EG19251A - Process for preparing of azabicyclo qiunolone carboxlic acids. - Google Patents

Process for preparing of azabicyclo qiunolone carboxlic acids.

Info

Publication number
EG19251A
EG19251A EG48390A EG48390A EG19251A EG 19251 A EG19251 A EG 19251A EG 48390 A EG48390 A EG 48390A EG 48390 A EG48390 A EG 48390A EG 19251 A EG19251 A EG 19251A
Authority
EG
Egypt
Prior art keywords
azabicyclo
qiunolone
preparing
alkyl
methyl
Prior art date
Application number
EG48390A
Other languages
English (en)
Inventor
Katherine Elizabeth Brighty
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of EG19251A publication Critical patent/EG19251A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EG48390A 1989-08-16 1990-08-14 Process for preparing of azabicyclo qiunolone carboxlic acids. EG19251A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/003489 WO1991002526A1 (en) 1989-08-16 1989-08-16 Azabicyclo quinolone carboxylic acids

Publications (1)

Publication Number Publication Date
EG19251A true EG19251A (en) 1994-09-29

Family

ID=22215165

Family Applications (1)

Application Number Title Priority Date Filing Date
EG48390A EG19251A (en) 1989-08-16 1990-08-14 Process for preparing of azabicyclo qiunolone carboxlic acids.

Country Status (30)

Country Link
EP (1) EP0413455B1 (bs)
JP (2) JPH072734B2 (bs)
KR (1) KR930004844B1 (bs)
CN (1) CN1025192C (bs)
AT (1) ATE124040T1 (bs)
AU (1) AU623801B2 (bs)
BA (1) BA98299A (bs)
CA (2) CA2023217C (bs)
CY (2) CY1969A (bs)
CZ (1) CZ281127B6 (bs)
DD (1) DD298399A5 (bs)
DE (3) DE19875052I2 (bs)
DK (1) DK0413455T3 (bs)
EG (1) EG19251A (bs)
ES (1) ES2074131T4 (bs)
FI (2) FI108228B (bs)
GR (1) GR3017072T3 (bs)
HK (1) HK1000207A1 (bs)
HU (2) HU219403B (bs)
IE (1) IE66202B1 (bs)
IL (1) IL95331A (bs)
LU (2) LU90310I2 (bs)
NL (2) NL980032I2 (bs)
NO (1) NO300214B1 (bs)
NZ (1) NZ234920A (bs)
PL (1) PL166381B1 (bs)
PT (1) PT94998B (bs)
RU (1) RU2049777C1 (bs)
WO (1) WO1991002526A1 (bs)
ZA (1) ZA906450B (bs)

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FR2675144B1 (fr) * 1991-04-10 1995-06-16 Bouchara Sa Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant.
DE69230005T2 (de) * 1991-06-19 2000-01-05 Pfizer Inc., New York Azaspirochinolone als antibakterielle Wirkstoffe
US5256791A (en) * 1992-03-02 1993-10-26 Pfizer Inc. Preparation of intermediates in the synthesis of quinoline antibiotics
EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
US5591766A (en) * 1993-12-03 1997-01-07 Cheil Foods & Chemicals, Inc. Solid oral formulations of pyridone carboxylic acids
PT812838E (pt) * 1994-02-04 2002-10-31 Dainippon Pharmaceutical Co Derivado de acido piridonacarboxilico substituido com o grupo amino biciclico seu ester seu sal e amina biciclica como seu intermediario
KR100389773B1 (ko) * 1995-02-02 2003-10-23 다이이찌 세이야꾸 가부시기가이샤 헤테로사이클릭화합물
JPH08213881A (ja) * 1995-02-02 1996-08-20 Fujitsu Ltd 周波数制御回路
DE69628158T2 (de) * 1995-02-07 2004-03-25 Daiichi Pharmaceutical Co., Ltd. Heterocyclische spiroderivate
WO1996039406A1 (en) * 1995-06-06 1996-12-12 Pfizer Inc. NOVEL CRYSTAL FORM OF ANHYDROUS 7-([1α, 5α, 6α]-6-AMINO-3-AZABICYCLO[3.1.0]HEX-3-YL)-6-FLUORO-1-(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, METHANESULFONIC ACID SALT
ATE221544T1 (de) * 1995-06-15 2002-08-15 Pfizer Verfahren zur herstellung von derivaten der ein peptid enthaltenden azabizylo-naphtyridin- carbonsäure
CN100395244C (zh) * 1996-02-09 2008-06-18 富山化学工业株式会社 喹诺酮羧酸衍生物或它们的盐类
AP788A (en) * 1996-08-26 1999-12-03 Pfizer Novel crystal form of anhydrous 7-(1a, 5a, 6a)-6-Amino-3-Azabicyclo(3.1.0) hex-3-YI)-6-Fluoro-1-(2,4- Difluorophenyl)-1,4-Dihydro-4-Oxo-1, 8-Naphthyridine-3-Carboxylic Acid, Methanesulfonic acid salt.
TW519542B (en) * 1996-09-27 2003-02-01 Daiichi Seiyaku Co Bicyclic amine derivative
PT947513E (pt) * 1996-10-25 2004-09-30 Daiichi Seiyaku Co Derivados de amina triciclicos
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
MA24500A1 (fr) 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
DE19733439A1 (de) * 1997-08-02 1999-02-04 Bayer Ag Neue 6-endo-Amino-3-azabicyclo(3.1.0)hexande, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von Chinolon- und Naphthyridincarbonsäure-Derviaten mit verbesserten Eigenschaften
BR9812644B1 (pt) 1997-09-15 2010-07-13 quinolonas antimicrobianas, composição farmacêutica e uso das mesmas.
US6184380B1 (en) * 1999-01-25 2001-02-06 Pfizer Inc. Process for preparing naphthyridones and intermediates
PA8464701A1 (es) * 1998-01-16 2000-09-29 Pfizer Prod Inc Procedimiento e intermedios para preparar naftiridonas
US7019142B2 (en) 1998-01-16 2006-03-28 Pfizer Inc. Process for preparing naphthyridones and intermediates
GB9820405D0 (en) * 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
JP4694669B2 (ja) 1999-03-17 2011-06-08 第一三共株式会社 医薬組成物
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
EP1341787A2 (en) 2000-12-14 2003-09-10 The Procter & Gamble Company Antimicrobial 2-pyridones, their compositions and uses
HUP0303410A3 (en) 2000-12-14 2005-12-28 Procter & Gamble Antimicrobial quinolones, pharmaceutical compositions containing them and their use
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
MXPA05000434A (es) 2002-07-08 2005-04-19 Ranbaxy Lab Ltd Derivados de hexano [3.1.0] azabiciclo 3,6-disustituido utiles como antagonistas de receptor muscarinico.
EP1534675B1 (en) 2002-08-23 2009-02-25 Ranbaxy Laboratories, Ltd. Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo¬3.1.0 hexane derivatives as muscarinic receptor antagonists
EP1618091A1 (en) 2003-04-09 2006-01-25 Ranbaxy Laboratories, Ltd. Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
US7592359B2 (en) 2003-04-10 2009-09-22 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
BRPI0409302A (pt) 2003-04-11 2006-04-11 Ranbaxy Lab Ltd derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos
WO2005026121A1 (en) * 2003-09-18 2005-03-24 Ranbaxy Laboratories Limited PROCESS FOR THE PREPARATION OF (1α, 5α, 6α)-6-AMINOMETHYL-3-BENZYL-3-AZABICYCLO[3.1.0]HEXANE
KR20110082635A (ko) 2006-03-28 2011-07-19 워너 칠콧 컴퍼니 엘엘씨 퀴놀론 중간체를 제조하기 위한 커플링 방법
ATE507219T1 (de) 2006-03-28 2011-05-15 Warner Chilcott Co Llc Malatsalze und polymorphe von (3s,5s)-7-ä3-amino- 5-methyl-piperidinylü-1-cyclopropyl-1,4-dihydro 8-methoxy-4-oxo-3-chinolincarbonsäure
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
EP2621902B1 (en) 2010-09-28 2017-04-12 Panacea Biotec Ltd 3-azabicyclo[3.1.0]hexane compounds useful for the treatment of cns disorders
CA3117319A1 (en) * 2018-10-05 2020-04-09 New York University Fused bicyclic heterocycles as thereapeutic agents
CN112442084B (zh) * 2020-12-03 2022-09-09 国药集团致君（深圳）制药有限公司 一种抗菌药中间体的制备方法
CN113307768B (zh) * 2021-04-29 2023-12-12 中国农业科学院兰州畜牧与兽药研究所 喹诺酮类衍生物及其制备方法和用途

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JPH0676400B2 (ja) * 1987-08-25 1994-09-28 大日本製薬株式会社 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
US4973091A (en) * 1989-09-20 1990-11-27 Truth Incorporated Sliding patio door dual point latch and lock

Also Published As

Publication number Publication date
CN1049501A (zh) 1991-02-27
DE69020262D1 (de) 1995-07-27
CZ281127B6 (cs) 1996-06-12
IE902950A1 (en) 1991-02-27
FI108228B (fi) 2001-12-14
CN1025192C (zh) 1994-06-29
FI103879B (fi) 1999-10-15
PL166381B1 (pl) 1995-05-31
NO300214B1 (no) 1997-04-28
ES2074131T4 (es) 1996-05-01
KR910004572A (ko) 1991-03-28
PT94998A (pt) 1991-04-18
AU623801B2 (en) 1992-05-21
FI964520A (fi) 1996-11-11
EP0413455A3 (en) 1991-10-09
DK0413455T3 (da) 1995-08-14
ES2074131T3 (es) 1995-09-01
NL980033I1 (nl) 1999-02-01
ZA906450B (en) 1992-03-25
PL286484A1 (en) 1991-05-20
FI920632A0 (fi) 1992-02-14
PT94998B (pt) 1997-05-28
DE19875052I2 (de) 2009-05-28
CA2127561A1 (en) 1991-02-17
NL980033I2 (nl) 1999-05-03
DE69020262T2 (de) 1995-10-26
CA2023217A1 (en) 1991-02-17
IL95331A0 (en) 1991-06-30
CA2127561C (en) 1998-07-28
NO920599L (no) 1992-04-14
HU211681A9 (en) 1995-12-28
EP0413455A2 (en) 1991-02-20
CY99010I2 (en) 2010-07-28
DD298399A5 (de) 1992-02-20
BA98299A (bs) 2001-09-14
NL980032I1 (nl) 1999-02-01
FI964520A0 (fi) 1996-11-11
LU90311I2 (fr) 1999-01-25
NZ234920A (en) 1992-06-25
FI103879B1 (fi) 1999-10-15
CY1969A (en) 1997-09-05
ATE124040T1 (de) 1995-07-15
LU90310I2 (fr) 1999-01-25
CZ402790A3 (en) 1996-04-17
IE66202B1 (en) 1995-12-13
IL95331A (en) 1995-07-31
DE19875050I2 (de) 2009-05-28
GR3017072T3 (en) 1995-11-30
JPH0386875A (ja) 1991-04-11
JPH072734B2 (ja) 1995-01-18
KR930004844B1 (ko) 1993-06-09
AU6104290A (en) 1991-02-21
HU219403B (hu) 2001-04-28
RU2049777C1 (ru) 1995-12-10
EP0413455B1 (en) 1995-06-21
WO1991002526A1 (en) 1991-03-07
NL980032I2 (nl) 1999-05-03
NO920599D0 (no) 1992-02-14
JPH07149758A (ja) 1995-06-13
JPH0819099B2 (ja) 1996-02-28
HK1000207A1 (en) 1998-02-06
CA2023217C (en) 1996-12-10

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