JP5188181B2 - 血中アルコール濃度上昇抑制用組成物 - Google Patents
血中アルコール濃度上昇抑制用組成物 Download PDFInfo
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- JP5188181B2 JP5188181B2 JP2007532189A JP2007532189A JP5188181B2 JP 5188181 B2 JP5188181 B2 JP 5188181B2 JP 2007532189 A JP2007532189 A JP 2007532189A JP 2007532189 A JP2007532189 A JP 2007532189A JP 5188181 B2 JP5188181 B2 JP 5188181B2
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Description
従来、飲酒後の血中アルコール濃度を低下させるまたは上昇を抑制する物質または組成物として、柿酢(特許文献1参照)、キャベツ、赤紫蘇、人参およびパセリの絞り汁の混合物(特許文献2参照)、オタネニンジンの水性溶媒抽出物のエタノール不溶物(特許文献3参照)、グリセロール(特許文献4参照)、茶抽出物とポルフィリン系色素を含有する組成物(特許文献5参照)、ペピノ抽出物(特許文献6参照)等が知られている。
すなわち、本発明の目的は、血中アルコール濃度上昇抑制用組成物を提供することにある。
(1)塩基性アミノ酸またはその塩を有効成分として含有する血中アルコール濃度上昇抑制用組成物。
(2)塩基性アミノ酸が、オルニチン、アルギニン、リジン、ヒスチジン、またはシトルリンである上記(1)の組成物。
(3)有機酸を含有する上記(1)または(2)の組成物。
(4)有機酸が、酢酸、乳酸、リンゴ酸、フマル酸、酒石酸、またはクエン酸である上記(3)の組成物。
(5)組成物が医薬または食品添加剤である、上記(1)〜(4)のいずれか1項の組成物。
(6)上記(5)の食品添加剤を含有する飲食品。
(7)塩基性アミノ酸またはその塩の有効量を、必要とする対象に投与または摂取させることを含む、血中アルコール濃度上昇抑制方法。
(8)塩基性アミノ酸が、オルニチン、アルギニン、リジン、ヒスチジン、またはシトルリンである上記(7)の方法。
(9)有機酸をさらに投与または摂取させることを含む、上記(7)または(8)の方法。
(10)有機酸が、酢酸、乳酸、リンゴ酸、フマル酸、酒石酸、またはクエン酸である上記(9)の方法。
(11)アルコール血中濃度上昇抑制用組成物の製造のための、塩基性アミノ酸またはその塩の使用。
(12)塩基性アミノ酸が、オルニチン、アルギニン、リジン、ヒスチジン、またはシトルリンである上記(11)の使用。
(13)有機酸をさらに使用することを含む、上記(11)または(12)の使用。
(14)有機酸が、酢酸、乳酸、リンゴ酸、フマル酸、酒石酸、またはクエン酸である上記(13)の使用。
酸付加塩としては、塩酸塩、硫酸塩、硝酸塩、リン酸塩等の無機酸塩、酢酸塩、マレイン酸塩、フマル酸塩、クエン酸塩、リンゴ酸塩、乳酸塩、α−ケトグルタル酸塩、グルコン酸塩、カプリル酸塩等の有機酸塩があげられる。
アンモニウム塩としては、アンモニウム、テトラメチルアンモニウム等の塩があげられる。
有機アミン付加塩としては、モルホリン、ピペリジン等の塩があげられる。
本発明で用いられる有機酸としては、酢酸、乳酸、リンゴ酸、フマル酸、酒石酸、クエン酸等があげられるが、酢酸またはクエン酸が好ましく、クエン酸がより好ましい。また、上記有機酸は、それぞれを単独で用いる他、2種以上の混合物として用いてもよい。
本発明の組成物を医薬として用いる場合、塩基性アミノ酸またはその塩をそのまま投与することも可能であるが、通常各種の製剤として提供するのが望ましい。
投与する剤形としては、例えば錠剤、散剤、顆粒剤、丸剤、懸濁剤、乳剤、浸剤・煎剤、カプセル剤、シロップ剤、液剤、エリキシル剤、エキス剤、チンキ剤、流エキス剤等の経口剤、注射剤、点滴剤、クリーム剤、坐剤等の非経口剤のいずれでもよいが、経口剤として好適に用いられる。
また、これら非経口剤においても、経口剤で例示した防腐剤、保存剤、フレーバー類、賦形剤、崩壊剤、滑沢剤、結合剤、界面活性剤、可塑剤などから選択される1種またはそれ以上の補助成分を添加することができる。
本発明の医薬の投与量および投与回数は、投与形態、患者の年齢、体重、治療すべき症状の性質もしくは重篤度により異なるが、通常、成人一日当り、塩基性アミノ酸またはその塩として通常は50mg〜30g、好ましくは100mg〜10g、特に好ましくは200mg〜3gとなるように一日一回ないし数回投与する。
投与期間は、特に限定されないが、通常は1日間〜1年間、好ましくは1週間〜3ヶ月間である。
本発明の食品添加剤は、必要に応じて他の食品添加剤を混合または溶解し、例えば粉末、顆粒、ペレット、錠剤、各種液剤の形態に加工、製造される。
また、本発明の飲食品は、例えば流動層造粒、攪拌造粒、押し出し造粒、転動造粒、気流造粒、圧縮成形造粒、解砕造粒、噴霧造粒、噴射造粒等の造粒方法、パンコーティング、流動層コーティング、ドライコーティング等のコーティング方法、パフドライ、過剰水蒸気法、フォームマット方法、マイクロ波加熱方法等の膨化方法、押出造粒機やエキストルーダー等の押出方法等を用いて製造することもできる。
本発明の飲食品は、血中アルコール濃度上昇抑制用の健康食品、機能性食品、栄養補助食品、特定保健用食品等の飲食品として用いることができる。
本発明の飲食品中への本発明の食品添加剤の添加量は、飲食品の種類、当該飲食品の摂取により期待する効果等に応じて適宜選択されるが、塩基性アミノ酸またはその塩として、通常は0.1〜90重量%、好ましくは0.5〜80重量%、特に好ましくは1〜70重量%含有するように添加される。
摂取期間は特に限定はないが、通常は1日間〜1年間、好ましくは1週間〜3ヶ月間である。
本発明の医薬または飲食品を、飲酒前、飲酒中または飲酒後に投与または摂取することにより、血中アルコール濃度の上昇を抑制することができる。
以下に、塩基性アミノ酸による血中アルコール濃度上昇抑制効果を調べた試験例を示す。
試験には、DBA/2Crマウス(オス、7週齢、日本エスエルシー社より購入)を用いた。飼育条件は、室温22±2℃、湿度35±15%、飼料および水は自由摂取とした。
各試験群は5匹のマウスで構成し、まずエタノールを体重1kgあたり4gとなるよう経口投与し、その30分後、対照群のマウスには蒸留水を、試験群1のマウスには体重1kgあたり2gのオルニチン塩酸塩(協和醗酵工業社製)を摂取させるように調製した水溶液を、試験群2のマウスには体重1kgあたり0.935gのオルニチン塩酸塩と1.065gのクエン酸(和光純薬社製)を摂取させるように調製した水溶液を経口投与した。
以上の結から、オルニチンによる血中アルコール濃度上昇抑制効果が明らかとなった。
試験例1において、試験群1のマウスに体重1kgあたり2gのヒスチジン(協和醗酵工業社製)を摂取させるように調製した水溶液を、試験群2のマウスに体重1kgあたり2gのヒスチジン塩酸塩(協和醗酵工業社製)を摂取するように調製した水溶液を経口投与した以外は、試験例1と同様の試験を行った。
以上の結果から、ヒスチジンによる血中アルコール濃度上昇抑制効果が明らかとなった。
試験例1において、試験群1のマウスに体重1kgあたり2gのリジンクエン酸塩(協和醗酵工業社製)を摂取させるように調製した水溶液を、試験群2のマウスに体重1kgあたり2gのシトルリン(協和醗酵工業社製)を摂取するように調製した水溶液を経口投与した以外は、試験例1と同様の試験を行った。
以上の結果から、リジン、シトルリンによる血中アルコール濃度上昇抑制効果が明らかとなった。
試験例1において対照群と試験群1の2群構成とし、試験群1のマウスに体重1kgあたり2gのリジン塩酸塩(協和醗酵工業社製)を摂取させるように調製した水溶液を経口投与した以外は、試験例1と同様の試験を行った。
以上の結果から、リジンによる血中アルコール濃度上昇抑制効果が明らかとなった。
試験例1において対照群と試験群1の2群構成とし、試験群1のマウスに体重1kgあたり1gのアルギニン(協和醗酵工業社製)を摂取させるように調製した水溶液を経口投与した以外は、試験例1と同様の試験を行った。
結果を図5に示す。図5より、試験群1において、特にエタノール投与後90分以内における血中エタノール濃度の上昇が顕著に抑制されることが示された。
以上の結果から、アルギニンによる血中アルコール濃度上昇抑制効果が明らかとなった。
以下に、本発明の実施例を示す。
オルニチン塩酸塩136.2kg(協和醗酵工業社製、L-オルニチン塩酸塩)、微結晶セルロース36.0kg(旭化成ケミカルズ社製、アビセルFD101)、ショ糖脂肪酸エステル6.6kg(第一工業製薬社製、DKエステルF-20W)、リン酸カルシウム1.2kg(太平化学産業社製、リン酸三カルシウム)およびβ-シクロデキストリン20.0kg(日本食品化工社製、セルデックスB-100)を、コニカルブレンダー(日本乾燥機株式会社製、CB-1200ブレンダー)を用いて混合した。得られた混合物をロータリー圧縮成形機(菊水制作所社製、VIRGO524SS1AY)を用いて、圧縮成形圧10kNで圧縮成形し、直径8mm、250mgの錠剤を製造した。
奈良機械製作所製M-2型(スクリーン0.5mm)で粉砕したクエン酸(協和ハイフーズ社製)1000g、オルニチン塩酸塩1000g、および還元麦芽糖水あめ(林原商事社製、粉末マビット50M)2747.5gの混合物を、水を用いて流動層造粒乾燥機(フロイント産業社製、FLO-5)で造粒した。得られた造粒物4557.6gにスクラロース(三栄源エフ・エフ・アイ社製)2.4gとショ糖脂肪酸エステル(長瀬産業社製、DKエステルF-20W)240gとを混合した。得られた混合物をロータリー圧縮成形機を用いて、圧縮成形圧10kNで圧縮成形し、直径9mm、300mgの錠剤を製造した。
オルニチン塩酸塩1.28kg、エリスリトール3kg(日研化学社製)、クエン酸0.05kg、人工甘味料3g、香料0.06kgを液温70℃で水50Lに攪拌溶解し、クエン酸でpHを3.3に調整後、プレート殺菌を用いて滅菌して瓶に充填後、パストライザー殺菌し、オルニチンおよびクエン酸を含有する飲料を製造した。
Claims (3)
- アミノ酸またはその塩としては、オルニチン、ヒスチジン、もしくはシトルリンまたはそれらの塩のみを有効成分として含有する血中アルコール濃度上昇抑制剤。
- 有機酸を含有する請求項1記載の血中アルコール濃度上昇抑制剤。
- 有機酸が、酢酸、乳酸、リンゴ酸、フマル酸、酒石酸、またはクエン酸である請求項2記載の血中アルコール濃度上昇抑制剤。
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JP2013124243A (ja) | 2011-12-15 | 2013-06-24 | Matsutani Chem Ind Ltd | 血中アルコール濃度上昇抑制剤 |
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