EE03561B1 - L(-)-karnitiini stabiilsete mittehügroskoopsete soolade valmistamismeetod - Google Patents

L(-)-karnitiini stabiilsete mittehügroskoopsete soolade valmistamismeetod

Info

Publication number
EE03561B1
EE03561B1 EEP199900361A EEP9900361A EE03561B1 EE 03561 B1 EE03561 B1 EE 03561B1 EE P199900361 A EEP199900361 A EE P199900361A EE P9900361 A EEP9900361 A EE P9900361A EE 03561 B1 EE03561 B1 EE 03561B1
Authority
EE
Estonia
Prior art keywords
carnitine
preparation
hygroscopic salts
stable non
salts
Prior art date
Application number
EEP199900361A
Other languages
English (en)
Estonian (et)
Inventor
Fassi Aldo
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of EE9900361A publication Critical patent/EE9900361A/xx
Publication of EE03561B1 publication Critical patent/EE03561B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/285—Polyhydroxy dicarboxylic acids having five or more carbon atoms, e.g. saccharic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
EEP199900361A 1997-02-25 1998-02-24 L(-)-karnitiini stabiilsete mittehügroskoopsete soolade valmistamismeetod EE03561B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI000409A IT1289974B1 (it) 1997-02-25 1997-02-25 Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
PCT/EP1998/001039 WO1998038157A1 (en) 1997-02-25 1998-02-24 Process for the preparation of stable, non-hygroscopic salts of l(-)carnitine and alkanoyl l(-)carnitines

Publications (2)

Publication Number Publication Date
EE9900361A EE9900361A (et) 2000-04-17
EE03561B1 true EE03561B1 (et) 2001-12-17

Family

ID=11376175

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900361A EE03561B1 (et) 1997-02-25 1998-02-24 L(-)-karnitiini stabiilsete mittehügroskoopsete soolade valmistamismeetod

Country Status (25)

Country Link
US (1) US6271258B1 (xx)
EP (1) EP1019362B1 (xx)
JP (1) JP2001513096A (xx)
KR (1) KR100538788B1 (xx)
CN (1) CN1248967A (xx)
AT (1) ATE222233T1 (xx)
AU (1) AU724276B2 (xx)
BR (1) BR9807761A (xx)
CA (1) CA2281630C (xx)
CZ (1) CZ290893B6 (xx)
DE (1) DE69807245T2 (xx)
DK (1) DK1019362T3 (xx)
EE (1) EE03561B1 (xx)
ES (1) ES2182290T3 (xx)
HU (1) HUP0001674A3 (xx)
IL (1) IL131256A (xx)
IS (1) IS5160A (xx)
IT (1) IT1289974B1 (xx)
NO (1) NO994110L (xx)
NZ (1) NZ337188A (xx)
PL (1) PL188762B1 (xx)
PT (1) PT1019362E (xx)
SK (1) SK115399A3 (xx)
TR (1) TR199902043T2 (xx)
WO (1) WO1998038157A1 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1312018B1 (it) * 1999-03-19 2002-04-04 Fassi Aldo Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina.
KR100461572B1 (ko) * 1999-03-27 2004-12-14 삼성정밀화학 주식회사 Ｌ-카르니틴 칼슘 염과 이의 제조방법
ES2322328T3 (es) * 1999-09-03 2009-06-19 Sigma-Tau Healthscience S.P.A. L-carnitina ultrafina, procedimientos de preparacion, composiciones que la contienen y procedimiento de uso de la misma.
IT1316988B1 (it) * 2000-02-10 2003-05-26 Sigma Tau Ind Farmaceuti Procedimento migliorato di preparazione industriale di mucati dellal-carnitina e di alcanoil l-carnitine.
IT1317013B1 (it) * 2000-04-12 2003-05-26 Biosalts Srl Sostanze dolcificanti, particolarmente per il caffe' ed il the'.
ITRM20020055A1 (it) * 2002-02-04 2003-08-04 Aldo Fassi Sali metallici di carnitine, integratori dietetici/nutritivi che li contengono e kit dietetici per contrastare disturbi sessuali in soggetti
CN101212956A (zh) * 2005-07-05 2008-07-02 隆萨股份公司 生产干肉碱粉末或颗粒的喷雾干燥法
US7523176B2 (en) * 2005-08-02 2009-04-21 International Business Machines Corporation Method, apparatus, and computer program product for reconfiguring a storage area network to support the execution of an application automatically upon execution of the application
JP2009514965A (ja) * 2005-11-07 2009-04-09 ペーク，エルエルシー 代謝障害を制御するための組成物およびその使用方法
CN101209975B (zh) * 2006-12-29 2010-12-01 沈阳科硕营养科技有限公司 左旋肉碱富马酸钙及其制备方法与用途
JP2011068563A (ja) * 2008-09-09 2011-04-07 Mitsubishi Rayon Co Ltd カルニチンフマル酸塩及びその製造方法
KR101291186B1 (ko) * 2010-07-23 2013-09-13 주식회사 셀트리온제약 Ｌ-카르니틴 1,5-나프탈렌다이설폰산염 및 이를 포함하는 약제학적 조성물
EP2425834A1 (en) * 2010-09-06 2012-03-07 Lonza Ltd. Process for the production of l-carnitine tartrate
CN108383741A (zh) * 2018-03-16 2018-08-10 开原亨泰化工有限公司 一种制备左旋肉碱成盐的新方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1230610A (en) * 1983-11-02 1987-12-22 Vincenzo Iannella Process for the the preparation of l(-)carnitine hydrochloride and of l(-)carnitine inner salt
EP0150688B1 (en) * 1983-12-28 1987-04-22 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
US5073376A (en) * 1989-12-22 1991-12-17 Lonza Ltd. Preparations containing l-carnitine
DE4111913A1 (de) * 1991-04-12 1992-10-15 Degussa Verfahren zur herstellung von l-carnitin aus d,l-carnitinnitrilsalzen
CH682485A5 (de) 1991-08-13 1993-09-30 Lonza Ag Verfahren zur Herstellung optisch aktiver Carbonsäuren durch Racematspaltung.
TW397686B (en) * 1993-08-11 2000-07-11 Takeda Chemical Industries Ltd Antacid compositions and pharmaceutical compositions
IT1272290B (it) * 1994-06-20 1997-06-16 Avantgarde Spa Sale della l-carnitina e composizioni farmaceutiche che lo contengono per il trattamento di affezioni cutanee
IT1276225B1 (it) * 1995-10-17 1997-10-27 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per
PL188558B1 (pl) 1996-05-31 2005-02-28 Sigma Tau Ind Farmaceuti Sole L(-)karnityny i alkanoilo L(-)karnityn, sposób ich wytwarzania i kompozycje farmaceutyczne zawierające takie sole

Also Published As

Publication number Publication date
NO994110D0 (no) 1999-08-25
CA2281630A1 (en) 1998-09-03
TR199902043T2 (xx) 1999-10-21
IS5160A (is) 1999-08-20
CZ290893B6 (cs) 2002-11-13
DE69807245D1 (de) 2002-09-19
EE9900361A (et) 2000-04-17
EP1019362A1 (en) 2000-07-19
PL335350A1 (en) 2000-04-25
BR9807761A (pt) 2000-03-21
CA2281630C (en) 2006-11-14
AU6822998A (en) 1998-09-18
IL131256A (en) 2003-07-31
JP2001513096A (ja) 2001-08-28
AU724276B2 (en) 2000-09-14
EP1019362B1 (en) 2002-08-14
DK1019362T3 (da) 2002-12-02
IT1289974B1 (it) 1998-10-19
ATE222233T1 (de) 2002-08-15
HUP0001674A1 (hu) 2000-09-28
KR20000075710A (ko) 2000-12-26
KR100538788B1 (ko) 2005-12-23
HUP0001674A3 (en) 2000-10-30
ITMI970409A1 (it) 1998-08-25
NZ337188A (en) 2000-05-26
US6271258B1 (en) 2001-08-07
IL131256A0 (en) 2001-01-28
CN1248967A (zh) 2000-03-29
DE69807245T2 (de) 2002-12-05
ES2182290T3 (es) 2003-03-01
PL188762B1 (pl) 2005-04-29
WO1998038157A1 (en) 1998-09-03
NO994110L (no) 1999-08-25
PT1019362E (pt) 2002-11-29
CZ302899A3 (cs) 2000-02-16
SK115399A3 (en) 2000-01-18

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

MM4A Lapsed by not paying the annual fees

Effective date: 20030224