MX2016005293A - Compuestos de prostaciclina, composiciones y metodos de uso de los mismos. - Google Patents

Compuestos de prostaciclina, composiciones y metodos de uso de los mismos.

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Publication number
MX2016005293A
MX2016005293A MX2016005293A MX2016005293A MX2016005293A MX 2016005293 A MX2016005293 A MX 2016005293A MX 2016005293 A MX2016005293 A MX 2016005293A MX 2016005293 A MX2016005293 A MX 2016005293A MX 2016005293 A MX2016005293 A MX 2016005293A
Authority
MX
Mexico
Prior art keywords
compounds
compositions
alkyl
methods
same
Prior art date
Application number
MX2016005293A
Other languages
English (en)
Other versions
MX378013B (es
Inventor
Perkins Walter
Malinin Vladimir
LEIFER Franziska
Konicek Donna
Li Zhili
Plaunt Adam
Original Assignee
Insmed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insmed Inc filed Critical Insmed Inc
Publication of MX2016005293A publication Critical patent/MX2016005293A/es
Publication of MX378013B publication Critical patent/MX378013B/es

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    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
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    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
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Abstract

Se proporcionan en la presente compuestos y composiciones de prostaciclina que comprenden los mismos. Específicamente, se describen compuestos de prostaciclina que comprende treprostinil covalentemente ligado a un alquilo C5-C18 lineal, alquilo C5-C18 ramificado, alquenilo C2-C18 lineal, alquenilo C3-C18 ramificado, arilo, aril-alquilo C1-C18 o un aminoácido o un péptido (por ejemplo, dipéptido, tripéptido, tetrapéptido). La unión, en una modalidad, es por medio de un carbamato, amida o enlace de éster. Los compuestos de prostaciclina proporcionados en la presente también pueden incluir al menos un átomo de hidrógeno substituido con al menos un átomo de deuterio. También se proporcionan métodos para tratar hipertensión pulmonar (por ejemplo, hipertensión arterial pulmonar) e hipertensión portopulmonar.
MX2016005293A 2013-10-25 2014-10-24 Ésteres alquílicos de treprostinil que tienen una longuitud de cadena de c14 a c18,y el uso de los mismos para el tratamiento de la hipertensión pulmonar. MX378013B (es)

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US201361895680P 2013-10-25 2013-10-25
US201361910703P 2013-12-02 2013-12-02
US201461950967P 2014-03-11 2014-03-11
US201462028758P 2014-07-24 2014-07-24
US201462042123P 2014-08-26 2014-08-26
PCT/US2014/062232 WO2015061720A2 (en) 2013-10-25 2014-10-24 Prostacyclin compounds, compositions and methods of use thereof

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