RU94046047A - Производные аминоуксусной кислоты в виде рацемата или d- и l-энантиомеров и их фармацевтически приемлемые соли, способ получения d- и l-энантиомеров производных аминоуксусной кислоты или их фармацевтически приемлемых солей и промежуточные d- и l-энантиомеры аминоуксусной кислоты в виде цинхонидиновой соли - Google Patents

Производные аминоуксусной кислоты в виде рацемата или d- и l-энантиомеров и их фармацевтически приемлемые соли, способ получения d- и l-энантиомеров производных аминоуксусной кислоты или их фармацевтически приемлемых солей и промежуточные d- и l-энантиомеры аминоуксусной кислоты в виде цинхонидиновой соли

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Publication number
RU94046047A
RU94046047A RU94046047/04A RU94046047A RU94046047A RU 94046047 A RU94046047 A RU 94046047A RU 94046047/04 A RU94046047/04 A RU 94046047/04A RU 94046047 A RU94046047 A RU 94046047A RU 94046047 A RU94046047 A RU 94046047A
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RU
Russia
Prior art keywords
enantiomers
aminoacetic acid
acid derivatives
derivatives
formula
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Application number
RU94046047/04A
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English (en)
Other versions
RU2111206C1 (ru
Inventor
Байлин Владимир
Ua]
Гу Чен Хуай
Пракаш Гель Ом
Us]
Юджин Марлатт Марк
Гордон Топлисс Джон
Original Assignee
Варнер-Ламберт Компани (US)
Варнер-Ламберт Компани
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Publication of RU94046047A publication Critical patent/RU94046047A/ru
Application granted granted Critical
Publication of RU2111206C1 publication Critical patent/RU2111206C1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/90—Xanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • C07D335/20—Thioxanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrane Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Объектом изобретения являются производные аминоуксусной кислоты формулы I, приведенной в описании, в виде рацемической смеси или энантиомера D или L и их фармацевтически приемлемые соли. Дальнейшим объектом изобретения является способ получения энантиомеров D и L производных аминоуксусной кислоты формулы I. Еще одним объектом изобретения являются энантиомеры D и L производных аминоуксусной кислоты формулы III, приведенной в описании, в виде цинхонидиновой соли, которые представляют собой промежуточные соединения для синтеза производных аминоуксусной кислоты формулы I.

Claims (1)

  1. Объектом изобретения являются производные аминоуксусной кислоты формулы I, приведенной в описании, в виде рацемической смеси или энантиомера D или L и их фармацевтически приемлемые соли. Дальнейшим объектом изобретения является способ получения энантиомеров D и L производных аминоуксусной кислоты формулы I. Еще одним объектом изобретения являются энантиомеры D и L производных аминоуксусной кислоты формулы III, приведенной в описании, в виде цинхонидиновой соли, которые представляют собой промежуточные соединения для синтеза производных аминоуксусной кислоты формулы I.
RU94046047/04A 1992-04-22 1993-04-16 Производные аминоуксусной кислоты в виде рацемата или d- и l-энантиомеров или их фармацевтически приемлемые соли, способ получения d- и l-энантиомеров производных аминоуксусной кислоты или их фармацевтически приемлемых солей и d- и l-энантиомеры аминоуксусной кислоты в виде цинхонидиновых солей RU2111206C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/872,742 US5264577A (en) 1992-04-22 1992-04-22 Cyclic amino acids and derivatives thereof
US872,742 1992-04-22
US872742 1992-04-22
PCT/US1993/003657 WO1993021176A1 (en) 1992-04-22 1993-04-16 Novel cyclic amino acids and derivatives thereof

Publications (2)

Publication Number Publication Date
RU94046047A true RU94046047A (ru) 1996-09-27
RU2111206C1 RU2111206C1 (ru) 1998-05-20

Family

ID=25360220

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94046047/04A RU2111206C1 (ru) 1992-04-22 1993-04-16 Производные аминоуксусной кислоты в виде рацемата или d- и l-энантиомеров или их фармацевтически приемлемые соли, способ получения d- и l-энантиомеров производных аминоуксусной кислоты или их фармацевтически приемлемых солей и d- и l-энантиомеры аминоуксусной кислоты в виде цинхонидиновых солей

Country Status (14)

Country Link
US (3) US5264577A (ru)
EP (1) EP0637305A1 (ru)
JP (1) JP3276960B2 (ru)
KR (3) KR100269758B1 (ru)
AU (1) AU672209B2 (ru)
CA (1) CA2133089C (ru)
CZ (1) CZ288529B6 (ru)
FI (1) FI944906A (ru)
MX (1) MX9302327A (ru)
NO (1) NO304828B1 (ru)
NZ (1) NZ252854A (ru)
RU (1) RU2111206C1 (ru)
SK (1) SK282479B6 (ru)
WO (1) WO1993021176A1 (ru)

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US5264577A (en) * 1992-04-22 1993-11-23 Warner-Lambert Company Cyclic amino acids and derivatives thereof
US5550110A (en) * 1992-04-22 1996-08-27 Warner-Lambert Company Endothelin Antagonists II
WO1995002574A1 (en) * 1993-07-14 1995-01-26 Smithkline Beecham Corporation Synthesis of acid addition salts of hydroxylamines
US5498719A (en) * 1994-01-31 1996-03-12 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Diastereoselective process leading to a key intermediate for the preparation of fluorinated reverse transcriptase inhibitors
US5623087A (en) * 1995-03-10 1997-04-22 Ndsu-Research Foundation Method for preparation of optically active diarylalanines
GB9621789D0 (en) * 1996-10-18 1996-12-11 Lilly Industries Ltd Pharmaceutical compounds
GB9626151D0 (en) * 1996-12-17 1997-02-05 Lilly Industries Ltd Pharmaceutical compounds
CN101544604B (zh) * 1998-11-20 2010-09-01 先灵公司 一种三环化合物
US6307048B1 (en) 1998-11-20 2001-10-23 Schering Corporation Enantioselective alkylation of tricyclic compounds
MXPA04005366A (es) * 2001-12-11 2004-09-27 Wyeth Corp Produccion de alfa-aminoacidos de n-sulfonilo y alfa-aminoacidos quiralmente puros.
KR100921641B1 (ko) * 2001-12-11 2009-10-14 와이어쓰 순수한 키랄성 β-아미노 알콜의 합성방법
CN101633625B (zh) * 2008-07-23 2013-02-13 江苏恒瑞医药股份有限公司 R-β-氨基苯丁酸衍生物的制备方法
CN115073314A (zh) * 2022-07-11 2022-09-20 吉尔多肽生物制药(大连市)有限公司 一种仲碳类甘氨酸的合成方法

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NL7306069A (ru) * 1973-05-02 1974-11-05
FI57743C (fi) * 1979-03-29 1980-10-10 Orion Yhtymae Oy Foerfarande foer framstaellning av nya 1,8-dihydroxi-10-acyl-9-antroner mot psoriasis
JPS5810525A (ja) * 1981-06-15 1983-01-21 Sagami Chem Res Center 光学活性な１−芳香族基置換−１−アルカノン類の製造方法
ATE56958T1 (de) * 1981-10-16 1990-10-15 Sandoz Ag 1,2,3,4,4a,5,10,10a-octahydrobenzo(g)chinolinderivate mit pharmazeutischer wirkung.
FR2580631B1 (fr) * 1985-04-17 1987-05-29 Cird Hydroxy-1 acyloxy-8 acyl-10 anthrones, leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique
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Also Published As

Publication number Publication date
FI944906A0 (fi) 1994-10-19
FI944906A (fi) 1994-10-19
KR100270305B1 (ko) 2000-10-16
KR100270306B1 (ko) 2000-10-16
KR950701331A (ko) 1995-03-23
RU2111206C1 (ru) 1998-05-20
JP3276960B2 (ja) 2002-04-22
CA2133089C (en) 2004-06-29
CZ288529B6 (cs) 2001-07-11
US5449778A (en) 1995-09-12
KR100269758B1 (ko) 2000-11-01
CZ256894A3 (en) 1995-04-12
AU4290393A (en) 1993-11-18
CA2133089A1 (en) 1993-10-28
SK128694A3 (en) 1995-05-10
SK282479B6 (sk) 2002-02-05
JPH07506100A (ja) 1995-07-06
NO304828B1 (no) 1999-02-22
NO944014D0 (no) 1994-10-21
MX9302327A (es) 1993-10-01
AU672209B2 (en) 1996-09-26
EP0637305A1 (en) 1995-02-08
US5380925A (en) 1995-01-10
US5264577A (en) 1993-11-23
WO1993021176A1 (en) 1993-10-28
NO944014L (no) 1994-12-21
NZ252854A (en) 1995-11-27

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Effective date: 20040417