EA201691993A1 - Вакцина к вирусу эпидемической диареи свиней - Google Patents

Вакцина к вирусу эпидемической диареи свиней

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Publication number
EA201691993A1
EA201691993A1 EA201691993A EA201691993A EA201691993A1 EA 201691993 A1 EA201691993 A1 EA 201691993A1 EA 201691993 A EA201691993 A EA 201691993A EA 201691993 A EA201691993 A EA 201691993A EA 201691993 A1 EA201691993 A1 EA 201691993A1
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Eurasian Patent Office
Prior art keywords
vaccine
pigs
epidemic diarrhea
pedv
virus
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EA201691993A
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English (en)
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Луис Алехандро Эрнандес
Арун В. Айер
Дайанна М. Мёрфи Джордан
Эбби Рей Паттерсон
Майкл Б. Руф
Эрик Мартин Вон
Джозеф Гилберт Виктория
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Бёрингер Ингельхайм Ветмедика, Инк.
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Publication of EA201691993A1 publication Critical patent/EA201691993A1/ru

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Abstract

Данное изобретение относится к вакцине для защиты свиньи от заболеваний, ассоциированных с вирусом эпидемической диареи свиней. Вакцина в общем случае включает инактивированный/убитый PEDV (например, химически инактивированный вирус PED) и/или рекомбинантный антиген PEDV и адъювант. Также обеспечиваются способы для защиты свиней от заболеваний, ассоциированных с PEDV, и способы получения вакцины вируса эпидемической диареи свиней.
EA201691993A 2014-04-03 2015-03-30 Вакцина к вирусу эпидемической диареи свиней EA201691993A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461974722P 2014-04-03 2014-04-03
PCT/US2015/023284 WO2015153425A1 (en) 2014-04-03 2015-03-30 Porcine epidemic diarrhea virus vaccine

Publications (1)

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EA201691993A1 true EA201691993A1 (ru) 2017-02-28

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US (2) US9950061B2 (ru)
EP (1) EP3125932A1 (ru)
JP (2) JP6395855B2 (ru)
KR (1) KR20160132494A (ru)
CN (2) CN112316129A (ru)
AU (1) AU2015241107B2 (ru)
CA (1) CA2943816A1 (ru)
EA (1) EA201691993A1 (ru)
MX (1) MX2016012845A (ru)
WO (1) WO2015153425A1 (ru)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104981252B (zh) * 2012-12-28 2019-06-18 勃林格殷格翰动物保健有限公司 包含支原体抗原的免疫原性组合物
US10280199B2 (en) 2014-02-07 2019-05-07 Phibro Animal Health Corporation Coronavirus proteins and antigens
WO2015138455A1 (en) 2014-03-11 2015-09-17 Regents Of The University Of Minnesota Porcine epidemic diarrhea virus vaccines and methods of use thereof
AU2015241107B2 (en) 2014-04-03 2019-10-03 Boehringer Ingelheim Animal Health USA Inc. Porcine epidemic diarrhea virus vaccine
US9713639B2 (en) * 2014-05-19 2017-07-25 Merial, Inc. Recombinant spike protein subunit based vaccine for porcine epidemic diarrhea virus (PEDV)
US20160008457A1 (en) * 2014-07-11 2016-01-14 Merial, Inc. Inactivated Vaccine for Porcine Epidemic Diarrhea Virus (PEDV)
EP3954385A1 (en) * 2014-07-11 2022-02-16 Zoetis Services LLC Novel vaccine compositions for porcine epidemic diarrhea virus
US10143738B2 (en) * 2014-09-12 2018-12-04 Intervet Inc. Vaccine for use in protecting a pig against porcine epidemic diarrhea virus
KR20170103874A (ko) * 2015-01-23 2017-09-13 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 돼지 유행성 설사병 바이러스를 위한 최적화된 합성 컨센서스 dna 백신의 면역원성
JP6824177B2 (ja) 2015-02-27 2021-02-03 アイオア・ステート・ユニバーシティー・リサーチ・ファンデーション・インコーポレーテッドＩｏｗａ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ Ｉｎｃｏｒｐｏｒａｔｅｄ 豚流行性下痢ウイルス株及びそれから得られる免疫原性組成物
GB2552441A (en) * 2015-10-22 2018-01-31 Royal Veterinary College Methods
TW201731525A (zh) * 2015-11-25 2017-09-16 薩斯喀徹溫大學 治療、預防及診斷豬流行性下痢病毒感染之方法
CN107304416A (zh) * 2016-04-19 2017-10-31 北京大伟嘉生物技术股份有限公司 一株猪流行性腹泻病毒及其培养方法和应用
JP6253210B1 (ja) 2016-08-17 2017-12-27 一般財団法人日本生物科学研究所 豚流行性下痢の予防又は治療方法、ワクチン、及びワクチンキット
PL3534939T3 (pl) 2016-11-03 2023-06-12 Boehringer Ingelheim Vetmedica Gmbh Szczepionka przeciw parwowirusowi świń i wirusowi zespołu rozrodczo-oddechowego świń oraz sposoby ich wytwarzania
AU2018212843A1 (en) * 2017-01-30 2019-06-27 Boehringer Ingelheim Animal Health USA Inc. Porcine coronavirus vaccines
WO2018188639A1 (zh) * 2017-04-13 2018-10-18 浙江海隆生物科技有限公司 猪流行性腹泻病毒s蛋白及其亚单位疫苗及其制备方法和应用
CN108822191B (zh) * 2017-04-13 2023-07-07 浙江海隆生物科技有限公司 猪流行性腹泻病毒s蛋白及其亚单位疫苗及其制备方法和应用
CN107698665B (zh) * 2017-10-26 2020-09-15 浙江大学 一种抗病毒多肽、编码基因、载体、宿主菌及应用
CN108118032A (zh) * 2017-12-12 2018-06-05 新疆希普生物科技股份有限公司 猪流行性腹泻病毒2型毒株的培养及灭活疫苗的研制
CN108219000B (zh) * 2018-01-17 2021-05-25 北京市农林科学院 一种pedv保护性抗原蛋白及其在乳酸菌中表达的方法
CN108362871A (zh) * 2018-02-07 2018-08-03 远见生物科技（上海）有限公司 用于中性粒细胞胞外诱捕网检测的试剂盒及检测方法
CN108486067B (zh) * 2018-02-11 2022-03-15 黑龙江正康生物技术股份有限公司 猪流行性腹泻病毒变异株及其制备的灭活疫苗和应用
US20210162039A1 (en) * 2018-05-11 2021-06-03 Kansas State University Research Foundation Multiepitope fusion antigens for vaccination and methods of making and using such antigens
CN109161534A (zh) * 2018-09-14 2019-01-08 中国农业科学院兰州兽医研究所 一株基因型2a的猪流行性腹泻病毒毒株及其在制备猪流行性腹泻疫苗中的应用
CN109022372B (zh) * 2018-09-19 2022-03-29 天康制药(苏州)有限公司 一种猪流行性腹泻病毒的培养方法
JP7284822B2 (ja) * 2018-09-20 2023-05-31 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 改変ｐｅｄｖスパイクタンパク質
US10905758B2 (en) * 2018-09-20 2021-02-02 Boehringer Ingelheim Vetmedica Gmbh Intranasal vector vaccine against porcine epidemic diarrhea
CN110967480A (zh) * 2018-09-28 2020-04-07 洛阳普泰生物技术有限公司 一种猪流行性腹泻病毒IgA抗体ELISA试剂盒的制备及应用
EP3934627A4 (en) 2019-03-04 2022-11-16 Novus International Inc. REDUCING THE RISK OF VIRUS INFECTION DUE TO VIRUS-CONTAINED FEED
CN110135157B (zh) * 2019-04-04 2021-04-09 国家计算机网络与信息安全管理中心 恶意软件同源性分析方法、系统、电子设备及存储介质
KR102213745B1 (ko) * 2019-04-16 2021-02-09 주식회사 바이오앱 돼지 유행성 설사병 바이러스 백신 조성물 및 이의 제조 방법
US11413347B2 (en) * 2019-09-02 2022-08-16 Reber Genetics Co., Ltd. Vaccine composition and method of preventing porcine epidemic diarrhea virus infection in swine
US20240261394A1 (en) * 2020-05-11 2024-08-08 University Of Virginia Patent Foundation Compositions and methods for inducing immune responses against class i fusion protein viruses
CN112063620A (zh) * 2020-06-16 2020-12-11 中国人民解放军陆军军医大学 抑制猪流行性腹泻病毒M基因表达的shRNA
CN112680421B (zh) * 2021-02-01 2022-09-13 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 具有广谱性中和猪流行性腹泻病毒的单克隆抗体及其应用
KR102675881B1 (ko) * 2021-03-25 2024-06-17 (주)셀엔백스 Pedv 스파이크 단백질 s1 유래 단백질 및 페리틴 유래 단백질을 포함하는 재조합 단백질 및 이의 용도
CN113292659B (zh) * 2021-05-19 2022-06-17 江苏省农业科学院 重组蛋白和猪流行性腹泻疫苗组合物
CA3222198A1 (en) 2021-06-03 2022-12-08 Mazen Animal Health Inc. Oral administration of coronavirus spike protein for altering cytokine levels and providing passive immunity to newborn pigs
CN113583141B (zh) * 2021-08-04 2023-03-03 江西农业大学 猪流行性腹泻病毒Nsp9蛋白、含该Nsp9蛋白的融合蛋白及其制备方法和应用
CN114395574B (zh) * 2022-01-18 2023-08-11 长沙爱科博生物科技有限公司 一种猪流行性腹泻病毒融合蛋白及其编码基因与应用
CN116024244B (zh) * 2022-08-04 2023-09-22 长沙爱科博生物科技有限公司 一种融合蛋白基因及其应用
CN115957349B (zh) * 2022-10-08 2024-04-05 华中农业大学 激活猪的pja1基因表达的制剂在制备猪抗猪流行性腹泻病毒感染药物中的应用
CN117143207B (zh) * 2023-09-05 2024-03-12 湖南派智生物科技有限公司 一种重组表位蛋白、编码基因、重组质粒、制备方法、工程菌及应用

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909462A (en) 1955-12-08 1959-10-20 Bristol Myers Co Acrylic acid polymer laxative compositions
US4394448A (en) 1978-02-24 1983-07-19 Szoka Jr Francis C Method of inserting DNA into living cells
US4769331A (en) 1981-09-16 1988-09-06 University Patents, Inc. Recombinant methods and materials
US5505941A (en) 1981-12-24 1996-04-09 Health Research, Inc. Recombinant avipox virus and method to induce an immune response
US5174993A (en) 1981-12-24 1992-12-29 Health Research Inc. Recombinant avipox virus and immunological use thereof
US5833975A (en) 1989-03-08 1998-11-10 Virogenetics Corporation Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US5364773A (en) 1991-03-07 1994-11-15 Virogenetics Corporation Genetically engineered vaccine strain
US4769330A (en) 1981-12-24 1988-09-06 Health Research, Incorporated Modified vaccinia virus and methods for making and using the same
US5338683A (en) 1981-12-24 1994-08-16 Health Research Incorporated Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins
US4745051A (en) 1983-05-27 1988-05-17 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
AU565354B2 (en) 1983-11-14 1987-09-10 Bio-Mimetics Inc. Bioadhesive compositions and methods of treatment therewith
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
IL84154A0 (en) 1986-10-16 1988-03-31 Microgenesys Inc Polypeptides derived from the envelope gene of human immunodeficiency virus in recombinant baculovirus infected insect cells and vaccines against acquired immune deficiency syndrome containing the same
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
WO1990001543A1 (fr) 1988-07-29 1990-02-22 Intracel Corporation Procede d'expression genetique de proteines heterologues par des cellules transfectees in vivo
CA2003300A1 (en) 1988-11-21 1990-05-21 Franklin Volvovitz Skin test and test kit for aids
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
DE69034078T2 (de) 1989-03-21 2004-04-01 Vical, Inc., San Diego Expression von exogenen Polynukleotidsequenzen in Wirbeltieren
US5552143A (en) 1989-03-24 1996-09-03 The Wistar Institute Of Anatomy & Biology Recombinant cytomegalovirus vaccine
US5591439A (en) 1989-03-24 1997-01-07 The Wistar Institute Of Anatomy And Biology Recombinant cytomegalovirus vaccine
GB9001766D0 (en) 1990-01-25 1990-03-28 Univ Court Of The University O Vaccines
KR100242671B1 (ko) 1991-03-07 2000-03-02 고돈 에릭 유전학적으로 처리한 백신 균주
US5997878A (en) 1991-03-07 1999-12-07 Connaught Laboratories Recombinant poxvirus-cytomegalovirus, compositions and uses
US5382425A (en) 1992-01-13 1995-01-17 Syntro Corporation Recombinant swinepox virus
US5643578A (en) 1992-03-23 1997-07-01 University Of Massachusetts Medical Center Immunization by inoculation of DNA transcription unit
US5846945A (en) 1993-02-16 1998-12-08 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
IL108915A0 (en) 1993-03-18 1994-06-24 Merck & Co Inc Polynucleotide vaccine against influenza virus
FR2711670B1 (fr) 1993-10-22 1996-01-12 Pasteur Institut Vecteur nucléotidique, composition le contenant et vaccin pour l'immunisation à l'encontre d'une hépatite.
DE69536091D1 (de) 1994-01-27 2010-09-09 Univ Massachusetts Medical Immunisierung durch Impfung von DNS Transkriptionseinheit
CA2188447C (en) 1994-04-29 2002-10-22 Falko-Gunter Falkner Recombinant poxviruses with foreign polynucleotides in essential regions
KR0179947B1 (ko) 1994-05-06 1999-03-20 윤인중 돼지 유행성 설사병과 전염성 위장염 바이러스 혼합 사독 유성백신의 제조방법
KR0143239B1 (ko) 1994-12-22 1998-07-01 김광희 돼지 유행성 설사병 예방약 생산을 위한 약독화 바이러스주
AU711702B2 (en) 1995-03-23 1999-10-21 Cambridge University Technical Services Limited Vectors for gene delivery
WO1998000166A1 (en) 1996-07-03 1998-01-08 Merial, Inc. Recombinant canine adenovirus (cav) containing exogenous dna
JP3003989B2 (ja) 1996-09-18 2000-01-31 全国農業協同組合連合会 豚流行性下痢ウイルス（ｐｅｄｖ）感受性細胞の作出法
US6183752B1 (en) 1997-02-05 2001-02-06 Pasteur Merieux Serums Et Vaccins Restenosis/atherosclerosis diagnosis, prophylaxis and therapy
KR100267745B1 (ko) 1998-01-10 2000-11-01 . 돼지 유행성설사병 바이러스의 특이 중화항체 검출방법
NZ506975A (en) 1999-01-18 2004-01-30 Lg Chemical Ltd Lipophilic microparticles containing a protein drug or antigen and formulation comprising same
KR100432977B1 (ko) 2001-04-19 2004-05-28 녹십자수의약품(주) 돼지 아미노펩티다제 엔을 이용한 돼지 유행성 설사병바이러스의 배양방법 및 그 생독 백신
EP1434859A2 (en) * 2001-07-25 2004-07-07 New York University Use of glycosylceramides as adjuvants for vaccines against infections and cancer
JP3812814B2 (ja) 2001-10-19 2006-08-23 株式会社微生物化学研究所 動物用多価オイルアジュバントワクチン
US7906311B2 (en) 2002-03-20 2011-03-15 Merial Limited Cotton rat lung cells for virus culture
KR100492820B1 (ko) 2002-04-16 2005-05-31 양문식 돼지 유행성 설사병 바이러스 중화 에피토프 및 이의 이용
US20070286872A1 (en) 2003-04-23 2007-12-13 Vanderbilt University Live Attenuated Nidovirus Vaccines
KR100502008B1 (ko) 2003-04-29 2005-07-18 녹십자수의약품(주) 약독화된 돼지 유행성설사병 바이러스, 그를 포함하는면역원성 조성물 및 상기 바이러스를 검출하는 방법
US7527967B2 (en) 2003-11-25 2009-05-05 Academia Sinica Recombinant baculovirus and virus-like particle
KR100622399B1 (ko) * 2004-01-14 2006-09-18 대한민국 불활화시킨 ｔｇｅｖ 및 ｐｅｄｖ을 함유하는 혼합불활화백신 및 그 제조방법
JP4873632B2 (ja) * 2004-01-21 2012-02-08 メリアル リミテッド 改良された不活化ｆｃｖワクチン
CN1323718C (zh) 2004-03-15 2007-07-04 中国农业科学院兰州兽医研究所 一种利用植物油佐剂制备动物病毒性、细菌性疫苗的方法
US7452542B2 (en) 2004-05-21 2008-11-18 Vanderbilt University Live attenuated coronavirus vaccines
CN1827172A (zh) 2005-04-27 2006-09-06 中国人民解放军军事医学科学院军事兽医研究所 以犬ⅱ型腺病毒为载体的猪病毒性传染病基因重组活疫苗及生产工艺
KR100737434B1 (ko) 2006-03-10 2007-07-09 대한민국 돼지전염성위장염바이러스, 유행성설사바이러스 및로타바이러스의 혼합생백신 및 이를 이용한 백신접종방법
RU2357755C2 (ru) 2006-09-27 2009-06-10 Виталий Александрович Сергеев Инактивированная вакцина против трансмиссивного гастроэнтерита свиней (тгс) и эпизоотической диареи свиней (эдс) из кишечного вируса искусственно зараженных безмолозивных поросят (вакцина тгэдс)
KR100773141B1 (ko) 2006-10-26 2007-11-02 재단법인서울대학교산학협력재단 돼지 유행성 설사 바이러스 ｏｒｆ3 폴리펩티드 변이체,그를 코딩하는 핵산, ｏｒｆ3 변이체 및 변이 유전자를이용하여 야생형과 약독화형 ｐｅｄｖ를 구별하는 방법 및야생형과 약독화형 ｐｅｄｖ를 구별하기 위한 키트
KR100773241B1 (ko) * 2006-12-06 2007-11-05 주식회사한국야쿠르트 돼지 유행성 설사병 바이러스에 대한 중화항원 및 그 응용
CN101117627B (zh) 2007-02-01 2010-07-14 中国农业科学院哈尔滨兽医研究所 猪流行性腹泻病毒弱毒疫苗株及其应用
CN101491673A (zh) 2008-12-26 2009-07-29 天津瑞普生物技术股份有限公司 猪传染性胃肠炎、猪流行性腹泻和猪轮状病毒的三联疫苗
KR101671528B1 (ko) 2010-12-14 2016-11-01 단국대학교 산학협력단 돼지 유행성 설사병 바이러스의 에피토프와 점막면역보조제를 발현하는 형질전환체 및 이를 포함하는 백신 조성물
KR20120066555A (ko) 2010-12-14 2012-06-22 단국대학교 산학협력단 돼지 유행성 설사병 바이러스의 에피토프 단백질을 발현하는 형질전환체 및 이를 포함하는 ｐｅｄｖ 백신 조성물
KR101680903B1 (ko) 2010-12-14 2016-11-30 단국대학교 산학협력단 돼지 유행성 설사병 바이러스의 에피토프와 로타바이러스 유전자를 발현하는 형질전환체 및 이를 포함하는 백신 조성물
CN102949718B (zh) 2011-08-26 2015-06-17 普莱柯生物工程股份有限公司 猪传染性胃肠炎病毒、猪流行性腹泻病毒和猪轮状病毒的三联活疫苗
CN102399806A (zh) 2011-12-16 2012-04-04 武汉华扬动物药业有限责任公司 猪流行性腹泻s1蛋白融合基因及重组巨大芽孢杆菌和应用
CN102988971B (zh) * 2012-12-04 2014-11-26 山东信得科技股份有限公司 一种猪流行性腹泻病毒基因工程亚单位口服疫苗的制备方法
CN103041385B (zh) 2013-01-29 2014-02-19 齐鲁动物保健品有限公司 一种猪传染性胃肠炎、流行性腹泻二联活疫苗及其制备方法
CN103585625B (zh) * 2013-11-29 2015-12-02 华南农业大学 一种猪流行性腹泻重组杆状病毒基因工程亚单位疫苗及其制备方法与应用
KR101442493B1 (ko) 2014-02-21 2014-09-26 우진 비앤지 주식회사 돼지유행성설사병바이러스 약독화주 및 이를 포함하는 돼지유행성 설사병 백신 조성물
WO2015138455A1 (en) * 2014-03-11 2015-09-17 Regents Of The University Of Minnesota Porcine epidemic diarrhea virus vaccines and methods of use thereof
CN103992989B (zh) * 2014-03-20 2015-02-25 广东海大畜牧兽医研究院有限公司 一种猪流行性腹泻病毒及其应用
AU2015241107B2 (en) 2014-04-03 2019-10-03 Boehringer Ingelheim Animal Health USA Inc. Porcine epidemic diarrhea virus vaccine

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