measured as in the case of the test solutions.
• the hyaluronidase activity inhibition ratio was calculated according to the formula described below.
• the hyaluronic acid degradation activity of each of a system including sodium cellulose sulfate and polyhydric alcohol, prepared in Example 1, and a system including only sodium cellulose sulfate prepared in Comparative Example 1 was examined.
• Inhibition ratio % Q 2 - Q 1 - Q E - Q 1 / Q 2 - Q 1
• Example 1 Using 0.50% aqueous solution of glycerin instead of 0.1% aqueous solution of glycerin, a solution of sodium cellulose sulfate having the concentration of 0.015 mg/mL was prepared according to Example 1. The prepared solution was subjected to examination of inhibition activity for hyaluronidase derived from bovine testis. As a result, the activity was 1.02 times higher than that of Comparative Example 1.
• Example 1 Using 10.0% aqueous solution of glycerin instead of 0.1 % aqueous solution of glycerin, a solution of sodium cellulose sulfate having the concentration of 0.015 mg/mL was prepared according to Example 1. The prepared solution was subjected to examination of inhibition activity for hyaluronidase derived from bovine testis. As a result, the activity was 1.07 times higher than that of Comparative Example 1.
• aqueous solution of 1,2-propanediol instead of aqueous solution of glycerin, solutions of sodium cellulose sulfate having the concentration of 0.015 mg/mL were prepared according to Example 1.
• concentrations of aqueous solution of 1,2-propanediol 0.10%, 0.50% and 10.0% were employed.
• the prepared solutions were independently subjected to examination of inhibition activity for hyaluronidase derived from bovine testis. As a result, the relative activity with respect to Comparative Example 1 was 1.02 times, 1.02 times and 1.03 times, respectively.
• aqueous solution of 1,3-butanediol instead of aqueous solution of glycerin, solutions of sodium cellulose sulfate having the concentration of 0.015 mg/mL were prepared according to Example 1.
• concentrations of aqueous solution of 1,3-butanediol 0.10%, 0.50% and 10.0% were employed.
• the prepared solutions were independently subjected to examination of inhibition activity for hyaluronidase derived from bovine testis. As a result, the relative activity with respect to Comparative Example 1 was 1.02 times, 1.03 times and 1.03 times, respectively.
• the toner of Production Example 22 in which pH was adjusted using citric acid and sodium citrate showed better stability compared to the aqueous solution in which pH was not adjusted.
• the cosmetic composition of the present invention has a moisturizing effect and high ability to inhibit hyaluronidase activity, and can reduce skin roughness caused by drying. Therefore, the composition may be utilized in various product forms.
• the cosmetic composition of the present invention can be provided to people with sensitive skin, who are highly sensitive to chemical substances contained in cosmetics.

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• 2007
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