EP1416052B1 - Verfahren zur herstellung von 1,4-dihydroxy-2-naphthoesäure - Google Patents

Verfahren zur herstellung von 1,4-dihydroxy-2-naphthoesäure Download PDF

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Publication number
EP1416052B1
EP1416052B1 EP02755845A EP02755845A EP1416052B1 EP 1416052 B1 EP1416052 B1 EP 1416052B1 EP 02755845 A EP02755845 A EP 02755845A EP 02755845 A EP02755845 A EP 02755845A EP 1416052 B1 EP1416052 B1 EP 1416052B1
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EP
European Patent Office
Prior art keywords
dihydroxy
dhna
naphthoic acid
producing
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP02755845A
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English (en)
French (fr)
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EP1416052A1 (de
EP1416052B8 (de
EP1416052A4 (de
Inventor
Yoshio Product Development Center SATO
Seiya Food Functionality Res. Institute MAKINO
Nobuo Food Funcrionality Res. Institute YODA
Kakuhei Food Functionality Res. Institute ISAWA
Tomonori Food Functionality Res. Ins. KAMIYAMA
Kenichi Food Functionality Res. Inst. HOJO
Mizue Product Development Center SAITO
Naoki Food Functionality Res. Inst. TAKETOMO
Keisuke Product Dev. Center FURUICHI
Shuji Food Functionality Res. Ins. IKEGAMI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Co Ltd
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Meiji Co Ltd
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Publication date
Application filed by Meiji Co Ltd filed Critical Meiji Co Ltd
Publication of EP1416052A1 publication Critical patent/EP1416052A1/de
Publication of EP1416052A4 publication Critical patent/EP1416052A4/de
Application granted granted Critical
Publication of EP1416052B1 publication Critical patent/EP1416052B1/de
Publication of EP1416052B8 publication Critical patent/EP1416052B8/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Claims (7)

  1. Verfahren zur Herstellung von 1,4-Dihydroxy-2-naphthalincarbonsäure, das umfasst eine Kultivierung von Mikroorganismen, ausgewählt aus der Gruppe, bestehend aus der Gattung Propionibacterium und der Gattung Bacillus, die geeignet sind zur Herstellung von 1,4-Dihydroxy-2-naphthalincarbonsäure, um auf diese Weise dem Mikroorganismus zu erlauben, 1,4-Dihydroxy-2-naphthalincarbonsäure in der Kulturbrühe zu produzieren, sowie Sammeln der so hergestellten 1,4-Dihydroxy-2-naphthalincarbonsäure.
  2. Das Verfahren zur Herstellung von 1,4-Dihydroxy-2-naphthalincarbonsäure nach Anspruch 1, wobei eine Kultivierung durchgeführt wird unter Verwendung eines Mediums, enthaltend ein Protease-behandeltes Magermilchpulver oder eines Mediums, enthaltend ein Protease-behandeltes Molkepulver.
  3. Das Verfahren zur Herstellung von 1,4-Dihydroxy-2-naphthalincarbonsäure nach Anspruch 1 oder 2, wobei als Additiv während der Kultivierung mindestens ein Additiv, ausgewählt aus einem Hefeextrakt und Laktose, eingesetzt wird.
  4. Das Verfahren zur Herstellung von 1,4-Dihydroxy-2-naphthalincarbonsäure nach einem der Ansprüche 1 bis 3, wobei nach Beendigung der Kultivierung, die Kulturbrühe auf 3 bis 20°C abgekühlt und gelagert wird.
  5. Das Verfahren zur Herstellung von 1,4-Dihydroxy-2-naphthalincarbonsäure nach Anspruch 1, wobei 1,4-Dihydroxy-2-naphthalincarbonsäure gesammelt wird durch Unterwerfung der Kulturbrühe, die 1,4-Dihydroxy-2-naphthalincarbonsäure enthält, unter eine Adsorptionschromatographie, gefolgt von Adsorption und Elution von 1,4-Dihydroxy-2-naphthalincarbonsäure.
  6. Das Verfahren zur Herstellung von 1,4-Dihydroxy-2-naphthalincarbonsäure nach Anspruch 5, wobei die auf diese Weise eluierte Lösung konzentriert wird.
  7. Das Verfahren zur Herstellung von 1,4-Dihydroxy-2-naphthalincarbonsäure nach einem der Ansprüche 1 bis 6, wobei der Mikroorganismus, der zur Herstellung von 1,4-Dihydroxy-2-naphthalinsäure geeignet ist, Propionibacterium freudenreichii ist.
EP02755845A 2001-08-10 2002-08-06 Verfahren zur herstellung von 1,4-dihydroxy-2-naphthoesäure Expired - Lifetime EP1416052B8 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001244475 2001-08-10
JP2001244475 2001-08-10
PCT/JP2002/008010 WO2003016544A1 (fr) 2001-08-10 2002-08-06 Procede d'elaboration d'acide 1,4-dihydroxy-2-naphtoique

Publications (4)

Publication Number Publication Date
EP1416052A1 EP1416052A1 (de) 2004-05-06
EP1416052A4 EP1416052A4 (de) 2005-10-12
EP1416052B1 true EP1416052B1 (de) 2012-09-12
EP1416052B8 EP1416052B8 (de) 2013-01-09

Family

ID=19074394

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02755845A Expired - Lifetime EP1416052B8 (de) 2001-08-10 2002-08-06 Verfahren zur herstellung von 1,4-dihydroxy-2-naphthoesäure

Country Status (9)

Country Link
US (4) US7374915B2 (de)
EP (1) EP1416052B8 (de)
JP (1) JP4070721B2 (de)
KR (1) KR100899615B1 (de)
CN (2) CN1820741A (de)
AU (1) AU2002323899B2 (de)
CA (1) CA2457055C (de)
NZ (1) NZ531192A (de)
WO (1) WO2003016544A1 (de)

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Publication number Priority date Publication date Assignee Title
US7374915B2 (en) 2001-08-10 2008-05-20 Meiji Dairies Corporation Process for producing 1,4-dihydroxy-2-naphthoic acid
CN102166018A (zh) * 2003-03-26 2011-08-31 明治乳业株式会社 稳定1,4-二羟基-2-萘甲酸的方法
NZ546286A (en) * 2003-10-01 2008-10-31 Meiji Dairies Corp Process for producing 1,4-dihydroxy-2-naphthoic acid
US7241809B2 (en) * 2003-12-22 2007-07-10 Meiji Dairies Corporation Method for treating inflammatory bowel diseases
WO2005072718A1 (ja) * 2004-01-28 2005-08-11 Kurume University 乳清発酵物を含有する医薬組成物
JP4507065B2 (ja) * 2004-02-12 2010-07-21 明治乳業株式会社 １，４−ジヒドロキシ−２−ナフトエ酸の安定化剤
CN1946412B (zh) 2004-04-13 2011-04-13 明治乳业株式会社 炎性肠病的预防和/或治疗剂
JP4073922B2 (ja) * 2005-03-18 2008-04-09 明治飼糧株式会社 ビフィズス菌増殖促進成分を含有する飼料組成物とその使用方法
JP5114200B2 (ja) * 2005-08-26 2013-01-09 株式会社明治 抗アレルギー剤
CA2675729C (en) * 2007-01-17 2015-05-12 Meiji Dairies Corporation Prophylactic and/or therapeutic agent for functional gastrointestinal disorders
EP2194118A4 (de) * 2007-11-27 2012-02-29 Meiji Dairies Corp Mittel und verfahren zur verbesserung der überlebensfähigkeit des milchsäurebakteriums und lebensmittelzusammensetzung
US20100322973A1 (en) * 2008-02-29 2010-12-23 Meiji Dairies Corpration Anti-allergic agent
WO2009150036A1 (en) * 2008-05-26 2009-12-17 Compagnie Gervais Danone Method for decreasing borborygmi by administering a bifidobacterium bacteria.
FR2960001A1 (fr) 2010-05-12 2011-11-18 Univ Rennes Vecteur recombinant pour la production et la secretion de sequences d'acides amines d'interet par les bacteries propioniques et ses applications
WO2011145737A1 (ja) * 2010-05-21 2011-11-24 株式会社明治 皮膚状態の改善用組成物
KR101342791B1 (ko) 2012-08-16 2013-12-19 주식회사 제이케이뉴트라 1,4-디히드록시-2-나프토산 생산능을 가지는 락토바실러스 카제이 ｌｐ1 균주 및 이의 이용
US11179427B2 (en) 2013-01-21 2021-11-23 Eth Zurich Baby food composition comprising viable propionic acid-producing bacteria
WO2014163031A1 (ja) * 2013-04-01 2014-10-09 株式会社明治 即効性の整腸剤
EP2829274A1 (de) 2013-07-25 2015-01-28 Institut National De La Recherche Agronomique Vektoren zur Herstellung und Sekretion von Substanzen von Interesse durch Bakterien und Anwendungen dafür
JP6607595B2 (ja) * 2014-06-16 2019-11-20 学校法人産業医科大学 １，４−ジヒドロキシ−２−ナフトエ酸誘導体
EP3294308A4 (de) 2015-05-14 2019-03-06 University of Puerto Rico Verfahren zur wiederherstellung der biozönose von neugeborenen
KR20170022343A (ko) 2015-08-20 2017-03-02 김태웅 유산균 발효액, 플로랄 워터 및 생약 추출물을 기반으로 하는 피부 알레르기의 예방, 개선제
WO2017117142A1 (en) 2015-12-28 2017-07-06 New York University Device and method of restoring microbiota of newborns
KR102127108B1 (ko) * 2018-06-26 2020-06-26 고려대학교산학협력단 프로피오니바크테리움 후레우덴레이키, 이의 배양액 또는 이의 사균체를 유효성분으로 함유하는 골질환의 예방 또는 치료용 조성물

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US7374915B2 (en) 2001-08-10 2008-05-20 Meiji Dairies Corporation Process for producing 1,4-dihydroxy-2-naphthoic acid

Also Published As

Publication number Publication date
CN1312285C (zh) 2007-04-25
US20110009491A1 (en) 2011-01-13
EP1416052A1 (de) 2004-05-06
US20080194688A1 (en) 2008-08-14
US7629155B2 (en) 2009-12-08
AU2002323899B9 (en) 2003-03-03
EP1416052B8 (de) 2013-01-09
US7834061B2 (en) 2010-11-16
US20040241815A1 (en) 2004-12-02
CN1539019A (zh) 2004-10-20
AU2002323899B2 (en) 2007-06-28
US8110607B2 (en) 2012-02-07
CA2457055A1 (en) 2003-02-27
US7374915B2 (en) 2008-05-20
CN1820741A (zh) 2006-08-23
JPWO2003016544A1 (ja) 2004-12-02
CA2457055C (en) 2013-10-08
JP4070721B2 (ja) 2008-04-02
WO2003016544A1 (fr) 2003-02-27
NZ531192A (en) 2005-07-29
KR20040032886A (ko) 2004-04-17
US20090312425A1 (en) 2009-12-17
EP1416052A4 (de) 2005-10-12
KR100899615B1 (ko) 2009-05-27

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