JP6052566B2 - 疲労臭抑制剤 - Google Patents
疲労臭抑制剤 Download PDFInfo
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- JP6052566B2 JP6052566B2 JP2011002237A JP2011002237A JP6052566B2 JP 6052566 B2 JP6052566 B2 JP 6052566B2 JP 2011002237 A JP2011002237 A JP 2011002237A JP 2011002237 A JP2011002237 A JP 2011002237A JP 6052566 B2 JP6052566 B2 JP 6052566B2
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- Prior art keywords
- fatigue
- odor
- ornithine
- salt
- food
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Description
<試験サンプルの調製>
ハードカプセルにオルニチン塩酸塩を250mg(オルニチンとして200mg)及びグリシンを222.6mg(オルニチンと窒素当量が等しい量)をそれぞれ充填し、オルニチン食品及びプラセボ食品(見せかけ食品:対照)とした。
20歳以上40歳未満の健康な男性19名に、プラセボ食品またはオルニチン食品を12錠摂取してもらい、その後自転車エルゴメーターを用いた漸増運動(一定時間毎に段階的に負荷重量が増加する運動)を疲労困憊になるまで行ってもらった。なお、試験食品摂取の際、各カプセルは、いずれも味や形状で試験食品の判断ができないようにし、試験は2群のクロスオーバー二重盲検により実施した。被験者には、運動開始前の30分間、運動中〜運動終了後の10分間および運動終了の15分目〜45分目に、手掌にポリエチレン製の手袋を密閉装着してもらった。上記所定の時間経過後、手袋内に蓄積した内容物を洗浄液とともに回収して試験サンプルとした。試験サンプル中のアンモニア量を疲労臭の量とし、液体クロマトグラフィーで定量した。
結果を図1および2に示す。図1に示すように、運動によって生じたアンモニア(疲労臭)が、オルニチン食品を摂取することにより有意に抑制された。また、図2に示すように、19名の被験者中15名が、プラセボ食品を摂取した場合と比較してオルニチン塩酸塩を摂取することにより疲労臭が抑制された。
Claims (2)
- オルニチン又はその塩を有効成分として含有することを特徴とする、一日当たりの投与量が、オルニチン又はその塩として400mg〜3gの範囲になるように製剤化された、運動直前摂取用の運動に起因する疲労臭の抑制剤。
- 疲労臭の抑制剤が、経口投与の形態で製剤化されることを特徴とする請求項1に記載の疲労臭の抑制剤。
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