WO2021051688A1 - Dispositif de mélange et d'ajout de micro-réactif - Google Patents

Dispositif de mélange et d'ajout de micro-réactif Download PDF

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Publication number
WO2021051688A1
WO2021051688A1 PCT/CN2019/126206 CN2019126206W WO2021051688A1 WO 2021051688 A1 WO2021051688 A1 WO 2021051688A1 CN 2019126206 W CN2019126206 W CN 2019126206W WO 2021051688 A1 WO2021051688 A1 WO 2021051688A1
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WO
WIPO (PCT)
Prior art keywords
container shell
liquid outlet
mixing
fixed
micro
Prior art date
Application number
PCT/CN2019/126206
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English (en)
Chinese (zh)
Inventor
陈俊林
黄飞
马娟
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陈俊林
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Publication date
Application filed by 陈俊林 filed Critical 陈俊林
Publication of WO2021051688A1 publication Critical patent/WO2021051688A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples

Definitions

  • the utility model relates to the technical field of chemical containers, in particular to a micro reagent mixing sampler.
  • Reagents also known as biochemical reagents or reagents, are mainly pure chemicals used in chemical reactions, analytical tests, research tests, teaching experiments, and chemical formulations. Most chemical tests involve mixing of various reagents. Generally, reagents are used in various Test tubes and glass containers.
  • the mixing test tube is generally mixed in the form of shaking.
  • the shaking and mixing is not complete, and when adding liquid to the test tube, it is easy to cause excessive liquid addition, leading to the test conclusion Inaccurate, for this reason, we propose a micro-reagent mixing and sampler.
  • the purpose of the present utility model is to provide a micro reagent mixing sampler to solve the problem proposed in the background art.
  • the test tube for mixing is generally mixed in the form of shaking. When mixing relatively viscous liquids, shaking and mixing It is not thorough, and when adding liquid to the test tube, it is easy to cause excessive addition of liquid, which leads to the problem of inaccurate test conclusions.
  • a micro reagent mixing sampler comprising a container shell, a sample adding bin and a liquid outlet nozzle, the container shell is installed with a mixing rod, and the mixing rod
  • the side surface is fixed with stirring fan blades
  • the sample adding chamber is installed on the side surface of the container shell
  • the side surface of the sample adding chamber is provided with a rotating shaft
  • the side surface of the rotating shaft is fixed with a baffle.
  • a liquid outlet is fixed on the lower end surface of the liquid outlet
  • a connecting rod is movably connected to the inside of the liquid outlet.
  • the lower end of the connecting rod is connected with a rotating handle, and an inner plate is arranged under the stirring fan.
  • the nozzle is installed on the right side of the inner plate, and a plugging pile penetrates through the inside of the outlet nozzle, a spring is fixed on the outer surface of the container shell, and a plugging plate is fixed on the side end surface of the spring.
  • the mixing rod penetrates the inside of the container shell, and a connecting shaft is installed at the connection between the mixing rod and the container shell, and the outer structure of the container shell is an inverted triangle structure.
  • the sample loading bin is fixedly connected to the side surface of the container shell, and the sample loading bins are symmetrically distributed with respect to the vertical center line of the container shell, and the inner wall of the sample loading bin is inlaid with graduation lines.
  • the rotating shaft forms a rotating structure between the sample loading compartment and the baffle, and the baffle is attached to the inside of the sample loading compartment.
  • a connecting structure is formed between the liquid outlet bin and the sample adding chamber, and the connecting rod is movably connected with the inner surface of the liquid outlet bin, the rotating handle and the connecting rod form a rotating structure, and the upper end surface of the connecting rod A sealed structure is formed with the opening on the lower bottom surface of the sample chamber.
  • the shape of the inner plate is arc-shaped, and the lower end of the inner plate and the outlet nozzle are in the same horizontal direction, the outlet nozzle adopts an inclined design, and blocks the space between the pile and the outer surface of the container shell
  • the spring forms an elastic structure between the blocking plate and the outer surface of the container shell, and the blocking plate and the liquid outlet hole of the scale line form a sealing structure.
  • the purpose of the mixing rod is to make the mixing rod drive the internal stirring fan to rotate, thereby increasing the mixing speed of the solution inside the container shell, and making the liquid with higher viscosity mix more thoroughly, and it is directly sealed inside the container shell Stirring, it will not be infected by the environment such as external bacteria.
  • the set sample chamber and the side surface of the container shell adopt an inclined design to avoid experimental errors caused by the solution remaining inside. The design is reasonable and easy to use;
  • the purpose of the set shaft is that the baffle can rotate to the inside of the sample chamber, which is easy to operate and does not need to be manually closed.
  • the baffle can automatically close the opening through the shaft, which reduces the number of operations and is easy to use.
  • the purpose of the liquid chamber is to partially leak the excess solution filled in the sample chamber to improve the precise control of the test solution;
  • the purpose of the inner plate is that it does not need to be turned over, and the operation is more convenient.
  • the elastic force of the elastic is used to seal the plugging plate and the side end surface of the graduation line, without manual blockage, which is convenient for use.
  • Figure 1 is a schematic diagram of the utility model structure
  • Figure 2 is a cross-sectional view of the interior of the container shell of the present invention.
  • Figure 3 is a cross-sectional view of the sample loading warehouse of the utility model.
  • this utility model provides a technical solution: a micro-reagent mixing and sampler, comprising a container shell 1, a sample loading chamber 5 and a liquid outlet nozzle 13, and a mixing rod is installed inside the container shell 1 2, and the side surface of the mixing rod 2 is fixed with a stirring fan 4, the sample chamber 5 is installed on the side surface of the container shell 1, and the side surface of the sample chamber 5 is provided with a rotating shaft 7, and the side surface of the rotating shaft 7 is fixed There is a baffle 8, the lower end surface of the sample chamber 5 is fixed with a liquid outlet chamber 9, and the inside of the liquid outlet chamber 9 is movably connected with a connecting rod 10, and the lower end surface of the connecting rod 10 is connected with a rotating handle 11 and a stirring fan 4 An inner plate 14 is provided below the inner plate 14.
  • the outlet nozzle 13 is installed on the right side of the inner plate 14, and a plugging pile 12 penetrates through the outlet nozzle 13, and the outer surface of the container shell 1 is fixed with a spring 16 and the spring 16
  • a plugging plate 15 is fixed on the side end surface of the container, the mixing rod 2 penetrates the inside of the container shell 1, and a connecting shaft 3 is installed at the connection between the mixing rod 2 and the container shell 1.
  • the outer structure of the container shell 1 is an inverted triangle structure, and its function
  • the purpose of the mixing rod 2 is that the user can rotate the mixing rod 2 so that the mixing rod 2 drives the internal stirring fan 4 to rotate, thereby increasing the mixing speed of the solution inside the container shell 1 and making the viscosity higher The liquid is mixed more thoroughly.
  • it is directly sealed inside the container shell 1 for stirring, and will not be infected by the environment such as external bacteria;
  • the sample compartment 5 is fixedly connected to the side surface of the container shell 1, and the sample compartment 5 is symmetrically distributed with respect to the vertical center line of the container shell 1.
  • the inner wall of the sample compartment 5 is inlaid with scale lines 6, and its function is to set
  • the sample chamber 5 and the side surface of the container shell 1 adopt an inclined design, which makes it easier for the solution to flow down from the inner wall of the container shell 1 and the inner wall of the sample chamber 5, avoiding experimental errors caused by the solution remaining inside, and the design is reasonable and easy to use ,
  • the rotating shaft 7 forms a rotating structure between the sample loading compartment 5 and the baffle 8, and the baffle 8 is attached to the inside of the sample loading compartment 5.
  • the purpose of the rotating shaft 7 is to make the inside of the sample loading compartment 5 When filling the solution, the baffle 8 can rotate to the inside of the sample chamber 5, which is easy to operate and does not need to be manually closed.
  • the torsion spring inside the rotating shaft 7 realizes the baffle 8 to automatically close the opening, reducing the number of operations and making it easy to use ;
  • a connecting structure is formed between the liquid outlet chamber 9 and the sample adding chamber 5, and the connecting rod 10 is movably connected to the inner surface of the liquid outlet chamber 9, the rotating handle 11 and the connecting rod 10 form a rotating structure, and the upper end surface of the connecting rod 10 It forms a sealed structure with the opening on the lower bottom surface of the sample chamber 5, and its function is to set the liquid outlet chamber 9 to partially leak the excess solution filled in the sample chamber 5 to improve the accuracy of the test solution.
  • the lower end of the sample chamber 5 has small openings, which will not cause large leakage of the solution inside the sample chamber 5.
  • the shape of the inner plate 14 is arc-shaped, and the lower end of the inner plate 14 is connected to the liquid outlet nozzle 13 Located in the same horizontal direction, the liquid outlet nozzle 13 adopts an inclined design, and the plugging pile 12 is movably connected with the outer surface of the container shell 1.
  • the spring 16 forms an elastic structure between the plugging plate 15 and the outer surface of the container shell 1.
  • the plugging plate 15 and the liquid outlet hole of the scale line 6 constitute a sealed structure.
  • the purpose of the inner plate 14 is to make the solution inside the container shell 1 pass through the arc-shaped inner plate 14 and all flow out of the liquid outlet nozzle 13 Compared with the traditional test tube, it does not need to be turned over, and the operation is more convenient.
  • the elastic force of the elastic 16 is used to realize the sealing of the side end surface of the blocking plate 15 and the scale line 6, without manual blocking, which is convenient for use.
  • the device is mainly composed of container shell 1, sample loading chamber 5 and liquid outlet nozzle 13.
  • the device When using the device, first place the device steadily, and then pass different reagents After the reagent tube is diluted, extend the port of the reagent tube into the baffle 8.
  • the rotating structure between the baffle 8 and the rotating shaft 7 causes the baffle 8 to rotate to the inside of the sample loading chamber 5, and then extend the reagent tube into the loading chamber 5.
  • the scale line 6 on the inner wall of the bin 5 controls the required volume;
  • the mixing blade 4 can be used to quickly mix the solution through the rotation between the mixing rod 2 and the connecting shaft 3.
  • the plugging pile 12 is held and pulled up to make the plugging pile 12 under The end surface is separated from the liquid outlet nozzle 13, and the mixed solution flows into the liquid outlet nozzle 13 through the arc-shaped inner plate 14 and then flows out of the device. This is the use process and working principle of the sample injector.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Un dispositif de mélange et d'ajout de micro-réactif, comprenant un boîtier de récipient (1), un bac de chargement d'échantillon (5) et une buse de décharge de liquide (13). Une tige de mélange (2) est montée à l'intérieur du boîtier de récipient (1), et une lame d'hélice d'agitation (4) est fixée sur une surface latérale de la tige de mélange (2). Le bac de chargement d'échantillon (5) est monté sur une surface latérale du boîtier de récipient (1). Un arbre rotatif (7) est disposé sur une surface latérale du bac de chargement d'échantillon (5). Une plaque de blocage (8) est fixée sur une surface latérale de l'arbre rotatif (7). Un bac de décharge de liquide (9) est monté et fixé sur une surface d'extrémité inférieure du bac de chargement d'échantillon (5). Une bielle (10) est reliée de manière mobile à l'intérieur du bac de décharge de liquide (9). Une poignée rotative (11) est reliée à une surface d'extrémité inférieure de la tige de liaison (10). Une plaque interne (14) est disposée sous la pale de l'hélice d'agitation (4). La buse de décharge de liquide (13) est montée sur un côté droit de la plaque interne (14), et une pointe d'obturation (12) pénètre à travers l'intérieur de la buse de décharge de liquide (13). Un ressort (16) est fixé sur une surface extérieure du boîtier de récipient (1), et une plaque d'obturation (15) est fixée sur une surface d'extrémité latérale du ressort (16). Le dispositif de mélange et d'ajout de micro-réactif peut mélanger simultanément une pluralité de groupes de solution de manière étanche de façon à éviter une interférence bactérienne externe, et utilise une agitation manuelle pour améliorer l'efficacité de mélange de solution.
PCT/CN2019/126206 2019-09-19 2019-12-18 Dispositif de mélange et d'ajout de micro-réactif WO2021051688A1 (fr)

Applications Claiming Priority (2)

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CN201921561474.8 2019-09-19
CN201921561474 2019-09-19

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WO2021051688A1 true WO2021051688A1 (fr) 2021-03-25

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112937178A (zh) * 2021-04-09 2021-06-11 扬州市恩壹广告传媒有限公司 一种具有主动防沉淀功能的自取式墨水瓶
CN113188896A (zh) * 2021-05-21 2021-07-30 长沙理工大学 一种实验系统的工作方法
CN115487735A (zh) * 2022-07-27 2022-12-20 济南欣恩医疗科技有限公司 一种核酸提取试剂生产用的混合装置以及工艺方法
CN116223180A (zh) * 2023-05-09 2023-06-06 兴化市东奥食品有限公司 一种液体食品检测用搅拌混合装置

Citations (10)

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US4141469A (en) * 1977-05-02 1979-02-27 Lee Thomas E Microdispensing dilution system
CN1199465A (zh) * 1995-10-12 1998-11-18 热诺米克股份有限公司 液体微量样品传送装置
JP2005514594A (ja) * 2001-10-19 2005-05-19 モノジェン インコーポレイテッド 液体ベースの試験とスライドベースの試験用のサンプルを抽出するように試料を処理する自動化システムおよび方法全システム最適化統合モデル
CN207056401U (zh) * 2017-05-27 2018-03-02 新昌县林昱机械科技有限公司 一种材料混合装置
CN108144660A (zh) * 2016-12-05 2018-06-12 Pva特普拉股份公司 用于容纳小体积液体样品的样品容器
CN207769619U (zh) * 2017-05-26 2018-08-28 石家庄京元粉末材料有限责任公司 搅拌式实验用配比加料装置
CN208427071U (zh) * 2018-06-20 2019-01-25 李建 一种麻醉剂用调配试管
CN109406674A (zh) * 2018-11-29 2019-03-01 江苏永安化工有限公司 一种流动相混合器、液相色谱分析仪以及二甲戊灵杂质分析方法
CN208586300U (zh) * 2018-07-30 2019-03-08 罗山县绿缘三元素生物科技有限公司 一种生物培养液混合用无菌搅拌装置
CN110075738A (zh) * 2019-05-24 2019-08-02 王永林 一种用于药学重症实验的配药装置

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141469A (en) * 1977-05-02 1979-02-27 Lee Thomas E Microdispensing dilution system
CN1199465A (zh) * 1995-10-12 1998-11-18 热诺米克股份有限公司 液体微量样品传送装置
JP2005514594A (ja) * 2001-10-19 2005-05-19 モノジェン インコーポレイテッド 液体ベースの試験とスライドベースの試験用のサンプルを抽出するように試料を処理する自動化システムおよび方法全システム最適化統合モデル
CN108144660A (zh) * 2016-12-05 2018-06-12 Pva特普拉股份公司 用于容纳小体积液体样品的样品容器
CN207769619U (zh) * 2017-05-26 2018-08-28 石家庄京元粉末材料有限责任公司 搅拌式实验用配比加料装置
CN207056401U (zh) * 2017-05-27 2018-03-02 新昌县林昱机械科技有限公司 一种材料混合装置
CN208427071U (zh) * 2018-06-20 2019-01-25 李建 一种麻醉剂用调配试管
CN208586300U (zh) * 2018-07-30 2019-03-08 罗山县绿缘三元素生物科技有限公司 一种生物培养液混合用无菌搅拌装置
CN109406674A (zh) * 2018-11-29 2019-03-01 江苏永安化工有限公司 一种流动相混合器、液相色谱分析仪以及二甲戊灵杂质分析方法
CN110075738A (zh) * 2019-05-24 2019-08-02 王永林 一种用于药学重症实验的配药装置

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112937178A (zh) * 2021-04-09 2021-06-11 扬州市恩壹广告传媒有限公司 一种具有主动防沉淀功能的自取式墨水瓶
CN113188896A (zh) * 2021-05-21 2021-07-30 长沙理工大学 一种实验系统的工作方法
CN113188896B (zh) * 2021-05-21 2022-08-16 长沙理工大学 一种实验系统的工作方法
CN115487735A (zh) * 2022-07-27 2022-12-20 济南欣恩医疗科技有限公司 一种核酸提取试剂生产用的混合装置以及工艺方法
CN116223180A (zh) * 2023-05-09 2023-06-06 兴化市东奥食品有限公司 一种液体食品检测用搅拌混合装置

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