EA201690623A1 - Простациклиновые соединения, композиции и способы их использования - Google Patents

Простациклиновые соединения, композиции и способы их использования

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Publication number
EA201690623A1
EA201690623A1 EA201690623A EA201690623A EA201690623A1 EA 201690623 A1 EA201690623 A1 EA 201690623A1 EA 201690623 A EA201690623 A EA 201690623A EA 201690623 A EA201690623 A EA 201690623A EA 201690623 A1 EA201690623 A1 EA 201690623A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
tripeptide
dipeptide
peptide
amino acid
Prior art date
Application number
EA201690623A
Other languages
English (en)
Other versions
EA031604B1 (ru
Inventor
Владимир Малинин
Уолтер Перкинс
Франциска Лейфер
Донна Коничек
Чжили Ли
Адам Плонт
Original Assignee
Инсмед Инкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Инсмед Инкорпорейтед filed Critical Инсмед Инкорпорейтед
Publication of EA201690623A1 publication Critical patent/EA201690623A1/ru
Publication of EA031604B1 publication Critical patent/EA031604B1/ru

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    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes

Abstract

Предложены простациклиновые соединения и композиции, содержащие простациклиновые соединения. Конкретно, описаны простациклиновые соединения, содержащие трепростинил, ковалентно связанный с линейным С-Салкилом, разветвленным С-Салкилом, линейным С-Салкенилом, разветвленным С-Салкенилом, арилом, арил-С-Салкилом или аминокислотой или пептидом (например дипептидом, трипептидом, тетрапептидом). Связь в одном воплощении представляет собой карбаматную, амидную или сложноэфирную связь. Предложенные простациклиновые соединения могут содержать также по меньшей мере один атом водорода, замещенный по меньшей мере одним атомом дейтерия. Также предложены способы лечения легочной гипертензии (например легочной артериальной гипертензии) и портолегочной гипертензии.
EA201690623A 2013-10-25 2014-10-24 Трепростинильные соединения, композиции и способы их использования EA031604B1 (ru)

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EP4236934A1 (en) 2020-10-28 2023-09-06 Insmed Incorporated Dry powder compositions of treprostinil prodrugs and methods of use thereof

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