DD298399A5 - Azabicyclo-chinolon-carbonsaeuren - Google Patents

Azabicyclo-chinolon-carbonsaeuren Download PDF

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Publication number
DD298399A5
DD298399A5 DD90343474A DD34347490A DD298399A5 DD 298399 A5 DD298399 A5 DD 298399A5 DD 90343474 A DD90343474 A DD 90343474A DD 34347490 A DD34347490 A DD 34347490A DD 298399 A5 DD298399 A5 DD 298399A5
Authority
DD
German Democratic Republic
Prior art keywords
mmol
azabicyclo
methyl
yield
compound
Prior art date
Application number
DD90343474A
Other languages
German (de)
English (en)
Inventor
Katherine E Brighty
Original Assignee
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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ������@���Kk�� filed Critical ������@���Kk��
Publication of DD298399A5 publication Critical patent/DD298399A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DD90343474A 1989-08-16 1990-08-15 Azabicyclo-chinolon-carbonsaeuren DD298399A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/003489 WO1991002526A1 (en) 1989-08-16 1989-08-16 Azabicyclo quinolone carboxylic acids

Publications (1)

Publication Number Publication Date
DD298399A5 true DD298399A5 (de) 1992-02-20

Family

ID=22215165

Family Applications (1)

Application Number Title Priority Date Filing Date
DD90343474A DD298399A5 (de) 1989-08-16 1990-08-15 Azabicyclo-chinolon-carbonsaeuren

Country Status (30)

Country Link
EP (1) EP0413455B1 (es)
JP (2) JPH072734B2 (es)
KR (1) KR930004844B1 (es)
CN (1) CN1025192C (es)
AT (1) ATE124040T1 (es)
AU (1) AU623801B2 (es)
BA (1) BA98299A (es)
CA (2) CA2127561C (es)
CY (1) CY1969A (es)
CZ (1) CZ281127B6 (es)
DD (1) DD298399A5 (es)
DE (3) DE19875052I2 (es)
DK (1) DK0413455T3 (es)
EG (1) EG19251A (es)
ES (1) ES2074131T4 (es)
FI (2) FI108228B (es)
GR (1) GR3017072T3 (es)
HK (1) HK1000207A1 (es)
HU (2) HU219403B (es)
IE (1) IE66202B1 (es)
IL (1) IL95331A (es)
LU (2) LU90311I2 (es)
NL (2) NL980032I2 (es)
NO (1) NO300214B1 (es)
NZ (1) NZ234920A (es)
PL (1) PL166381B1 (es)
PT (1) PT94998B (es)
RU (1) RU2049777C1 (es)
WO (1) WO1991002526A1 (es)
ZA (1) ZA906450B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
FR2675144B1 (fr) * 1991-04-10 1995-06-16 Bouchara Sa Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant.
CA2111463C (en) * 1991-06-19 1997-08-26 Bingwei V. Yang Azaspiro quinolone antibacterial agents
US5256791A (en) * 1992-03-02 1993-10-26 Pfizer Inc. Preparation of intermediates in the synthesis of quinoline antibiotics
EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
US5591766A (en) * 1993-12-03 1997-01-07 Cheil Foods & Chemicals, Inc. Solid oral formulations of pyridone carboxylic acids
JP2848538B2 (ja) * 1994-02-04 1999-01-20 大日本製薬株式会社 ２環性アミノ基で置換されたピリドンカルボン酸誘導体、そのエステルおよびその塩ならびにこれらの中間体たる２環性アミン
DK0807630T3 (da) * 1995-02-02 2003-09-01 Daiichi Seiyaku Co Heterocykliske forbindelser
JPH08213881A (ja) * 1995-02-02 1996-08-20 Fujitsu Ltd 周波数制御回路
WO1996024593A1 (fr) * 1995-02-07 1996-08-15 Daiichi Pharmaceutical Co., Ltd. Derives spiro heterocycliques
ES2117426T3 (es) * 1995-06-06 1998-08-01 Pfizer Forma cristalina de la sal anhidra compuesta de los acidos 7-((1a,5a,6a)-6-amino-3-azabiciclo(3.1.0.)hex-3-il)-6-fluoro-1-(2,4-difluorofenil)-1,4-dihidro-4-oxo-1,8-naftiridina-3-carboxilico y metanosulfonico.
JP3029293B2 (ja) * 1995-06-15 2000-04-04 ファイザー・インコーポレーテッド ジペプチドを含む、アザビシクロナフチリジンカルボン酸の誘導体を調製するための方法
CA2242242C (en) * 1996-02-09 2001-08-07 Toyama Chemical Co., Ltd. Quinolonecarboxylic acid derivatives or salts thereof
AP788A (en) * 1996-08-26 1999-12-03 Pfizer Novel crystal form of anhydrous 7-(1a, 5a, 6a)-6-Amino-3-Azabicyclo(3.1.0) hex-3-YI)-6-Fluoro-1-(2,4- Difluorophenyl)-1,4-Dihydro-4-Oxo-1, 8-Naphthyridine-3-Carboxylic Acid, Methanesulfonic acid salt.
TW519542B (en) * 1996-09-27 2003-02-01 Daiichi Seiyaku Co Bicyclic amine derivative
AU4723197A (en) * 1996-10-25 1998-05-22 Daiichi Pharmaceutical Co., Ltd. Tricyclic amine derivatives
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
MA24500A1 (fr) 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
DE19733439A1 (de) * 1997-08-02 1999-02-04 Bayer Ag Neue 6-endo-Amino-3-azabicyclo(3.1.0)hexande, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von Chinolon- und Naphthyridincarbonsäure-Derviaten mit verbesserten Eigenschaften
SK286420B6 (sk) 1997-09-15 2008-09-05 The Procter & Gamble Company Zlúčenina so štruktúrou chinolónu, farmaceutický prostriedok s jej obsahom a jej použitie
PA8464701A1 (es) * 1998-01-16 2000-09-29 Pfizer Prod Inc Procedimiento e intermedios para preparar naftiridonas
US7019142B2 (en) 1998-01-16 2006-03-28 Pfizer Inc. Process for preparing naphthyridones and intermediates
US6184380B1 (en) * 1999-01-25 2001-02-06 Pfizer Inc. Process for preparing naphthyridones and intermediates
GB9820405D0 (en) * 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
CN1343128B (zh) 1999-03-17 2010-04-21 第一制药株式会社 药物组合物
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
JP2004515548A (ja) 2000-12-14 2004-05-27 ザ プロクター アンド ギャンブル カンパニー 抗微生物キノロン
AU3089302A (en) 2000-12-14 2002-06-24 Procter & Gamble Antimicrobial 2-pyridones, their compositions and uses
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
CA2492121A1 (en) 2002-07-08 2004-01-15 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
ATE423769T1 (de) 2002-08-23 2009-03-15 Ranbaxy Lab Ltd Fluor- und sulfonylaminohaltige, 3,6- disubstituierte azabicyclo 3.1.0 hexanderivate als muscarinrezeptorantagonisten
US7517905B2 (en) 2003-04-09 2009-04-14 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2003214535B2 (en) 2003-04-10 2009-09-03 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
JP2006522787A (ja) 2003-04-11 2006-10-05 ランバクシー ラボラトリーズ リミテッド ムスカリン様受容体アンタゴニストとしてのアザビシクロ誘導体
EP1670759A1 (en) * 2003-09-18 2006-06-21 Ranbaxy Laboratories Limited PROCESS FOR THE PREPARATION OF (1a, 5a, 6a)-6-AMINOME THYL-3-BENZYL-3-AZABICYCLO 3.1.0 HEXANE
CA2647454A1 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
BRPI0709772B8 (pt) 2006-03-28 2021-05-25 The Protecter & Gamble Company sais de malato e polimorfos do ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-diidro-8-metóxi-4-oxo-3-quinolinocarboxílico
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
JP2013542929A (ja) 2010-09-28 2013-11-28 パナセア バイオテック リミテッド 新規ビシクロ環化合物
EP3856735B1 (en) * 2018-10-05 2023-09-06 New York University Fused bicyclic heterocycles as therapeutic agents
CN112442084B (zh) * 2020-12-03 2022-09-09 国药集团致君（深圳）制药有限公司 一种抗菌药中间体的制备方法
CN113307768B (zh) * 2021-04-29 2023-12-12 中国农业科学院兰州畜牧与兽药研究所 喹诺酮类衍生物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0676400B2 (ja) * 1987-08-25 1994-09-28 大日本製薬株式会社 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
US4973091A (en) * 1989-09-20 1990-11-27 Truth Incorporated Sliding patio door dual point latch and lock

Also Published As

Publication number Publication date
ES2074131T4 (es) 1996-05-01
CN1025192C (zh) 1994-06-29
ATE124040T1 (de) 1995-07-15
FI920632A0 (fi) 1992-02-14
DK0413455T3 (da) 1995-08-14
BA98299A (bs) 2001-09-14
FI964520A (fi) 1996-11-11
GR3017072T3 (en) 1995-11-30
HU219403B (hu) 2001-04-28
HU211681A9 (en) 1995-12-28
RU2049777C1 (ru) 1995-12-10
NZ234920A (en) 1992-06-25
ES2074131T3 (es) 1995-09-01
NO920599D0 (no) 1992-02-14
NL980032I1 (nl) 1999-02-01
WO1991002526A1 (en) 1991-03-07
IL95331A (en) 1995-07-31
JPH072734B2 (ja) 1995-01-18
FI964520A0 (fi) 1996-11-11
AU623801B2 (en) 1992-05-21
LU90311I2 (fr) 1999-01-25
IL95331A0 (en) 1991-06-30
CA2127561A1 (en) 1991-02-17
FI103879B (fi) 1999-10-15
JPH0819099B2 (ja) 1996-02-28
CZ402790A3 (en) 1996-04-17
FI103879B1 (fi) 1999-10-15
EG19251A (en) 1994-09-29
DE69020262D1 (de) 1995-07-27
NL980033I1 (nl) 1999-02-01
CA2127561C (en) 1998-07-28
KR910004572A (ko) 1991-03-28
CY1969A (en) 1997-09-05
CN1049501A (zh) 1991-02-27
PT94998B (pt) 1997-05-28
FI108228B (fi) 2001-12-14
NO300214B1 (no) 1997-04-28
PL286484A1 (en) 1991-05-20
DE19875052I2 (de) 2009-05-28
HK1000207A1 (en) 1998-02-06
EP0413455A2 (en) 1991-02-20
DE69020262T2 (de) 1995-10-26
NL980032I2 (nl) 1999-05-03
IE902950A1 (en) 1991-02-27
NL980033I2 (nl) 1999-05-03
NO920599L (no) 1992-04-14
ZA906450B (en) 1992-03-25
KR930004844B1 (ko) 1993-06-09
CA2023217A1 (en) 1991-02-17
EP0413455A3 (en) 1991-10-09
LU90310I2 (fr) 1999-01-25
DE19875050I2 (de) 2009-05-28
JPH07149758A (ja) 1995-06-13
CZ281127B6 (cs) 1996-06-12
PT94998A (pt) 1991-04-18
PL166381B1 (pl) 1995-05-31
JPH0386875A (ja) 1991-04-11
IE66202B1 (en) 1995-12-13
EP0413455B1 (en) 1995-06-21
AU6104290A (en) 1991-02-21
CA2023217C (en) 1996-12-10

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Legal Events

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IF04 In force in the year 2004

Expiry date: 20100816