JP4507065B2 - 1,4−ジヒドロキシ−2−ナフトエ酸の安定化剤 - Google Patents
1,4−ジヒドロキシ−2−ナフトエ酸の安定化剤 Download PDFInfo
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- JP4507065B2 JP4507065B2 JP2004035385A JP2004035385A JP4507065B2 JP 4507065 B2 JP4507065 B2 JP 4507065B2 JP 2004035385 A JP2004035385 A JP 2004035385A JP 2004035385 A JP2004035385 A JP 2004035385A JP 4507065 B2 JP4507065 B2 JP 4507065B2
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- VOJUXHHACRXLTD-UHFFFAOYSA-N 1,4-dihydroxy-2-naphthoic acid Chemical compound C1=CC=CC2=C(O)C(C(=O)O)=CC(O)=C21 VOJUXHHACRXLTD-UHFFFAOYSA-N 0.000 title claims description 22
- 239000003381 stabilizer Substances 0.000 title claims description 15
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 29
- 235000013305 food Nutrition 0.000 claims description 21
- CIWBSHSKHKDKBQ-DUZGATOHSA-N D-araboascorbic acid Natural products OC[C@@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-DUZGATOHSA-N 0.000 claims description 17
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- VOJUXHHACRXLTD-UHFFFAOYSA-M 1,4-dihydroxy-2-naphthoate Chemical compound C1=CC=C2C(O)=CC(C([O-])=O)=C(O)C2=C1 VOJUXHHACRXLTD-UHFFFAOYSA-M 0.000 description 42
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Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Non-Alcoholic Beverages (AREA)
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Description
(1)エリソルビン酸を有効成分とする1,4−ジヒドロキシ−2−ナフトエ酸の安定化剤。
(2)エリソルビン酸が、遊離の酸、エステル、塩からなる群より選ばれる少なくとも1種であること、を特徴とする前記(1)に記載の安定化剤。
(3)前記(1)又は(2)に記載の安定化剤を医薬品の容量に対し0.01%(W/V)以上含有してなること、を特徴とする1,4−ジヒドロキシ−2−ナフトエ酸含有医薬品。
(4)前記(1)又は(2)に記載の安定化剤を飲食品の容量に対し0.01%(W/V)以上含有してなること、を特徴とする1,4−ジヒドロキシ−2−ナフトエ酸含有飲食品。
(5)前記(1)又は(2)に記載の安定化剤を分析用剤の容量に対し0.01%(W/V)以上含有してなること、を特徴とする1,4−ジヒロドキシ−2−ナフトエ酸含有分析用剤。
試料10.0gをビーカーに採取する。10%-アスコルビン酸ナトリウム水溶液1ml、イオン交換水18.8ml、53.5%ZnSO4・7H2O水溶液(W/V)0.1ml、17.2%K4Fe(CN)6・3H2O水溶液0.1ml←林課長に確認しますを加え、撹拌する(ULTRA-TURRAX T-25,8000rpm×1min)。1N-HClでpH4.6に調整し、メタノールを30g添加する。一次ろ過後(ADVANTEC No.5A)、精密ろ過する(MILLIPORE0.45μmメンブランフィルター)。ろ液をHPLC(カラム:Cadenza CD-C18(4.6×150mm、インタクト(社)製)、移動相:アセトニトリル、メタノール、蒸留水及び酢酸(15:25:190:0.1、vol/vol/vol/vol、アンモニア水溶液でpH7に調整 )、検出器:UV検出器、検出波長:254nm、流速:1.0ml/min、カラム温度:45℃、試料注入量:150μl)に供する。検量線は、DHNA標品(046-22422、和光純薬工業(社)製)の1 mg/ml(メタノール溶液)標準原液を調製し、メタノールで適宜希釈した溶液を用いて作成する。
試料10mlを400mlメスフラスコに採取する。1%-アスコルビン酸ナトリウム水溶液:メタノール=1:1でメスアップする。5ml採取し、10ml遠沈管に移し遠心分離する(久保田テーブルトップ遠心機KUBOTA5100,3000rpm×3min)。上清をろ過し(MILLIPORE0.45μmメンブランフィルター)、HPLCサンプルとし、試験例1と同様の方法で測定する。
表1に示す配合で、ニュージーランドチェダーチーズを粉砕してチーズ溶融釜に入れ、プロピオン酸菌乳清発酵物(ホエー粉培地でWO03/016544-A1実施例2に準じて製造。DHNAとして10μg/ml含有)、チーズ乳化剤としてポリリン酸ナトリウム、安定化剤としてエリソルビン酸ナトリウムを1.0%、水をそれぞれ添加した後、常法にしたがって、チーズ溶融釜のジャケットに蒸気を通じて、200mmHg/cm2の減圧下で脱気しつつ撹拌して、87℃まで昇温して溶融した。溶融チーズを酸素透過度の低いプラスチックフィルム包材(旭化成プロダクツ製「飛竜」)に密封充填し、平板状に整形、冷却してDHNA含有チーズを得た。これを5ヶ月間10℃および30℃で保存し、1ヶ月ごとにDHNA含量を測定し、チーズ内部の色調の変化も観察した。
表1に示す配合で安定化剤としてエリソルビン酸ナトリウムの代わりにアスコルビン酸ナトリウムを1%添加する以外は実施例と同様の操作で比較例を得た。これを5ヶ月間10℃および30℃で保存し、1ヶ月ごとにDHNA含量を測定し、実施例と比較した。
Claims (5)
- エリソルビン酸を有効成分とする1,4−ジヒドロキシ−2−ナフトエ酸の安定化剤。
- エリソルビン酸が、遊離の酸、エステル、塩からなる群より選ばれる少なくとも1種であること、を特徴とする請求項1記載の安定化剤。
- 請求項1又は2記載の安定化剤を医薬品の容量に対し0.01%(W/V)以上含有してなること、を特徴とする1,4−ジヒドロキシ−2−ナフトエ酸含有医薬品。
- 請求項1又は2記載の安定化剤を飲食品の容量に対し0.01%(W/V)以上含有してなること、を特徴とする1,4−ジヒドロキシ−2−ナフトエ酸含有飲食品。
- 請求項1又は2記載の安定化剤を分析用剤の容量に対し0.01%(W/V)以上含有してなること、を特徴とする1,4−ジヒドロキシ−2−ナフトエ酸含有分析用剤。
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JP2004035385A JP4507065B2 (ja) | 2004-02-12 | 2004-02-12 | 1,4−ジヒドロキシ−2−ナフトエ酸の安定化剤 |
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JP2005225794A JP2005225794A (ja) | 2005-08-25 |
JP4507065B2 true JP4507065B2 (ja) | 2010-07-21 |
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JP2004035385A Expired - Fee Related JP4507065B2 (ja) | 2004-02-12 | 2004-02-12 | 1,4−ジヒドロキシ−2−ナフトエ酸の安定化剤 |
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JP5877798B2 (ja) * | 2011-01-24 | 2016-03-08 | 株式会社明治 | 液状食品及びその製造方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10108672A (ja) * | 1996-10-04 | 1998-04-28 | Meiji Milk Prod Co Ltd | ビフィズス因子の活性増強・安定化剤 |
WO2003016544A1 (fr) * | 2001-08-10 | 2003-02-27 | Meiji Dairies Corporation | Procede d'elaboration d'acide 1,4-dihydroxy-2-naphtoique |
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JPH10108672A (ja) * | 1996-10-04 | 1998-04-28 | Meiji Milk Prod Co Ltd | ビフィズス因子の活性増強・安定化剤 |
WO2003016544A1 (fr) * | 2001-08-10 | 2003-02-27 | Meiji Dairies Corporation | Procede d'elaboration d'acide 1,4-dihydroxy-2-naphtoique |
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