EP1436630A2 - Systeme automatise et procede de traitement de specimens permettant d'extraire des echantillons se pretant a l'examen aussi bien en masse liquide qu'entre lame et lamelle - Google Patents

Systeme automatise et procede de traitement de specimens permettant d'extraire des echantillons se pretant a l'examen aussi bien en masse liquide qu'entre lame et lamelle

Info

Publication number
EP1436630A2
EP1436630A2 EP02803287A EP02803287A EP1436630A2 EP 1436630 A2 EP1436630 A2 EP 1436630A2 EP 02803287 A EP02803287 A EP 02803287A EP 02803287 A EP02803287 A EP 02803287A EP 1436630 A2 EP1436630 A2 EP 1436630A2
Authority
EP
European Patent Office
Prior art keywords
fluid
receptacle
sample
container
head
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02803287A
Other languages
German (de)
English (en)
Inventor
Norman J. Pressman
William J. Mayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MonoGen Inc
Original Assignee
MonoGen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MonoGen Inc filed Critical MonoGen Inc
Publication of EP1436630A2 publication Critical patent/EP1436630A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

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    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
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    • B01D61/18—Apparatus therefor
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    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49815—Disassembling
    • Y10T29/49822—Disassembling by applying force
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/53—Means to assemble or disassemble
    • Y10T29/53039—Means to assemble or disassemble with control means energized in response to activator stimulated by condition sensor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/112499—Automated chemical analysis with sample on test slide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/12—Condition responsive control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Definitions

  • the invention relates to processing fluid specimens, e.g., biological fluid specimens, to extract samples for testing.
  • Advanced screening and diagnostic methods are often based on the detection of molecules, molecular events, or foreign organisms both within (i.e., intracellular) and external to (i.e., extracellular) suspicious, atypical, infected, and/or cancer cells. Specimens from patients are collected when patients undergo screening, diagnostic or therapeutic monitoring examinations.
  • Examples of screening examinations during which such specimens are collected include examinations for lung cancer as evidenced by sputum analyses, colorectal cancer, cervical cancer as evidenced by PAP smears and pelvic gynecological examinations, bladder cancer as evidenced by voided urine analyses, and skin cancer examinations.
  • These specimens need to be processed before expert medical professionals and analytical instruments (e.g., cytotechnologists, pathologists, hematologists, blood chemistry analyzers, flow cytometers, spectrometers) can evaluate, interpret and classify/diagnose samples from these specimens.
  • analytical instruments e.g., cytotechnologists, pathologists, hematologists, blood chemistry analyzers, flow cytometers, spectrometers
  • Specimen processing may involve many diverse steps including, but not limited to specimen collection, cell dispersal, disaggregation of mucous, fixation, aliquoting, homogenization, cell-deposition, staining, cellular molecular labeling, and glass microscope-slide coverslipping techniques.
  • the outcome or byproducts of specimen processing protocols are patient samples that are ready for subsequent human or machine assessment.
  • two types of cytopathology samples are prepared depending upon whether the clinical material will be subjected to intracellular or extracellular analyses.
  • Samples prepared for intracellular cytopathology analyses are either microscope slide-based (for expert human review or machine assessment) or liquid-based for assessment by flow cytometers, PCR analyzers and/or other analytical instruments.
  • Samples prepared for extracellular cytopathology analyses are predominantly Hquid samples collected or subsequently placed into test tubes, vials or other sample containers for biomedical liquid samples.
  • Slide-based preparations can be produced by several techniques, such as conventional cervical-vaginal Papanicolaou (PAP) smears or by improved means such as LBP (liquid-based preparation) technologies that result in thin-layer or mono layers of cells deposited onto glass microscope slides for improved visualization and/or machine analysis.
  • PAP cervical-vaginal Papanicolaou
  • LBP liquid-based preparation
  • the MonoGen MONOPREPTM LBP instrument which is disclosed in the aforementioned provisional application No. 60/372,080 and in the aforementioned non- provisional application filed concurrently herewith, is an example of such a slide and sample preparation device.
  • sample preparations i.e., LBP slides
  • intracellular analyses include molecular diagnostic tests that determine the presence, absence, overexpression or underexpression of proteins (e.g., immunocytochemistry techniques) or other molecules found within cells or organelles (e.g., nuclear, nucleolar, mitochondrial, cytoplasmic) including the detection of cytogenetic molecular changes in DNA structure (e.g., sequencing) and content (e.g., in situ hybridization techniques).
  • proteins e.g., immunocytochemistry techniques
  • organelles e.g., nuclear, nucleolar, mitochondrial, cytoplasmic
  • Liquid samples are often produced for machine analyses of extracellular content. These samples include test tubes of heparinized blood for blood chemistry tests (e.g., SGOT, NA, K, CA, Alkaline Phosphatase, PSA, BUN/creatinine ratio, hemoglobin, hematocrit, blood gluocose, and HDL and LDL cholesterol content).
  • SGOT heparinized blood for blood chemistry tests
  • PCR i.e., Polymerase Chain Reaction
  • NASBA Nucleic Acid Strand-Based Amplification
  • microarray genetyping hybrid capture, direct hybridization, sequencing, spectrometers, liquid chromatography, fluorescent antibody detection, antigen detection, immunochemistry, enzyme chemistry, DNA analysis, nuclear probe detection, viral and RNA quantification, flow micro fluorometric cytometers, and cell sorters.
  • Tests on these liquid samples include, but are not limited to tests for chlamydia, cytomegalovirus (CMV) including detection of CMV antigens by EIA, trachomatis detection by direct and amplified probes, hepatitis (B and C) core IgG and IgM and surface antibodies and antigens, pneumonia including by direct probe techniques, HIV-1 detection by detection and quanitification by direct and amplified probes, and mycobacteria turberculosis DNA and RNA quantitation and detection via direct and amplified probes.
  • CMV cytomegalovirus
  • tests can be based upon either intracellular assays (e.g., slide-based samples) or extracellular assays (e.g., liquid samples). Examples include tests ' for the detection of STDs including gonorrhea, trachomatis, and chlamydia (GTC).
  • intracellular assays e.g., slide-based samples
  • extracellular assays e.g., liquid samples. Examples include tests ' for the detection of STDs including gonorrhea, trachomatis, and chlamydia (GTC).
  • GTC chlamydia
  • Machines already exist to take specimens collected at the point-of-care (POC) site and produce LBP microscope slide-based samples e.g., the MonoGen MONOPREPTM LBP system referenced above, and the Cytyc THINPREP ® 2000 and 3000 LBP machines.
  • Other machines already exist to take POC specimens and produce liquid samples e.g., blood chemistry analyzers from Olympus America, Inc.
  • the invention is a system and method for processing specimens to extract samples for both liquid (i.e., extracellular) and slide-based (i.e., intracellular) testing. It is an improvement on the LBP device, system and method disclosed in the aforementioned provisional application No. 60/372,080 and in the aforementioned non-provisional application filed concurrently herewith; and, like that LBP device and system, is compatible with post-processing machines, and can be interfaced with other devices as well as a central hospital or laboratory information system.
  • the machine according to this invention is a "platform instrument" that can produce all required liquid samples and slide-based samples for essentially all cytopathology tests, whether performed by visual examination by expert humans or analytical instruments, and/or whether performed based upon cytomorphological, cytogenetic, molecular diagnostic, microbiological, virological or other technologies and techniques. This is accomplished in a safe, fast, automated and efficient manner.
  • the integration of the need for both types of samples from a single specimen minimizes the risk of introducing clerical errors associated with mislabeling and mishandling of patient specimens, samples, and associated data. This integration also minimizes the risk of producing disparate results from a variety of types of assays that are each based upon non- representative samples from the specimens of a single patient.
  • One aspect of the invention relates to a method and apparatus for obtaining different types of samples from a fluid specimen in a container.
  • the container is supported in the apparatus, and the specimen is placed in fluid communication with a fluid sampling station of the apparatus, which removes fluid from the container and places in a sample receptacle.
  • the specimen is also placed in fluid communication with a specimen acquisition station of the apparatus, which removes fluid from the container, separates particulate matter from the removed fluid, and forms a sample layer of particulate matter.
  • the two sampling operations can be carried out in any order.
  • the method and apparatus may be automated for processing multiple specimens in respective containers.
  • the specimen containers may be transported seriatim along a processing path, and may first be subjected to an optional preprocessing operation.
  • the two sampling operations can be carried out in any order.
  • Sample receptacles used to collect fluid samples can be fed to the fluid sampling station automatically along a path that intersects the container processing path. Movement of containers and receptacles along their respective paths can be synchronized.
  • the sample layer formed at the specimen acquisition station may be transferred to a slide.
  • the term "slide” encompasses glass microscope slides as well as any other substrate on which a sample may be placed for subsequent testing or analysis.
  • the receptacle for collecting a fluid sample, e.g., for use at the fluid sampling station.
  • the receptacle has a hollow body for receiving and holding fluid.
  • a one-way valve is carried by the body and has a fluid flow passage between the exterior and the interior of the body. The valve is pressure-actuated to permit fluid flow into the body interior when the exterior pressure exceeds the interior pressure, and prevents outflow of fluid from the body under the influence of any other relative pressure conditions. There is also a vent in the body remote from the valve.
  • the valve has an inlet portion opening to the exterior of the body, and an outlet portion opening to the body interior.
  • the flow passage extends between the inlet portion and the outlet portion. At least a portion of the flow passage is resiliently biased to a closed position when the interior and exterior pressures are substantially equal, and is expandable to allow fluid flow into the body in response to a positive pressure differential across the valve from the inlet portion to the outlet portion.
  • the valve preferably is made of resilient material, e.g., an elastomer, and preferably is configured so that it can be coupled directly to the fluid source to be sampled.
  • Fig. la is a top plan view of the LBP device disclosed in the aforementioned provisional application No. 60/372,080 and in the aforementioned non-provisional application filed concurrently herewith, showing a modification according to this invention;
  • Fig. lb is a schematic diagram of the operating sequence of the LBP device, adapted in accordance with this invention.
  • FIG. 2 is a schematic illustration of the fluid sampling draw station according to this invention.
  • Fig. 3 is a schematic detail view of the fluid sampling draw station of Fig. 2;
  • Fig. 4 is a schematic detail plan view showing how the fluid sampling draw station of this invention interfaces with the LBP device; and
  • Fig. 5 is a schematic view showing sample fluid extraction for testing.
  • DETAILED DESCRIPTION OF BEST MODE Fig. la shows the overall arrangement of the aforementioned LBP device, which transports multiple specimen containers sequentially through various processing stations and produces fixed specimens on slides, each slide being bar-coded and linked through a data management system (DMS) to the vial and the patient from which it came.
  • each container has a special internal processing assembly detachably coupled to its cover, and is transported through the LBP device on a computer- controlled transport (conveyor) 240, in its own receptacle 246.
  • the conveyor has thirty receptacles.
  • the containers and the receptacles are keyed so that the containers proceed along the processing path in the proper orientation, and cannot rotate independently of their respective receptacles.
  • the containers first pass a bar code reader 230 (at a data acquisition station), where the vial bar code is read, and then proceed stepwise through the following processing stations of the LBP device: an uncapping station 400 including a cap disposal operation; a preprocessing station 500; a filter loading station 600; a specimen acquisition and filter disposal station 700; and a re-capping station 800.
  • an uncapping station 400 including a cap disposal operation
  • a preprocessing station 500 a filter loading station 600
  • a specimen acquisition and filter disposal station 700 a specimen acquisition and filter disposal station 700
  • a re-capping station 800 These six stations are structured for parallel processing, meaning that all of these stations can operate simultaneously on different specimens in their respective containers, and independently of the other.
  • the conveyor will not advance until all of these operating stations have completed their respective tasks.
  • the preprocessing station is the location at which preprocessing operations, such as specimen dispersal within its container, are performed prior to the container and its specimen moving on for further handling.
  • the preprocessing station typically performs a dispersal operation.
  • the dispersal operation is performed by a mechanical mixer, which rotates at a fixed speed and for a fixed duration within the specimen container.
  • the mixer serves to disperse large particulates and microscopic particulates, such as human cells, within the liquid-based specimen by homogenizing the specimen.
  • the specimen may contain subcellular sized objects such as molecules in crystalline or other conformational forms.
  • a chemical agent may be introduced to the specimen at the preprocessing station to, for example, dissolve certain crystalline structures and allow the molecules to be dispersed throughout the liquid-based specimen through chemical diffusion processes without the need for mechanical agitation.
  • a chemical preprocessing station introduces its dispersing agent through the preprocessing head.
  • An integrated system 900 that includes additional bar code readers, slide cassettes, handling mechanisms for slide cassettes and individual slides, and a slide presentation station 702 at which the specimen acquisition station transfers a representative sample from a specimen to a fresh microscope slide.
  • An optional auto loading mechanism 300 automatically loads and unloads specimen vials onto and from the transport mechanism. All stations and mechanisms are computer-controlled.
  • Fig. lb shows the operating sequence of the LBP device. This, is the top-level table from which the operating software is structured.
  • the vial uncapping station 400 has a rotary gripper that unscrews the cover from the vial, and discards it into a biosafety disposable waste handling bag. Before doing so, however, the uncapping head presses on the center of the cover to detach the internal processing assembly from the cover.
  • the preprocessing (mixing) station 500 has an expanding collet that grips the processing assembly, lifts it slightly and moves (e.g., spins) it in accordance with a specimen-specific stirring protocol (speed and duration).
  • the filter loading station 600 dispenses a specimen-specific filter type into a particulate matter separation chamber (manifold) at the top of the processing assembly.
  • the specimen acquisition station 700 has a suction head that seals to the filter at the top of the processing assembly and first moves the processing assembly slowly to re-suspend particulate matter in the liquid-based specimen. Then the suction head draws a vacuum on the filter to aspirate the liquid-based specimen from the vial and past the filter, leaving a thin layer of cells on the bottom surface of the filter. Thereafter the thin layer specimen is transferred to a fresh slide, and the container moves to the re-capping station, where a foil-type seal is applied.
  • a fluid sampling draw station 100 which is adapted to engage the processing assembly (stirrer) present in any of the specimen containers processed by the LBP device.
  • the fluid sampling draw station 100 is located just after (downstream of) the mixing station 500 of the LBP device.
  • the fluid sampling draw station instead could be located downstream of the specimen acquisition station 700.
  • sample receptacles in the form of special molded plastic test tubes 102 are used to collect specimen fluid at the fluid sampling draw station 100, to be processed by other preprocessing devices, or external PCR or other test protocols, devices, or systems.
  • Test tube 102 preferably is transparent to a sensor, and is designed to collect about 5 ml of specimen fluid, although smaller or larger test tubes or other types of sample receptacles could be employed.
  • Each test tube 102 preferably is laser-etched with a unique machine-readable bar code number 103.
  • the test tubes themselves and/or their closure caps 105 may be color-coded to distinguish specimen types (e.g., blood, urine, sputum, gastrointestinal, cervical, prostate). Specimen types may also be distinguished by employing receptacles (test tubes) of different size or height.
  • Test tube 102 is fitted with a thermoplastic elastomer one-way valve 104, e.g., a flap valve, on one end.
  • a thermoplastic elastomer one-way valve 104 e.g., a flap valve
  • the resilient nature of the valve material normally keeps the small flow passage therein squeezed tightly shut without the potential of sample leakage.
  • This valve has an exposed frontal surface 112, the purpose of which is to act as a gasket when it is coupled to the element from which it is to draw fluid.
  • that element is the suction tube 43 of the processing assembly (stirrer) 40 already in the specimen container 20, which is on the conveyor of the LBP device.
  • the exposed tip of the valve, adjacent the inlet port 108 preferably is tapered so as to enter and positively seal against the upper end of the stirrer suction tube 43.
  • the normally closed very small flow passage through outlet port 110 is formed in a tapered tip that is exposed to the test tube interior.
  • the opposite end of the test tube is open, but can be sealed after filling by a cap 105 (e.g., sealed with an elastomer stopper).
  • One-way valve 104 is actuated by elevating the pressure on its inlet port 108 relative to the pressure on its outlet port 110.
  • a vacuum applied to the open end of the test tube also is applied to outlet port 110 of the valve, causing fluid to be drawn through the normally closed valve flow passage therein in only one direction - inwardly.
  • pressurization of specimen container 20 would force fluid through stirrer tube 43 and one-way valve 104, into test tube 102.
  • valve 104 After filling and capping, neither a positive pressure within test tube 102 nor rough handling of the test tube can force fluid back out through one-way valve 104. This eliminates a source of potential biohazard and cross-sample contamination.
  • the resilient material of valve 104 can be coaxed mechanically to allow outflow of fluid.
  • Fig. 5 shows one example of how a sample of the collected fluid can be extracted from a test tube 102.
  • a syringe 103 may be used to access fluid through the one-way valve 104.
  • the action of the one-way valve allows a blunt-faced cannula to enter the test tube 102 without damaging the self-sealing characteristics of the valve.
  • Either a hand-held syringe or a mechanically actuated cannula can be used for this purpose.
  • the fluid sampling draw station 100 moves the test tube 102 downwardly to force-couple the one-way valve 104 to the stirrer 40 in a specimen container 20 presented to the station.
  • a vacuum cap 120 fitted with a gasket is coupled to the distal (uncapped) end of the test tube to draw fluid up through the hollow stirrer tube 43 and through the one-way valve 104.
  • the vacuum cap 120 is connected to the LBP system vacuum source and is controlled by a solenoid valve.
  • the same pneumatic actuator (not shown) that forces the one-way valve 104 into engagement with the stirrer 40 also presses the vacuum cap 120 against the test tube to make the vacuum seal.
  • a conventional fluid-level control system includes liquid-level sensors 106 that monitor the aspiration process and signal operation cut-off to a controller when the proper level is reached.
  • a bar code reader 109 (see Fig. 4) reads the bar code on the test tube, links the test tube bar code number to the bar code number of the specimen container (e.g., vial), and the acquired data is entered into the data management system (DMS).
  • DMS data management system
  • a cap 105 is applied to the distal end of the test tube at a capping station 107.
  • Actuation of the fluid sampling draw station 100 preferably is governed by the particular processing protocol for each specimen. Accordingly, there may be specimen containers 20 from which no fluid sample is drawn, in which case the fluid sampling draw station will remain idle while such a container dwells there. It is also possible for the fluid sampling draw station to draw a variable fluid volume, again dependent on the particular processing protocol for each specimen. To accomplish that, a plurality of vertically spaced fluid level sensors 106 would monitor the changing level of fluid in the test tube 102, and liquid draw would be terminated when the specified fluid volume is acquired.
  • Fig. 4 shows details of how the fluid sampling draw station 100 interfaces with the
  • empty test tubes 102 are loaded in a vibratory bin feeder 114, which orients the test tubes valve-end-down and dispenses them via a gravity- operated track into a transport feed mechanism, such as a bandolier carrier or ribbon feeder 116.
  • This transport mechanism indexes the test tubes laterally of the container transport conveyor 240 of the LBP device (top to bottom as seen in Fig. 4, left to right as seen in Fig. 2). This may be accomplished, e.g., by means of a walking beam escapement operated by two air cylinders (not shown). One cylinder delivers linear motion, while the other supplies the engage/disengage function.
  • the bandolier carrier 116 also allows the. vertical motion of a test tube required to clamp the valve tip seal 112 to the stirrer tube 43 during aspiration.
  • Test tube capping takes place at a capping station 107, as mentioned above.
  • a molded elastomer stopper 105 is escapement-fed from a supply bowl (not shown) and pressed into the open top of the test tube to form a seal.
  • stoppers 105 are supplied to the unit in pre-loaded tubes and escaped from the tube into a pressing chamber (not shown), where an air-operated actuator forces the stopper onto the test tube neck.
  • An air blow/vacuum system 130 cleans any residual fluid from the tip of the oneway valve 104. Filled test tubes are then ejected from the carrier 116 at an ejection station, where they are delivered to a collection bin 118.
  • the one-way valve could be made of any suitable resilient material, or could be made of a harder material that is coated or otherwise joined to a resilient material in those areas that require flexibility for sealing.
  • sample receptacles e.g., test tubes
  • any suitable mechanism(s) such as direct feed by a vibratory bowl feeder, or individual placement and removal by a pick-and-place mechanism.
  • the invention in its broadest aspects does not require specimen premixing, or any type of specimen preprocessing. Nor does it require the use of specimen vials that come prepackaged with the special internal processing assembly 40 shown in Fig. 2 and disclosed in the aforementioned provisional application No. 60/372,080 and the aforementioned non-provisional application filed concurrently herewith. Nor does it require a conveyor to feed specimens to the operating stations/heads automatically. And it does not require use of the specific type of specimen acquisition/slide-making station 700 disclosed in those applications and described above.
  • LBP processes and machines such as the Cytyc THINPREP ® 2000 and 3000 LBP devices, could be used to make the slide-based samples in accordance with this novel method for processing fluid specimens to obtain both liquid samples and slide-based samples.
  • the specimen container, microscope slide, filter, and liquid sample receptacle can be placed manually into the device by a machine operator. .

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Clinical Laboratory Science (AREA)
  • Water Supply & Treatment (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Container Filling Or Packaging Operations (AREA)
  • Microscoopes, Condenser (AREA)
  • Specific Conveyance Elements (AREA)
  • Closing Of Containers (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Devices For Opening Bottles Or Cans (AREA)
  • Filtering Materials (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Supplying Of Containers To The Packaging Station (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne un appareil et un procédé permettant le traitement de spécimens notamment des spécimens biologiques, pour en extraire des échantillons se prêtant à l'examen, les uns en masse liquide (échantillons extracellulaires), les autres entre lame et lamelle (échantillons intracellulaires). Les deux types d'échantillons peuvent s'obtenir à partir d'un seul spécimen fluide. Un poste de prélèvement de fluide essore le fluide d'un récipient à spécimen et le place dans un tube à échantillon. Un poste d'acquisition de spécimen vide de son fluide le récipient sépare du fluide d'essorage la matière particulaire (ici, les cellules), et forme une couche échantillon de matière particulaire qui est transportée sur une lame. Les deux opérations de prélèvement peuvent se faire dans n'importe quel ordre. Le tube à échantillon fluide peut comporter un dispositif spécial de clapet. L'appareil peut être automatisé pour traiter plusieurs spécimens fluides dans leurs récipients respectifs. La machine de l'invention est un instrument en plate-forme capable de réaliser tous les échantillons liquides et sur plaque dont il y a en général besoin pour sensiblement tous les examens de cytopathologie.
EP02803287A 2001-10-19 2002-10-21 Systeme automatise et procede de traitement de specimens permettant d'extraire des echantillons se pretant a l'examen aussi bien en masse liquide qu'entre lame et lamelle Withdrawn EP1436630A2 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US33009201P 2001-10-19 2001-10-19
US330092P 2001-10-19
US37208002P 2002-04-15 2002-04-15
US372080P 2002-04-15
US37365802P 2002-04-19 2002-04-19
US373658P 2002-04-19
PCT/US2002/033461 WO2003054552A2 (fr) 2001-10-19 2002-10-21 Systeme automatise et procede de traitement de specimens permettant d'extraire des echantillons se pretant a l'examen aussi bien en masse liquide qu'entre lame et lamelle

Publications (1)

Publication Number Publication Date
EP1436630A2 true EP1436630A2 (fr) 2004-07-14

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EP02789230A Withdrawn EP1438252A1 (fr) 2001-10-19 2002-10-21 Appareil et procede de desoperculage d'un contenant
EP02789229A Withdrawn EP1438590A1 (fr) 2001-10-19 2002-10-21 Procede et systeme de manipulation d'articles
EP02789227A Expired - Lifetime EP1436585B1 (fr) 2001-10-19 2002-10-21 Appareil et procede de melange de prelevements dans des fioles
EP02792196A Ceased EP1436586A2 (fr) 2001-10-19 2002-10-21 Systeme et procede automatises de traitement d'echantillons multiples a base de liquide
EP02773810A Expired - Lifetime EP1438559B1 (fr) 2001-10-19 2002-10-21 Systeme de mesure de controle de flux et procede de commande de filtration d'echantillons a base liquide
EP02803287A Withdrawn EP1436630A2 (fr) 2001-10-19 2002-10-21 Systeme automatise et procede de traitement de specimens permettant d'extraire des echantillons se pretant a l'examen aussi bien en masse liquide qu'entre lame et lamelle
EP02789228A Expired - Lifetime EP1438562B1 (fr) 2001-10-19 2002-10-21 Appareil et procede de distribution d'articles
EP02789226A Withdrawn EP1436629A1 (fr) 2001-10-19 2002-10-21 Cassette universelle pour plaquettes de microscope
EP02784158A Withdrawn EP1436199A1 (fr) 2001-10-19 2002-10-21 Appareil et procede de scellement d'une fiole d'echantillon
EP02789217A Withdrawn EP1438561A2 (fr) 2001-10-19 2002-10-21 Procede et systeme de filtration destines a obtenir une couche cytologique

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EP02789230A Withdrawn EP1438252A1 (fr) 2001-10-19 2002-10-21 Appareil et procede de desoperculage d'un contenant
EP02789229A Withdrawn EP1438590A1 (fr) 2001-10-19 2002-10-21 Procede et systeme de manipulation d'articles
EP02789227A Expired - Lifetime EP1436585B1 (fr) 2001-10-19 2002-10-21 Appareil et procede de melange de prelevements dans des fioles
EP02792196A Ceased EP1436586A2 (fr) 2001-10-19 2002-10-21 Systeme et procede automatises de traitement d'echantillons multiples a base de liquide
EP02773810A Expired - Lifetime EP1438559B1 (fr) 2001-10-19 2002-10-21 Systeme de mesure de controle de flux et procede de commande de filtration d'echantillons a base liquide

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EP02789228A Expired - Lifetime EP1438562B1 (fr) 2001-10-19 2002-10-21 Appareil et procede de distribution d'articles
EP02789226A Withdrawn EP1436629A1 (fr) 2001-10-19 2002-10-21 Cassette universelle pour plaquettes de microscope
EP02784158A Withdrawn EP1436199A1 (fr) 2001-10-19 2002-10-21 Appareil et procede de scellement d'une fiole d'echantillon
EP02789217A Withdrawn EP1438561A2 (fr) 2001-10-19 2002-10-21 Procede et systeme de filtration destines a obtenir une couche cytologique

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EP (10) EP1438252A1 (fr)
JP (10) JP2005506538A (fr)
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CN (8) CN1329733C (fr)
AT (3) ATE365312T1 (fr)
AU (5) AU2002365134A1 (fr)
CA (11) CA2463940C (fr)
DE (3) DE60220937T2 (fr)
ES (1) ES2289152T3 (fr)
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