PT94998A - Processo para a preparacao de acidos carboxilicos quinolona azabiciclicos - Google Patents

Processo para a preparacao de acidos carboxilicos quinolona azabiciclicos

Info

Publication number
PT94998A
PT94998A PT94998A PT9499890A PT94998A PT 94998 A PT94998 A PT 94998A PT 94998 A PT94998 A PT 94998A PT 9499890 A PT9499890 A PT 9499890A PT 94998 A PT94998 A PT 94998A
Authority
PT
Portugal
Prior art keywords
carboxylic acids
azinic
cycle
preparation
alkyl
Prior art date
Application number
PT94998A
Other languages
English (en)
Other versions
PT94998B (pt
Inventor
Katherine Elizabeth Brighty
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of PT94998A publication Critical patent/PT94998A/pt
Publication of PT94998B publication Critical patent/PT94998B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT94998A 1989-08-16 1990-08-14 Processo para a preparacao de acidos carboxilicos quinolona azabiciclicos PT94998B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/003489 WO1991002526A1 (en) 1989-08-16 1989-08-16 Azabicyclo quinolone carboxylic acids

Publications (2)

Publication Number Publication Date
PT94998A true PT94998A (pt) 1991-04-18
PT94998B PT94998B (pt) 1997-05-28

Family

ID=22215165

Family Applications (1)

Application Number Title Priority Date Filing Date
PT94998A PT94998B (pt) 1989-08-16 1990-08-14 Processo para a preparacao de acidos carboxilicos quinolona azabiciclicos

Country Status (30)

Country Link
EP (1) EP0413455B1 (pt)
JP (2) JPH072734B2 (pt)
KR (1) KR930004844B1 (pt)
CN (1) CN1025192C (pt)
AT (1) ATE124040T1 (pt)
AU (1) AU623801B2 (pt)
BA (1) BA98299A (pt)
CA (2) CA2023217C (pt)
CY (2) CY1969A (pt)
CZ (1) CZ281127B6 (pt)
DD (1) DD298399A5 (pt)
DE (3) DE19875050I2 (pt)
DK (1) DK0413455T3 (pt)
EG (1) EG19251A (pt)
ES (1) ES2074131T4 (pt)
FI (2) FI108228B (pt)
GR (1) GR3017072T3 (pt)
HK (1) HK1000207A1 (pt)
HU (2) HU219403B (pt)
IE (1) IE66202B1 (pt)
IL (1) IL95331A (pt)
LU (2) LU90310I2 (pt)
NL (2) NL980032I2 (pt)
NO (1) NO300214B1 (pt)
NZ (1) NZ234920A (pt)
PL (1) PL166381B1 (pt)
PT (1) PT94998B (pt)
RU (1) RU2049777C1 (pt)
WO (1) WO1991002526A1 (pt)
ZA (1) ZA906450B (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
FR2675144B1 (fr) * 1991-04-10 1995-06-16 Bouchara Sa Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant.
ATE184603T1 (de) * 1991-06-19 1999-10-15 Pfizer Azaspirochinolone als antibakterielle wirkstoffe
US5256791A (en) * 1992-03-02 1993-10-26 Pfizer Inc. Preparation of intermediates in the synthesis of quinoline antibiotics
EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
US5591766A (en) * 1993-12-03 1997-01-07 Cheil Foods & Chemicals, Inc. Solid oral formulations of pyridone carboxylic acids
WO1995021163A1 (fr) * 1994-02-04 1995-08-10 Dainippon Pharmaceutical Co., Ltd. Derive d'acide pyridonecarboxylique substitue par un groupe amino bicyclique, ester et sel de celui-ci, et amine bicyclique utilisee en tant qu'intermediaire pour celui-ci
CA2212007C (en) * 1995-02-02 2004-09-14 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives substitued by a bicyclic amino group
JPH08213881A (ja) * 1995-02-02 1996-08-20 Fujitsu Ltd 周波数制御回路
TW466237B (en) * 1995-02-07 2001-12-01 Daiichi Seiyaku Co Heterocyclic spiro-derivative
EP0789697B1 (en) * 1995-06-06 1998-06-17 Pfizer Inc. CRYSTAL FORM OF ANHYDROUS 7-((1a,5a, 6a)-6-AMINO-3-AZABICYCLO ( 3.1. 0]HEX-3-YL)-6-FLUORO-1-(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, METHANESULFONIC ACID SALT
DE69622715T2 (de) * 1995-06-15 2002-11-14 Pfizer Inc., New York Verfahren zur herstellung von derivaten der ein peptid enthaltenden azabizylo-naphtyridin-carbonsäure
IL124944A (en) * 1996-02-09 2003-06-24 Toyama Chemical Co Ltd Quinolonecarboxylic acid derivatives or their salts and pharmaceutical compositions containing them
AP788A (en) * 1996-08-26 1999-12-03 Pfizer Novel crystal form of anhydrous 7-(1a, 5a, 6a)-6-Amino-3-Azabicyclo(3.1.0) hex-3-YI)-6-Fluoro-1-(2,4- Difluorophenyl)-1,4-Dihydro-4-Oxo-1, 8-Naphthyridine-3-Carboxylic Acid, Methanesulfonic acid salt.
TW519542B (en) * 1996-09-27 2003-02-01 Daiichi Seiyaku Co Bicyclic amine derivative
DK0947513T3 (da) 1996-10-25 2004-08-30 Daiichi Seiyaku Co Tricykliske aminderivater
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
MA24500A1 (fr) 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
DE19733439A1 (de) * 1997-08-02 1999-02-04 Bayer Ag Neue 6-endo-Amino-3-azabicyclo(3.1.0)hexande, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von Chinolon- und Naphthyridincarbonsäure-Derviaten mit verbesserten Eigenschaften
HUP0100051A3 (en) 1997-09-15 2002-08-28 Procter & Gamble Antimicrobial quinolones, their compositions and uses
US6184380B1 (en) * 1999-01-25 2001-02-06 Pfizer Inc. Process for preparing naphthyridones and intermediates
PA8464701A1 (es) * 1998-01-16 2000-09-29 Pfizer Prod Inc Procedimiento e intermedios para preparar naftiridonas
US7019142B2 (en) 1998-01-16 2006-03-28 Pfizer Inc. Process for preparing naphthyridones and intermediates
GB9820405D0 (en) * 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
CN1343128B (zh) 1999-03-17 2010-04-21 第一制药株式会社 药物组合物
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
ATE304539T1 (de) 2000-12-14 2005-09-15 Procter & Gamble Antimikrobielle chinolone
IL155678A0 (en) 2000-12-14 2003-11-23 Procter & Gamble Antimicrobial 2-pyridones, their compositions and uses
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
EA200500173A1 (ru) 2002-07-08 2005-08-25 Рэнбакси Лабораториз Лимитед Производные 3,6-дизамещенного азабицикло[3.1.0]гексана в качестве антагонистов мускариновых рецепторов
US7288562B2 (en) 2002-08-23 2007-10-30 Ranbaxy Laboratories Limited Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
US7517905B2 (en) 2003-04-09 2009-04-14 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
DE60313898T2 (de) 2003-04-10 2008-01-17 Ranbaxy Laboratories, Ltd. Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten
EP1626957A1 (en) 2003-04-11 2006-02-22 Ranbaxy Laboratories Limited Azabicyclo derivatives as muscarinic receptor antagonists
WO2005026121A1 (en) * 2003-09-18 2005-03-24 Ranbaxy Laboratories Limited PROCESS FOR THE PREPARATION OF (1α, 5α, 6α)-6-AMINOMETHYL-3-BENZYL-3-AZABICYCLO[3.1.0]HEXANE
WO2007110834A2 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company Malate salts, and polymorphs of (3s,5s)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
JP2009531418A (ja) 2006-03-28 2009-09-03 ザ プロクター アンド ギャンブル カンパニー キノロン中間体調製のためのカップリング方法
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
BR112013007566A2 (pt) 2010-09-28 2016-08-02 Panacea Biotec Ltd novos compostos bicíclicos
US20210395222A1 (en) * 2018-10-05 2021-12-23 New York University Fused Bicyclic Heterocycles as Therapeutic Agents
CN112442084B (zh) * 2020-12-03 2022-09-09 国药集团致君（深圳）制药有限公司 一种抗菌药中间体的制备方法
CN113307768B (zh) * 2021-04-29 2023-12-12 中国农业科学院兰州畜牧与兽药研究所 喹诺酮类衍生物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0676400B2 (ja) * 1987-08-25 1994-09-28 大日本製薬株式会社 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
US4973091A (en) * 1989-09-20 1990-11-27 Truth Incorporated Sliding patio door dual point latch and lock

Also Published As

Publication number Publication date
JPH0819099B2 (ja) 1996-02-28
EP0413455A2 (en) 1991-02-20
DE19875052I2 (de) 2009-05-28
HU219403B (hu) 2001-04-28
DK0413455T3 (da) 1995-08-14
GR3017072T3 (en) 1995-11-30
WO1991002526A1 (en) 1991-03-07
NL980032I1 (nl) 1999-02-01
CN1025192C (zh) 1994-06-29
ES2074131T4 (es) 1996-05-01
EG19251A (en) 1994-09-29
CA2127561A1 (en) 1991-02-17
NO300214B1 (no) 1997-04-28
EP0413455A3 (en) 1991-10-09
DE69020262T2 (de) 1995-10-26
FI103879B (fi) 1999-10-15
CN1049501A (zh) 1991-02-27
JPH0386875A (ja) 1991-04-11
NO920599L (no) 1992-04-14
CZ402790A3 (en) 1996-04-17
RU2049777C1 (ru) 1995-12-10
DD298399A5 (de) 1992-02-20
BA98299A (bs) 2001-09-14
KR910004572A (ko) 1991-03-28
NL980032I2 (nl) 1999-05-03
ATE124040T1 (de) 1995-07-15
DE19875050I2 (de) 2009-05-28
FI920632A0 (fi) 1992-02-14
FI103879B1 (fi) 1999-10-15
CA2023217A1 (en) 1991-02-17
IE902950A1 (en) 1991-02-27
DE69020262D1 (de) 1995-07-27
KR930004844B1 (ko) 1993-06-09
ZA906450B (en) 1992-03-25
PT94998B (pt) 1997-05-28
NZ234920A (en) 1992-06-25
NL980033I2 (nl) 1999-05-03
IE66202B1 (en) 1995-12-13
HU211681A9 (en) 1995-12-28
FI964520A (fi) 1996-11-11
FI108228B (fi) 2001-12-14
JPH07149758A (ja) 1995-06-13
HK1000207A1 (en) 1998-02-06
CY1969A (en) 1997-09-05
LU90310I2 (fr) 1999-01-25
CA2127561C (en) 1998-07-28
JPH072734B2 (ja) 1995-01-18
AU6104290A (en) 1991-02-21
NL980033I1 (nl) 1999-02-01
PL166381B1 (pl) 1995-05-31
AU623801B2 (en) 1992-05-21
IL95331A (en) 1995-07-31
LU90311I2 (fr) 1999-01-25
IL95331A0 (en) 1991-06-30
EP0413455B1 (en) 1995-06-21
CY99010I2 (en) 2010-07-28
FI964520A0 (fi) 1996-11-11
ES2074131T3 (es) 1995-09-01
PL286484A1 (en) 1991-05-20
CZ281127B6 (cs) 1996-06-12
NO920599D0 (no) 1992-02-14
CA2023217C (en) 1996-12-10

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Effective date: 19901116

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Effective date: 19970218

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

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Effective date: 20090818