EE05033B1 - Kristalliline bis[(E)-7-[4-(4-fluorofenl)-6-isopropl-2-[metl(metlsulfonl)amino]primidiin-5- l](3R,5S)-3,5-dihdrokshept-6-enool happe]kaltsiumisool - Google Patents

Kristalliline bis[(E)-7-[4-(4-fluorofenl)-6-isopropl-2-[metl(metlsulfonl)amino]primidiin-5- l](3R,5S)-3,5-dihdrokshept-6-enool happe]kaltsiumisool

Info

Publication number
EE05033B1
EE05033B1 EEP200100359A EEP200100359A EE05033B1 EE 05033 B1 EE05033 B1 EE 05033B1 EE P200100359 A EEP200100359 A EE P200100359A EE P200100359 A EEP200100359 A EE P200100359A EE 05033 B1 EE05033 B1 EE 05033B1
Authority
EE
Estonia
Prior art keywords
methylsulfonyl
fluorophenyl
isopropyl
amino
methyl
Prior art date
Application number
EEP200100359A
Other languages
English (en)
Estonian (et)
Inventor
Philip Taylor Nigel
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of EE200100359A publication Critical patent/EE200100359A/xx
Publication of EE05033B1 publication Critical patent/EE05033B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EEP200100359A 1999-01-09 1999-12-23 Kristalliline bis[(E)-7-[4-(4-fluorofenl)-6-isopropl-2-[metl(metlsulfonl)amino]primidiin-5- l](3R,5S)-3,5-dihdrokshept-6-enool happe]kaltsiumisool EE05033B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9900339.4A GB9900339D0 (en) 1999-01-09 1999-01-09 Chemical compounds
PCT/GB1999/004439 WO2000042024A1 (fr) 1999-01-09 1999-12-23 Sel cristallin de calcium bis[(e)-7-[ 4-(4- fluorophenyl)- 6-isopropyl-2- [methyl (methylsulfonyl) amino] pyrimidine-5-yl] (3r,5s)-3, 5-dihydroxyhept -6-acide enoique]

Publications (2)

Publication Number Publication Date
EE200100359A EE200100359A (et) 2002-12-16
EE05033B1 true EE05033B1 (et) 2008-06-16

Family

ID=10845719

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100359A EE05033B1 (et) 1999-01-09 1999-12-23 Kristalliline bis[(E)-7-[4-(4-fluorofenl)-6-isopropl-2-[metl(metlsulfonl)amino]primidiin-5- l](3R,5S)-3,5-dihdrokshept-6-enool happe]kaltsiumisool

Country Status (32)

Country Link
US (2) US6589959B1 (fr)
EP (1) EP1144389B1 (fr)
JP (2) JP4996786B2 (fr)
KR (1) KR100645858B1 (fr)
CN (1) CN1213033C (fr)
AT (1) ATE282027T1 (fr)
AU (1) AU762909B2 (fr)
BR (1) BR9916786A (fr)
CA (1) CA2356212C (fr)
CZ (1) CZ299843B6 (fr)
DE (1) DE69921855T2 (fr)
DK (1) DK1144389T3 (fr)
EE (1) EE05033B1 (fr)
ES (1) ES2232194T3 (fr)
GB (1) GB9900339D0 (fr)
HK (1) HK1040989B (fr)
HU (1) HU228116B1 (fr)
ID (1) ID29432A (fr)
IL (1) IL143977A0 (fr)
IN (2) IN213326B (fr)
IS (1) IS2410B (fr)
MX (1) MX223771B (fr)
NO (1) NO320189B1 (fr)
NZ (1) NZ512560A (fr)
PL (1) PL201800B1 (fr)
PT (1) PT1144389E (fr)
RU (1) RU2236404C2 (fr)
SI (1) SI1144389T1 (fr)
SK (1) SK285807B6 (fr)
TR (1) TR200101894T2 (fr)
WO (1) WO2000042024A1 (fr)
ZA (1) ZA200105187B (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9900339D0 (en) * 1999-01-09 1999-02-24 Zeneca Ltd Chemical compounds
GB0001621D0 (en) 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
GB0003305D0 (en) * 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
DE10135493A1 (de) * 2001-07-20 2003-01-30 Jobst Krauskopf Pharmazeutische Zusammensetzung zur Behandlung von Hypercholesterinämie
GB0218781D0 (en) * 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
US20080293750A1 (en) * 2002-10-17 2008-11-27 Anna Helgadottir Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
US20060019269A1 (en) * 2002-10-17 2006-01-26 Decode Genetics, Inc. Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
WO2004096785A1 (fr) * 2003-04-25 2004-11-11 Nippon Chemiphar Co., Ltd. Sel d'acide (2s,3s)-3-[[(1s)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxyrane-2-carboxylique
GB0312896D0 (en) * 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) * 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
TW200526596A (en) * 2003-11-24 2005-08-16 Teva Pharma Crystalline ammonium salts of rosuvastatin
WO2005077916A1 (fr) * 2004-01-19 2005-08-25 Ranbaxy Laboratories Limited Sels des inhibiteurs de hmg-coa reductase et leur utilisation
CZ200486A3 (cs) * 2004-01-16 2005-08-17 Zentiva, A.S. Způsob výroby hemivápenaté soli (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxy-6-heptenové kyseliny
EP1737828A1 (fr) * 2004-01-19 2007-01-03 Ranbaxy Laboratories Limited Sels de magnesium amorphes de la rosuvastatine
US8158362B2 (en) * 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
US20100216863A1 (en) * 2004-01-30 2010-08-26 Decode Genetics Ehf. Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
US7241800B2 (en) 2004-03-17 2007-07-10 Mai De Ltd. Anhydrous amorphous form of fluvastatin sodium
EP1797046A2 (fr) * 2004-09-27 2007-06-20 Ranbaxy Laboratories Limited Nouvelles methodes de preparation de calcium de rosuvastatine amorphe et nouvelle forme polymorphe de sodium de rosuvastatine
CA2594692A1 (fr) * 2005-01-31 2006-08-03 Ciba Specialty Chemicals Holding Inc. Formes cristallines de sel de rosuvastatine calcique
CA2612587C (fr) 2005-06-24 2013-02-19 Lek Pharmaceuticals D.D. Procede de preparation de rosuvastatine calcique amorphe depourvue d'impuretes
CZ299215B6 (cs) * 2005-06-29 2008-05-21 Zentiva, A. S. Zpusob výroby hemivápenaté soli (E)-7-[4-(4-fluorofenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl] (3R,5S)-3,5-dihydroxy-6-heptenovékyseliny
TW200800917A (en) * 2005-08-16 2008-01-01 Teva Pharma Crystalline rosuvastatin intermediate
HU227696B1 (en) * 2006-04-13 2011-12-28 Egyt Gyogyszervegyeszeti Gyar Zinc salt of rosuvastatin, process for its preparation and pharmaceutical compositions containing it
WO2008015563A2 (fr) * 2006-08-04 2008-02-07 Glenmark Pharmaceuticals Limited Sels de rosuvastatine et procédés permettant de les préparer
US7994178B2 (en) * 2006-09-18 2011-08-09 Teva Pharmaceutical Industries, Ltd. Crystalline rosuvastatin calcium and compositions thereof for treatment of hyperlipidaemia
WO2008124121A1 (fr) * 2007-04-06 2008-10-16 Scidose, Llc Polythérapie associant des statines et des 1,4-dihydropyridine-3,5-dicarboxydiesters et combinaisons de ceux-ci
US20080249156A1 (en) * 2007-04-09 2008-10-09 Palepu Nageswara R Combinations of statins and anti-obesity agent and glitazones
KR20090127904A (ko) * 2007-04-09 2009-12-14 싸이도우스 엘엘씨. 스타틴과 항비만제의 복합물
CA2725052C (fr) 2008-05-27 2014-09-16 Changzhou Pharmaceutical Factory Co., Ltd. Procede de preparation de la rosuvastatine calcique et de ses intermediaires
EP2336116A1 (fr) * 2009-12-16 2011-06-22 LEK Pharmaceuticals d.d. Procédé pour la préparation d'intermédiaires clé pour la synthèse de rosuvastatine ou de ses sels pharmaceutiquement acceptables
WO2011074016A1 (fr) 2009-12-17 2011-06-23 Matrix Laboratories Ltd Nouvelles formes polymorphes de rosuvastatine calcique et procédé de préparation de ces dernières
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
WO2012069394A1 (fr) 2010-11-22 2012-05-31 Basf Se Système à composants multiples de sel de calcium de rosuvastatine et de sorbitol
EP2699552A1 (fr) 2011-04-18 2014-02-26 Basf Se Système cristallin à multiples constituants constitué de sel de calcium de rosuvastatine et de vanilline
WO2014050874A1 (fr) * 2012-09-27 2014-04-03 東和薬品株式会社 Nouvelle forme cristalline de rosuvastatine de calcium et son procédé de fabrication
RO129060B1 (ro) 2013-04-25 2014-11-28 Antibiotice S.A. Compoziţie farmaceutică stabilă cu rosuvastatină calcică amorfă
CN103755643A (zh) * 2013-12-31 2014-04-30 连云港金康医药科技有限公司 瑞苏伐他汀钙盐i晶型
CN105153040B (zh) * 2015-10-15 2018-04-13 江苏师范大学 瑞舒伐他汀钙新晶型及其制备方法
WO2017183040A1 (fr) 2016-04-18 2017-10-26 Morepen Laboratories Limited Nouvelle forme polymorphe de rosuvastatine calcique cristalline et nouveaux procédés pour la rosuvastatine calcique cristalline et amorphe
CN105837516B (zh) * 2016-05-16 2018-07-10 山东新时代药业有限公司 一种瑞舒伐他汀钙晶型及其制备方法
WO2022228551A1 (fr) * 2021-04-30 2022-11-03 江苏恒瑞医药股份有限公司 Schéma d'administration pour agoniste du récepteur de la thrombopoïétine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2648897B2 (ja) * 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
GB9900339D0 (en) * 1999-01-09 1999-02-24 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
ZA200105187B (en) 2002-09-23
IN213326B (fr) 2008-01-25
PL201800B1 (pl) 2009-05-29
JP4996786B2 (ja) 2012-08-08
NZ512560A (en) 2003-08-29
ATE282027T1 (de) 2004-11-15
PT1144389E (pt) 2005-02-28
US6589959B1 (en) 2003-07-08
WO2000042024A1 (fr) 2000-07-20
SK9632001A3 (en) 2001-12-03
ID29432A (id) 2001-08-30
KR20010101390A (ko) 2001-11-14
NO320189B1 (no) 2005-11-07
HUP0104828A3 (en) 2002-10-28
MX223771B (en) 2004-10-27
CN1213033C (zh) 2005-08-03
DK1144389T3 (da) 2005-02-14
IN2001MU00758A (fr) 2005-06-17
NO20013368D0 (no) 2001-07-06
HUP0104828A2 (hu) 2002-07-29
DE69921855T2 (de) 2005-11-24
HK1040989B (zh) 2005-05-06
SI1144389T1 (en) 2005-06-30
CA2356212A1 (fr) 2000-07-20
GB9900339D0 (en) 1999-02-24
DE69921855D1 (en) 2004-12-16
IN2003MU00223A (fr) 2005-03-04
CN1333756A (zh) 2002-01-30
CZ299843B6 (cs) 2008-12-10
EP1144389A1 (fr) 2001-10-17
IS5977A (is) 2001-06-22
JP2010090128A (ja) 2010-04-22
CZ20012460A3 (cs) 2001-10-17
HU228116B1 (en) 2012-11-28
BR9916786A (pt) 2001-10-16
EE200100359A (et) 2002-12-16
CA2356212C (fr) 2009-08-04
AU1882600A (en) 2000-08-01
SK285807B6 (sk) 2007-08-02
TR200101894T2 (tr) 2001-12-21
KR100645858B1 (ko) 2006-11-14
JP2002539078A (ja) 2002-11-19
ES2232194T3 (es) 2005-05-16
US20040009997A1 (en) 2004-01-15
HK1040989A1 (en) 2002-06-28
IS2410B (is) 2008-10-15
PL348775A1 (en) 2002-06-17
MXPA01006953A (es) 2001-10-01
NO20013368L (no) 2001-09-05
EP1144389B1 (fr) 2004-11-10
IL143977A0 (en) 2002-04-21
RU2236404C2 (ru) 2004-09-20
AU762909B2 (en) 2003-07-10

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20161223