ES2074131T3 - Acidos azabicicloquinolonacarboxilicos. - Google Patents

Acidos azabicicloquinolonacarboxilicos.

Info

Publication number
ES2074131T3
ES2074131T3 ES90308331T ES90308331T ES2074131T3 ES 2074131 T3 ES2074131 T3 ES 2074131T3 ES 90308331 T ES90308331 T ES 90308331T ES 90308331 T ES90308331 T ES 90308331T ES 2074131 T3 ES2074131 T3 ES 2074131T3
Authority
ES
Spain
Prior art keywords
alkyl
methyl
formula
attached
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90308331T
Other languages
English (en)
Other versions
ES2074131T4 (es
Inventor
Katherine Elizabeth Brighty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES2074131T3 publication Critical patent/ES2074131T3/es
Application granted granted Critical
Publication of ES2074131T4 publication Critical patent/ES2074131T4/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

ACIDOS QUINOLONA CARBOXILICOS 7-SUSTITUIDOS POR GRUPOS AZABICICLO TIENEN ACTIVIDAD ANTIBACTERIANA.
ES90308331T 1989-08-16 1990-07-30 Acidos azabicicloquinolonacarboxilicos. Expired - Lifetime ES2074131T4 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/003489 WO1991002526A1 (en) 1989-08-16 1989-08-16 Azabicyclo quinolone carboxylic acids

Publications (2)

Publication Number Publication Date
ES2074131T3 true ES2074131T3 (es) 1995-09-01
ES2074131T4 ES2074131T4 (es) 1996-05-01

Family

ID=22215165

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90308331T Expired - Lifetime ES2074131T4 (es) 1989-08-16 1990-07-30 Acidos azabicicloquinolonacarboxilicos.

Country Status (30)

Country Link
EP (1) EP0413455B1 (es)
JP (2) JPH072734B2 (es)
KR (1) KR930004844B1 (es)
CN (1) CN1025192C (es)
AT (1) ATE124040T1 (es)
AU (1) AU623801B2 (es)
BA (1) BA98299A (es)
CA (2) CA2127561C (es)
CY (1) CY1969A (es)
CZ (1) CZ281127B6 (es)
DD (1) DD298399A5 (es)
DE (3) DE19875052I2 (es)
DK (1) DK0413455T3 (es)
EG (1) EG19251A (es)
ES (1) ES2074131T4 (es)
FI (2) FI108228B (es)
GR (1) GR3017072T3 (es)
HK (1) HK1000207A1 (es)
HU (2) HU219403B (es)
IE (1) IE66202B1 (es)
IL (1) IL95331A (es)
LU (2) LU90310I2 (es)
NL (2) NL980033I2 (es)
NO (1) NO300214B1 (es)
NZ (1) NZ234920A (es)
PL (1) PL166381B1 (es)
PT (1) PT94998B (es)
RU (1) RU2049777C1 (es)
WO (1) WO1991002526A1 (es)
ZA (1) ZA906450B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
FR2675144B1 (fr) * 1991-04-10 1995-06-16 Bouchara Sa Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant.
JPH0678335B2 (ja) * 1991-06-19 1994-10-05 ファイザー・インコーポレーテッド アザスピロキノロン化合物、その製法および抗菌組成物
US5256791A (en) * 1992-03-02 1993-10-26 Pfizer Inc. Preparation of intermediates in the synthesis of quinoline antibiotics
EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
US5591766A (en) * 1993-12-03 1997-01-07 Cheil Foods & Chemicals, Inc. Solid oral formulations of pyridone carboxylic acids
US5990106A (en) * 1994-02-04 1999-11-23 Dainippon Pharmaceutical Co., Ltd. Bicyclic amino group-substituted pyridonecarboxylic acid derivatives, esters thereof and salts thereof, and bicyclic amines useful as intermediates thereof
CA2212007C (en) * 1995-02-02 2004-09-14 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives substitued by a bicyclic amino group
JPH08213881A (ja) * 1995-02-02 1996-08-20 Fujitsu Ltd 周波数制御回路
PT816355E (pt) * 1995-02-07 2003-09-30 Daiichi Seiyaku Co Derivados espiro-heterociclicos
CA2223404C (en) * 1995-06-06 2001-01-16 Thomas A. Morris Novel crystal form of anhydrous 7-(¬1.alpha., 5.alpha., 6.alpha.|-6-amino-3-azabicyclo¬3.1.0|hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt
CA2224616C (en) * 1995-06-15 2000-05-02 Michael J. Castaldi Process for preparing derivatives of azabicyclo naphthyridine carboxylic acid comprising a dipeptide
CN1100053C (zh) * 1996-02-09 2003-01-29 富山化学工业株式会社 喹诺酮羧酸衍生物或它们的盐类
AP788A (en) * 1996-08-26 1999-12-03 Pfizer Novel crystal form of anhydrous 7-(1a, 5a, 6a)-6-Amino-3-Azabicyclo(3.1.0) hex-3-YI)-6-Fluoro-1-(2,4- Difluorophenyl)-1,4-Dihydro-4-Oxo-1, 8-Naphthyridine-3-Carboxylic Acid, Methanesulfonic acid salt.
TW519542B (en) * 1996-09-27 2003-02-01 Daiichi Seiyaku Co Bicyclic amine derivative
ATE267191T1 (de) 1996-10-25 2004-06-15 Daiichi Seiyaku Co Tricyclische aminderivate
MA24500A1 (fr) 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
DE19733439A1 (de) * 1997-08-02 1999-02-04 Bayer Ag Neue 6-endo-Amino-3-azabicyclo(3.1.0)hexande, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von Chinolon- und Naphthyridincarbonsäure-Derviaten mit verbesserten Eigenschaften
PL339408A1 (en) 1997-09-15 2000-12-18 Procter & Gamble Antimicrobial quinolones, agents containing them and their applications
US6184380B1 (en) * 1999-01-25 2001-02-06 Pfizer Inc. Process for preparing naphthyridones and intermediates
PA8464701A1 (es) * 1998-01-16 2000-09-29 Pfizer Prod Inc Procedimiento e intermedios para preparar naftiridonas
US7019142B2 (en) 1998-01-16 2006-03-28 Pfizer Inc. Process for preparing naphthyridones and intermediates
GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
KR100768034B1 (ko) 1999-03-17 2007-10-17 다이이찌 세이야꾸 가부시기가이샤 의약 조성물
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
AU3089102A (en) 2000-12-14 2002-06-24 Procter & Gamble Antimicrobial quinolones
NZ525570A (en) 2000-12-14 2005-04-29 Procter & Gamble Antimicrobial 2-pyridones, their compositions and uses
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
WO2004004629A2 (en) 2002-07-08 2004-01-15 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
JP2006501236A (ja) 2002-08-23 2006-01-12 ランバクシー ラボラトリーズ リミテッド ムスカリン性レセプター拮抗薬としてのフルオロおよびスルホニルアミノ含有３，６−二置換アザビシクロ（３．１．０）ヘキサン誘導体
US7517905B2 (en) 2003-04-09 2009-04-14 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
WO2004089363A1 (en) 2003-04-10 2004-10-21 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2004228452A1 (en) 2003-04-11 2004-10-21 Ranbaxy Laboratories Limited Azabicyclo derivatives as muscarinic receptor antagonists
EP1670759A1 (en) * 2003-09-18 2006-06-21 Ranbaxy Laboratories Limited PROCESS FOR THE PREPARATION OF (1a, 5a, 6a)-6-AMINOME THYL-3-BENZYL-3-AZABICYCLO 3.1.0 HEXANE
JP2009531418A (ja) 2006-03-28 2009-09-03 ザ プロクター アンド ギャンブル カンパニー キノロン中間体調製のためのカップリング方法
MX2008012328A (es) 2006-03-28 2008-10-09 Procter & Gamble Sales de malato, y polimorfos de acido (3s,5s)-7-[3-amino-5-metil- piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolinc arboxilico.
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
BR112013007566A2 (pt) 2010-09-28 2016-08-02 Panacea Biotec Ltd novos compostos bicíclicos
WO2020073031A1 (en) * 2018-10-05 2020-04-09 New York University Fused bicyclic heterocycles as thereapeutic agents
CN112442084B (zh) * 2020-12-03 2022-09-09 国药集团致君（深圳）制药有限公司 一种抗菌药中间体的制备方法
CN113307768B (zh) * 2021-04-29 2023-12-12 中国农业科学院兰州畜牧与兽药研究所 喹诺酮类衍生物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0676400B2 (ja) * 1987-08-25 1994-09-28 大日本製薬株式会社 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
US4973091A (en) * 1989-09-20 1990-11-27 Truth Incorporated Sliding patio door dual point latch and lock

Also Published As

Publication number Publication date
WO1991002526A1 (en) 1991-03-07
AU623801B2 (en) 1992-05-21
KR930004844B1 (ko) 1993-06-09
CN1025192C (zh) 1994-06-29
EP0413455A3 (en) 1991-10-09
DE19875050I2 (de) 2009-05-28
NL980032I2 (nl) 1999-05-03
JPH072734B2 (ja) 1995-01-18
LU90310I2 (fr) 1999-01-25
LU90311I2 (fr) 1999-01-25
PL286484A1 (en) 1991-05-20
HU211681A9 (en) 1995-12-28
NL980033I2 (nl) 1999-05-03
JPH07149758A (ja) 1995-06-13
EP0413455A2 (en) 1991-02-20
KR910004572A (ko) 1991-03-28
RU2049777C1 (ru) 1995-12-10
NO300214B1 (no) 1997-04-28
ZA906450B (en) 1992-03-25
EG19251A (en) 1994-09-29
CA2127561A1 (en) 1991-02-17
CZ402790A3 (en) 1996-04-17
CA2023217A1 (en) 1991-02-17
CZ281127B6 (cs) 1996-06-12
NO920599L (no) 1992-04-14
FI108228B (fi) 2001-12-14
JPH0819099B2 (ja) 1996-02-28
ATE124040T1 (de) 1995-07-15
IL95331A (en) 1995-07-31
CA2023217C (en) 1996-12-10
NL980033I1 (nl) 1999-02-01
BA98299A (bs) 2001-09-14
AU6104290A (en) 1991-02-21
PT94998A (pt) 1991-04-18
CA2127561C (en) 1998-07-28
FI964520A0 (fi) 1996-11-11
DD298399A5 (de) 1992-02-20
FI920632A0 (fi) 1992-02-14
PT94998B (pt) 1997-05-28
HU219403B (hu) 2001-04-28
PL166381B1 (pl) 1995-05-31
GR3017072T3 (en) 1995-11-30
ES2074131T4 (es) 1996-05-01
FI103879B (fi) 1999-10-15
CN1049501A (zh) 1991-02-27
CY1969A (en) 1997-09-05
DK0413455T3 (da) 1995-08-14
DE69020262D1 (de) 1995-07-27
DE19875052I2 (de) 2009-05-28
NZ234920A (en) 1992-06-25
HK1000207A1 (en) 1998-02-06
NO920599D0 (no) 1992-02-14
DE69020262T2 (de) 1995-10-26
IE66202B1 (en) 1995-12-13
EP0413455B1 (en) 1995-06-21
IL95331A0 (en) 1991-06-30
IE902950A1 (en) 1991-02-27
JPH0386875A (ja) 1991-04-11
NL980032I1 (nl) 1999-02-01
FI964520A (fi) 1996-11-11
FI103879B1 (fi) 1999-10-15

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Spc suppl protection certif: C9800036

Filing date: 19981130

SPCG Supplementary protection certificate granted

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Spc suppl protection certif: C9800036

Filing date: 19981130

Expiry date: 20130703

Effective date: 20020514

SPCF Request for supplementary protection certificate filed

Free format text: ALATROFLOXACINO (TROVAN IV)

Spc suppl protection certif: C9800035

Filing date: 19981130

SPCG Supplementary protection certificate granted

Free format text: ALATROFLOXACINO (TROVAN IV)

Spc suppl protection certif: C9800035

Filing date: 19981130

Expiry date: 20130703

Effective date: 20030901