WO2000048568A1 - Cosmetic compositions - Google Patents
Cosmetic compositions Download PDFInfo
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- WO2000048568A1 WO2000048568A1 PCT/US2000/004083 US0004083W WO0048568A1 WO 2000048568 A1 WO2000048568 A1 WO 2000048568A1 US 0004083 W US0004083 W US 0004083W WO 0048568 A1 WO0048568 A1 WO 0048568A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/54—Polymers characterized by specific structures/properties
- A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
- A61K2800/5426—Polymers characterized by specific structures/properties characterized by the charge cationic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/54—Polymers characterized by specific structures/properties
- A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
- A61K2800/5428—Polymers characterized by specific structures/properties characterized by the charge amphoteric or zwitterionic
Definitions
- the present invention relates to cosmetic compositions.
- cosmetic compositions with high moisturisation efficacy without high levels of tack.
- the compositions further display good in-use rub-in and absorption characteristics, as well as excellent skin feel, skin softness, and skin smoothness benefits.
- Skin is made up of several layers of cells which coat and protect the keratin and collagen fibrous proteins that form the skeleton of its structure.
- the outermost of these layers, referred to as the stratum corneum is known to be composed of 25nm protein bundles surrounded by 8nm thick layers.
- Anionic surfactants and organic solvents typically penetrate the stratum corneum membrane and, by delipidization (i.e. removal of the lipids from the stratum corneum), destroy its integrity. This destruction of the skin surface topography leads to a rough feel and may eventually permit the surfactant or solvent to interact with the keratin, creating irritation.
- compositions which will assist the stratum comeum in maintaining its barrier and water-retention functions at optimum performance in spite of deleterious interactions which the skin may encounter in washing, work, and recreation.
- Desirable properties of cosmetic cream and lotion compositions are good skin feel, water retention, moisturisation, absorption, and rub-in characteristics.
- the skin feel of a composition perceived by the consumer as skin softness or skin smoothness, is related to the emollients of a composition which form a film or layer upon application to the skin.
- the abso ⁇ tion and rub-in characteristics of a composition relate to its physical behaviour under mechanical stress which is affected by the rheological profile of the composition.
- Many cosmetic cream and lotion compositions are known to provide varying degrees of emolliency, barrier and water-retention (moisturising) benefits.
- compositions which show low levels of stickiness or tack whilst providing high levels of moisturisation, as well as providing excellent skin feel, skin softness and skin smoothness benefits.
- compositions comprising a polymeric film forming agent e.g. polyquaternium-10, a hydroxy acid, a physical exfoliant and a carrier for use in improving the smoothness of skin.
- a polymeric film forming agent e.g. polyquaternium-10
- a hydroxy acid e.g. a hydroxy acid
- a physical exfoliant e.g. a hydroxy acid
- a carrier for use in improving the smoothness of skin.
- the inco ⁇ oration of polymeric film forming agents in compositions comprising hydroxy acids is described as having an unexpected effect on the ability of the resulting compositions to increase the skin smoothness benefits.
- Polymeric film forming agents such as polyquaternium-10 are described in US-A-
- compositions comprising 4% glycerin and 0.2% polyquaternium-10.
- the compositions may further comprise emollients in combination with cationic surfactants.
- compositions comprising evaporative solvents, polymeric film forming agents, and topically active agents.
- the compositions are described as providing an enhancement in the effective activity of a topically active agent and specifically, that the film forming polymer has an ability to enhance the effective activity of the topically active agent.
- compositions comprising water soluble polyols such as glycerine and cationic film forming polymers such as polyquaternium-10 are described in for example, WO96/17917 and WO96/17916. Such compositions however also comprise greater than, or equal to, 4% of anionic or amphoteric surfactants and are intended for use as a rinse off product.
- compositions are provided with low levels of stickiness or tack.
- the compositions also show good abso ⁇ tion, insulation and water retention properties, in addition to skin feel, skin softness and skin smoothness benefits and excellent moisturisation characteristics.
- a leave-on cosmetic composition suitable for topical application to the skin comprising: a) from about 6% to from about 20% of a polyhydric alcohol, or mixtures thereof; and b) a cation containing polymer selected from cationic, basic, amphoteric and zwitterionic polymers, or mixtures thereof; wherein said composition comprises less than 4% of an anionic, zwitterionic or amphoteric surfactant.
- the compositions of the invention display high moisturisation efficacy without the associated high levels of tack, as well as good rheological, abso ⁇ tion and insulation properties, in addition to skin feel, skin softness and skin smoothness benefits.
- a cosmetic method of treatment of the skin comprising applying to the skin a composition according to the present invention.
- a cation containing polymer selected from cationic, basic, amphoteric and zwitterionic polymers, or mixtures thereof, for reducing tack in a skin care composition comprising from about 6% to from about 20% of a polyhydric alcohol, or mixtures thereof.
- a composition comprising from about 6% to from about 20% of a polyhydric alcohol, or mixtures thereof; and a cation containing polymer selected from cationic, basic, amphoteric and zwitterionic polymers, or mixtures thereof for a leave-on skin care application.
- compositions of the present invention comprise a polyhydric alcohol together with an essential cation containing polymer component, as well as various optional ingredients as indicated below. All levels and ratios are by weight of total composition, unless otherwise indicated. Chain length and degrees of ethoxylation are also specified on a weight average basis.
- tack or "tackiness”, as used herein, in relation to a leave-on composition means the ability of a composition to lightly bond to skin surfaces where the composition has been applied, upon the application of light pressure and within a short time-scale.
- sticking or "sticky” as used herein, is a term often used by consumers to describe their perception of the tack, either actual or perceived of a composition.
- the term "leave-on" in relation to skin care compositions means that it intended to be used without a rinsing step, such that after applying the composition to the skin, the leave-on composition is preferably left on the skin for a period of at least about 15 minutes, more preferably at least about 30 minutes, even more preferably at least about 1 hour, most preferably for at least several hours, e.g., up to about 12 hours.
- ampholytic means a polymer which comprises cationic and anionic monomers.
- copolymer means the combination of more than one chemically different monomer.
- zwitterionic means a compound which bears both positive and negative charges and exists as a dipolar ion in a wide range of pH.
- amphoteric as used herein, means a compound which exhibits cationic behaviour at low pH and anionic behaviour at high pH. At intermediate pH, called the isoelectric point, the compound bears both positive and negative charges i.e. it is a dipolar ion.
- basic means a polymer which shows increasing cationic charge with decreasing pH.
- skin conditioning agent means a material which is capable of providing a cosmetic conditioning benefit to the skin such as moisturization, humectancy
- non-occlusive means that the component as so described does not substantially or block the passage of air and moisture through the skin surface.
- the present compositions can be used for any suitable pu ⁇ ose.
- the present compositions are suitable for topical application to the skin.
- the skin care compositions can be in the form of creams, lotions, gels, and the like.
- the cosmetic compositions herein are in the form of an emulsion of one or more oil phases in an aqueous continuous phase.
- compositions herein comprise at least one polyhydric alcohol.
- the compositions of the present invention preferably comprise from about 6% to about 20%, more preferably from about 7% to about 15%, and especially from about 8% to about 12% by weight of the polyhydric alcohol, or mixtures thereof.
- Suitable polyhydric alcohols for use herein include polyalkylene glycols and more preferably alkylene polyols and their derivatives, including propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol and derivatives thereof, sorbitol, hydroxypropyl sorbitol, erythritol, threitol, pentaerythritol, xylitol, glucitol, mannitol, hexylene glycol, butylene glycol (e.g., 1,3-butylene glycol), hexane triol (e.g., 1,2,6- hexanetriol), trimethylol propane, neopentyl glycol, glycerine, ethoxylated glycerine and propoxylated glycerine.
- alkylene polyols and their derivatives including propylene glycol, dipropylene glycol, polypropylene glyco
- Preferred polyhydric alcohols of the present invention are selected from glycerine, butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol and derivatives thereof, hexane triol, ethoxylated glycerine and propoxylated glycerine, or mixtures thereof.
- Most preferred polyhydric alcohols for use in the present invention are glycerine and polyethylene glycol and derivatives thereof, or mixtures thereof.
- the weight ratio of the cation containing polymer to polyhydric alcohol is preferably in the range of from about 1 :200 to about 1 : 1 and more preferably in the range of from about 1 : 100 to about 1 :5.
- compositions herein comprise at least one cation containing polymer as hereinbefore defined selected from cationic, basic, amphoteric and zwitterionic polymers, or mixtures thereof.
- compositions of the present invention preferably comprise from about 0.01% to about 20%, more preferably from about 0.05% to about 5%, and especially from about 0.1% to about 1% by weight of the cation containing polymer, or mixtures thereof.
- the cation containing polymers herein are water soluble, dispersible or swellable.
- 'water swellable is meant the ability of the cation containing polymers to increase in volume or expand in aqueous solution.
- Suitable cationic polymers for compositions herein include cationic polysaccharides or derivatives thereof, cationic homo or copolymers of dimethyldiallylammonium chloride, cationic copolymers comprising vinylpyrrolidone; cationic copolymers comprising acrylic acid or derivatives thereof, cationic homo or copolymers of ethanaminium, N,N,N- trimethyl-2-[(2-methyl-l-oxo-2-propenyl)oxy]-,chloride, Polyquaternium-2 and quaternised chitosan, or mixtures thereof.
- Preferred cation containing polymer for compositions herein are cationic polysaccharides or derivatives thereof.
- Suitable non-limiting examples of cationic polysaccharides include the following: cellulose; hydroxyalkylcelluloses e.g. hydroxyethyl cellulose; cationic cellulosic derivatives having a molecular weight in the range of from 120,000 to 2,000,000, involving quaternary ammonium groupings, such as, for example a polymeric quaternary ammonium salt of hydroxyethyl cellulose reacted with a trimethyl ammonium subsitituted epoxide, more specifically, cellulose ⁇ -ether modified with ⁇ -[2-hydroxy-3- trimethylammonio)propyl]- ⁇ -hydroxypoly(oxy-l, 2-ethanediyl)chloride, known in the industry under the (CTFA) trade designation Polyquaternium-10, commercially available from Union Carbide Co ⁇ oration (Danbury, Conn., USA) as "JR" and "LR” e.g.
- starches for example, cationic starches such as, 2-hydroxy-3-trimethyl ammonium chloride propyl ether of starch, commercially available under the trade name "Sta-Loc 300" and “Sta-Loc 400” from Staley Inc.
- Suitable cationic polysaccharide gum derivatives include derivatives of polymers based on galactomannan copolymer known as guar gum.
- guar gum derivatives of polymers based on galactomannan copolymer known as guar gum.
- compounds such as hydroxypropyl guar gums, commercially available under the trade name "Jaguar HP-60", “Jaguar HP-8", “Jaguar HP-79", “Jaguar HP- 120", “Jaguar HP-200", from Rh ⁇ ne- Poulenc or "Galactasol” available from Aqualon; hydroxypropyl guar hydroxypropyltrimonium chloride commercially available under the trade name "Jaguar C-162" from Rh ⁇ ne-Poulenc; or polymeric compounds such as guar hydroxypropyltrimonium chloride, commercially available for example under the trade name "Jaguar C-14S", “Jaguar C-17", “Jaguar
- Suitable cationic homo or copolymers of dimethyldiallylammonium chloride for use herein are poly(dimethyldiallylammonium chloride) commercially available under the trade designation Polyquaternium-6 or trade names "Merquat 100" from Calgon (Pittsburg, PA, USA), "Agequat 400” from CPS Chemical Company (West Memphis, AR, USA), or "Mirapol 100” from Rh ⁇ ne-Poulenc; and the polymeric quaternary ammonium salt consisting of acrylamide and dimethyl diallyl ammonium chloride monomers commercially available under the trade designation Polyquaternium-7 or trade names "Merquat 550" from Calgon (Pittsburg, PA, USA).
- Suitable cationic copolymers comprising vinylpyrrolidone for use herein include the polyvinylpyrrolidone N,N-dimethyl aminoethyl methacrylic acid copolymer diethyl sulfate solution commercially available under the trade designation Polyquatemium-11 or trade name "Gafquat 755N” from ISP (Wayne, NJ, USA); the polymeric quaternary ammonium salt formed from methylvinylimidazolium chloride and vinylpyrrolidone commercially available under the trade designation Polyquatemium-16 or trade name "Luviquat FC 370" from BASF (Parsippany, NJ, USA); the vinylpyrrolidone/methacrylamidopropyltrimethylammonium chloride copolymer commercially available under the trade designation Polyquaternium-28 or trade name
- Gafquat HS-100 from ISP (Wayne, NJ, USA); the polymeric quaternary ammonium salt consisting of vinylpyrrolidone and quatemised imidazoline monomers commercially available under the trade designation Polyquaternium-44 or trade name "Luviquat MS- 370" from BASF (Parsippany, NJ, USA); and the quaternary ammonium salt prepared by the reaction of vinylcaprolactam and vinylpyrrolidone with methylvinylimidazolium methosulfate commercially available under the trade designation Polyquaternium-46 or trade name "Luviquat Hold” from BASF (Parsippany, NJ, USA).
- Suitable cationic copolymers comprising acrylic acid or derivatives thereof include the polymeric quaternary ammonium salt prepared by the reaction of ethylmethacrylate/abietylmethacrylate/diethylaminoethyl methacrylate copolymer with dimethyl sulfate commercially available under the trade designation Polyquatemium-12; the polymeric material; and the copolymer of acrylamide, acrylamidopropyltrimonium chloride, 2-amidopropylacrylamide sulfonate and DMAPA monomers commercially available under the trade designation Polyquaternium-43 or trade name "Bozequat 4000" from Societe Francaise Hoescht.
- Suitable cationic homo or copolymers of ethanaminium, N,N,N-trimethyl-2-[(2-methyl-l- oxo-2-propenyl)oxy]-,chloride, useful herein are the polymeric material commercially available under the trade designation Polyquaternium-45 or trade name "Plex 3073L” from Rohm GmbH (Germany); the polymeric material, ethanaminium, N,N,N-trimethyl- 2-[(2-methyl-l-oxo-2-propenyl)oxy]-,chloride, polymer with 2-propenamide commercially available under the trade designation Polyquatemium-32 or trade name "Salcare SC92" from Allied Colloids (Bradford, N.Yorkshire, UK); and the polymeric material, ethanaminium, N,N,N-trimethyl-2-[(2-methyl- 1 -oxo-2-propenyl)oxy]-,chloride, homopolymer commercially available under the trade designation Polyquatern
- Suitable cationic polymers useful herein are poly(oxy-l,2- ethanediyl)(dimethyliminio)- 1 ,3 -propanediylimino carbonyl-imino- 1 ,2-propanediyl(- dimethyliminio)-l,2-ethanediyl dichloride known in the industry as Polyquaternium-2 and commercially available under the trade name Mirapol A- 15 from Rh ⁇ ne-Poulenc; and dihydroxypropyl chitosan trimonium chloride commercially available under the trade designation Polyquatemium-29 or trade name Kytamer KC from Amerchol.
- Suitable amphoteric polymers for the compositions herein include combinations of tertiary amine monomers combined with anionic monomers and may further include non- ionic monomers, for example, a methacrylamidopropyldimethyl ammonium/acrylic acid copolymer; and polymers derived from methacrylamidoethylcarboxymethylhydroxyethyl amine monomers as shown below:
- Suitable basic polymers for the compositions herein include include homopolymers of tertiary amine derivatives and copolymers with non-ionic monomers.
- suitable materials include the polyvinylpyrrolidone/dimethylaminoethylmethacrylate copolymer prepared from vinylpyrrolidone and dimethylaminoethylmethacrylate monomers commercially available under the trade designation
- PVP/Dimethylaminoethylmethacrylate copolymer or trade name "Copolymer 845/937/958" from ISP (Wayne, NJ, USA); Amine derived polymers such as ethyleneimine polymers which conform to the general formula (CH 2 CH NH) n ; such as
- PEI-10 where n has an average value of 10, commercially available under the trade name
- n has an average value of 1400, commercially available under the tradename "Nalco 634" from Nalco.
- Suitable zwitterionic polymers for the compositions herein include polymers derived from a methacrylamidopropylbetaine monomer such as a copolymer of methacrylamidopropylbetaine and a non-ionic monomer.
- a methacrylamidopropylbetaine monomer such as a copolymer of methacrylamidopropylbetaine and a non-ionic monomer.
- An example of such a polymer is a copolymer of vinylpyrrolidone/methacrylamidopropylbetaine.
- Preferred cation containing polymers for compositions herein are cationic polymers.
- Preferred cationic polymers for use herein are cationic polysaccharides or derivatives thereof selected from cationic cellulosic derivatives, cationic polysaccharide gum derivatives, or mixtures thereof. Most preferred cationic polymeric film forming materials of the compositions of the present invention are selected from polyquaternium-
- guar hydroxypropyltrimonium chloride hydroxypropyl guar gums, or mixtures thereof. Even most preferred for use in the present invention is polyquaternium-10.
- compositions of the present invention comprise less than 4% of an anionic surfactant, zwitterionic or amphoteric surfactant, more preferably less than 2% and most preferably less than 1% of an anionic surfactant, zwitterionic or amphoteric surfactant .
- compositions of the present invention comprise an anionic surfactant
- the composition has a ratio of cation containing polymer to anionic surfactant of greater than 1.
- compositions herein may comprise from about 0% to about 2%, and more preferably from about 0.01% to about 1% of a Cs to C30 fatty acid.
- compositions of the present invention comprise at least one polymeric thickening agent.
- the polymeric thickening agents useful herein preferably have a number average molecular weight of greater than 20,000, more preferably greater than 50,000 and especially greater than 100,000.
- monovalent to multivalent metal ion levels should preferably less than 1%, more preferably less than 0.25% and even more preferably less than 0.05% so as not to unduly interfere with the stability of the polymers.
- compositions of the present invention comprise from about 0.01% to about 10%, preferably from about 0.1% to about 8% and most preferably from about 0.5% to about 5% by weight of the composition of the polymeric thickening agent, or mixtures thereof.
- compositions comprising polyol like humectants and polymeric thickening agents
- a physical association of the polyol like humectant with any polymeric thickening agents present in the composition may occur.
- This physical association between the polyol like humectant and the polymeric thickening agents may further exacerbate the stickiness already displayed in compositions comprising high levels of polyol like humectants alone.
- Preferred polymer thickening agents for use herein include non-ionic thickening agents and anionic thickening agents, or mixtures thereof.
- Suitable non-ionic thickening agents include polyacrylamide polymers, crosslinked poly(N-vinylpyrrolidones), polysaccharides, natural or synthetic gums, polyvinylpyrrolidone, and polyvinylalcohol.
- Suitable anionic thickening agents include acrylic acid/ethyl acrylate copolymers, carboxyvinyl polymers and crosslinked copolymers of alkyl vinyl ethers and maleic anhydride.
- Particularly preferred thickening agents for use herein are the non-ionic polyacrylamide polymers, and acrylic acid/ethyl acrylate copolymers, or mixtures thereof.
- non-ionic polyacrylamide polymers useful herein are substituted polyacrylamides, branched or unbranched. These polymers are non-ionic water dispersible polymers which can be formed from a variety of monomers including acrylamide and methacrylamide which are unsubstituted or substituted with one or two alkyl groups (preferably C ⁇ -C 5 ).
- acrylate amides and methacrylate amides in which the amide nitrogen is unsubstituted, or substituted with one or two C ⁇ -C 5 alkyl groups (preferably: methyl, ethyl or propyl), for example, acrylamide, methacrylamide, N- methacrylamide, N-methylmethacrylamide, N,N-dimethylmethacrylamide and N,N- dimethylacrylamide.
- C ⁇ -C 5 alkyl groups preferably: methyl, ethyl or propyl
- acrylamide, methacrylamide, N- methacrylamide, N-methylmethacrylamide, N,N-dimethylmethacrylamide and N,N- dimethylacrylamide These monomers are generally disclosed in US Pat. No. 4,963,348 to Bolich, Jr. et al., issued Oct, 16., 1990, inco ⁇ orated by reference herein.
- These copolymers may optionally be formed using conventional neutral crosslinking agents such as dialkenyl compounds.
- 1,000,000 preferably greater than about 1,500,000 and range up to about 30,000,000.
- these non-ionic polyacrylamides are predispersed in a water-immiscible solvent such as mineral oil and the like, containing a high HLB surfactant (HLB from about 7 to about
- polyacrylamide polymers useful herein include multi-block copolymers of acrylamides and substituted acrylamides with acrylic acids and substituted acrylic acids.
- Commercially available examples of these multi-block copolymers include Hypan SR150H, SS500V, SS500W, SSSA100H, from Lipo Chemicals, Inc., (Patterson, NJ).
- Crosslinked poly(N-vinylpyrrolidones) useful herein include those described in U.S. Patent No. 5,139,770, to Shih et al, issued August
- gelling agents typically contain from about 0.25% to about 1% by weight of a crosslinking agent selected from the group consisting of divinyl ethers and diallyl ethers of terminal diols containing from about 2 to about 12 carbon atoms, divinyl ethers and diallyl ethers of polyethylene glycols containing from about 2 to about 600 units, dienes having from about 6 to about 20 carbon atoms, divinyl benzene, vinyl and allyl ethers of pentaerythritol, and the like.
- these gelling agents typically have a viscosity from about
- cps 25,000 mPa.s (cps) to about 40,000 mPa.s (cps) when measured as a 5%> aqueous solution at 25°C using a Brookfield RVT viscometer with Spindle #6 at 10 ⁇ .
- Commercially available examples of these polymers include ACP-1120, ACP-1179, and ACP-1180, available from International Speciality Products (Wayne, NJ).
- Polysaccharides A wide variety of polysaccharides are suitable for use herein.
- polysaccharides are meant gelling agents containing a backbone of repeating sugar (i.e. carbohydrate) units.
- Non-limiting examples of polysaccharide gelling agents include those selected from the group consisting of cellulose, carboxymethyl hydroxyethylcellulose, cellulose acetate propionate carboxylate, hydroxyethylcellulose, hydroxyethyl ethylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, methyl hydroxyethylcellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof. Also useful herein are the alkyl substituted celluloses.
- the hydroxy groups of the cellulose polymer is hydroyxalkylated (preferably hydroxyethylated or hydroxypropylated) to form a hydroxyalkylated cellulose which is then further modified with a C10-C30 straight chain or branched chain alkyl group through an ether linkage.
- these polymers are ethers of C10-C30 straight or branched chain alcohols with hydroxyalkylcelluloses.
- alkyl groups useful herein include those selected from the group consisting of stearyl, isostearyl, lauryl, myristyl, cetyl, isocetyl, cocoyl (i.e.
- the hydroxyethyl molar substitution is greater than 3.0.
- Preferred among the alkyl hydroxyalkyl cellulose ethers is the material given the CTFA designation cetyl hydroxyethylcellulose, which is the ether of cetyl alcohol and hydroxyethylcellulose. This material is sold under the tradename Natrosol® CS Plus from Aqualon Co ⁇ oration.
- polysaccharides include scleroglucans comprising a linear chain of (l->3) linked glucose units with a (l->6) linked glucose every three units, a commercially
- Gums Other thickening agents useful herein include materials selected from acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, camitine, carrageenan, dextrin, gelatin, gellan gum, hectorite, hyaluroinic acid, hydrated silica, hydroxypropyl chitosan, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, and mixtures thereof. Also useful are acrylic acid/ethyl acrylate copolymers and the carboxyvinyl polymers sold by the B.F. Goodrich Company under the trade mark of Carbopol resins. Suitable
- Carbopol resins are described in WO98/22085.
- Preferred crosslinking agents are C4-C20 dienes, preferably C6 to C16 dienes, and most preferably C8 to C12 dienes.
- a particularly preferred copolymer is one formed from methyl vinyl ether and maleic anhydride wherein the copolymer has been crosslinked with decadiene, and wherein the polymer when diluted as a 0.5% aqueous solution at pH 7 at 25°C has a viscosity of 50,000-70,000 mPa.s (cps) when measured using a Brookfield RTV viscometer, spindle #7 at 10 rpm.
- This copolymer has the CTFA designation PVM/MA decadiene crosspolymer and is commercially available as Stabileze T M 06 from International Specialty Products (Wayne NJ). Oil Phase
- the cosmetic compositions herein are in the form of an emulsion of one or more oil phases in an aqueous continuous phase, each oil phase comprises a single oily component or a mixture of oily components in miscible or homogeneous form. Different oil phases contain different materials or combinations of materials from each other.
- the total level of oil phase components in the compositions of the invention is typically from about 0.1% to about 60%>, preferably from about 1% to about 30%, more preferably from about 1% to about 10% and most preferably from 1.3% to 8%.
- the oil phase components of the compositions herein comprise an emollient material or mixtures thereof, a polyol carboxylic acid ester and a silicone oil, or mixtures thereof.
- the oil phase preferably comprises additional oily components such as a natural or synthetic oils selected from mineral, vegetable, and animal oils, fats and waxes, fatty acid esters, fatty alcohols, fatty acids and mixtures thereof.
- oily components are present in an amount of from about 0.1% to about 15%, more preferably from about 1% to about 10% by weight of composition.
- Preferred for use herein are for example, saturated and unsaturated fatty alcohols such as behenyl alcohol, cetyl alcohol and stearyl alcohol and hydrocarbons such as mineral oils or petrolatum. Further examples suitable for use herein are disclosed in WO98/22085. Preferred embodiments herein comprise from about 0.1% to about 10% by weight of an unsaturated fatty acid or ester as described in WO98/22085.
- compositions of the present invention can comprise emollient materials selected from branched chain hydrocarbons having an weight average molecular weight of from about 100 to about 15,000, preferably from about 100 to 1000; compounds of formula I:
- Rl is selected from H or CH3, R ⁇ , R3 and R ⁇ are independently selected from
- R ⁇ is selected from optionally hydroxy or C 1 -C4 alkyl substituted benzyl and Rg is selected from C1-C20 branched or straight chain alkyl; and mixtures thereof.
- Suitable branched chain hydrocarbons for use herein are selected from isododecane, isohexadecane, isoeicosane, isooctahexacontane, isohexapentacontahectane, isopentacontaoctactane, and mixture thereof.
- Suitable for use herein are branched chain aliphatic hydrocarbons sold under the trade name Permethyl (RTM) and commercially available from Presperse Inc., P.O. Box 735, South Plainfield, NJ. 07080, U.S.A.
- Suitable ester emollient materials of Formula I above include, but are not limited to, methyl isostearate, isopropyl isostearate, isostearyl neopentanoate. isononyl isononanoate, isodecyl octanoate, isodecyl isononanoate, tridecyl isononanoate, myristyl octanoate, octyl pelargonate, octyl isononanoate, myristyl myristate, myristyl neopentanoate, myristyl octanoate, myristyl propionate, isopropyl myristate and mixtures thereof.
- Suitable ester emollient materials of Formula (II) include but are not limited to C 12- 15 alkyl benzoates.
- Preferred emollients for use herein are isohexadecane, isooctacontane, isononyl i ' sononanoate, isodecyl octanoate, isodecyl isononanoate, tridecyl isononanoate, myristyl octanoate, octyl isononanoate, myristyl myristate, methyl isostearate, isopropyl isostearate, C12-15 alkyl benzoates and mixtures thereof.
- emollients for use herein are isohexadecane, isononyl isononanoate, . methyl isostearate, isopropyl isostearate, or mixtures thereof.
- the emollient material is preferably present in the compositions at a level of from about 0.1%) to about 10%), preferably from about 0.1% to about 8%, especially from about 0.5% to about 5% by weight of composition.
- compositions of the present invention may further comprise as an additional emollient, a polyol carboxylic acid ester.
- compositions of the present invention preferably comprise from about 0.01% to about 20%), more preferably from about 0.1 % to about 15%, and especially from about 0.1% to about 10% by weight of the polyol ester.
- the level of polyol ester by weight of the oil in the composition is preferably from about 1% to about 30%>, more preferably from about 5% to about 20%).
- the weight ratio of the carboxylic acid polyol ester to the emollient material is preferably in the range of from about 5: 1 to about 1 :5, more preferably in the range of from 2:1 to about 1 :2.
- the preferred polyol polyesters useful in this invention are C1-C30 mono- and polyesters of sugars and related materials.
- esters are derived from a sugar or polyol moiety and one or more carboxylic acid moieties. Depending on the constituent acid and sugar, these esters can be in either liquid or solid form at room temperature. Examples include: glucose tetraoleate, the galactose tetraesters of oleic acid, the sorbitol tetraoleate, sucrose tetraoleate, sucrose pentaoleate, sucrose hexaoleate, sucrose heptaoleate, sucrose octaoleate, sorbitol hexaester in which the carboxylic acid ester moieties are palmitoleate and arachidate in a 1 :2 molar ratio, and the octaester of sucrose wherein the esterifying carboxylic acid moieties are laurate, linoleate and behenate in a 1:3:4 molar ratio.
- Silicone Oil The present compositions preferably comprise, at least one silicone oil phase.
- Silicone oil phase(s) generally comprises from about 0.1% to about 20%, preferably from about 0.5% to about 10%), more preferably from about 0.5% to about 5%, of the composition.
- The, or each, silicone oil phase preferably comprises one or more silicone components.
- Silicone components can be fluids, including straight chain, branched and cyclic silicones.
- Suitable silicone fluids useful herein include silicones inclusive of polyalkyl siloxane fluids, polyaryl siloxane fluids, cyclic and linear polyalkylsiloxanes, polyalkoxylated silicones, amino and quaternary ammonium modified silicones, polyalkylaryl siloxanes or a polyether siloxane copolymer and mixtures thereof.
- the silicone fluids can be volatile or non- volatile.
- Silicone fluids generally have a weight average molecular weight of less than about 200,000. Suitable silicone fluids have a molecular weight of about 100,000 or less, preferably about 50,000 or less, most preferably about 10,000 or less.
- the silicone fluid is selected from silicone fluids having a weight average molecular weight in the range from about 100 to about 50,000 and preferably from about 200 to about 40,000.
- silicone fluids have a viscosity ranging from about 0.65 to about 600,000 mm 1 , preferably from about 0.65 to about 10,000 mm 2 .s -1 at 25°C. The viscosity can be measured by means of a glass capillary viscometer as set forth in Dow Coming Co ⁇ orate Test Method CTM0004, July 29, 1970.
- Suitable polydimethyl siloxanes that can be used herein include those available, for example, from the General Electric Company as the SF and Viscasil (RTM) series and from Dow Coming as the Dow Coming 200 series.
- essentially non-volatile polyalkylarylsiloxanes for example, polymethylphenylsiloxanes, having viscosities of about 0.65 to 30,000 mm ⁇ .s " ' at 25°C.
- siloxanes are available, for example, from the General Electric Company as SF 1075 methyl phenyl fluid or from Dow Coming as 556 Cosmetic Grade Fluid.
- Cyclic polydimethylsiloxanes suitable for use herein are those having a ring structure inco ⁇ orating from about 3 to about 7 (CH3)2SiO moieties.
- the silicone fluid is selected from dimethicone, decamethylcyclopentasiloxane, octamethylcyclotetrasiloxane, phenyl methicone, and mixtures thereof.
- Silicone gums can also be used herein.
- the term "silicone gum” herein means high molecular weight silicones having a weight average molecular weight in excess of about 200,000 and preferably from about 200,000 to about 4,000,000. Iincluded are nonvolatile polyalkyl and polyaryl siloxane gums.
- a silicone oil phase comprises a silicone gum or a mixture of silicones including the silicone gum.
- silicone gums typically have a viscosity at 25°C in excess of about 1,000,000 mrn ⁇ s'l.
- the silicone gums include dimethicones as described by Petrarch and others including US-A-4,152,416, May 1, 1979 to Spitzer, et al, and Noll, Walter, Chemistry and Technology of Silicones. New York: Academic Press 1968. Also describing silicone gums are General Electric Silicone Rubber Product Data Sheets SE 30, SE 33, SE 54 and SE 76.
- silicone gums include polydimethylsiloxane, (polydimethylsiloxane)(methylvinylsiloxane) copolymer, poly(dimethylsiloxane)- (diphenyl)(methylvinylsiloxane) copolymer and mixtures thereof.
- Preferred silicone gums for use herein are silicone gums having a molecular weight of from about 200,000 to about 4,000,000 selected from dimethiconol, and dimethicone and mixtures thereof.
- a silicone phase herein preferably comprises a silicone gum inco ⁇ orated into the composition as part of a silicone gum-fluid blend.
- the silicone gum When the silicone gum is inco ⁇ orated as part of a silicone gum-fluid blend, the silicone gum preferably constitutes from about 5% to about 40%), especially from about 10% to 20% by weight of the silicone gum- fluid blend.
- Suitable silicone gum-fluid blends herein are mixtures consisting essentially of: (i) a silicone having a molecular weight of from about 200,000 to about 4,000,000 selected from dimethiconol, fluorosilicone and dimethicone and mixtures thereof; and (ii) a carrier which is a silicone fluid, the carrier having a viscosity from about 0.65 mm ⁇ .s " !
- silicone gum-based component has a final viscosity of from about 100 mm ⁇ .s' ⁇ to about 100,000 mm ⁇ .s'l, preferably from 500 mm ⁇ .s'l to about 10,000 mm ⁇ .s'l
- An especially preferred silicone-gum fluid blend based component for use in the compositions herein is a dimethiconol gum having a molecular weight of from about
- silicone components suitable for use in a silicone oil phase herein are crosslinked polyorganosiloxane polymers, optionally dispersed in a fluid carrier.
- the crosslinked polyorganosiloxane polymers together with its carrier (if present) comprises 0.1 % to about 20%, preferably from about 0.5% to about 10%>, more preferably from about 0.5% to about 5%> of the composition.
- Such polymers comprise polyorganosiloxane polymers crosslinked by a crosslinking agent. Suitable crosslinking agents are disclosed in WO98/22085. Examples of suitable polyorganosiloxane polymers for use herein include methyl vinyl dimethicone, methyl vinyl diphenyl dimethicone and methyl vinyl phenyl methyl diphenyl dimethicone.
- crosslinked polyorganosiloxane polymers for use herein are silicone vinyl crosspolymer mixtures available under the tradename KSG supplied by Shinetsu Chemical Co., Ltd, for example KSG-15, KSG- 16, KSG-17, KSG-18. These materials contain a combination of crosslinked polyorganosiloxane polymer and silicone fluid. Particularly preferred for use herein especially in combination with the organic amphiphilic emulsifier material is KSG-18.
- KSG-15, KSG- 16, KSG-17 and KSG-18 are cyclomethicone dimethicone/vinyl dimethicone crosspolymer, dimethicone dimethicone/vinyl dimethicone crosspolymer, cyclomethicone dimethicone/vinyl dimethicone crosspolymer and phenyl trimethicone dimethicone/phenyl vinyl dimethicone crosspolymer, respectively.
- silicone components suitable for use in a silicone oil phase herein 5 includes polydiorganosiloxane-polyoxyalkylene copolymers containing at least one polydiorganosiloxane segment and at least one polyoxyalkylene segment.
- Suitable polydiorganosiloxane segments and copolymers thereof are disclosed in WO98/22085.
- Suitable polydiorganosiloxane-polyalkylene copolymers are available commercially under the tradenames Belsil (RTM) from Wacker-Chemie GmbH, Geschafts Symposium S, Postfach -10 D-8000 Kunststoff 22 and Abil (RTM) from Th.
- a particularly preferred copolymer fluid blend for use herein includes Dow Coming DC3225C which has the CTFA designation Dimethicone/Dimethicone copolyol.
- a further preferred component of the compositions herein is an organic amphiphilic surfactant which is capable of forming smectic lyotropic crystals in product or when the product is being applied to the skin at ambient or elevated temperatures.
- the organic amphiphilic surfactant has been found to be especially valuable herein for improving the stability and skin feel of the compositions of the invention.
- the compositions Preferably the compositions
- non-ionic amphiphilic surfactants at a level of from about 0.01 % to about 4%, preferably from about 0.05%> to about 3%, and more preferably from about 0.08%) to about 2%.
- Preferred classes of non-ionic amphiphilic surfactants suitable herein and their properties are disclosed in WO98/22085, inco ⁇ orated herein by reference.
- Preferred herein are the mono-, di- and tri-acyl sugar esters and mixtures thereof wherein
- the acyl substituents contain from about 8 to about 24, preferably from about 8 to about 20 carbon atoms and 0,1 or 2 unsaturated moieties and polyethylene glycol derivatives.
- High preferred herein is a fatty acid ester blend based on a mixture of sorbitan or sorbitol fatty acid ester and sucrose fatty acid ester, the fatty acid in each instance being preferably Cg-C24, more preferably C10-C20.
- compositions of the present invention may comprise additional humectants which are preferably present at a level of from about 0.01% to about 20%, more preferably from about 0.1% to about 15% and especially from about 0.5% to about 15%.
- Suitable additional humectants useful herein are sodium 2-pyrrolidone-5-carboxylate (NaPCA), guanidine; glycolic acid and glycolate salts (e.g. ammonium and quaternary alkyl ammonium); lactic acid and lactate salts (e.g. ammonium and quaternary alkyl ammonium); aloe vera in any of its variety of forms (e.g., aloe vera gel); hyaluronic acid and derivatives thereof (e.g., salt derivatives such as sodium hyaluronate); lactamide monoethanolamine; acetamide monoethanolamine; urea; panthenol and derivatives thereof; and mixtures thereof.
- NaPCA sodium 2-pyrrolidone-5-carboxylate
- guanidine glycolic acid and glycolate salts
- lactic acid and lactate salts e.g. ammonium and quaternary alkyl ammonium
- aloe vera in any of
- At least part (up to about 5% by weight of composition) of an additional humectant can be inco ⁇ orated in the form of an admixture with a particulate cross-linked hydrophobic acrylate or methacrylate copolymer, itself preferably present in an amount of from about 0.1%) to about 10%), which can be added either to the aqueous or disperse phase.
- This copolymer is particularly valuable for reducing shine and controlling oil while helping to provide effective moisturization benefits and is described in further detail by WO96/03964, inco ⁇ orated herein by reference.
- Preferred additional humectants are selected from urea, panthenol and mixtures thereof.
- urea is preferably present in a level of from about 0.1% to about 20%, more preferably from about 0.5% to about 10% and especially from about 1% to about 5% by weight of composition.
- the oil phase and organic amphiphilic surfactant when present are premixed in water at a temperature above the Kraft Point of the organic amphiphilic surfactant (but preferably below about 60°C) to form a liquid crystal/oil in water dispersion prior to addition of the urea.
- the urea is found to be especially effective herein in combination with the amphiphilic emulsifier surfactant and the polyol fatty acid polyester for providing outstanding skin moisturisation and softening in the context of an oil-in-water skin care emulsion composition.
- optional ingredients such as additional thickening agents, non-occlusive moisturisers, neutralising agents, perfumes, colouring agents and surfactants, can also be added to the skin compositions herein.
- thickeners useful herein are water-soluble glyceryl poly(meth)acrylate lubricants (such as Hispagel®); polyglycerylmethacrylate lubricants available under the trademark Lubrajel (RTM) from Guardian Chemical Co ⁇ oration, 230 Marcus Blvd., Hauppage, N.Y. 11787, and mixtures thereof.
- Lubrajels can be described as hydrates or clathrates which are formed by the reaction of sodium glycerate with a methacrylic acid polymer. Thereafter, the hydrate or clathrate is stabilized with a small amount of propylene glycol, followed by controlled hydration of the resulting product.
- Lubrajels are marketed in a number of grades of varying glycerate: polymer ratio and viscosity. Suitable Lubrajels include Lubrajel TW, Lubrajel CG and Lubrajel MS, Lubrajel WA, Lubrajel DV and so-called Lubrajel Oil.
- additional cation containing polymers may be added to the compositions herein.
- additional cation containing polymers include an ampholytic polymer.
- Suitable ampholytic polymers include the copolymer of dimethyldiallyl ammonium chloride and acrylic acid commercially available under the trade designation Polyquaternium-22 or trade name "Merquat 280" from Calgon (Pittsburg, PA, USA); the polymeric quaternary ammonium salt of acrylic acid, diallyl dimethyl ammonium chloride and acrylamide commercially available under the trade designation Polyquatemium-39 or trade name "Merquat Plus 3330" and “Merquat Plus 3331” from Calgon (Pittsburg, PA, USA) and the quaternary ammonium salt formed by the polymerisation of acrylic acid, methyl acrylate and methacrylamidopropyltrimonium chloride commercially available under the trade designation Polyquaternium-47 or trade name "Merquat 200 IN” from Calgon (Pittsburg, PA, USA
- Neutralizing agents suitable for use in neutralizing acidic group containing hydrophilic gelling agents herein include sodium hydroxide, potassium hydroxide, ammonium hydroxide, monoethanolamine, diethanolamine, amino methyl propanol, tris-buffer and triethanolamine.
- compositions of the invention are generally in emulsion form and are preferably formulated so as to have a product viscosity of at least about 4,000 mPa.s and preferably in the range from about 4,000 to about 300,000 mPa.s, more preferably from about 8,000 to about 250,000 mPa.s and especially from about 10,000 to about 200,000 mPa.s and even more especially from about 10,000 to about 150,000 mPa.s (25°C, neat, Brookfield RVT, T-C Spindle at 5 ⁇ ms and Heliopath Stand).
- compositions of the invention can also contain from about 0.01%> to about 10%, preferably from about 0.1% to about 5% of a panthenol moisturizer.
- the panthenol moisturizer can be selected from D-panthenol ([R]-2,4-dihydroxy-N-[3-hydroxypropyl)]- 3,3-dimethylbutamide), DL-panthenol, calcium pantothenate, royal jelly, panthetine, pantotheine, panthenyl ethyl ether, pangamic acid, pyridoxin, pantoyl lactose and Vitamin B complex.
- keratolytic agents/desquamation agents such as salicylic acid; proteins and polypeptides and derivatives thereof; water-soluble or solubilizable preservatives preferably at a level of from about 0.1% to about 5%>, such as Germall 115, methyl, ethyl, propyl and butyl esters of hydroxybenzoic acid, benzyl alcohol, EDTA, Euxyl (RTM) K400, Bromopol (2-bromo-2-nitropropane-l,3-diol) and phenoxypropanol; anti-bacterials such as Irgasan (RTM) and phenoxyethanol (preferably at levels of from 0.1% to about 5%); soluble or colloidally-soluble moisturising agents such as hylaronic acid and starch-grafted sodium polyacrylates such as Sanwet (RTM) LM-1000, JJVt-1500 and IM-2500 available from Celanese Superabsorbent Materials, Portsmith
- sunscreening agents are also useful herein.
- a wide variety of sunscreening agents are described in U.S. Patent No. 5,087,445, to Haffey et al., issued February 11, 1992; U.S. Patent No. 5,073,372, to Turner et al., issued December 17, 1991 ; U.S. Patent No. 5,073,371, to Turner et al. issued December 17, 1991; and Segarin, et al., at Chapter VIII, pages 189 et seq., of Cosmetics Science and Technology.
- sunscreens which are useful in the compositions of the invention are those selected from 2-ethylhexyl p-methoxycinnamate, 2-ethylhexyl N,N-dimethyl-p-aminobenzoate, p- aminobenzoic acid, 2-phenylbenzimidazole-5-sulfonic acid, octocrylene, oxybenzone, homomenthyl salicylate, octyl salicylate, 4,4'-methoxy-t-butyldibenzoylmethane, 4- isopropyl dibenzoylmethane, 3-benzylidene camphor, 3-(4-methylbenzylidene) camphor, titanium dioxide, zinc oxide, silica, iron oxide, Parsol MCX, Eusolex 6300, Octocrylene, Parsol 1789, and mixtures thereof. Still other useful sunscreens are those disclosed in U.S. Patent No. 4,937,370, to Sabatelli, issued June
- the sunscreens can comprise from about 0.5%> to about 20%> of the compositions useful herein. Exact amounts will vary depending upon the sunscreen chosen and the desired Sun Protection Factor (SPF). SPF is a commonly used measure of photoprotection of a sunscreen against erythema. See Federal Register, Vol. 43, No. 166, pp. 38206-38269, August 25, 1978.
- compositions of the present invention can additionally comprise from about 0.1% to about 5% by weight of aluminium starch octenylsuccinate.
- Aluminium starch octenylsuccinate is the aluminium salt of the reaction product of octenylsuccinic anhydride with starch and is commercially available under the trade name from Dry Flo National Starch & Chemical Ltd. Dry Flo is useful herein from the viewpoint of skin feel and application characteristics.
- compositions of the present invention comprise particulate materials having a refractive index of from about
- the particulate materials being dispersed in the composition and having a median particle size of from about 2 to about 30 ⁇ m.
- the particulates useful herein have relatively narrow distributions, by which is meant that more than 50% of the particles fall within 3 ⁇ m either side of the respective median value. Also preferred is that more than 50%, preferably more than 60%, more preferably more than 70% of particles fall within the size ranges prescribed for the respective median values.
- Suitable particulate materials are organic or organosilicone and preferably organosilicone polymers. Preferred particles are free-flowing, solid, materials. By “solid” is meant that the particles are not hollow.
- Suitable organic particulate materials include those made of polymethylsilsesquioxane, referenced above, polyamide, polythene, polyacrylonitrile, polyacrylic acid, polymethacrylic acid, polystyrene, polytetrafluoroethylene (PTFE) and poly(vinylidene chloride). Copolymers derived from monomers of the aforementioned materials can also be used.
- Inorganic materials include silica and boron nitride.
- Tospearl® 145 which has a median particle size of about 4.5 ⁇ m
- EA-209® from Kobo which is an ethylene / acrylic acid copolymer having a median particle size of about 10 ⁇ m, or mixtures thereof.
- pigments are titanium dioxide, predispersed titanium dioxide from Kobo e.g. Kobo GWL75CAP, iron oxides, acyglutamate iron oxides, ultramarine blue, D&C dyes, carmine, and mixtures thereof. Depending upon the type of composition, a mixture of pigments will normally be used.
- the preferred pigments for use herein from the viewpoint of moisturisation, skin feel, skin appearance and emulsion compatibility are treated pigments.
- the pigments can be treated with compounds such as amino acids, silicones, lecithin and ester oils.
- compositions of the present invention can also comprise a safe and effective amount of a vitamin B3 compound.
- the compositions of the present invention preferably comprise from about 0.01% to about 50%, more preferably from about 0.1% to about 20%), even more preferably from about 0.5% to about 10%, and still more preferably from about 1% to about 8%, most preferably from about 1.5% to about 6%, of the vitamin B3 compound.
- vitamin B3 compound means a compound having the formula:
- R is - CONH2 (i.e., niacinamide), - COOH (i.e., nicotinic acid) or - CH2OH (i.e., nicotinyl alcohol); derivatives thereof; and salts of any of the foregoing.
- exemplary derivatives of the foregoing vitamin B3 compounds include nicotinic acid esters, including non-vasodilating esters of nicotinic acid, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxide and niacinamide N-oxide.
- Suitable esters of nicotinic acid include nicotinic acid esters of C ⁇ -C22 > preferably C1-
- non-vasodilating means that the ester does not commonly yield a visible flushing response after application to the skin in the subject compositions (the majority of the general population would not experience a visible flushing response, although such compounds may cause vasodilation not visible to the naked eye).
- Non-vasodilating esters of nicotinic acid include tocopherol nicotinate and inositol hexanicotinate; tocopherol nicotinate is preferred.
- a more complete description of vitamin B3 compounds is given in WO 98/22085. Examples of the above vitamin B3 compounds are well known in the art and are commercially available from a number of sources, e.g., the Sigma Chemical Company (St. Louis, MO); ICN Biomedicals, Inc. (Irvin, CA) and Aldrich Chemical Company (Milwaukee, WI).
- One or more vitamin B3 compounds may be used herein.
- Preferred vitamin B3 compounds are niacinamide and tocopherol nicotinate. Niacinamide is more preferred.
- the compositions of the present invention also contain a retinoid.
- the vitamin B3 compound and retinoid provide unexpected benefits in regulating skin condition, especially in therapeutically regulating signs of skin aging, more especially wrinkles, lines, and pores. Without intending to be bound or otherwise limited by theory, it is believed that the vitamin B3 compound increases the conversion of certain retinoids to trans-retinoic acid, which is believed to be the biologically active form of the retinoid, to provide synergistic regulation of skin condition (namely, increased conversion for retinol, retinol esters, and retinal).
- the vitamin B3 compound unexpectedly mitigates redness, inflammation, dermatitis and the like which may otherwise be associated with topical application of retinoid (often referred to, and hereinafter alternatively referred to as "retinoid dermatitis").
- retinoid dermatitis also referred to, and hereinafter alternatively referred to as "retinoid dermatitis"
- the combined vitamin B3 compound and retinoid tend to increase the amount and activity of thioredoxin, which tends to increase collagen expression levels via the protein AP-1. Therefore, the present invention enables reduced active levels, and therefore reduced potential for retinoid dermatitis, while retaining significant positive skin conditioning benefits.
- higher levels of retinoid may still be used to obtain greater skin conditioning efficacy, without undesirable retinoid dermatitis occurring.
- retinoid includes all natural and/or synthetic analogs of Vitamin A or retinol-like compounds which possess the biological activity of Vitamin A in the skin as well as the geometric isomers and stereoisomers of these compounds.
- the retinoid is preferably retinol, retinol esters (e.g., C2 - C22 alkyl esters of retinol, including retinyl palmitate, retinyl acetate, retinyl proprionate), retinal, and/or retinoic acid (including all- trans retinoic acid and/or 13-cis-retinoic acid), more preferably retinoids other than retinoic acid.
- retinoids include all natural and/or synthetic analogs of Vitamin A or retinol-like compounds which possess the biological activity of Vitamin A in the skin as well as the geometric isomers and stereoisomers of these compounds.
- the retinoid is preferably retinol, retinol esters
- retinoids are retinol, retinyl palmitate, retinyl acetate, retinyl proprionate, retinal and combinations thereof. More preferred are retinol and retinyl palmitate.
- the retinoid may be included as the substantially pure material, or as an extract obtained by suitable physical and/or chemical isolation from natural (e.g., plant) sources.
- compositions preferably contain from or about 0.005%> to or about 2%, more preferably 0.01% to about 2% retinoid.
- Retinol is most preferably used in an amount of from or about 0.01%> to or about 0.15%; retinol esters are most preferably used in an amount of from about 0.01%> to about 2% (e.g., about 1%).
- the pH of the compositions herein is greater than 4, preferably greater than 4.25 and more preferably greater than 4.75, also preferably less than 9, more preferably less than 8 and even more preferably less than 7.
- the water content of the compositions herein is generally from about 30%> to about 98.89%, preferably from about 50% to about 95%) and especially from about 60% to about 90% by weight.
- compositions of the invention are preferably in the form of a moisturising cream or lotion, which can be applied to the skin as a leave-on product.
- the invention is illustrated by the following examples.
- Arlatone 2121 5 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
- Myrj 59 7 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Stearyl Alcohol 0.38 0.40 0.32 0.48 0.80 1.2 Cetyl Alcohol 0.80 1.00 0.72 0.72 1.80 0.80
- DC Q2-1403 10 1.60 1.60 1.80 1.50 2.00 2.50 Tocopherol acetate 0.50 0.25 0.25 0.75 0.50 -
- compositions are made as follows:
- a first premix of anionic thickening agents (if present), glycerine/TiO2 premix, cation containing polymer, Arlatone 2121 when present, and other water soluble ingredients apart from urea, is prepared by admixing in water and heating to about 80°C.
- Sepigel 305 (polyacrylamide) is not added until the mixture is cooled to 60°C.
- the Sepigel 305 is added under shear and then the NaOH solution added.
- EDTA, silicone oil, and then urea solution (lg dissolved in 1ml of water) are then added to the resulting oil-in-water emulsion and the mixture is cooled before adding minor ingredients.
- the composition is ready for packaging.
- compositions display high moisturisation efficacy without the associated high levels of tack, as well as good rheological, abso ⁇ tion and insulation properties, in addition to skin feel, skin softness and skin smoothness benefits.
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Abstract
Description
Claims
Priority Applications (8)
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JP2000599360A JP2003518003A (en) | 1999-02-19 | 2000-02-17 | Cosmetic composition |
CN00805439A CN1346261A (en) | 1999-02-19 | 2000-02-17 | Cosmetic compositions |
AU34942/00A AU772497B2 (en) | 1999-02-19 | 2000-02-17 | Cosmetic compositions |
CA002362352A CA2362352A1 (en) | 1999-02-19 | 2000-02-17 | Cosmetic compositions |
EP00913504A EP1257252A1 (en) | 1999-02-19 | 2000-02-17 | Cosmetic compositions |
BR0008336-4A BR0008336A (en) | 1999-02-19 | 2000-02-17 | Non-rinse cosmetic composition |
PCT/US2000/004083 WO2000048568A1 (en) | 1999-02-19 | 2000-02-17 | Cosmetic compositions |
KR1020017010581A KR20010102276A (en) | 1999-02-19 | 2000-02-17 | Cosmetic compositions |
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GBGB9903926.5A GB9903926D0 (en) | 1999-02-19 | 1999-02-19 | Cosmetic compositions |
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PCT/US2000/004083 WO2000048568A1 (en) | 1999-02-19 | 2000-02-17 | Cosmetic compositions |
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JP (1) | JP2003518003A (en) |
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CN (1) | CN1346261A (en) |
AU (1) | AU772497B2 (en) |
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WO2000071093A1 (en) * | 1999-05-25 | 2000-11-30 | The Procter & Gamble Company | Niacinamide compositions with reduced tack |
WO2008066193A1 (en) | 2006-11-27 | 2008-06-05 | Chisso Corporation | Cosmetic composition |
US9770609B2 (en) | 2015-04-01 | 2017-09-26 | Neat Feat Products Limited | Urea based skin treatment |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN102065850A (en) * | 2008-07-07 | 2011-05-18 | 博磊科技股份有限公司 | Electrostatically charged nasal application multipurpose product and method |
JP2012509250A (en) * | 2008-08-28 | 2012-04-19 | トルテック コーポレーション | Antihistamine and antihistamine-like nasal product and method |
CN101721341A (en) * | 2009-11-12 | 2010-06-09 | 中国人民解放军海军医学研究所 | Washing-free bath lotion and preparation method thereof |
JP5955279B2 (en) * | 2013-07-04 | 2016-07-20 | アース製薬株式会社 | How to increase the amount of moisturizing ingredients |
KR102390010B1 (en) * | 2020-01-17 | 2022-04-26 | 김범수 | Anti-irritant cosmetic composition containing guar gum derivative |
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US4438095A (en) * | 1980-03-18 | 1984-03-20 | Societe Anonyme Dite: L'oreal | New cosmetic compositions for hair or skin conditioning, and the application thereof |
US4675178A (en) * | 1985-05-02 | 1987-06-23 | Calgon Corporation | Use of cationic polymers (polydimethyldialkyl ammonium chloride-acrylamide copolymers and dimethyldialkyl ammonium chloride) to increase deposition and/or retention of active agent (S) of deodorant formulations on surfaces |
EP0501714A2 (en) * | 1991-02-23 | 1992-09-02 | Unilever Plc | Cationic compositions for skin |
WO1994003150A1 (en) * | 1992-08-07 | 1994-02-17 | Unilever Plc | Washing composition |
-
1999
- 1999-02-19 GB GBGB9903926.5A patent/GB9903926D0/en not_active Ceased
-
2000
- 2000-02-17 BR BR0008336-4A patent/BR0008336A/en not_active IP Right Cessation
- 2000-02-17 JP JP2000599360A patent/JP2003518003A/en not_active Abandoned
- 2000-02-17 WO PCT/US2000/004083 patent/WO2000048568A1/en not_active Application Discontinuation
- 2000-02-17 CA CA002362352A patent/CA2362352A1/en not_active Abandoned
- 2000-02-17 AU AU34942/00A patent/AU772497B2/en not_active Ceased
- 2000-02-17 KR KR1020017010581A patent/KR20010102276A/en not_active Application Discontinuation
- 2000-02-17 CN CN00805439A patent/CN1346261A/en active Pending
- 2000-02-17 CZ CZ20013016A patent/CZ20013016A3/en unknown
- 2000-02-17 EP EP00913504A patent/EP1257252A1/en not_active Withdrawn
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US4438095A (en) * | 1980-03-18 | 1984-03-20 | Societe Anonyme Dite: L'oreal | New cosmetic compositions for hair or skin conditioning, and the application thereof |
US4675178A (en) * | 1985-05-02 | 1987-06-23 | Calgon Corporation | Use of cationic polymers (polydimethyldialkyl ammonium chloride-acrylamide copolymers and dimethyldialkyl ammonium chloride) to increase deposition and/or retention of active agent (S) of deodorant formulations on surfaces |
EP0501714A2 (en) * | 1991-02-23 | 1992-09-02 | Unilever Plc | Cationic compositions for skin |
WO1994003150A1 (en) * | 1992-08-07 | 1994-02-17 | Unilever Plc | Washing composition |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000071093A1 (en) * | 1999-05-25 | 2000-11-30 | The Procter & Gamble Company | Niacinamide compositions with reduced tack |
WO2008066193A1 (en) | 2006-11-27 | 2008-06-05 | Chisso Corporation | Cosmetic composition |
EP2116224A1 (en) * | 2006-11-27 | 2009-11-11 | Chisso Corporation | Cosmetic composition |
EP2116224A4 (en) * | 2006-11-27 | 2013-01-02 | Jnc Corp | Cosmetic composition |
US9770609B2 (en) | 2015-04-01 | 2017-09-26 | Neat Feat Products Limited | Urea based skin treatment |
Also Published As
Publication number | Publication date |
---|---|
KR20010102276A (en) | 2001-11-15 |
AU3494200A (en) | 2000-09-04 |
CN1346261A (en) | 2002-04-24 |
CZ20013016A3 (en) | 2002-02-13 |
EP1257252A1 (en) | 2002-11-20 |
CA2362352A1 (en) | 2000-08-24 |
GB9903926D0 (en) | 1999-04-14 |
BR0008336A (en) | 2002-01-29 |
JP2003518003A (en) | 2003-06-03 |
AU772497B2 (en) | 2004-04-29 |
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