EG24081A - 4-Substituted-9-deoxo-9a-aza-9a-homerythromycin derivatives - Google Patents

4-Substituted-9-deoxo-9a-aza-9a-homerythromycin derivatives

Info

Publication number
EG24081A
EG24081A EG64098A EG64098A EG24081A EG 24081 A EG24081 A EG 24081A EG 64098 A EG64098 A EG 64098A EG 64098 A EG64098 A EG 64098A EG 24081 A EG24081 A EG 24081A
Authority
EG
Egypt
Prior art keywords
homerythromycin
deoxo
aza
derivatives
substituted
Prior art date
Application number
EG64098A
Other languages
English (en)
Inventor
Brians S Bronk
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EG24081(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of EG24081A publication Critical patent/EG24081A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EG64098A 1997-06-11 1998-06-09 4-Substituted-9-deoxo-9a-aza-9a-homerythromycin derivatives EG24081A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11

Publications (1)

Publication Number Publication Date
EG24081A true EG24081A (en) 2008-05-11

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
EG64098A EG24081A (en) 1997-06-11 1998-06-09 4-Substituted-9-deoxo-9a-aza-9a-homerythromycin derivatives

Country Status (50)

Country Link
US (4) US6420536B1 (US06559137-20030506-C00182.png)
EP (1) EP0988310B9 (US06559137-20030506-C00182.png)
JP (2) JP3315704B2 (US06559137-20030506-C00182.png)
KR (1) KR100396168B1 (US06559137-20030506-C00182.png)
CN (4) CN101691390A (US06559137-20030506-C00182.png)
AP (1) AP1231A (US06559137-20030506-C00182.png)
AR (1) AR013086A1 (US06559137-20030506-C00182.png)
AT (1) ATE251173T1 (US06559137-20030506-C00182.png)
AU (1) AU749816B2 (US06559137-20030506-C00182.png)
BG (1) BG64391B1 (US06559137-20030506-C00182.png)
BR (1) BRPI9810519B8 (US06559137-20030506-C00182.png)
CA (1) CA2293823C (US06559137-20030506-C00182.png)
CO (1) CO4950611A1 (US06559137-20030506-C00182.png)
CZ (1) CZ298556B6 (US06559137-20030506-C00182.png)
DE (2) DE122004000018I2 (US06559137-20030506-C00182.png)
DK (1) DK0988310T3 (US06559137-20030506-C00182.png)
DZ (1) DZ2514A1 (US06559137-20030506-C00182.png)
EA (1) EA002441B1 (US06559137-20030506-C00182.png)
EG (1) EG24081A (US06559137-20030506-C00182.png)
ES (1) ES2205487T3 (US06559137-20030506-C00182.png)
FR (1) FR04C0013I2 (US06559137-20030506-C00182.png)
GT (1) GT199800077A (US06559137-20030506-C00182.png)
HK (3) HK1028048A1 (US06559137-20030506-C00182.png)
HN (1) HN1998000086A (US06559137-20030506-C00182.png)
HR (1) HRP980314B1 (US06559137-20030506-C00182.png)
HU (2) HU228005B1 (US06559137-20030506-C00182.png)
ID (1) ID22992A (US06559137-20030506-C00182.png)
IL (1) IL132809A0 (US06559137-20030506-C00182.png)
IS (1) IS1998B (US06559137-20030506-C00182.png)
LU (1) LU91076I9 (US06559137-20030506-C00182.png)
MA (1) MA24564A1 (US06559137-20030506-C00182.png)
ME (1) ME00876B (US06559137-20030506-C00182.png)
MY (1) MY123354A (US06559137-20030506-C00182.png)
NL (1) NL300150I2 (US06559137-20030506-C00182.png)
NO (1) NO316911B1 (US06559137-20030506-C00182.png)
NZ (2) NZ514871A (US06559137-20030506-C00182.png)
OA (1) OA11224A (US06559137-20030506-C00182.png)
PA (1) PA8452201A1 (US06559137-20030506-C00182.png)
PE (1) PE79699A1 (US06559137-20030506-C00182.png)
PL (1) PL191601B1 (US06559137-20030506-C00182.png)
PT (1) PT988310E (US06559137-20030506-C00182.png)
RS (1) RS49675B (US06559137-20030506-C00182.png)
SI (1) SI0988310T1 (US06559137-20030506-C00182.png)
SK (1) SK284171B6 (US06559137-20030506-C00182.png)
TN (1) TNSN98082A1 (US06559137-20030506-C00182.png)
TW (1) TW472060B (US06559137-20030506-C00182.png)
UA (1) UA67744C2 (US06559137-20030506-C00182.png)
UY (1) UY25040A1 (US06559137-20030506-C00182.png)
WO (1) WO1998056802A1 (US06559137-20030506-C00182.png)
ZA (1) ZA985017B (US06559137-20030506-C00182.png)

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JP3897983B2 (ja) * 1999-05-18 2007-03-28 ファイザー・プロダクツ・インク マクロライド系抗生物質の新規結晶
WO2000071557A1 (en) * 1999-05-24 2000-11-30 Pfizer Products Inc. 13-methyl-erythromycin derivatives
US6465437B1 (en) 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
ATE315042T1 (de) * 1999-08-24 2006-02-15 Abbott Lab 9a-azalide mit antibakterieller wirkung
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
US6608033B1 (en) * 1999-08-27 2003-08-19 Pfizer Inc. Treatment or prevention of coccidiosis
PT1250343E (pt) * 2000-01-27 2003-11-28 Pfizer Prod Inc Composicoes de antibioticos de azalida
JP2004516233A (ja) * 2000-04-27 2004-06-03 ファイザー・プロダクツ・インク 哺乳動物の細菌若しくは原生動物感染症を治療するか又は予防するためのアザライド抗生組成物の使用
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US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
JP2008526948A (ja) * 2005-01-14 2008-07-24 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ 抗マラリア活性を有する９ａ−カルバモイルおよびチオカルバモイルアザライド
WO2009055557A1 (en) * 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
WO2010048601A1 (en) 2008-10-24 2010-04-29 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
AU2010292010B2 (en) 2009-09-10 2016-01-07 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
SI2550286T1 (sl) 2010-03-22 2016-04-29 Cempra Pharmaceuticals, Inc. Kristalne oblike makrolida in njihove uporabe
RU2608390C2 (ru) 2010-05-20 2017-01-18 Семпра Фармасьютикалз, Инк. Способы получения макролидов и кетолидов, и промежуточных соединений для их получения
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
US8940880B2 (en) * 2010-09-20 2015-01-27 Novartis Ag Process for the preparation of 9-deoxo-9a-homoerythromycin A, modified in the C-4″ of the cladinose ring by an epoxide group
CA2814333A1 (en) * 2010-10-10 2012-04-19 Synovo Gmbh Anti-inflammatory macrolides
WO2013004116A1 (zh) * 2011-07-06 2013-01-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
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RU2658050C2 (ru) 2012-03-27 2018-06-19 Семпра Фармасьютикалз, Инк. Парентеральные составы для введения макролидных антибиотиков
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法
EP3027634B1 (en) * 2013-07-31 2018-03-21 Farma GRS, d.o.o. Process for preparation of tulathromycin
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) * 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) * 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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Also Published As

Publication number Publication date
HRP980314B1 (en) 2004-04-30
KR100396168B1 (ko) 2003-08-27
DE69818665T2 (de) 2004-04-29
US20020061858A1 (en) 2002-05-23
TNSN98082A1 (fr) 2005-03-15
UY25040A1 (es) 2000-09-29
CN1243766C (zh) 2006-03-01
JP3315704B2 (ja) 2002-08-19
HUP0002209A2 (hu) 2000-12-28
AP9801255A0 (en) 1998-06-30
HK1068893A1 (en) 2005-07-29
NO316911B1 (no) 2004-06-21
DZ2514A1 (fr) 2003-02-01
NZ514871A (en) 2003-08-29
PE79699A1 (es) 1999-08-25
US6777393B2 (en) 2004-08-17
EA002441B1 (ru) 2002-04-25
IS5252A (is) 1999-11-16
CN1793155B (zh) 2010-05-12
AR013086A1 (es) 2000-12-13
EP0988310B9 (en) 2006-03-08
EP0988310B1 (en) 2003-10-01
PT988310E (pt) 2003-12-31
DE122004000018I2 (de) 2011-01-13
BRPI9810519B8 (pt) 2022-11-16
HUP0002209A3 (en) 2003-05-28
US20040023896A1 (en) 2004-02-05
ME00876B (me) 2012-06-20
NL300150I1 (nl) 2004-08-02
LU91076I2 (fr) 2004-07-05
ZA985017B (en) 1999-12-17
EP0988310A1 (en) 2000-03-29
CZ298556B6 (cs) 2007-11-07
CN1566129A (zh) 2005-01-19
EA199901015A1 (ru) 2000-06-26
DE122004000018I1 (de) 2004-09-30
GT199800077A (es) 1999-12-02
DK0988310T3 (da) 2003-12-15
WO1998056802A1 (en) 1998-12-17
ATE251173T1 (de) 2003-10-15
OA11224A (en) 2003-07-16
BG103945A (en) 2000-07-31
KR20010013632A (ko) 2001-02-26
YU58699A (US06559137-20030506-C00182.png) 2002-08-12
HK1028048A1 (en) 2001-02-02
SK168399A3 (en) 2000-11-07
SK284171B6 (sk) 2004-10-05
MY123354A (en) 2006-05-31
BG64391B1 (bg) 2004-12-30
AU749816B2 (en) 2002-07-04
HU228005B1 (en) 2012-08-28
BRPI9810519B1 (pt) 2012-02-22
US6936592B2 (en) 2005-08-30
PL191601B1 (pl) 2006-06-30
JP2000514098A (ja) 2000-10-24
AP1231A (en) 2003-12-11
CN1793155A (zh) 2006-06-28
PL337505A1 (en) 2000-08-28
HUS1200028I1 (hu) 2016-08-29
CA2293823A1 (en) 1998-12-17
CZ442199A3 (cs) 2000-07-12
CN101691390A (zh) 2010-04-07
PA8452201A1 (es) 2000-05-24
NL300150I2 (nl) 2004-09-01
HN1998000086A (es) 1999-03-08
FR04C0013I1 (US06559137-20030506-C00182.png) 2004-06-11
FR04C0013I2 (US06559137-20030506-C00182.png) 2005-10-21
ES2205487T3 (es) 2004-05-01
MA24564A1 (fr) 1998-12-31
IS1998B (is) 2005-03-15
CA2293823C (en) 2004-02-17
LU91076I9 (en) 2018-07-02
JP2002316933A (ja) 2002-10-31
AU7347598A (en) 1998-12-30
IL132809A0 (en) 2001-03-19
NZ500660A (en) 2002-03-01
US6420536B1 (en) 2002-07-16
CO4950611A1 (es) 2000-09-01
HRP980314A2 (en) 1999-04-30
HK1088014A1 (en) 2006-10-27
SI0988310T1 (en) 2004-02-29
US20040180842A1 (en) 2004-09-16
DE69818665D1 (de) 2003-11-06
CN1172947C (zh) 2004-10-27
UA67744C2 (uk) 2004-07-15
ID22992A (id) 1999-12-23
CN1259136A (zh) 2000-07-05
BRPI9810519A (pt) 2000-09-19
TW472060B (en) 2002-01-11
NO996106D0 (no) 1999-12-10
RS49675B (sr) 2007-11-15
NO996106L (no) 2000-02-10

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