HK1040989B - 晶狀的雙[(e)-7-[4-(4-氟苯基)-6-異丙基-2-[甲基(甲基磺酰基)氨基]嘧啶-5-基](3r,5s)-3,5-二羥基庚-6-烯酸]鈣鹽 - Google Patents
晶狀的雙[(e)-7-[4-(4-氟苯基)-6-異丙基-2-[甲基(甲基磺酰基)氨基]嘧啶-5-基](3r,5s)-3,5-二羥基庚-6-烯酸]鈣鹽Info
- Publication number
- HK1040989B HK1040989B HK02102104.7A HK02102104A HK1040989B HK 1040989 B HK1040989 B HK 1040989B HK 02102104 A HK02102104 A HK 02102104A HK 1040989 B HK1040989 B HK 1040989B
- Authority
- HK
- Hong Kong
- Prior art keywords
- dihydroxyhept
- methylsulfonyl
- pyrimidin
- fluorophenyl
- isopropyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9900339.4A GB9900339D0 (en) | 1999-01-09 | 1999-01-09 | Chemical compounds |
PCT/GB1999/004439 WO2000042024A1 (en) | 1999-01-09 | 1999-12-23 | Crystalline bis[(e)-7- [ 4-(4- fluorophenyl)- 6-isopropyl-2- [methyl (methylsulfonyl) amino] pyrimidin -5-yl] (3r,5s)-3, 5-dihydroxyhept -6-enoic acid]calcium salt |
Publications (2)
Publication Number | Publication Date |
---|---|
HK1040989A1 HK1040989A1 (en) | 2002-06-28 |
HK1040989B true HK1040989B (zh) | 2005-05-06 |
Family
ID=10845719
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK02102104.7A HK1040989B (zh) | 1999-01-09 | 2002-03-19 | 晶狀的雙[(e)-7-[4-(4-氟苯基)-6-異丙基-2-[甲基(甲基磺酰基)氨基]嘧啶-5-基](3r,5s)-3,5-二羥基庚-6-烯酸]鈣鹽 |
Country Status (32)
Country | Link |
---|---|
US (2) | US6589959B1 (zh) |
EP (1) | EP1144389B1 (zh) |
JP (2) | JP4996786B2 (zh) |
KR (1) | KR100645858B1 (zh) |
CN (1) | CN1213033C (zh) |
AT (1) | ATE282027T1 (zh) |
AU (1) | AU762909B2 (zh) |
BR (1) | BR9916786A (zh) |
CA (1) | CA2356212C (zh) |
CZ (1) | CZ299843B6 (zh) |
DE (1) | DE69921855T2 (zh) |
DK (1) | DK1144389T3 (zh) |
EE (1) | EE05033B1 (zh) |
ES (1) | ES2232194T3 (zh) |
GB (1) | GB9900339D0 (zh) |
HK (1) | HK1040989B (zh) |
HU (1) | HU228116B1 (zh) |
ID (1) | ID29432A (zh) |
IL (1) | IL143977A0 (zh) |
IN (2) | IN213326B (zh) |
IS (1) | IS2410B (zh) |
MX (1) | MX223771B (zh) |
NO (1) | NO320189B1 (zh) |
NZ (1) | NZ512560A (zh) |
PL (1) | PL201800B1 (zh) |
PT (1) | PT1144389E (zh) |
RU (1) | RU2236404C2 (zh) |
SI (1) | SI1144389T1 (zh) |
SK (1) | SK285807B6 (zh) |
TR (1) | TR200101894T2 (zh) |
WO (1) | WO2000042024A1 (zh) |
ZA (1) | ZA200105187B (zh) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9900339D0 (en) * | 1999-01-09 | 1999-02-24 | Zeneca Ltd | Chemical compounds |
GB0001621D0 (en) * | 2000-01-26 | 2000-03-15 | Astrazeneca Ab | Pharmaceutical compositions |
GB0003305D0 (en) * | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
DE10135493A1 (de) * | 2001-07-20 | 2003-01-30 | Jobst Krauskopf | Pharmazeutische Zusammensetzung zur Behandlung von Hypercholesterinämie |
GB0218781D0 (en) * | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
US20080293750A1 (en) * | 2002-10-17 | 2008-11-27 | Anna Helgadottir | Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment |
US20060019269A1 (en) * | 2002-10-17 | 2006-01-26 | Decode Genetics, Inc. | Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment |
ATE493393T1 (de) * | 2003-04-25 | 2011-01-15 | Nippon Chemiphar Co | Salze von (2s,3s)-3- ää(1s)-1-isobutoxymethyl-3- methylbutylücarbamoylü oxirane-2-carbonsäure |
GB0312896D0 (en) * | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
UY28501A1 (es) * | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
GB0322552D0 (en) | 2003-09-26 | 2003-10-29 | Astrazeneca Uk Ltd | Therapeutic treatment |
GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
CA2546701C (en) * | 2003-11-24 | 2010-07-27 | Teva Pharmaceutical Industries Ltd. | Crystalline ammonium salts of rosuvastatin |
CZ200486A3 (cs) * | 2004-01-16 | 2005-08-17 | Zentiva, A.S. | Způsob výroby hemivápenaté soli (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxy-6-heptenové kyseliny |
EP1709008A1 (en) * | 2004-01-19 | 2006-10-11 | Ranbaxy Laboratories Limited | Salts of hmg-coa reductase inhibitors and use thereof |
WO2005077917A1 (en) * | 2004-01-19 | 2005-08-25 | Ranbaxy Laboratories Limited | Amorphous salts of rosuvastatin |
US20100216863A1 (en) * | 2004-01-30 | 2010-08-26 | Decode Genetics Ehf. | Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment |
US8158362B2 (en) * | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
US7241800B2 (en) | 2004-03-17 | 2007-07-10 | Mai De Ltd. | Anhydrous amorphous form of fluvastatin sodium |
EP1797046A2 (en) * | 2004-09-27 | 2007-06-20 | Ranbaxy Laboratories Limited | Novel processes for preparing amorphous rosuvastatin calcium and a novel polymorphic form of rosuvastatin sodium |
JP2008528542A (ja) * | 2005-01-31 | 2008-07-31 | チバ ホールディング インコーポレーテッド | ロスバスタチンカルシウム塩の結晶形 |
US9150518B2 (en) | 2005-06-24 | 2015-10-06 | Lek Pharmaceuticals, D.D. | Process for preparing amorphous rosuvastatin calcium of impurities |
CZ299215B6 (cs) * | 2005-06-29 | 2008-05-21 | Zentiva, A. S. | Zpusob výroby hemivápenaté soli (E)-7-[4-(4-fluorofenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl] (3R,5S)-3,5-dihydroxy-6-heptenovékyseliny |
US7868169B2 (en) * | 2005-08-16 | 2011-01-11 | Teva Pharmaceutical Industries, Ltd. | Crystalline rosuvastatin intermediate |
HU227696B1 (en) * | 2006-04-13 | 2011-12-28 | Egyt Gyogyszervegyeszeti Gyar | Zinc salt of rosuvastatin, process for its preparation and pharmaceutical compositions containing it |
WO2008015563A2 (en) * | 2006-08-04 | 2008-02-07 | Glenmark Pharmaceuticals Limited | Salts of rosuvastatin and processes for their preparation |
BRPI0706062A2 (pt) * | 2006-09-18 | 2011-03-22 | Teva Pharma | rosuvastatina cálcica cristalina |
WO2008124121A1 (en) * | 2007-04-06 | 2008-10-16 | Scidose, Llc | Co-therapy with and combinations of statins and 1,4-dihydropyridine-3,5-dicarboxydiesters |
WO2008124122A1 (en) * | 2007-04-09 | 2008-10-16 | Scidose, Llc | Combinations of statins and anti-obesity agent and glitazones |
MX2009010925A (es) * | 2007-04-09 | 2009-11-02 | Scidose Llc | Combinaciones de estatinas y agente anti-obesidad. |
WO2009143776A1 (zh) | 2008-05-27 | 2009-12-03 | 常州制药厂有限公司 | 瑞舒伐他汀钙盐的制备方法及其中间体 |
EP2336116A1 (en) * | 2009-12-16 | 2011-06-22 | LEK Pharmaceuticals d.d. | Process for the preparation of key intermediates for the synthesis of rosuvastatin or pharmaceutically acceptable salts thereof |
WO2011074016A1 (en) | 2009-12-17 | 2011-06-23 | Matrix Laboratories Ltd | Novel polymorphic forms of rosuvastatin calcium and process for preparation of the same |
US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
US9249108B2 (en) | 2010-11-22 | 2016-02-02 | Basf Se | Multicomponent system of rosuvastatin calcium salt and sorbitol |
CA2832343A1 (en) | 2011-04-18 | 2012-10-26 | Basf Se | Multicomponent crystalline system of rosuvastatin calcium salt and vanillin |
WO2014050874A1 (ja) * | 2012-09-27 | 2014-04-03 | 東和薬品株式会社 | ロスバスタチンカルシウムの新規結晶形態およびその製造方法 |
RO129060B1 (ro) | 2013-04-25 | 2014-11-28 | Antibiotice S.A. | Compoziţie farmaceutică stabilă cu rosuvastatină calcică amorfă |
CN103755643A (zh) * | 2013-12-31 | 2014-04-30 | 连云港金康医药科技有限公司 | 瑞苏伐他汀钙盐i晶型 |
CN105153040B (zh) * | 2015-10-15 | 2018-04-13 | 江苏师范大学 | 瑞舒伐他汀钙新晶型及其制备方法 |
WO2017183040A1 (en) | 2016-04-18 | 2017-10-26 | Morepen Laboratories Limited | New polymorphic form of crystalline rosuvastatin calcium & novel processes for crystalline as well as amorphous rosuvastatin calcium |
CN105837516B (zh) * | 2016-05-16 | 2018-07-10 | 山东新时代药业有限公司 | 一种瑞舒伐他汀钙晶型及其制备方法 |
TW202302090A (zh) * | 2021-04-30 | 2023-01-16 | 大陸商江蘇恒瑞醫藥股份有限公司 | 血小板生成素受體激動劑的給藥方案 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2648897B2 (ja) * | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
GB9900339D0 (en) * | 1999-01-09 | 1999-02-24 | Zeneca Ltd | Chemical compounds |
-
1999
- 1999-01-09 GB GBGB9900339.4A patent/GB9900339D0/en not_active Ceased
- 1999-12-23 BR BR9916786-7A patent/BR9916786A/pt not_active Application Discontinuation
- 1999-12-23 EP EP99962471A patent/EP1144389B1/en not_active Expired - Lifetime
- 1999-12-23 PT PT99962471T patent/PT1144389E/pt unknown
- 1999-12-23 PL PL348775A patent/PL201800B1/pl unknown
- 1999-12-23 IL IL14397799A patent/IL143977A0/xx not_active IP Right Cessation
- 1999-12-23 ES ES99962471T patent/ES2232194T3/es not_active Expired - Lifetime
- 1999-12-23 SK SK963-2001A patent/SK285807B6/sk not_active IP Right Cessation
- 1999-12-23 AU AU18826/00A patent/AU762909B2/en not_active Ceased
- 1999-12-23 HU HU0104828A patent/HU228116B1/hu unknown
- 1999-12-23 DK DK99962471T patent/DK1144389T3/da active
- 1999-12-23 CA CA002356212A patent/CA2356212C/en not_active Expired - Fee Related
- 1999-12-23 ID IDW00200101470A patent/ID29432A/id unknown
- 1999-12-23 JP JP2000593592A patent/JP4996786B2/ja not_active Expired - Lifetime
- 1999-12-23 SI SI9930731T patent/SI1144389T1/xx unknown
- 1999-12-23 EE EEP200100359A patent/EE05033B1/xx not_active IP Right Cessation
- 1999-12-23 CN CNB998155047A patent/CN1213033C/zh not_active Expired - Lifetime
- 1999-12-23 RU RU2001122164/04A patent/RU2236404C2/ru not_active IP Right Cessation
- 1999-12-23 US US09/869,462 patent/US6589959B1/en not_active Expired - Lifetime
- 1999-12-23 WO PCT/GB1999/004439 patent/WO2000042024A1/en active IP Right Grant
- 1999-12-23 NZ NZ512560A patent/NZ512560A/en not_active IP Right Cessation
- 1999-12-23 KR KR1020017008546A patent/KR100645858B1/ko not_active IP Right Cessation
- 1999-12-23 AT AT99962471T patent/ATE282027T1/de active
- 1999-12-23 TR TR2001/01894T patent/TR200101894T2/xx unknown
- 1999-12-23 DE DE69921855T patent/DE69921855T2/de not_active Expired - Lifetime
- 1999-12-23 CZ CZ20012460A patent/CZ299843B6/cs not_active IP Right Cessation
-
2001
- 2001-06-08 IN IN758MU2001 patent/IN213326B/en unknown
- 2001-06-22 ZA ZA200105187A patent/ZA200105187B/en unknown
- 2001-06-22 IS IS5977A patent/IS2410B/is unknown
- 2001-07-06 NO NO20013368A patent/NO320189B1/no not_active IP Right Cessation
- 2001-07-06 MX MXPA01006953 patent/MX223771B/es active IP Right Grant
-
2002
- 2002-03-19 HK HK02102104.7A patent/HK1040989B/zh not_active IP Right Cessation
-
2003
- 2003-02-14 IN IN223MU2003 patent/IN2003MU00223A/en unknown
- 2003-04-10 US US10/410,650 patent/US20040009997A1/en not_active Abandoned
-
2009
- 2009-11-16 JP JP2009260812A patent/JP2010090128A/ja active Pending
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE | Patent expired |
Effective date: 20191222 |