JP5955279B2 - How to increase the amount of moisturizing ingredients - Google Patents

Description

  The present invention relates to a method for increasing the amount of a moisturizing component attached to keratin, which is a skin component.

Conventionally, as a method of moisturizing in order to improve the dry state of the skin, a method of suppressing transepidermal water loss using a compound having good adhesion to the skin and having hydrophobicity, a hygroscopic agent, and a moisturizing agent are applied to the skin. For example, a method for enhancing the hydration effect by blending in a base is used.
Occlusion agents such as petrolatum ointment and water-in-oil emulsions are used as a method for suppressing transepidermal water loss. In addition, methods for enhancing the hydration effect include polysaccharides such as hyaluronic acid and chitin, proteins such as collagen and elastin, polyhydric alcohols such as sorbitol, ethylene glycol and glycerin, pyrrolidone carboxylate soda and lactate soda. Organic acid salts and the like are used.

  However, in the above moisturizing method, if a large amount of a moisturizing agent or the like is added to the cosmetic to enhance the moisturizing effect, an unpleasant feeling such as a sticky feeling or a slimy feeling may be given. Therefore, from the viewpoint of these improvements and the improvement of aging and stability against microorganisms, studies have been made on compounds having a polyethylene glycol structure in the side chain as compounds having an excellent moisturizing effect (see, for example, Patent Document 1). .

JP 2003-171257 A

Conventionally studied as a method of enhancing the moisturizing effect on the skin are the invention of the compound or composition itself having the moisturizing effect, and the method of increasing the number and use of the moisturizing agent. Moreover, the evaluation regarding the moisturizing effect is also sensual, and there is no one that has confirmed the influence on keratin, which is a component of the skin.
Therefore, the present invention provides a method for increasing the amount of moisturizing component adhering to keratin, which is a skin component, so that the effect of the moisturizing component can be obtained for a long time and in a small amount.

  As a result of intensive studies to solve the above problems, the present inventors have found that the amount of moisturizing component attached to keratin can be remarkably increased by using cationized cellulose, thereby completing the present invention. It came.

That is, the present invention is achieved by the following (1) or (2).
(1) A method of increasing the amount of moisturizing component attached to keratin using cationized cellulose.
(2) The method of increasing the adhesion amount of the moisturizing component according to (1), wherein the moisturizing component is at least one of a polyhydric alcohol and a fatty acid ester.

  According to the present invention, the amount of moisturizing component attached to keratin, which is a skin component, can be remarkably increased. Therefore, even if the amount of the moisturizing component used is small, a moisturizing effect equivalent to or higher than the conventional one is expected. Furthermore, since the adhesion amount of the moisturizing component is increased, the durability of the moisturizing effect can be expected.

The present invention provides a method for increasing the amount of moisturizing component attached to keratin using cationized cellulose.

In the present invention, the cationized cellulose is a cellulose derivative having a cation group composed of quaternary ammonium and having a cationic property as a whole, specifically, O- [2-hydroxy-3- (chloride) Trimethylammonio) propyl] hydroxyethylcellulose (also known as “polyquaternium 10”).
Among these, there are those having different molecular weights and cationization degrees, but they can be appropriately selected and used as long as the effects of the present invention are exhibited. The molecular weight is, for example, in the range of 10,000 to 3,000,000. Is more preferable, and the range of 50,000 to 2,000,000 is more preferable. The degree of cationization is preferably in the range of, for example, 0.1 to 5% by mass as the nitrogen atom content (% by mass).
The cationized cellulose selected from the above range can be suitably used in the present invention because it can remarkably increase the amount of the moisturizing component attached to keratin, and is easily adapted.
In addition to the above, for example, O- [2-hydroxy-3- (lauryldimethylammonio) propyl] hydroxyethylcellulose can be used as the cationized cellulose.
These may be used alone or in combination.

In the present invention, by using cationized cellulose together with a moisturizing component, the adhesion amount of the moisturizing component to keratin, which is a constituent component of the skin, can be increased.
By improving the adhesion amount of the moisturizing component to keratin, even if the amount of the moisturizing component used is small, a moisturizing effect equivalent to or higher than that of the conventional one can be obtained, which is efficient without loss. Moreover, since the moisturizing component adhering to keratin increases, it is expected that the moisturizing effect is sustained over a longer period.
Further, when the method according to the present invention is used continuously (continuously performed for a certain period), further improvement of the moisturizing effect is expected.

Examples of the moisturizing component in the present invention include polyethylene glycol, glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexylene glycol, Polyhydric alcohols such as 1,2-hexanediol and 1,2-octanediol; cetyl octoate, myristyl lactate, cetyl lactate, myristyl myristate, isopropyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, etc. Fatty acid esters; plant extracts such as peach, loofah, aloe, maroni, kumazasa, birch, tomato, cucumber, oyster, apple, mandarin; seaweed extract such as wakame, kombu, iwanori; jojoba oil, avocado oil, armo Natural oils such as dough oil, nutka oil, olive oil, cacao butter, sesame oil, persic oil, castor oil, palm oil, mink oil, beef tallow, lard, soybean oil; wax such as carnauba wax, whale wax, beeswax, lanolin; Hydrocarbons such as paraffin, white petrolatum, ceresin, squalane, squalene; fatty acids such as myristic acid, lauric acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, lanolinic acid; lauryl alcohol, cetyl alcohol, stearyl alcohol Alcohols such as oleyl alcohol; synthetic fats and oils such as monoglyceride and triglyceride; sugars such as sorbitol, glucose, sucrose, xylose, erythritol, mannitol, trehalose, xylit, hyaluronic acid, sodium hyaluronate; ascorbic acid and Vitamins such as salt, tocopherol, tocopherol acetate, pantothenic acid and salts thereof, lipoic acid, ferulic acid, γ-oryzanol, carnitine; rice bran extract, rice germ oil, urea, ceramide, etc. Among these, cationized cellulose Polyhydric alcohols and fatty acid esters are preferred because they are easily attached to and familiar with keratin, among which glycerin and isopropyl myristate are more preferred.
These may be used alone or in combination.

Examples of the method according to the present invention include non-therapeutic use modes such as lotion, milky lotion, cream, lotion, cosmetic liquid, cosmetics, bath preparation, ointment and the like.
In the case of these usage modes, the addition amount of cationized cellulose in the entire product is preferably from 0.1 to 10% by mass because the effects of the present invention are exhibited, familiarity is not present, and there is no sticky feeling. -3 mass% is more preferable.
In the above use mode, other components may be used together with the cationized cellulose and the moisturizing component as long as the effects of the present invention are not impaired. For example, a solvent, a fragrance, a surfactant, a pigment, a crude drug, an enzyme, Examples thereof include polymer compounds and inorganic salts.

  Specifically, solvents such as water, methanol, ethanol, propanol, butanol; fragrances such as lavender oil, jasmine oil, lemon oil, cedar oil, cypress oil, geraniol, citronellal, eugenol, limonene, phenethyl alcohol; glycerin fatty acid ester , Nonionic surfactants such as sorbitan fatty acid ester, polyoxyethylene castor oil, polyglycerin fatty acid ester and block polymer; anionic interfaces such as sodium α-olefin sulfonate, sodium lauryl sulfate, sodium polyoxyethylene lauryl sulfate Activating agents; amphoteric surfactants such as alkylbetaines and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaines; cationic interfaces such as alkylamine salts and quaternary ammonium salts Sexual agents: Blue No. 1, Red No. 106, Yellow No. 4, Green No. 3, pigments such as chlorophyll, riboflavin, safflower, etc .; Herbal medicines such as trypsin, papain, protease, lysozyme, pepsin; gum arabic, tragacanth gum, guar gum, locust bean gum, gelatin, shellac, rosin, casein, carboxymethylcellulose Polymer compounds such as sodium, hydroxyethyl cellulose, sodium alginate, crystalline cellulose; sodium chloride, potassium chloride, sodium carbonate, magnesium carbonate, sodium bicarbonate, sesquicarbonate Examples include sodium, sodium sulfate, aluminum sulfate, sodium nitrate, potassium nitrate, sodium phosphate, sodium polyphosphate, calcium hydrogen phosphate, sulfur, anhydrous silicic acid, talc, sodium hydroxide, borax, calcium oxide and the like.

  In the method according to the present invention, the amount of the moisturizing component attached to the keratin may be directly measured by the amount of the moisturizing component attached to the keratin, and the content of the moisturizing component at the time of preparation in the solution containing the moisturizing component; It can also be determined from the difference from the moisturizing component content after contacting the solution with keratin. The content of the moisturizing component can be measured by various analysis methods, for example, by gas chromatography.

  Hereinafter, the present invention will be described specifically by way of examples. However, the present invention is not limited to only these examples.

(Test Example 1: Concentrated glycerin)
Samples A to E shown in Table 1 were prepared using polyquaternium 10 (trade name: Kachinal LC-100, manufactured by Toho Chemical Industry Co., Ltd.) as the cationized cellulose and concentrated glycerin as the moisturizing component.
Next, specimens A to E were diluted 100-fold with purified water, 10 mL was weighed, and placed in a centrifuge tube along with 500 mg of wool-derived keratin (trade name: Keratin from wool, manufactured by Tokyo Chemical Industry Co., Ltd.). The centrifuge tube was shaken in warm water at 40 ° C. for 15 minutes at 120 times / minute, and then centrifuged (3500 rpm, 12 minutes). After concentrating the resulting supernatant, concentrated glycerin was quantified by an internal standard method using gas chromatography.

By measuring by gas chromatography, the amount of decrease in concentration of concentrated glycerin from the time of preparation was regarded as the amount of concentration of concentrated glycerin on keratin, and the adhesion rate of concentrated glycerin on keratin was determined by the following formula. The test was performed three times for each specimen, and the average value was defined as the adhesion rate.
Adhesion rate = [(concentrated glycerol concentration at 100-fold dilution of specimen x amount of collected supernatant)-detected amount of concentrated glycerol by gas chromatography] / (concentrated glycerol concentration at 100-fold dilution of specimen x collected amount of supernatant) ) × 100 (mass%)

  Table 2 shows the result of the concentration ratio of concentrated glycerin to keratin and its standard error.

  Sample E to which polyquaternium 10 was not added had an adhesion rate of 19.1%, whereas Samples A to D all exceeded 60%, and the adhesion rate of concentrated glycerin to keratin was greatly increased. It turns out that it improves. From this, it was revealed that polyquaternium 10 contributed to an increase in the amount of concentrated glycerin attached to keratin.

(Test Example 2: Fatty acid ester)
Samples F and G listed in Table 3 were prepared in the same manner as in Test Example 1 except that the moisturizing component was changed from concentrated glycerin to isopropyl myristate, and the adhesion rate of isopropyl myristate to keratin was determined by gas chromatography. .
Table 3 shows the adhesion rate of isopropyl myristate to keratin and the standard error thereof in specimens F and G. Note that sorbitan oleate and POE sorbitan monooleate are nonionic surfactants and were used to dissolve isopropyl myristylate, which is a moisturizing component, in water.

  It has been found that even when isopropyl myristate is used as a moisturizing component, the adhesion rate to keratin is increased by adding polyquaternium 10 as in the case of concentrated glycerin.

Claims (2)

Using a bath agent comprising a salt of O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose and glycerin, a method of increasing the adhesion amount of glycerin relative to keratin. Using a bath agent comprising a salt of O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose and glycerin, and, without the use of anionic surfactants or anionic polymers, glycerin for keratin A method to increase the amount of adhesion.